ES8704482A1 - Procedimiento para la preparacion de silibinina extenta de isosilibina - Google Patents
Procedimiento para la preparacion de silibinina extenta de isosilibinaInfo
- Publication number
- ES8704482A1 ES8704482A1 ES554022A ES554022A ES8704482A1 ES 8704482 A1 ES8704482 A1 ES 8704482A1 ES 554022 A ES554022 A ES 554022A ES 554022 A ES554022 A ES 554022A ES 8704482 A1 ES8704482 A1 ES 8704482A1
- Authority
- ES
- Spain
- Prior art keywords
- parts
- weight
- ethyl acetate
- dry
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title abstract 4
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title abstract 4
- 229950000628 silibinin Drugs 0.000 title abstract 4
- 235000014899 silybin Nutrition 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 208000019423 liver disease Diseases 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 15
- 239000002244 precipitate Substances 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/04—Arrangements using dry fillers, e.g. using slag wool
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR SILIBININA EXENTA DE ISOSILIBININA. COMPRENDE: A) SUSPENDER EN 0,7 A 1,5 PARTES EN PESO DE ACETATO DE ETILO SATURADO DE AGUA, UNA PARTE EN PESO DEL POLVO PARDUSCO; B) DEJAR REPOSAR UNO O DOS DIAS LA SUSPENSION DE A); C) SEPARAR POR SUCCION PRECIPITADO; D) LAVAR CON 0,07 A 0,15 PARTES EN PESO DE ACETATO DE ETILO SATURADO CON AGUA, Y FRIO EL PRECIPITADO DE C); E) SECAR EN VACIO Y ENTRE 30 Y 50JC AL PRECIPITADO; F) DISOLVER A TEMPERATURA DE EBULLICION EL PRECIPITADO SECO EN 30 A 50 PARTES EN PESO DE ACETATO DE ETILO SECO; G) TRATAR EN REFLUJO LA SOLUCION DE F), DURANTE DOS HORAS, CON 0,2 A 0,4 PARTES EN PESO DE CARBON ACTIVO; H) FILTRAR LA SOLUCION; I) CONCENTRAR EL FILTRADO, ENTRE 30 Y 50JC Y EN VACIO, PARA ELIMINAR LAS 11/12 PARTES DEL DISOLVENTE UTILIZADO; J) AÑADIR AL CONCENTRADO DE I) DE 0,5 A 0,8 PARTES EN PESO DE ACETATO DE ETILO SATURADO DE AGUA; K) DEJAR REPOSAR LA SOLUCION DURANTE 5 A 10 HORAS; L) SEPARAR POR FILTRACION LA SILIBININA PRECIPITADA; M) SUSPENDER LA SILIBININA EN 0,9 PARTES A 1,8 PARTES EN PESO DE ACETATO DE ETILO TECNICO; N) FILTRAR DICHA SUSPENSION; /) SECAR EN VACIO, ENTRE 30 Y 50JC, AL FILTRADO; O) MOLER AL PRODUCTO PRELIMINARMENTE SECADO; Y P) SECAR EN VACIO ENTRE 30 Y 50JC AL PRODUCTO MOLOIDO. EL POLVO PARDUSCO ES UNA MEZCLA DE 70 A 80% DE POLIHIDROXIFENILCROMANOMA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3442641 | 1984-11-22 | ||
| DE19853537656 DE3537656A1 (de) | 1984-11-22 | 1985-10-23 | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES554022A0 ES554022A0 (es) | 1987-04-01 |
| ES8704482A1 true ES8704482A1 (es) | 1987-04-01 |
Family
ID=25826741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES549119A Expired ES8609312A1 (es) | 1984-11-22 | 1985-11-21 | Procedimiento para la preparacion de silibinina exenta de isosilibina |
| ES554022A Expired ES8704482A1 (es) | 1984-11-22 | 1986-04-16 | Procedimiento para la preparacion de silibinina extenta de isosilibina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES549119A Expired ES8609312A1 (es) | 1984-11-22 | 1985-11-21 | Procedimiento para la preparacion de silibinina exenta de isosilibina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4871763A (es) |
| JP (1) | JPH0678228B2 (es) |
| AR (1) | AR241268A1 (es) |
| AT (1) | AT391315B (es) |
| BE (1) | BE903694A (es) |
| CA (1) | CA1337125C (es) |
| CH (1) | CH660008A5 (es) |
| CS (1) | CS271321B2 (es) |
| DE (1) | DE3537656A1 (es) |
| DK (3) | DK166541B1 (es) |
| EG (1) | EG17710A (es) |
| ES (2) | ES8609312A1 (es) |
| FI (1) | FI84065C (es) |
| FR (1) | FR2573426B1 (es) |
| GB (1) | GB2167746B (es) |
| HU (1) | HU195504B (es) |
| IE (1) | IE59209B1 (es) |
| IT (1) | IT1207508B (es) |
| LU (1) | LU86164A1 (es) |
| MX (1) | MX172175B (es) |
| NL (1) | NL192204C (es) |
| NO (1) | NO160206C (es) |
| PL (1) | PL146889B1 (es) |
| PT (1) | PT81531B (es) |
| SE (1) | SE457957B (es) |
| YU (1) | YU43690B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3357383B2 (ja) * | 1991-08-14 | 2002-12-16 | 昌宏 黒田 | 低分子化植物性組成物 |
| DE4401902C2 (de) * | 1994-01-24 | 2000-02-03 | Madaus Ag | Verwendung von Flavolignanen als Adjuvans in der Tumortherapie |
| FR2719451B1 (fr) * | 1994-05-04 | 1996-07-26 | Apcis Sa | Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité. |
