AR247402A1 - Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos - Google Patents
Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidosInfo
- Publication number
- AR247402A1 AR247402A1 AR87307119A AR30711987A AR247402A1 AR 247402 A1 AR247402 A1 AR 247402A1 AR 87307119 A AR87307119 A AR 87307119A AR 30711987 A AR30711987 A AR 30711987A AR 247402 A1 AR247402 A1 AR 247402A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- halo
- alkyl
- substituted
- hydrogen
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PREPARACION DE DERIVADOS C-20 AMINO SUSTITUIDOS DE FORMULA 1, DONDE R ES GRUPO DE FORMULA (A) E (I) R3 Y R4 SON HIDROGENO, ALQUILO, CICLOALQUILO O UN GRUPO -(CH2)(N)HPH,EXCEPTO QUE R3 Y R4 NO PUEDEN SER HIDROGENO SIMULTANEAMENTE; N ES CERO, 1 O 2 Y PH ES FENILO SUSTITUIDO O NO POR HALO, ALQUILO O ALCOXI O (II) R3 Y R4 JUNTO CON EL ATOMO DE NITROGENO ADYACENTE FORMA UN ANILLO MONOCICLICODE 5 A 12 ATAMOS EN EL ANILLO O SISTEMAS ANULARES BICICLICOS O TRICICLICOS QUE TIENEN DE 8 A 20 MIEMBROS DONDE UNO DE LOS ATOMOS DE LOS ANILLOS, PUEDE SER OXIGENO Y LOS CARBONO PUEDEN ESTAR SUSTITUIDOS POR ALQUILO, ALQUENILO, ALQUINILO, ALCOXI, HIDROXILO, HALO, HALOALQUILO,-N(ALQUILO C1-4)2, -N(CH2)(M), -CON(ALQUILO)2, -CON(CH2)(M), CIANO, ETILENDIOXI, BENCILO, FENILO, O FENILO SUSTITUIDO POR HALO, ALQUILO O ALCOXI; M ES 4,5,6 O 7, R1 ES FORMULA (B), R2 ES HIDROGENO, HIDROXILO O FORMULA (C) EN DONDE SE HACE REACCIONAR UN ALDEHIDO DE FORMULA 2, CON UNA AMINA DE FORMULA 3 Y ACIDOFORMICO COMO AGENTE RE DUCTOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/846,446 US4921947A (en) | 1986-03-31 | 1986-03-31 | Process for preparing macrolide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR247402A1 true AR247402A1 (es) | 1994-12-29 |
Family
ID=25297965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR87307119A AR247402A1 (es) | 1986-03-31 | 1987-03-26 | Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4921947A (es) |
| EP (1) | EP0240264B1 (es) |
| JP (1) | JPH0710876B2 (es) |
| KR (1) | KR900001166B1 (es) |
| CN (1) | CN1018647B (es) |
| AR (1) | AR247402A1 (es) |
| AT (1) | ATE66678T1 (es) |
| AU (1) | AU593894B2 (es) |
| CA (1) | CA1292737C (es) |
| DE (1) | DE3772423D1 (es) |
| DK (1) | DK172935B1 (es) |
| EG (1) | EG18550A (es) |
| ES (1) | ES2028865T3 (es) |
| GR (1) | GR3002764T3 (es) |
| HK (1) | HK82492A (es) |
| HU (1) | HU199864B (es) |
| IE (1) | IE61018B1 (es) |
| IL (1) | IL82005A (es) |
| NZ (1) | NZ219784A (es) |
| PT (1) | PT84561B (es) |
| ZA (1) | ZA872201B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638458A1 (fr) * | 1988-10-27 | 1990-05-04 | Adir | Nouveaux derives de la tylosine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5354708A (en) * | 1992-06-04 | 1994-10-11 | Taskar Nikhil R | Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine |
| TW226373B (es) * | 1992-07-15 | 1994-07-11 | Pfizer | |
| WO1994021657A1 (en) * | 1993-03-18 | 1994-09-29 | Pfizer Inc. | Antibacterial 16-membered ring macrolides containing olefins at c-20 |
| ATE151767T1 (de) * | 1993-07-15 | 1997-05-15 | Pfizer | Amid-derivate von 16-gliedrige heterocyclen als antibiotische macrolide |
| ES2076107B1 (es) * | 1993-09-20 | 1996-04-01 | Pfizer | Derivados de antibioticos macrolidos de anillos de 16 miembros. |
| EP0778283A3 (en) * | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotic macrolides |
| DE102004027417A1 (de) * | 2004-06-04 | 2005-12-22 | Basf Ag | Verbundelement |
| SI3184526T1 (sl) | 2005-12-13 | 2019-03-29 | Incyte Holdings Corporation | Derivati pirolo(2,3-D)pirimidina kot inhibitorji Janus kinaze |
| EP2077271A4 (en) * | 2006-05-01 | 2010-09-15 | Taisho Pharmaceutical Co Ltd | Macrolide derivative |
| SI2089408T1 (sl) * | 2006-07-28 | 2012-02-29 | Intervet Int Bv | Postopek za sintezo makrolidov |
| KR101456308B1 (ko) | 2006-07-28 | 2014-11-03 | 인터벳 인터내셔널 비.브이. | 마크롤라이드 합성 방법 |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| BR112013012502A2 (pt) | 2010-11-19 | 2019-03-06 | Incyte Corporation | pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak |
| EP2640725B1 (en) | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EP2721028B1 (en) | 2011-06-20 | 2015-11-04 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| EP2782922B1 (en) | 2011-11-25 | 2017-12-20 | Bayer Intellectual Property GmbH | Antibacterial tylosin derivatives and methods for their preparation |
| CN102382159B (zh) * | 2011-12-07 | 2013-11-13 | 齐鲁动物保健品有限公司 | 一种替米考星的制备方法 |
| EP3489239B1 (en) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
| DK2999707T3 (en) * | 2013-05-23 | 2018-06-06 | Bayer Animal Health Gmbh | Tylosin derivatives and process for their preparation. |
| CN105837648B (zh) * | 2015-11-02 | 2018-07-06 | 湖北龙翔药业科技股份有限公司 | 一种磷酸替米考星的制备方法 |
| CN108299531B (zh) * | 2018-01-23 | 2021-02-05 | 郑州大学 | 甲哌泰万菌素可药用盐及其制备方法 |
| CN111269275A (zh) * | 2020-03-09 | 2020-06-12 | 浙江康牧药业有限公司 | 一种替米考星的制备方法 |
| CN117304241B (zh) * | 2023-11-30 | 2024-03-01 | 中国农业科学院饲料研究所 | 一种大环内酯类化合物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| JPS58146595A (ja) * | 1982-02-25 | 1983-09-01 | Satoshi Omura | マクロライド系抗生物質 |
| US4454314A (en) * | 1982-08-02 | 1984-06-12 | Pfizer Inc. | Antibacterial mycaminosyl tylonolide and related macrolide derivatives |
| IL69666A (en) * | 1982-09-13 | 1987-10-20 | Lilly Co Eli | 20-amino-20-deoxo-5-o-mycaminosyl-23-o-mycinosyltylonolide derivatives,their preparation and veterinary antibiotic use |
| US4443436A (en) * | 1982-09-13 | 1984-04-17 | Eli Lilly And Company | C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin |
| US4468511A (en) * | 1983-02-28 | 1984-08-28 | Eli Lilly And Company | C-20- And C-23-Modified macrolide derivatives |
-
1986
- 1986-03-31 US US06/846,446 patent/US4921947A/en not_active Expired - Lifetime
-
1987
- 1987-03-25 ZA ZA872201A patent/ZA872201B/xx unknown
- 1987-03-25 IL IL82005A patent/IL82005A/xx not_active IP Right Cessation
- 1987-03-25 CA CA000532905A patent/CA1292737C/en not_active Expired - Lifetime
- 1987-03-26 PT PT84561A patent/PT84561B/pt unknown
- 1987-03-26 DK DK198701540A patent/DK172935B1/da not_active IP Right Cessation
- 1987-03-26 AU AU70670/87A patent/AU593894B2/en not_active Expired
- 1987-03-26 JP JP62075752A patent/JPH0710876B2/ja not_active Expired - Lifetime
- 1987-03-26 AR AR87307119A patent/AR247402A1/es active
- 1987-03-26 EG EG182/87A patent/EG18550A/xx active
- 1987-03-26 HU HU871328A patent/HU199864B/hu unknown
- 1987-03-26 NZ NZ219784A patent/NZ219784A/xx unknown
- 1987-03-27 EP EP87302663A patent/EP0240264B1/en not_active Expired - Lifetime
- 1987-03-27 KR KR1019870002839A patent/KR900001166B1/ko not_active Expired
- 1987-03-27 IE IE79687A patent/IE61018B1/en not_active IP Right Cessation
- 1987-03-27 AT AT87302663T patent/ATE66678T1/de not_active IP Right Cessation
- 1987-03-27 DE DE8787302663T patent/DE3772423D1/de not_active Expired - Lifetime
