ES8601234A1 - Procedimiento para la obtencion de un ester de acido carboxilico - Google Patents
Procedimiento para la obtencion de un ester de acido carboxilicoInfo
- Publication number
- ES8601234A1 ES8601234A1 ES535242A ES535242A ES8601234A1 ES 8601234 A1 ES8601234 A1 ES 8601234A1 ES 535242 A ES535242 A ES 535242A ES 535242 A ES535242 A ES 535242A ES 8601234 A1 ES8601234 A1 ES 8601234A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- acid esters
- steroids
- carboxylic acid
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001733 carboxylic acid esters Chemical class 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 2
- -1 CARBOXYL Chemical class 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Fats And Perfumes (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DE ACIDO CARBOXILICO DE FORMULA (I) EN LA QUE R REPRESENTA ALQUILO CON 1 A 4 ATOMOS DE CARBONO. CONSISTE EN LA REACCION DE UN COMPUESTO 9B11B-OXO DE FORMULA (II) EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) CON CLORURO DE HIDROGENO O UN MEDIO QUE LIBERA CLORURO DE HIDROGENO. LA REACCION SE LLEVA A CABO EN MEDIO ANHIDRO EN UN DISOLVENTE INERTE A LA TEMPERATURA AMBIENTE. TAMBIEN SE PUEDEN OBTENER LOS COMPUESTOS DE FORMULA (I) TRATANDO OTROS COMPUESTOS DE PARTIDA SEGUN METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFICACIA ANTIINFLAMATORIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH451283 | 1983-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES535242A0 ES535242A0 (es) | 1985-11-01 |
| ES8601234A1 true ES8601234A1 (es) | 1985-11-01 |
Family
ID=4277476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535242A Expired ES8601234A1 (es) | 1983-08-18 | 1984-08-17 | Procedimiento para la obtencion de un ester de acido carboxilico |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4607028A (es) |
| EP (1) | EP0135476B1 (es) |
| JP (1) | JPS6058999A (es) |
| KR (1) | KR850001725A (es) |
| AT (1) | ATE37186T1 (es) |
| AU (1) | AU3204484A (es) |
| CA (1) | CA1234564A (es) |
| CY (1) | CY1593A (es) |
| DD (1) | DD227966A5 (es) |
| DE (1) | DE3474025D1 (es) |
| DK (1) | DK160993C (es) |
| ES (1) | ES8601234A1 (es) |
| FI (1) | FI80888C (es) |
| GR (1) | GR80131B (es) |
| HK (1) | HK42791A (es) |
| HU (1) | HUT34991A (es) |
| IL (1) | IL72702A0 (es) |
| NO (1) | NO160212C (es) |
| PT (1) | PT79106B (es) |
| SG (1) | SG32091G (es) |
| ZA (1) | ZA846406B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78144A0 (en) * | 1985-04-04 | 1986-07-31 | Draco Ab | Novel androstane-17beta-carboxylic acid esters |
| WO1990015816A1 (en) * | 1989-06-16 | 1990-12-27 | The Upjohn Company | Suramin type compounds and angiostatic steroids to inhibit angiogenesis |
| FR2701262B1 (fr) * | 1993-02-05 | 1995-03-24 | Roussel Uclaf | Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires. |
| JPH07119308A (ja) * | 1993-10-27 | 1995-05-09 | Koa:Kk | 移動作業床による外壁貼りの吊り支え工法並にその装置 |
| GB9501286D0 (en) * | 1995-01-24 | 1995-03-15 | Ciba Geigy Ag | Pharmaceutical compositions and preparations thereof |
| US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
| AUPP583198A0 (en) * | 1998-09-11 | 1998-10-01 | Soltec Research Pty Ltd | Mousse composition |
| GB0015876D0 (en) * | 2000-06-28 | 2000-08-23 | Novartis Ag | Organic compounds |
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6787532B2 (en) * | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| GB0019172D0 (en) * | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| US6750210B2 (en) * | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| US6858593B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| WO2002012265A1 (en) * | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY!-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT |
| US6777400B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6759398B2 (en) * | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| UA77656C2 (en) * | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| US7291608B2 (en) * | 2001-04-30 | 2007-11-06 | Glaxo Group Limited | Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α |
