FI906438L - Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi Download PDF

Info

Publication number: FI906438L
Authority: FI; Finland
Prior art keywords: steroid; carboxylic acid; acid derivatives; therapeutically useful; preparing novel
Prior art date: 1989-12-29

Application number

FI906438A

Other languages

English (en)

Swedish (sv)

Other versions

FI94418B (fi

FI906438A0 (fi

FI94418C (fi

Inventor

Gary Alan Flynn

Philippe Bey

Thomas Robert Blohm

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-29

Filing date

1990-12-28

Publication date

1991-06-30

1990-12-28 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-12-28 Publication of FI906438A0 publication Critical patent/FI906438A0/fi

1991-06-30 Publication of FI906438L publication Critical patent/FI906438L/fi

1995-05-31 Publication of FI94418B publication Critical patent/FI94418B/fi

1995-09-11 Application granted granted Critical

1995-09-11 Publication of FI94418C publication Critical patent/FI94418C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI906438A 1989-12-29 1990-12-28 Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi FI94418C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US45886989A	1989-12-29	1989-12-29
US45886989		1989-12-29
US58075990		1990-09-11
US07/580,759 US5100917A (en)	1989-12-29	1990-09-11	Novel a-nor-steroid-3-carboxylic acid derivatives

Publications (4)

Publication Number	Publication Date
FI906438A0 FI906438A0 (fi)	1990-12-28
FI906438L true FI906438L (fi)	1991-06-30
FI94418B FI94418B (fi)	1995-05-31
FI94418C FI94418C (fi)	1995-09-11

Family

ID=27039140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI906438A FI94418C (fi)	1989-12-29	1990-12-28	Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi

Country Status (20)

Country	Link
US (1)	US5100917A (fi)
EP (1)	EP0435321B1 (fi)
JP (1)	JP3039996B2 (fi)
KR (3)	KR0178468B1 (fi)
CN (4)	CN1033809C (fi)
AT (1)	ATE126232T1 (fi)
AU (1)	AU634326B2 (fi)
CA (1)	CA2033392C (fi)
DE (1)	DE69021530T2 (fi)
DK (1)	DK0435321T3 (fi)
ES (1)	ES2078291T3 (fi)
FI (1)	FI94418C (fi)
GR (1)	GR3017559T3 (fi)
HU (1)	HU210340B (fi)
IE (1)	IE67511B1 (fi)
IL (1)	IL96790A (fi)
MX (1)	MX9203338A (fi)
NO (1)	NO180719C (fi)
NZ (1)	NZ236589A (fi)
PT (1)	PT96394B (fi)