- 1987-03-27 ES ES198787302663T patent/ES2028865T3/es not_active Expired - Lifetime
- 1987-03-27 CN CN87102397A patent/CN1018647B/zh not_active Expired
-
1991
- 1991-09-19 GR GR91401376T patent/GR3002764T3/el unknown
-
1992
- 1992-10-22 HK HK824/92A patent/HK82492A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ219784A (en) | 1989-01-27 |
| AU7067087A (en) | 1987-10-08 |
| DK154087D0 (da) | 1987-03-26 |
| EP0240264A3 (en) | 1987-11-19 |
| PT84561B (pt) | 1989-11-10 |
| EP0240264B1 (en) | 1991-08-28 |
| US4921947A (en) | 1990-05-01 |
| CA1292737C (en) | 1991-12-03 |
| DK172935B1 (da) | 1999-10-11 |
| GR3002764T3 (en) | 1993-01-25 |
| ZA872201B (en) | 1988-10-26 |
| PT84561A (en) | 1987-04-01 |
| KR870008906A (ko) | 1987-10-21 |
| ATE66678T1 (de) | 1991-09-15 |
| KR900001166B1 (ko) | 1990-02-27 |
| HU199864B (en) | 1990-03-28 |
| JPS62240681A (ja) | 1987-10-21 |
| JPH0710876B2 (ja) | 1995-02-08 |
| EP0240264A2 (en) | 1987-10-07 |
| CN87102397A (zh) | 1987-10-07 |
| HK82492A (en) | 1992-10-30 |
| HUT43087A (en) | 1987-09-28 |
| DK154087A (da) | 1987-10-01 |
| AU593894B2 (en) | 1990-02-22 |
| IE61018B1 (en) | 1994-09-07 |
| IL82005A0 (en) | 1987-10-20 |
| IE870796L (en) | 1987-09-30 |
| ES2028865T3 (es) | 1992-07-16 |
| IL82005A (en) | 1991-08-16 |
| DE3772423D1 (de) | 1991-10-02 |
| EG18550A (en) | 1993-10-30 |
| CN1018647B (zh) | 1992-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR247402A1 (es) | Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos | |
| KR850003890A (ko) | 1H-이미다조[4,5c]-퀴놀린-4-아민의 제조방법 | |
| MX171822B (es) | Proceso quimico | |
| ES8705387A1 (es) | Un procedimiento para preparar derivados de n-aril-n-(4-piperidinil)-alcoxialquilamida | |
| ES454160A1 (es) | Un procedimiento para la preparacion de nuevas pirazincarbo-xamidas. | |
| AR241474A1 (es) | Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina. | |
| FI810389L (fi) | Foerfarande foer framstaellning av substituerade imidazolderivat | |
| ES8801618A1 (es) | Un procedimiento para preparar derivados de arilciclobutilalquilamina | |
| AR240941A2 (es) | Procedimiento para preparar compuestos de pirazolopirimidinas | |
| ES8700253A1 (es) | Procedimiento para preparar compuestos de 5-alquil-1-fenil- -2-piperazinoalquilpirazolin-3-ona | |
| ES8706148A1 (es) | Un procedimiento para preparar nuevos derivados de carbapenem. | |
| ES8102106A1 (es) | Un procedimiento para preparar benzoxazepinas | |
| DE3372095D1 (en) | Novel phenylpiperazine derivatives and process for producing the same | |
| ES405479A1 (es) | Un procedimiento para la preparacion de derivados de benzo-diacepina. | |
| GB984023A (en) | 17-acetyl-16,17-secoandrost-9(11)-en-16-al derivatives and their preparation | |
| ES8403891A1 (es) | Un procedimiento para la preparacion de un derivado del acido furiloxazolila-cetico | |
| ATE34169T1 (de) | Verfahren zur herstellung von methyl-nmethylanthranilat. | |
| IE44449L (en) | Morphanthridines | |
| HUT50833A (en) | Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives | |
| ES8706615A1 (es) | Un procedimiento para la preparacion de nuevos derivados de diamina. | |
| ES2002111A6 (es) | Un procedimiento para preparar pirimido-(2,1-b)-benzotiazoles | |
| ES8801321A1 (es) | Procedimiento para preparar compuestos dimeros de derivados de aminoacidos. | |
| ES2034252T3 (es) | Procedimiento para la preparacion de compuestos macrolidos. | |
| JPS5283753A (en) | Benzotriazole | |
| FR2312255B1 (es) |