| JP2003095382A (ja) * | 2001-09-25 | 2003-04-03 | Ishikawajima Harima Heavy Ind Co Ltd | タンクのマンホール構造 |
| GB0202216D0 (en) * | 2002-01-31 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
| US20050175545A1 (en) * | 2002-02-04 | 2005-08-11 | Keith Biggadike | Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist |
| GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
| GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| GB0615108D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1384372A (en) * | 1971-01-20 | 1975-02-19 | Glaxo Lab Ltd | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
| GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
| JPS5297597A (en) * | 1976-02-09 | 1977-08-16 | Walt Disney Prod | Guide device of ship |
| JPS5938239B2 (ja) * | 1976-02-12 | 1984-09-14 | グラクソ・ラボラトリ−ス・リミテツド | 新規ステロイド化合物 |
| CH628355A5 (de) * | 1976-02-24 | 1982-02-26 | Ciba Geigy Ag | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
| CH634081A5 (en) * | 1977-04-13 | 1983-01-14 | Ciba Geigy Ag | Process for the preparation of novel androstadiene-17beta-carboxylic acid esters |
| ZA814440B (en) * | 1980-07-10 | 1982-10-27 | Otsuka Pharma Co Ltd | Soft steroids having anti-inflammatory activity |
-
1984
- 1984-08-09 US US06/639,033 patent/US4607028A/en not_active Expired - Lifetime
- 1984-08-13 EP EP84810397A patent/EP0135476B1/de not_active Expired
- 1984-08-13 AT AT84810397T patent/ATE37186T1/de active
- 1984-08-13 DE DE8484810397T patent/DE3474025D1/de not_active Expired
- 1984-08-15 FI FI843219A patent/FI80888C/fi not_active IP Right Cessation
- 1984-08-16 CA CA000461216A patent/CA1234564A/en not_active Expired
- 1984-08-16 IL IL72702A patent/IL72702A0/xx unknown
- 1984-08-17 ZA ZA846406A patent/ZA846406B/xx unknown
- 1984-08-17 AU AU32044/84A patent/AU3204484A/en not_active Abandoned
- 1984-08-17 DK DK396284A patent/DK160993C/da not_active IP Right Cessation
- 1984-08-17 ES ES535242A patent/ES8601234A1/es not_active Expired
- 1984-08-17 NO NO843298A patent/NO160212C/no unknown
- 1984-08-17 GR GR80131A patent/GR80131B/el unknown
- 1984-08-17 HU HU843129A patent/HUT34991A/hu unknown
- 1984-08-17 DD DD84266390A patent/DD227966A5/de unknown
- 1984-08-17 KR KR1019840004956A patent/KR850001725A/ko not_active Withdrawn
- 1984-08-17 JP JP59170498A patent/JPS6058999A/ja active Granted
- 1984-08-17 PT PT79106A patent/PT79106B/pt not_active IP Right Cessation
-
1991
- 1991-05-02 SG SG320/91A patent/SG32091G/en unknown
- 1991-05-30 HK HK427/91A patent/HK42791A/xx not_active IP Right Cessation
-
1992
- 1992-04-03 CY CY1593A patent/CY1593A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO160212C (no) | 1989-03-22 |
| ES535242A0 (es) | 1985-11-01 |
| EP0135476A2 (de) | 1985-03-27 |
| ATE37186T1 (de) | 1988-09-15 |
| ZA846406B (en) | 1985-03-27 |
| KR850001725A (ko) | 1985-04-01 |
| FI80888C (fi) | 1990-08-10 |
| NO160212B (no) | 1988-12-12 |
| CY1593A (en) | 1992-04-03 |
| HUT34991A (en) | 1985-05-28 |
| CA1234564A (en) | 1988-03-29 |
| DK396284D0 (da) | 1984-08-17 |
| EP0135476B1 (de) | 1988-09-14 |
| US4607028A (en) | 1986-08-19 |
| DD227966A5 (de) | 1985-10-02 |
| SG32091G (en) | 1991-06-21 |
| DE3474025D1 (en) | 1988-10-20 |
| GR80131B (en) | 1984-12-19 |
| DK160993C (da) | 1991-11-04 |
| FI843219A0 (fi) | 1984-08-15 |
| PT79106B (en) | 1986-11-14 |
| FI80888B (fi) | 1990-04-30 |
| IL72702A0 (en) | 1984-11-30 |
| JPH0253440B2 (es) | 1990-11-16 |
| NO843298L (no) | 1985-02-19 |
| AU3204484A (en) | 1985-02-21 |
| EP0135476A3 (en) | 1985-12-18 |
| JPS6058999A (ja) | 1985-04-05 |
| DK160993B (da) | 1991-05-13 |
| FI843219L (fi) | 1985-02-19 |
| PT79106A (en) | 1984-09-01 |
| DK396284A (da) | 1985-02-19 |
| HK42791A (en) | 1991-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |