ES8604162A1 - Procedimiento para preparar nuevos bencimidazoles - Google Patents
Procedimiento para preparar nuevos bencimidazolesInfo
- Publication number
- ES8604162A1 ES8604162A1 ES544116A ES544116A ES8604162A1 ES 8604162 A1 ES8604162 A1 ES 8604162A1 ES 544116 A ES544116 A ES 544116A ES 544116 A ES544116 A ES 544116A ES 8604162 A1 ES8604162 A1 ES 8604162A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- formula
- benzmidazoles
- alkylsulfonil
- prepare new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENCIMIDAZOLES, DE SUS TAUTOMEROS Y SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE R1 ES ALQUILSULFINILO O ALQUILSULFONILO; R3 ES HIDROGENO O ALCOXI; Y R2 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE OXIDACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 REPRESENTA UN GRUPO ALQUILSULFONILO O ALQUILSULFINILO CON 1 A 3 ATOMOS DE CARBONO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, CON UN OXIDANTE CONVENCIONAL, A UNA TEMPERATURA COMPRENDIDA ENTRE C80JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INSUFICIENCIAS CARDIACAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3346575A DE3346575A1 (de) | 1983-12-23 | 1983-12-23 | Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604162A1 true ES8604162A1 (es) | 1986-01-16 |
| ES544116A0 ES544116A0 (es) | 1986-01-16 |
Family
ID=6217793
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538929A Expired ES8601913A1 (es) | 1983-12-23 | 1984-12-21 | Procedimiento para preparar bencimidazoles |
| ES544119A Expired ES8604165A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
| ES544116A Expired ES8604162A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
| ES544118A Expired ES8604164A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
| ES544117A Expired ES8604163A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538929A Expired ES8601913A1 (es) | 1983-12-23 | 1984-12-21 | Procedimiento para preparar bencimidazoles |
| ES544119A Expired ES8604165A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544118A Expired ES8604164A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
| ES544117A Expired ES8604163A1 (es) | 1983-12-23 | 1985-06-13 | Procedimiento para preparar nuevos bencimidazoles |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0148431A1 (es) |
| JP (1) | JPS60156676A (es) |
| KR (1) | KR850004467A (es) |
| AU (1) | AU3704284A (es) |
| DD (1) | DD232697A5 (es) |
| DE (1) | DE3346575A1 (es) |
| DK (1) | DK597484A (es) |
| ES (5) | ES8601913A1 (es) |
| FI (1) | FI845084L (es) |
| HU (1) | HU193073B (es) |
| IL (1) | IL73897A0 (es) |
| NO (1) | NO845169L (es) |
| PT (1) | PT79718B (es) |
| ZA (1) | ZA849972B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU85544A1 (fr) * | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
| DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| FR2677020B1 (fr) * | 1991-05-31 | 1993-08-27 | Cird Galderma | Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique. |
| US5821258A (en) * | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
| TR199800127T1 (xx) * | 1995-08-02 | 1998-04-21 | Newcastle University Ventures Limited | Benzimidazol bile�ikleri. |
| US5942532A (en) * | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| BR0206161A (pt) | 2001-10-19 | 2005-02-01 | Ortho Mcneil Pharm Inc | 2-fenil benzimidazóis e imidazo-[4,5]-piridinas como inibidores de cds1/chk2 e adjuvantes para quimioterapia ou terapia por radiação no tratamento de câncer |