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CA2126203A1 (en) *	1991-12-20	1993-07-08	Stephen V. Frye	Inhibitors of 5-alpha-testosterone reductase
HUT71514A (en) *	1992-05-21	1995-12-28	Endorecherche Inc	Inhibitors of testosterone 5 alfa-reductase activity and pharmaceutical compositions containing the same
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
US5561124A (en) *	1992-11-18	1996-10-01	Webb; Robert L.	17-α-acyl steroids which inhibit 5-α-reductase
GB9224148D0 (en) *	1992-11-18	1993-01-06	Smithkline Beecham Corp	Compounds
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US8512718B2 (en)	2000-07-03	2013-08-20	Foamix Ltd.	Pharmaceutical composition for topical application
IL152486A0 (en)	2002-10-25	2003-05-29	Meir Eini	Alcohol-free cosmetic and pharmaceutical foam carrier
US8486376B2 (en)	2002-10-25	2013-07-16	Foamix Ltd.	Moisturizing foam containing lanolin
EP1556009B2 (en)	2002-10-25	2021-07-21	Foamix Pharmaceuticals Ltd.	Cosmetic and pharmaceutical foam
US7700076B2 (en)	2002-10-25	2010-04-20	Foamix, Ltd.	Penetrating pharmaceutical foam
US8119109B2 (en) *	2002-10-25	2012-02-21	Foamix Ltd.	Foamable compositions, kits and methods for hyperhidrosis
US9265725B2 (en)	2002-10-25	2016-02-23	Foamix Pharmaceuticals Ltd.	Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20080138296A1 (en)	2002-10-25	2008-06-12	Foamix Ltd.	Foam prepared from nanoemulsions and uses
US7820145B2 (en) *	2003-08-04	2010-10-26	Foamix Ltd.	Oleaginous pharmaceutical and cosmetic foam
US8900554B2 (en)	2002-10-25	2014-12-02	Foamix Pharmaceuticals Ltd.	Foamable composition and uses thereof
US10117812B2 (en)	2002-10-25	2018-11-06	Foamix Pharmaceuticals Ltd.	Foamable composition combining a polar solvent and a hydrophobic carrier
US7704518B2 (en) *	2003-08-04	2010-04-27	Foamix, Ltd.	Foamable vehicle and pharmaceutical compositions thereof
US8119150B2 (en)	2002-10-25	2012-02-21	Foamix Ltd.	Non-flammable insecticide composition and uses thereof
US9668972B2 (en) *	2002-10-25	2017-06-06	Foamix Pharmaceuticals Ltd.	Nonsteroidal immunomodulating kit and composition and uses thereof
US9211259B2 (en)	2002-11-29	2015-12-15	Foamix Pharmaceuticals Ltd.	Antibiotic kit and composition and uses thereof
US7575739B2 (en)	2003-04-28	2009-08-18	Foamix Ltd.	Foamable iodine composition
FR2857968B1 (fr) *	2003-07-25	2006-02-03	Inovat Sarl	Nouveaux derives steroides et leurs utilisations therapeuthique
US8795693B2 (en)	2003-08-04	2014-08-05	Foamix Ltd.	Compositions with modulating agents
US8486374B2 (en)	2003-08-04	2013-07-16	Foamix Ltd.	Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
BRPI0612448A2 (pt) *	2005-05-09	2010-11-23	Foamix Ltd	composição espumosa de sacarìdeo
US20080152596A1 (en) *	2005-07-19	2008-06-26	Foamix Ltd.	Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US20080260655A1 (en) *	2006-11-14	2008-10-23	Dov Tamarkin	Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2009007785A2 (en) *	2006-11-14	2009-01-15	Foamix Ltd.	Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
US8636982B2 (en)	2007-08-07	2014-01-28	Foamix Ltd.	Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en)	2007-11-30	2016-09-13	Foamix Pharmaceuticals Ltd.	Foam containing benzoyl peroxide
WO2010041141A2 (en)	2008-10-07	2010-04-15	Foamix Ltd.	Oil-based foamable carriers and formulations
WO2009072007A2 (en)	2007-12-07	2009-06-11	Foamix Ltd.	Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
CA2712120A1 (en) *	2008-01-14	2009-07-23	Foamix Ltd.	Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US20120087872A1 (en)	2009-04-28	2012-04-12	Foamix Ltd.	Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
WO2011013008A2 (en)	2009-07-29	2011-02-03	Foamix Ltd.	Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en)	2009-07-29	2011-02-03	Foamix Ltd.	Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US10029013B2 (en)	2009-10-02	2018-07-24	Foamix Pharmaceuticals Ltd.	Surfactant-free, water-free formable composition and breakable foams and their uses
