FI117160B - Nestemäiset HCG-koostumukset - Google Patents
Nestemäiset HCG-koostumukset Download PDFInfo
- Publication number
- FI117160B FI117160B FI973745A FI973745A FI117160B FI 117160 B FI117160 B FI 117160B FI 973745 A FI973745 A FI 973745A FI 973745 A FI973745 A FI 973745A FI 117160 B FI117160 B FI 117160B
- Authority
- FI
- Finland
- Prior art keywords
- hcg
- rec
- buffer
- pharmaceutical composition
- mannitol
- Prior art date
Links
- 102000011022 Chorionic Gonadotropin Human genes 0.000 title claims abstract description 7
- 108010062540 Chorionic Gonadotropin Proteins 0.000 title claims abstract description 7
- 229940084986 human chorionic gonadotropin Drugs 0.000 title claims abstract description 7
- 230000003019 stabilising effect Effects 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 239000000594 mannitol Substances 0.000 claims abstract description 26
- 235000010355 mannitol Nutrition 0.000 claims abstract description 26
- 229930195725 Mannitol Natural products 0.000 claims abstract description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 24
- 239000008363 phosphate buffer Substances 0.000 claims abstract description 16
- 239000000872 buffer Substances 0.000 claims abstract description 12
- 239000008362 succinate buffer Substances 0.000 claims abstract description 12
- 239000008351 acetate buffer Substances 0.000 claims abstract description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000011550 stock solution Substances 0.000 claims description 7
- 239000007853 buffer solution Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000008366 buffered solution Substances 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 abstract description 16
- 239000005720 sucrose Substances 0.000 abstract description 16
- 150000005846 sugar alcohols Polymers 0.000 abstract description 5
- 125000000185 sucrose group Chemical group 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 22
- 239000000203 mixture Substances 0.000 description 21
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 15
- 238000011993 High Performance Size Exclusion Chromatography Methods 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 7
- 235000011007 phosphoric acid Nutrition 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 4
- 102000006771 Gonadotropins Human genes 0.000 description 4
- 108010086677 Gonadotropins Proteins 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000002622 gonadotropin Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000004007 reversed phase HPLC Methods 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000012669 liquid formulation Substances 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- DTAFLBZLAZYRDX-UHFFFAOYSA-N OOOOOO Chemical compound OOOOOO DTAFLBZLAZYRDX-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 2
- XQJMXPAEFMWDOZ-UHFFFAOYSA-N 3exo-benzoyloxy-tropane Natural products CN1C(C2)CCC1CC2OC(=O)C1=CC=CC=C1 XQJMXPAEFMWDOZ-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- IEFJWDNGDZAYNZ-BYPYZUCNSA-N Gly-Glu Chemical compound NCC(=O)N[C@H](C(O)=O)CCC(O)=O IEFJWDNGDZAYNZ-BYPYZUCNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010002311 N-glycylglutamic acid Proteins 0.000 description 1
- QQXLDOJGLXJCSE-UHFFFAOYSA-N N-methylnortropinone Natural products C1C(=O)CC2CCC1N2C QQXLDOJGLXJCSE-UHFFFAOYSA-N 0.000 description 1
- QIZDQFOVGFDBKW-DHBOJHSNSA-N Pseudotropine Natural products OC1C[C@@H]2[N+](C)[C@H](C1)CC2 QIZDQFOVGFDBKW-DHBOJHSNSA-N 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- -1 pH: · 7.0 Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI973745A FI117160B (fi) | 1995-03-21 | 1997-09-22 | Nestemäiset HCG-koostumukset |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP9501055 | 1995-03-21 | ||
| PCT/EP1995/001055 WO1996029095A1 (fr) | 1995-03-21 | 1995-03-21 | Compositions liquides de gonadotrophine chorionique de l'homme |
| FI973745A FI117160B (fi) | 1995-03-21 | 1997-09-22 | Nestemäiset HCG-koostumukset |
| FI973745 | 1997-09-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI973745A0 FI973745A0 (fi) | 1997-09-22 |
| FI973745L FI973745L (fi) | 1997-11-11 |
| FI117160B true FI117160B (fi) | 2006-07-14 |
Family
ID=8165977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973745A FI117160B (fi) | 1995-03-21 | 1997-09-22 | Nestemäiset HCG-koostumukset |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6706681B1 (fr) |
| EP (1) | EP0814841B1 (fr) |
| JP (1) | JP4165718B2 (fr) |
| KR (1) | KR100377967B1 (fr) |
| AT (1) | ATE209930T1 (fr) |
