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ES8801266A1 - Un procedimiento para preparar nuevos compuestos heterociclicos condensados con benceno - Google Patents

Un procedimiento para preparar nuevos compuestos heterociclicos condensados con benceno

Info

Publication number
ES8801266A1
ES8801266A1 ES557041A ES557041A ES8801266A1 ES 8801266 A1 ES8801266 A1 ES 8801266A1 ES 557041 A ES557041 A ES 557041A ES 557041 A ES557041 A ES 557041A ES 8801266 A1 ES8801266 A1 ES 8801266A1
Authority
ES
Spain
Prior art keywords
benzene
preparing new
procedure
compounds condensed
carboxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557041A
Other languages
English (en)
Other versions
ES557041A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848427124A external-priority patent/GB8427124D0/en
Priority claimed from GB858513399A external-priority patent/GB8513399D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8801266A1 publication Critical patent/ES8801266A1/es
Publication of ES557041A0 publication Critical patent/ES557041A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE PREPARAR NUEVOS COMPUESTOS HETEROCICLICOS CONDENSADOS CON BENCENO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN AGENTE DE INTRODUCCION PARA -R4A, EFECTUANDOSE LA REACCION EN UN DISOLVENTE CONMVENCIONAL Y A TEMPERATURAS QUE VAN DESDE EL ENFRIAMIENTO AL CALENTAMIENTO, PARA OBTENER LOS COMPUESTOS DESEADOS DE FORMULA (I), DONDE R1 ES HALOGENO, NITRO, AMINO, HIDROXI, ALQUILO INFERIOR, ALCOXI INFERIOR SUSTITUIDO POR CARBOXI O CARBOXI PROTEGIDO, ACILAMINO QUE PUEDE TENER UN ALQUILO INFERIOR EN EL RESTO DE AMINO, O ARILOXI QUE PUEDE TENER UN HALOGENO; R2 ES H O HALOGENO; X ES OXIGENO Y OTROS; Y A1 ES UN GRUPO DE FORMULAS (III) O (IV). TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD VASODILATADORA.
ES557041A 1984-10-26 1986-09-01 Un procedimiento para preparar nuevos compuestos heterociclicos condensados con benceno Expired ES8801266A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848427124A GB8427124D0 (en) 1984-10-26 1984-10-26 Benzene-fused heterocyclic compound
GB858513399A GB8513399D0 (en) 1985-05-28 1985-05-28 Heterocyclic compound

Publications (2)

Publication Number Publication Date
ES8801266A1 true ES8801266A1 (es) 1987-12-16
ES557041A0 ES557041A0 (es) 1987-12-16

Family

ID=26288380

Family Applications (2)

Application Number Title Priority Date Filing Date
ES548205A Expired ES8702139A1 (es) 1984-10-26 1985-10-25 Un procedimiento para preparar un nuevo compuesto heteroci- clico condensado con benceno
ES557041A Expired ES8801266A1 (es) 1984-10-26 1986-09-01 Un procedimiento para preparar nuevos compuestos heterociclicos condensados con benceno

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES548205A Expired ES8702139A1 (es) 1984-10-26 1985-10-25 Un procedimiento para preparar un nuevo compuesto heteroci- clico condensado con benceno

Country Status (16)

Country Link
US (2) US4675324A (es)
EP (1) EP0180352B1 (es)
JP (1) JPH0649702B2 (es)
KR (1) KR860003259A (es)
CN (1) CN85108618A (es)
AT (1) ATE89825T1 (es)
AU (1) AU4855185A (es)
DE (1) DE3587362T2 (es)
DK (1) DK493185A (es)
ES (2) ES8702139A1 (es)
FI (1) FI853757A7 (es)
GR (1) GR852593B (es)
HU (1) HUT40124A (es)
NO (1) NO854275L (es)
PH (1) PH21213A (es)
SU (1) SU1375137A3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839368A (en) * 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
US4816467A (en) * 1987-01-09 1989-03-28 Farmitalia Carlo Erba S.R.L Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
EP0286346B1 (en) * 1987-04-09 1994-04-06 E.I. Du Pont De Nemours And Company Insecticidal substituted indazoles
JP2602037B2 (ja) * 1987-10-31 1997-04-23 持田製薬株式会社 １−アシル−２，３−ジヒドロ−４（１ｈ）−キノリノン−４−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物
US5192768A (en) * 1990-09-14 1993-03-09 Kyowa Hakko Kogyo Co., Ltd. Pyrazoloquinoline derivatives
EP0765314B1 (en) 1994-06-15 2003-05-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators
US5865170A (en) * 1997-07-23 1999-02-02 Moles; Randall C. Customizable mouthpiece for scuba-divers
ES2282693T3 (es) * 2002-11-22 2007-10-16 Active Biotech Ab Pirazoloquinolinas con actividad inmunomodulante.
WO2005023182A2 (en) * 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
JP2008531579A (ja) * 2005-02-24 2008-08-14 ニトロメッド インコーポレーティッド 酸化窒素増強利尿化合物、組成物および使用方法
MY147780A (en) 2006-12-29 2013-01-31 Abbvie Deutschland Carboxamide compounds and their use as calpain inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009079A1 (es) * 1968-05-22 1970-01-30 Sandoz Sa
US3624102A (en) * 1969-05-21 1971-11-30 Warner Lambert Co Substituted benzopyranopyrazoles
EP0022078B1 (de) * 1979-06-21 1984-07-25 Ciba-Geigy Ag Pyrazolochinoline, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate enthaltend diese Verbindungen
US4524146A (en) * 1982-12-08 1985-06-18 Ciba-Geigy Corporation Certain -2-heterocycle substituted pyrazoloquinolines

Also Published As

Publication number Publication date
GR852593B (es) 1985-12-24
CN85108618A (zh) 1986-08-27
ES8702139A1 (es) 1986-12-16
EP0180352A3 (en) 1988-03-30
DE3587362D1 (de) 1993-07-01
FI853757L (fi) 1986-04-27
US4767780A (en) 1988-08-30
JPH0649702B2 (ja) 1994-06-29
SU1375137A3 (ru) 1988-02-15
ES557041A0 (es) 1987-12-16
DE3587362T2 (de) 1993-09-09
KR860003259A (ko) 1986-05-21
EP0180352A2 (en) 1986-05-07
US4675324A (en) 1987-06-23
ES548205A0 (es) 1986-12-16
FI853757A7 (fi) 1986-04-27
HUT40124A (en) 1986-11-28
NO854275L (no) 1986-04-28
AU4855185A (en) 1986-05-01
JPS61112076A (ja) 1986-05-30
ATE89825T1 (de) 1993-06-15
EP0180352B1 (en) 1993-05-26
FI853757A0 (fi) 1985-09-30
DK493185D0 (da) 1985-10-25
PH21213A (en) 1987-08-21
DK493185A (da) 1986-04-27

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