US9849142B2 (en)	2009-10-02	2017-12-26	Foamix Pharmaceuticals Ltd.	Methods for accelerated return of skin integrity and for the treatment of impetigo
JP5527236B2 (ja) *	2011-01-31	2014-06-18	信越化学工業株式会社	ポジ型化学増幅レジスト材料、パターン形成方法及び酸分解性ケトエステル化合物
MX2020012139A (es)	2016-09-08	2021-01-29	Vyne Pharmaceuticals Inc	Composiciones y metodos para tratar rosacea y acne.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3336338A (en) *	1963-09-13	1967-08-15	Squibb & Sons Inc	A-nor-cholestatriene-21-oic acid 21->24 lactones
US3600425A (en) *	1963-09-13	1971-08-17	Squibb & Sons Inc	Synthesis of steroids
US3484476A (en) *	1963-09-13	1969-12-16	Squibb & Sons Inc	A-nor steroids
US3424751A (en) *	1965-10-20	1969-01-28	Du Pont	Selected 2-formyl-and 2alpha-(cyanoamidino)-a-nor-5alpha-androstane derivatives
US3492359A (en) *	1966-01-14	1970-01-27	Squibb & Sons Inc	11,12-oxo and/or oxy substituted a-norpregnenes
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1990
- 1990-09-11 US US07/580,759 patent/US5100917A/en not_active Expired - Fee Related
- 1990-12-21 NZ NZ236589A patent/NZ236589A/xx unknown
- 1990-12-26 IL IL9679090A patent/IL96790A/en not_active IP Right Cessation
- 1990-12-27 NO NO905608A patent/NO180719C/no not_active IP Right Cessation
- 1990-12-27 CN CN90110188A patent/CN1033809C/zh not_active Expired - Fee Related
- 1990-12-27 AU AU68447/90A patent/AU634326B2/en not_active Ceased
- 1990-12-28 DE DE69021530T patent/DE69021530T2/de not_active Expired - Fee Related
- 1990-12-28 FI FI906438A patent/FI94418C/fi not_active IP Right Cessation
- 1990-12-28 DK DK90125681.8T patent/DK0435321T3/da active
- 1990-12-28 HU HU908495A patent/HU210340B/hu not_active IP Right Cessation
- 1990-12-28 IE IE472090A patent/IE67511B1/en not_active IP Right Cessation
- 1990-12-28 EP EP90125681A patent/EP0435321B1/en not_active Expired - Lifetime
- 1990-12-28 AT AT90125681T patent/ATE126232T1/de not_active IP Right Cessation
- 1990-12-28 KR KR1019900023009A patent/KR0178468B1/ko not_active Expired - Fee Related
- 1990-12-28 PT PT96394A patent/PT96394B/pt not_active IP Right Cessation
- 1990-12-28 ES ES90125681T patent/ES2078291T3/es not_active Expired - Lifetime
- 1990-12-28 CA CA002033392A patent/CA2033392C/en not_active Expired - Fee Related
- 1990-12-28 JP JP2415397A patent/JP3039996B2/ja not_active Expired - Fee Related
1992
- 1992-06-29 MX MX9203338A patent/MX9203338A/es unknown
1994
- 1994-12-21 CN CN94119555A patent/CN1127256A/zh active Pending
- 1994-12-21 CN CN94119557A patent/CN1127258A/zh active Pending
- 1994-12-21 CN CN94119556A patent/CN1036200C/zh not_active Expired - Fee Related
1995
- 1995-09-28 GR GR950402672T patent/GR3017559T3/el unknown
1998
- 1998-09-29 KR KR1019980040652A patent/KR0178471B1/ko not_active Expired - Fee Related
- 1998-09-29 KR KR1019980040651A patent/KR0178470B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6844790A (en)	1991-07-04
CN1127256A (zh)	1996-07-24
JPH04134094A (ja)	1992-05-07
MX9203338A (es)	1992-09-01
AU634326B2 (en)	1993-02-18
IE904720A1 (en)	1991-07-17
CN1036200C (zh)	1997-10-22
EP0435321A2 (en)	1991-07-03
NO180719B (no)	1997-02-24
IE67511B1 (en)	1996-04-03
HUT56379A (en)	1991-08-28
EP0435321B1 (en)	1995-08-09
CN1127258A (zh)	1996-07-24
KR910011887A (ko)	1991-08-07
FI94418B (fi)	1995-05-31
HU210340B (en)	1995-03-28
CA2033392C (en)	2002-08-27
GR3017559T3 (en)	1995-12-31
DE69021530D1 (de)	1995-09-14
PT96394B (pt)	1998-10-30
NO905608L (no)	1991-07-01
DK0435321T3 (da)	1995-09-18
FI906438A0 (fi)	1990-12-28
CA2033392A1 (en)	1991-06-30
NO180719C (no)	1997-06-04
CN1033809C (zh)	1997-01-15
ATE126232T1 (de)	1995-08-15
KR0178468B1 (ko)	1999-04-01
ES2078291T3 (es)	1995-12-16
CN1127257A (zh)	1996-07-24
IL96790A0 (en)	1991-09-16
JP3039996B2 (ja)	2000-05-08
US5100917A (en)	1992-03-31
PT96394A (pt)	1991-10-15
FI94418C (fi)	1995-09-11
DE69021530T2 (de)	1996-02-01
NZ236589A (en)	1993-02-25
KR0178471B1 (ko)	1999-04-01
KR0178470B1 (ko)	1999-04-01
IL96790A (en)	1995-03-15
CN1052866A (zh)	1991-07-10
NO905608D0 (no)	1990-12-27
HU908495D0 (en)	1991-07-29
EP0435321A3 (en)	1992-04-29

