IS3378A7 - 1,4 - Dihydropyridines, og aðferð við framleiðslu þess svo og notkun þess í lækningaskyni - Google Patents

1,4 - Dihydropyridines, og aðferð við framleiðslu þess svo og notkun þess í lækningaskyni

Info

Publication number: IS3378A7
Authority: IS; Iceland
Prior art keywords: methyl; dihydropyridines; manufacture; well; therapeutic use
Prior art date: 1987-08-03

Application number

IS3378A

Other languages

English (en)

Other versions

IS1549B (is

Inventor

Fernandez Torija Carlos

Alvaro Galiano Ramos Joaquin

Original Assignee

Almirall-Prodesfarma, S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-03

Filing date

1988-08-02

Publication date

1989-02-04

1988-08-02 Application filed by Almirall-Prodesfarma, S.A. filed Critical Almirall-Prodesfarma, S.A.

1989-02-04 Publication of IS3378A7 publication Critical patent/IS3378A7/is

1994-06-08 Publication of IS1549B publication Critical patent/IS1549B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IS3378A 1987-08-03 1988-08-02 1,4 - Dihydropyridines, og aðferð við framleiðsluþess svo og notkun þess í lækningaskyni IS1549B (is)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP87401799A EP0302980B1 (fr)	1987-08-03	1987-08-03	1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (2)

Publication Number	Publication Date
IS3378A7 true IS3378A7 (is)	1989-02-04
IS1549B IS1549B (is)	1994-06-08

Family

ID=8198243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS3378A IS1549B (is)	1987-08-03	1988-08-02	1,4 - Dihydropyridines, og aðferð við framleiðsluþess svo og notkun þess í lækningaskyni

Country Status (34)

Country	Link
US (1)	US4952592A (is)
EP (1)	EP0302980B1 (is)
JP (1)	JPH0733383B2 (is)
KR (1)	KR960001724B1 (is)
CN (1)	CN1038587C (is)
AT (1)	ATE61588T1 (is)
BE (1)	BE1001055A4 (is)
CA (2)	CA1306261C (is)
CH (1)	CH675999A5 (is)
CZ (1)	CZ282077B6 (is)
DD (1)	DD282008A5 (is)
DE (2)	DE3768658D1 (is)
DK (1)	DK430288A (is)
ES (1)	ES2007543A6 (is)
FI (1)	FI91406C (is)
GB (1)	GB2208861B (is)
GR (2)	GR880100507A (is)
HU (1)	HU204523B (is)
IE (1)	IE60358B1 (is)
IL (1)	IL87321A (is)
IN (1)	IN167550B (is)
IS (1)	IS1549B (is)
IT (1)	IT1235013B (is)
LU (1)	LU87297A1 (is)
MA (1)	MA21344A1 (is)
NO (1)	NO170934C (is)
NZ (1)	NZ225661A (is)
PH (1)	PH25645A (is)
PT (1)	PT88173B (is)
RU (1)	RU2036922C1 (is)
SK (1)	SK541388A3 (is)
TN (1)	TNSN88081A1 (is)
YU (1)	YU46547B (is)
ZA (1)	ZA885684B (is)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5242933A (en) *	1990-07-10	1993-09-07	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
ES2166462T3 (es) *	1995-08-02	2002-04-16	Smithkline Beecham Corp	Antagonistas del receptor de la endotelina.
RU2168987C2 (ru) *	1997-04-15	2001-06-20	Санкт-Петербургская Государственная Химико-Фармацевтическая Академия	Гипотензивное средство
RU2155036C2 (ru) *	1998-11-11	2000-08-27	Азад Зияд Оглы Абышев	Средство для лечения ишемической болезни сердца
IT1304513B1 (it) *	1998-12-30	2001-03-19	Endura Spa	Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
NZ521853A (en) *	2000-04-11	2003-11-28	Sankyo Co	Stabilized pharmaceutical compositions containing a calcium blocker
RU2187303C2 (ru) *	2000-10-12	2002-08-20	Азад Зияд Оглы Абышев	Способ получения таблеток диуманкала - forte по 0,01 г
AU2003250483A1 (en)	2002-08-19	2004-03-11	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
WO2006014930A2 (en) *	2004-07-26	2006-02-09	Cotherix, Inc.	Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP2111863B1 (en)	2005-10-26	2012-03-28	Asahi Kasei Pharma Corporation	Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
ES2382009T3 (es)	2006-12-01	2012-06-04	Bristol-Myers Squibb Company	Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
US8883844B2 (en)	2010-09-24	2014-11-11	Nitrogenix Inc.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
BR112015026513A2 (pt)	2013-04-17	2017-07-25	Pfizer	derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
FI3911648T3 (fi)	2019-01-18	2025-01-10	Astrazeneca Ab	6'-[[[(1s,3s)-3-[[5-(difluorometoksi)-2-pyrimidinyyli]amino]syklopentyyli]amino][1(2h),3'-bipyridin]-2-oni pcsk9:n estäjänä ja menetelmät sen käyttöön