| JP2006513159A (ja) * | 2002-11-01 | 2006-04-20 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体 |
| US7132440B2 (en) | 2003-04-17 | 2006-11-07 | Janssen Pharmaceutica, N.V. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
| ES2362102T3 (es) | 2004-06-30 | 2011-06-28 | Janssen Pharmaceutica Nv | Eteres de bencimidazol e imidazopiridina sustituidos con arilo como agentes anticáncer. |
| AU2011345747A1 (en) | 2010-12-24 | 2013-06-06 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound and use for pest control thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH350763A (de) * | 1958-10-14 | 1960-12-15 | Ciba Geigy | Verwendung von Azolverbindungen als Schutzmittel gegen ultraviolette Strahlung |
| DE1447733B2 (de) * | 1963-12-23 | 1977-04-21 | Hoechst Ag, 6000 Frankfurt | 2-(3,5-dihydroxyphenyl)-benzimidazolderivate |
| IL23847A (en) * | 1964-08-07 | 1969-02-27 | Merck & Co Inc | Benzimidazoles useful as antifungals |
| FR1569337A (es) * | 1968-06-18 | 1969-05-30 | ||
| DE2742093A1 (de) * | 1977-09-19 | 1979-03-29 | Cassella Ag | Verfahren zur herstellung von 2-(3'- bzw. 4'-aminophenyl)-5(bzw. 6) -aminobenzimidazolen |
| DE2927987A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel |
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
-
1983
- 1983-12-23 DE DE3346575A patent/DE3346575A1/de not_active Withdrawn
-
1984
- 1984-12-08 EP EP84114999A patent/EP0148431A1/de not_active Withdrawn
- 1984-12-13 DK DK597484A patent/DK597484A/da not_active Application Discontinuation
- 1984-12-20 JP JP59269563A patent/JPS60156676A/ja active Pending
- 1984-12-20 PT PT79718A patent/PT79718B/pt unknown
- 1984-12-21 FI FI845084A patent/FI845084L/fi not_active Application Discontinuation
- 1984-12-21 IL IL73897A patent/IL73897A0/xx unknown
- 1984-12-21 HU HU844808A patent/HU193073B/hu unknown
- 1984-12-21 DD DD84271449A patent/DD232697A5/de unknown
- 1984-12-21 ZA ZA849972A patent/ZA849972B/xx unknown
- 1984-12-21 AU AU37042/84A patent/AU3704284A/en not_active Abandoned
- 1984-12-21 KR KR1019840008220A patent/KR850004467A/ko not_active Withdrawn
- 1984-12-21 NO NO845169A patent/NO845169L/no unknown
- 1984-12-21 ES ES538929A patent/ES8601913A1/es not_active Expired
-
1985
- 1985-06-13 ES ES544119A patent/ES8604165A1/es not_active Expired
- 1985-06-13 ES ES544116A patent/ES8604162A1/es not_active Expired
- 1985-06-13 ES ES544118A patent/ES8604164A1/es not_active Expired
- 1985-06-13 ES ES544117A patent/ES8604163A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60156676A (ja) | 1985-08-16 |
| ZA849972B (en) | 1986-08-27 |
| HUT37763A (en) | 1986-02-28 |
| FI845084A7 (fi) | 1985-06-24 |
| ES8604165A1 (es) | 1986-01-16 |
| ES538929A0 (es) | 1985-11-16 |
| ES8601913A1 (es) | 1985-11-16 |
| ES544118A0 (es) | 1986-01-16 |
| DK597484D0 (da) | 1984-12-13 |
| EP0148431A1 (de) | 1985-07-17 |
| ES544117A0 (es) | 1986-01-16 |
| PT79718B (de) | 1986-12-30 |
| ES8604164A1 (es) | 1986-01-16 |
| FI845084L (fi) | 1985-06-24 |
| HU193073B (en) | 1987-08-28 |
| DE3346575A1 (de) | 1985-07-04 |
| DD232697A5 (de) | 1986-02-05 |
| PT79718A (de) | 1985-01-01 |
| NO845169L (no) | 1985-06-24 |
| ES544116A0 (es) | 1986-01-16 |
| IL73897A0 (en) | 1985-03-31 |
| DK597484A (da) | 1985-06-24 |
| AU3704284A (en) | 1985-07-04 |
| KR850004467A (ko) | 1985-07-15 |
| ES544119A0 (es) | 1986-01-16 |
| ES8604163A1 (es) | 1986-01-16 |
| FI845084A0 (fi) | 1984-12-21 |
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