Publication	Publication Date	Title
FI906438L (fi)	1991-06-30	Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
FI885409A7 (fi)	1989-05-24	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridatsiiniamiinijohdannaisten valmistamiseksi
FI883249A7 (fi)	1989-01-11	Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
FI890282L (fi)	1989-07-21	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
PT88596A (pt)	1988-10-01	Process for preparing 2-anilinopyrimidine derivatives useful aspesticidas
FI881180L (fi)	1988-09-14	Menetelmä terapeuttisesti käytettävien tetrahydronaftaleenijohdannaisten valmistamiseksi
FI892881A7 (fi)	1989-12-14	Menetelmä terapeuttisesti käyttökelpoisten aminohappojohdannaisten va lmistamiseksi
FI905941A7 (fi)	1991-06-07	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten 2-asyyliaminotiatsolijohdannaisten valmistamiseksi
FI882638L (fi)	1988-12-06	Menetelmä terapeuttisesti käyttökelpoisten booriaminohappojohdannaisten valmistamiseksi
FI893467L (fi)	1990-01-21	Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
FI880816A7 (fi)	1988-09-24	Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliinijohdannaisten valmistamiseksi
FI883050L (fi)	1988-12-25	Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi
FI894217L (fi)	1990-03-08	1-adamantaanijohdannaisten valmistusmenetelmä
FI883632L (fi)	1989-02-05	Menetelmä uusien, terapeuttisesti käyttökelpoisten eetterien valmistamiseksi
FI873350A7 (fi)	1988-02-05	Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI883603A7 (fi)	1989-02-04	Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI884627A7 (fi)	1989-04-10	Menetelmä uusien terapeuttisesti käyttökelpoisten dideoksisytidiinijohdannaisten valmistamiseksi
FI880467A7 (fi)	1988-08-05	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
FI883672A7 (fi)	1989-02-08	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI884910A7 (fi)	1989-04-28	Menetelmä terapeuttisesti käyttökelpoisten bentsopyraanijohdannaisten valmistamiseksi
FI881525A7 (fi)	1988-10-02	Menetelmä uusien terapeuttisesti käyttökelpoisten N-aryylipiperatsiiniasetamidijohdannaisten valmistamiseksi
FI885560A7 (fi)	1988-11-30	Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
FI893003L (fi)	1989-12-21	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FI884660L (fi)	1989-04-13	Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
FI906101A7 (fi)	1991-06-21	Menetelmä 6-hydroksinikotiinihapon valmistamiseksi

Legal Events

Date	Code	Title	Description
1995-05-02	BB	Publication of examined application
2004-08-31	FG	Patent granted	Owner name: MERRELL DOW PHARMACEUTICALS INC.
2005-06-30	MA	Patent expired