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3441648A (en) *	1967-02-07	1969-04-29	Smithkline Corp	Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) *	1972-04-18	1977-06-21	Bayer Aktiengesellschaft	1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) *	1982-10-27	1984-05-04	Yoshitomi Pharmaceut Ind Ltd	１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES8507495A1 (es) *	1984-03-27	1985-09-01	Inst Investigacion Desarrollo	Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) *	1984-03-27	1993-04-21	Delagrange Lab	1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) *	1985-02-26	1994-02-02	富山化学工業株式会社	新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) *	1984-09-01	1989-06-07	FISONS plc	Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) *	1987-03-05	1989-08-21	Yamanouchi Pharmaceut Co Ltd	ピリジン誘導体及び該化合物を含有する肝疾患治療剤

1987
- 1987-08-03 AT AT87401799T patent/ATE61588T1/de active
- 1987-08-03 DE DE8787401799T patent/DE3768658D1/de not_active Expired - Lifetime
- 1987-08-03 EP EP87401799A patent/EP0302980B1/fr not_active Expired - Lifetime
1988
- 1988-07-27 LU LU87297A patent/LU87297A1/fr unknown
- 1988-07-29 YU YU147088A patent/YU46547B/sh unknown
- 1988-07-29 DE DE3825962A patent/DE3825962A1/de not_active Withdrawn
- 1988-07-29 CA CA000573422A patent/CA1306261C/fr not_active Expired - Lifetime
- 1988-08-01 MA MA21587A patent/MA21344A1/fr unknown
- 1988-08-01 DD DD88318537A patent/DD282008A5/de not_active IP Right Cessation
- 1988-08-01 FI FI883603A patent/FI91406C/fi not_active IP Right Cessation
- 1988-08-01 NO NO883406A patent/NO170934C/no unknown
- 1988-08-01 JP JP63192591A patent/JPH0733383B2/ja not_active Expired - Lifetime
- 1988-08-02 GB GB8818356A patent/GB2208861B/en not_active Expired - Lifetime
- 1988-08-02 CN CN88106537A patent/CN1038587C/zh not_active Expired - Fee Related
- 1988-08-02 PT PT88173A patent/PT88173B/pt not_active IP Right Cessation
- 1988-08-02 CZ CS885413A patent/CZ282077B6/cs not_active IP Right Cessation
- 1988-08-02 DK DK430288A patent/DK430288A/da not_active Application Discontinuation
- 1988-08-02 IT IT8848259A patent/IT1235013B/it active
- 1988-08-02 IL IL87321A patent/IL87321A/xx not_active IP Right Cessation
- 1988-08-02 IS IS3378A patent/IS1549B/is unknown
- 1988-08-02 TN TNTNSN88081A patent/TNSN88081A1/fr unknown
- 1988-08-02 SK SK5413-88A patent/SK541388A3/sk unknown
- 1988-08-02 KR KR1019880009867A patent/KR960001724B1/ko not_active Expired - Fee Related
- 1988-08-02 CH CH2922/88A patent/CH675999A5/fr not_active IP Right Cessation
- 1988-08-02 US US07/227,373 patent/US4952592A/en not_active Expired - Fee Related
- 1988-08-02 BE BE8800893A patent/BE1001055A4/fr not_active IP Right Cessation
- 1988-08-02 HU HU884065A patent/HU204523B/hu not_active IP Right Cessation
- 1988-08-02 IE IE236488A patent/IE60358B1/en not_active IP Right Cessation
- 1988-08-02 NZ NZ225661A patent/NZ225661A/xx unknown
- 1988-08-02 ES ES8802413A patent/ES2007543A6/es not_active Expired
- 1988-08-02 GR GR880100507A patent/GR880100507A/el unknown
- 1988-08-03 ZA ZA885684A patent/ZA885684B/xx unknown
- 1988-08-03 IN IN556/MAS/88A patent/IN167550B/en unknown
- 1988-08-03 PH PH37337A patent/PH25645A/en unknown
1990
- 1990-08-28 CA CA000615848A patent/CA1306262C/fr not_active Expired - Lifetime
1991
- 1991-05-22 GR GR91400660T patent/GR3001984T3/el unknown
1992
- 1992-03-31 RU SU925011204A patent/RU2036922C1/ru active

