FI102974B1 - Menetelmä optisesti aktiivisten transglysidihappoestereiden entsyaattiseksi valmistamiseksi - Google Patents
Menetelmä optisesti aktiivisten transglysidihappoestereiden entsyaattiseksi valmistamiseksiInfo
- Publication number
- FI102974B1 FI102974B1 FI935712A FI935712A FI102974B1 FI 102974 B1 FI102974 B1 FI 102974B1 FI 935712 A FI935712 A FI 935712A FI 935712 A FI935712 A FI 935712A FI 102974 B1 FI102974 B1 FI 102974B1
- Authority
- FI
- Finland
- Prior art keywords
- optically active
- acid esters
- ester
- transglycic
- trans
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 6
- 239000002253 acid Substances 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- HALONVPKHYIEQU-JGVFFNPUSA-N (2r,3s)-3-phenyloxirane-2-carboxylic acid Chemical compound OC(=O)[C@@H]1O[C@H]1C1=CC=CC=C1 HALONVPKHYIEQU-JGVFFNPUSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241001661345 Moesziomyces antarcticus Species 0.000 abstract 1
- 150000008038 benzoazepines Chemical class 0.000 abstract 1
- 150000007657 benzothiazepines Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- -1 trans-3-phenylglycidic acid ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9202208A NL9202208A (nl) | 1992-12-18 | 1992-12-18 | Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. |
| NL9202208 | 1992-12-18 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI935712A0 FI935712A0 (fi) | 1993-12-17 |
| FI935712L FI935712L (fi) | 1994-06-19 |
| FI102974B FI102974B (fi) | 1999-03-31 |
| FI102974B1 true FI102974B1 (fi) | 1999-03-31 |
Family
ID=19861657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI935712A FI102974B1 (fi) | 1992-12-18 | 1993-12-17 | Menetelmä optisesti aktiivisten transglysidihappoestereiden entsyaattiseksi valmistamiseksi |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5407828A (fi) |
| EP (1) | EP0602740B1 (fi) |
| JP (1) | JP3781788B2 (fi) |
| AT (1) | ATE176931T1 (fi) |
| CA (1) | CA2111595C (fi) |
| DE (1) | DE69323600T2 (fi) |
| DK (1) | DK0602740T3 (fi) |
| ES (1) | ES2129491T3 (fi) |
| FI (1) | FI102974B1 (fi) |
| IL (1) | IL108029A (fi) |
| NL (1) | NL9202208A (fi) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1249777B (it) * | 1990-05-17 | 1995-03-18 | Zambon Spa | Processo per la preparazione di intermedi per la sintesi del diltiazem |
| JP3610600B2 (ja) * | 1994-08-22 | 2005-01-12 | チッソ株式会社 | 光学活性エンド−２−ノルボルネオール類の製造方法 |
| ES2216495T3 (es) | 1998-02-17 | 2004-10-16 | G.D. SEARLE & CO. | Procedimiento para la resolucion enzimatica de lactamas. |
| IT1302261B1 (it) * | 1998-09-24 | 2000-09-05 | Zambon Spa | Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli |
| CN101027277A (zh) * | 2004-07-23 | 2007-08-29 | 帝斯曼知识产权资产管理有限公司 | (2r,3r)－2－羟基－3－氨基－3－芳基－丙酰胺和(2r,3r)－2－羟基－3－氨基－3－芳基－丙酸烷基酯的制备方法 |
| CN107446960A (zh) * | 2017-09-30 | 2017-12-08 | 湖南理工学院 | 一种采用生物酶催化立体选择性拆分2,3‑二苯基丙酸对映体的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE117018T1 (de) * | 1986-10-17 | 1995-01-15 | Novo Nordisk As | Positionsmässig nicht spezifische lipase von candida-arten; verfahren für ihre herstellung und ihre verwendung. |
| US5273898A (en) * | 1986-10-17 | 1993-12-28 | Noro Nordisk A/S | Thermally stable and positionally non-specific lipase isolated from Candida |
| JP2641935B2 (ja) * | 1987-09-28 | 1997-08-20 | ノボ‐ノルディスク アクティーゼルスカブ | リパーゼの固定化方法 |
| NL8801311A (nl) * | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
| IL91453A0 (en) * | 1988-09-02 | 1990-04-29 | Tanabe Seiyaku Co | Preparation of optically active 3-phenyl-glycidic acid esters |
| US6521445B1 (en) * | 1988-10-26 | 2003-02-18 | Sepracor, Inc. | Process for preparing optically active glycidate esters |
| US5244803A (en) * | 1989-09-13 | 1993-09-14 | Tanabe Seiyaku Co., Ltd. | Process for preparing optically active 3-phenylglycidic acid esters |
| FR2672600B1 (fr) * | 1991-02-08 | 1994-10-14 | Synthelabo | Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle. |
-
1992
- 1992-12-18 NL NL9202208A patent/NL9202208A/nl not_active Application Discontinuation
-
1993
- 1993-12-13 US US08/165,344 patent/US5407828A/en not_active Expired - Lifetime
- 1993-12-13 AT AT93203495T patent/ATE176931T1/de active
- 1993-12-13 ES ES93203495T patent/ES2129491T3/es not_active Expired - Lifetime
- 1993-12-13 EP EP93203495A patent/EP0602740B1/en not_active Expired - Lifetime
- 1993-12-13 DK DK93203495T patent/DK0602740T3/da active
- 1993-12-13 DE DE69323600T patent/DE69323600T2/de not_active Expired - Lifetime
- 1993-12-15 IL IL10802993A patent/IL108029A/en not_active IP Right Cessation
- 1993-12-16 JP JP31669193A patent/JP3781788B2/ja not_active Expired - Fee Related
- 1993-12-16 CA CA002111595A patent/CA2111595C/en not_active Expired - Fee Related
- 1993-12-17 FI FI935712A patent/FI102974B1/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| JP3781788B2 (ja) | 2006-05-31 |
| CA2111595A1 (en) | 1994-06-19 |
| FI935712A0 (fi) | 1993-12-17 |
| FI935712L (fi) | 1994-06-19 |
| US5407828A (en) | 1995-04-18 |
| FI102974B (fi) | 1999-03-31 |
| JPH06335399A (ja) | 1994-12-06 |
| DK0602740T3 (da) | 1999-09-27 |
| DE69323600D1 (de) | 1999-04-01 |
| IL108029A (en) | 1998-09-24 |
| IL108029A0 (en) | 1994-04-12 |
| EP0602740A1 (en) | 1994-06-22 |
| NL9202208A (nl) | 1994-07-18 |
| DE69323600T2 (de) | 1999-09-23 |
| ES2129491T3 (es) | 1999-06-16 |
| ATE176931T1 (de) | 1999-03-15 |
| EP0602740B1 (en) | 1999-02-24 |
| CA2111595C (en) | 2004-12-14 |
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