| DE19501266A1 (de) * | 1995-01-18 | 1996-07-25 | Madaus Ag | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US6379714B1 (en) | 1995-04-14 | 2002-04-30 | Pharmaprint, Inc. | Pharmaceutical grade botanical drugs |
| DE69824223T2 (de) | 1997-03-19 | 2004-09-30 | Unilever N.V. | Vorrichtung zum Handhaben von Gegenständen |
| GB2327607B8 (en) * | 1997-07-31 | 2005-03-30 | Litton Internat Company Ltd | A process for producing a herbal extract composition |
| DE10053384A1 (de) * | 2000-10-27 | 2002-05-08 | Bionorica Arzneimittel Gmbh | Pharmazeutische Zubereitung aus Mariendistel und Terpenen |
| US6699900B2 (en) * | 2001-04-07 | 2004-03-02 | Jan E. Zielinski | Hydrophilic and lipophilic silibinin pro-forms |
| DE10360954B3 (de) * | 2003-12-23 | 2005-08-18 | Esparma Gmbh | Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen |
| BG65997B1 (bg) * | 2005-03-29 | 2010-09-30 | "Софарма" Ад | Метод за получаване на силибинин |
| WO2009062737A1 (en) | 2007-11-15 | 2009-05-22 | Madaus Gmbh | Silibinin component for the treatment of hepatitis |
| JP5841048B2 (ja) * | 2009-05-14 | 2016-01-06 | エウロメッド・エセ・ア | ウイルス性肝炎の治療のための非晶質シリビニン |
| WO2011051742A1 (en) | 2009-10-28 | 2011-05-05 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| CN103408539B (zh) * | 2013-08-28 | 2016-04-06 | 天津泰阳制药有限公司 | 高纯度水飞蓟宾的生产方法 |
| CA3011192A1 (en) * | 2016-01-15 | 2017-07-20 | Universitat Hamburg | Flavonoide-type compounds bearing an o-rhamnosyl residue |
| KR20230058156A (ko) | 2020-09-29 | 2023-05-02 | 무니색하 매다사니 | 실리범 마리아넘 식물 물질로부터 생리활성 화합물의 추출 및 이의 이용 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773932A (en) * | 1968-06-01 | 1973-11-20 | Madaus & Co Dr | Method for recovering silymarin comprising polyhydroxyphenyl chromanones |
| DE1767666C3 (de) * | 1968-06-01 | 1986-07-31 | Dr. Madaus & Co, 5000 Koeln | Pharmazeutische Zubereitung gegen Lebererkrankungen |
| DE1923082C3 (de) * | 1969-05-06 | 1985-08-22 | Dr. Madaus & Co, 5000 Koeln | Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch |
| DE2416302B2 (de) * | 1974-04-04 | 1978-02-02 | Dr. Madaus & Co, 5000 Köln | Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| BE885558A (fr) * | 1980-10-07 | 1981-04-07 | Madaus & Co Dr | Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique |
| DE3225688A1 (de) * | 1982-07-09 | 1984-01-12 | Suschnik Matthias Dr | Verfahren zur gewinnung von silymarin aus silybum marianum |
-
1985
- 1985-10-23 DE DE19853537656 patent/DE3537656A1/de active Granted
- 1985-11-11 GB GB08527809A patent/GB2167746B/en not_active Expired
- 1985-11-12 CH CH4854/85A patent/CH660008A5/de not_active IP Right Cessation
- 1985-11-13 LU LU86164A patent/LU86164A1/de unknown
- 1985-11-14 NL NL8503136A patent/NL192204C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854536A patent/FI84065C/fi not_active IP Right Cessation
- 1985-11-19 AT AT0337285A patent/AT391315B/de not_active IP Right Cessation
- 1985-11-20 CS CS858379A patent/CS271321B2/cs unknown
- 1985-11-20 CA CA000495805A patent/CA1337125C/en not_active Expired - Fee Related
- 1985-11-20 SE SE8505488A patent/SE457957B/sv not_active IP Right Cessation
- 1985-11-20 YU YU1812/85A patent/YU43690B/xx unknown
- 1985-11-21 EG EG741/85A patent/EG17710A/xx active
- 1985-11-21 DK DK537685A patent/DK166541B1/da not_active IP Right Cessation
- 1985-11-21 ES ES549119A patent/ES8609312A1/es not_active Expired
- 1985-11-21 PL PL1985256373A patent/PL146889B1/pl unknown
- 1985-11-21 PT PT81531A patent/PT81531B/pt not_active IP Right Cessation
- 1985-11-21 NO NO854657A patent/NO160206C/no unknown
- 1985-11-21 IT IT8522933A patent/IT1207508B/it active
- 1985-11-21 IE IE292785A patent/IE59209B1/en not_active IP Right Cessation
- 1985-11-21 HU HU854449A patent/HU195504B/hu not_active IP Right Cessation
- 1985-11-22 FR FR8517320A patent/FR2573426B1/fr not_active Expired
- 1985-11-22 MX MX009231A patent/MX172175B/es unknown
- 1985-11-22 AR AR85302358A patent/AR241268A1/es active
- 1985-11-22 BE BE2/60851A patent/BE903694A/fr not_active IP Right Cessation
-
1986
- 1986-04-16 ES ES554022A patent/ES8704482A1/es not_active Expired
-
1988
- 1988-03-18 US US07/171,176 patent/US4871763A/en not_active Expired - Fee Related
-
1991
- 1991-01-29 JP JP3009169A patent/JPH0678228B2/ja not_active Expired - Lifetime
- 1991-11-20 DK DK189491A patent/DK164866C/da not_active IP Right Cessation
-
1992
- 1992-09-17 DK DK199201145A patent/DK172879B1/da active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20040503 |