Also Published As

Publication number	Publication date
FI883603A7 (fi)	1989-02-04
TNSN88081A1 (fr)	1990-07-10
PT88173B (pt)	1995-03-01
IE882364L (en)	1989-02-03
KR960001724B1 (ko)	1996-02-03
CZ282077B6 (cs)	1997-05-14
RU2036922C1 (ru)	1995-06-09
DE3825962A1 (de)	1989-02-16
NO170934B (no)	1992-09-21
GB2208861A (en)	1989-04-19
IT8848259A0 (it)	1988-08-02
CN1038587C (zh)	1998-06-03
NZ225661A (en)	1990-08-28
FI91406C (fi)	1994-06-27
IL87321A0 (en)	1989-01-31
CZ541388A3 (en)	1997-01-15
GR880100507A (el)	1989-05-25
DD282008A5 (de)	1990-08-29
GR3001984T3 (en)	1992-11-23
KR890003743A (ko)	1989-04-17
YU46547B (sh)	1993-11-16
NO883406L (no)	1989-02-06
SK278775B6 (sk)	1998-02-04
YU147088A (en)	1990-04-30
GB8818356D0 (en)	1988-09-07
NO170934C (no)	1992-12-30
ZA885684B (en)	1989-04-26
PT88173A (pt)	1989-06-30
PH25645A (en)	1991-08-21
IT1235013B (it)	1992-06-16
LU87297A1 (fr)	1989-02-02
EP0302980B1 (fr)	1991-03-13
CA1306261C (fr)	1992-08-11
EP0302980A1 (fr)	1989-02-15
IN167550B (is)	1990-11-10
HU204523B (en)	1992-01-28
ATE61588T1 (de)	1991-03-15
DK430288A (da)	1989-02-03
JPH0733383B2 (ja)	1995-04-12
IS1549B (is)	1994-06-08
GB2208861B (en)	1991-07-17
CA1306262C (fr)	1992-08-11
DK430288D0 (da)	1988-08-02
MA21344A1 (fr)	1989-04-01
FI883603A0 (fi)	1988-08-01
IL87321A (en)	1993-04-04
JPH01294675A (ja)	1989-11-28
AU2033088A (en)	1989-02-09
NO883406D0 (no)	1988-08-01
DE3768658D1 (de)	1991-04-18
HUT54142A (en)	1991-01-28
SK541388A3 (en)	1998-02-04
AU606441B2 (en)	1991-02-07
US4952592A (en)	1990-08-28
IE60358B1 (en)	1994-06-29
CH675999A5 (en)	1990-11-30
ES2007543A6 (es)	1989-06-16
BE1001055A4 (fr)	1989-06-20
FI91406B (fi)	1994-03-15
CN1031531A (zh)	1989-03-08

Publication	Publication Date	Title
IS1549B (is)	1994-06-08	1,4 - Dihydropyridines, og aðferð við framleiðsluþess svo og notkun þess í lækningaskyni
NO963506L (no)	1996-10-22	4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler
FI900307A0 (fi)	1990-01-19	Menetelmä valmistaa terapeuttisesti aktiivista 3-/3-okso-(2,3)-dihydropyridatsin-6-yyli/-2-fenyyli-pyratsolo/1,5-a/pyridiinijohdannaisia
DK84088A (da)	1988-08-21	Naphthalenderivater med anvendelse som antiallergiske og antiinflammatoriske midler
HUT47580A (en)	1989-03-28	Process for production of tricycle oxindole derivatives decreasing inflammation
FI99013B (fi)	1997-06-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi
DE3566263D1 (de)	1988-12-22	Novel cyanoimidazole nucleoside derivatives
FI810103L (fi)	1981-07-17	Nya 2,3-dihydro-imidazo /1,2-b/ pyridazinderivat foerfarande foer deras framstaellning och deras terapeutiska anvaendning
SE8605255D0 (sv)	1986-12-08	4h-benzo(4,5)cyclohepta(1,2-b)thiophene derivatives
NO176277C (no)	1995-03-08	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder
HUT45255A (en)	1988-06-28	Process for producing furo/3,4-b/pyridine derivatives and pharmaceutical compositions comprising these compounds
PL293117A1 (en)	1992-12-28	Method of obtaining substituted alkenic acid and its derivatives
PT83883A (en)	1987-01-01	Process for the preparation of 4h-benzo]4,5"cyclohepta]1,2-b"thiophene derivatives
PT79509A (en)	1984-12-01	Method for preparing diphenylsulfide derivatives
JPS52112626A (en)	1977-09-21	Production of dioxopyrazolopyridine