| AU (1) | AU707796B2 (fr) |
| BR (1) | BR9510567A (fr) |
| DE (1) | DE69524456T2 (fr) |
| DK (1) | DK0814841T3 (fr) |
| ES (1) | ES2166841T3 (fr) |
| FI (1) | FI117160B (fr) |
| NO (1) | NO318997B1 (fr) |
| PT (1) | PT814841E (fr) |
| UA (1) | UA61053C2 (fr) |
| WO (1) | WO1996029095A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319504B1 (en) | 1996-06-24 | 2001-11-20 | University Of Maryland Biotechnology Institute | Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin |
| TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| EP0972520B9 (fr) * | 1997-01-30 | 2006-03-22 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Composition lyophilisee de mp52 humaine de proteines morphogenetiques osseuses |
| HU1300063D0 (hu) | 2000-02-22 | 2003-03-28 | Serono Lab | Tisztított hCG |
| EP1336410A4 (fr) * | 2000-08-04 | 2005-10-12 | Chugai Pharmaceutical Co Ltd | Preparations proteiniques a injecter |
| FR2869979B1 (fr) * | 2004-05-06 | 2006-08-04 | Packinox Sa | Echangeur thermique a plaques |
| KR101105871B1 (ko) * | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
| KR20080106636A (ko) * | 2007-06-04 | 2008-12-09 | 동아제약주식회사 | 사람 융모성 성선자극호르몬 함유 즉시 사용형 주사 용액 |
| EP2219607B1 (fr) * | 2007-11-01 | 2012-08-15 | Merck Serono S.A. | Formulations liquides de HL |
| TWI532495B (zh) * | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| WO2011108010A2 (fr) * | 2010-03-05 | 2011-09-09 | Intas Biopharmaceuticals Limited | Préparation liquide thermostable de gonadotropines |
| EP2417982A1 (fr) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilisation de gonadotrophines |
| US20120265129A1 (en) | 2011-04-15 | 2012-10-18 | Neuralight Hd, Llc | Methods for Chronic Pain Management and Treatment using HCG |
| US8680086B2 (en) | 2011-04-15 | 2014-03-25 | Neuralight Hd, Llc | Methods for chronic pain management and treatment using HCG |
| WO2014063071A1 (fr) | 2012-10-18 | 2014-04-24 | Neuralight Hd, Llc | Traitement de la dépression et du tspt |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL88233A (en) * | 1987-11-03 | 1993-08-18 | Genentech Inc | Gamma interferon formulation |
| IE64738B1 (en) * | 1990-03-20 | 1995-09-06 | Akzo Nv | Stabilized gonadotropin containing preparations |
| US5385230A (en) * | 1991-01-11 | 1995-01-31 | Minnesota Mining And Manufacturing Company | Adjustable tray assembly for use in desk drawers |
| JP2966592B2 (ja) * | 1991-07-20 | 1999-10-25 | 萩原 義秀 | 安定化されたヒトモノクローナル抗体製剤 |
| IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
-
1995
- 1995-03-21 WO PCT/EP1995/001055 patent/WO1996029095A1/fr not_active Ceased
- 1995-03-21 ES ES95944848T patent/ES2166841T3/es not_active Expired - Lifetime
- 1995-03-21 JP JP52800396A patent/JP4165718B2/ja not_active Expired - Lifetime
- 1995-03-21 AT AT95944848T patent/ATE209930T1/de active
- 1995-03-21 DE DE69524456T patent/DE69524456T2/de not_active Expired - Lifetime
- 1995-03-21 BR BR9510567A patent/BR9510567A/pt not_active IP Right Cessation
- 1995-03-21 DK DK95944848T patent/DK0814841T3/da active
- 1995-03-21 PT PT95944848T patent/PT814841E/pt unknown
- 1995-03-21 UA UA97105098A patent/UA61053C2/uk unknown
- 1995-03-21 EP EP95944848A patent/EP0814841B1/fr not_active Expired - Lifetime
- 1995-03-21 KR KR1019970706266A patent/KR100377967B1/ko not_active Expired - Lifetime
- 1995-03-21 AU AU21106/95A patent/AU707796B2/en not_active Expired
-
1997
- 1997-03-21 US US08/913,748 patent/US6706681B1/en not_active Expired - Lifetime
- 1997-09-18 NO NO19974309A patent/NO318997B1/no not_active IP Right Cessation
- 1997-09-22 FI FI973745A patent/FI117160B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1006365A1 (en) | 1999-02-26 |
| NO974309D0 (no) | 1997-09-18 |
| NO318997B1 (no) | 2005-05-30 |
| KR19980702859A (ko) | 1998-08-05 |
| EP0814841A2 (fr) | 1998-01-07 |
| PT814841E (pt) | 2002-03-28 |
| FI973745A0 (fi) | 1997-09-22 |
| EP0814841B1 (fr) | 2001-12-05 |
| NO974309L (no) | 1997-10-14 |
| WO1996029095A1 (fr) | 1996-09-26 |
| UA61053C2 (en) | 2003-11-17 |
| JPH11502205A (ja) | 1999-02-23 |
| US6706681B1 (en) | 2004-03-16 |
| KR100377967B1 (ko) | 2003-06-12 |
| DE69524456D1 (de) | 2002-01-17 |
| JP4165718B2 (ja) | 2008-10-15 |
| ES2166841T3 (es) | 2002-05-01 |
| FI973745L (fi) | 1997-11-11 |
| AU707796B2 (en) | 1999-07-22 |
| DK0814841T3 (da) | 2002-03-04 |
| DE69524456T2 (de) | 2002-08-01 |
| ATE209930T1 (de) | 2001-12-15 |
| BR9510567A (pt) | 1998-06-23 |
| AU2110695A (en) | 1996-10-08 |
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