ES8505973A1 - Un procedimiento para la preparacion de derivados de pirimidinatriona - Google Patents
Un procedimiento para la preparacion de derivados de pirimidinatrionaInfo
- Publication number
- ES8505973A1 ES8505973A1 ES531498A ES531498A ES8505973A1 ES 8505973 A1 ES8505973 A1 ES 8505973A1 ES 531498 A ES531498 A ES 531498A ES 531498 A ES531498 A ES 531498A ES 8505973 A1 ES8505973 A1 ES 8505973A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- febarbamate
- metal salt
- preparation
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SOFSSZFBVOGIKD-UHFFFAOYSA-N pyrimidine-2,4,5-trione Chemical class O=C1NC(=O)C(=O)C=N1 SOFSSZFBVOGIKD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- QHZQILHUJDRDAI-UHFFFAOYSA-N febarbamate Chemical compound O=C1N(CC(COCCCC)OC(N)=O)C(=O)NC(=O)C1(CC)C1=CC=CC=C1 QHZQILHUJDRDAI-UHFFFAOYSA-N 0.000 abstract 2
- 229960005182 febarbamate Drugs 0.000 abstract 2
- 206010002820 Antisocial behaviour Diseases 0.000 abstract 1
- 206010022998 Irritability Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 208000024823 antisocial personality disease Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRIMIDINATRIONA.COMPRENDE: HACER REACCIONAR UNA MONO-SAL DE METAL ALCALINO DE UN COMPUESTO DE FORMULA (I) DONDE R3 ES UN ATOMO DE HIDROGENO, CON UN AGENTE DE ALQUILACION R3HAL EN DONDE HAL ES UN ATOMO DE HALOGENO EN PRESENCIA DE O,2 MOLES DE UN ACIDO DE FORMULA (I), POR MOL DE SAL DE METAL ALCALINO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838309813A GB8309813D0 (en) | 1983-04-12 | 1983-04-12 | Pyrimidinetrione derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8505973A1 true ES8505973A1 (es) | 1985-06-16 |
| ES531498A0 ES531498A0 (es) | 1985-06-16 |
Family
ID=10540932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531498A Granted ES531498A0 (es) | 1983-04-12 | 1984-04-11 | Un procedimiento para la preparacion de derivados de pirimidinatriona |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US4611057A (es) |
| EP (1) | EP0125046B1 (es) |
| JP (1) | JPS59205370A (es) |
| AR (1) | AR240317A1 (es) |
| AT (1) | AT388917B (es) |
| AU (1) | AU554056B2 (es) |
| BE (1) | BE899385A (es) |
| BG (1) | BG65031A (es) |
| BR (1) | BR8401679A (es) |
| CA (1) | CA1247619A (es) |
| CH (1) | CH658653A5 (es) |
| CS (1) | CS276389B6 (es) |
| DD (1) | DD222018A5 (es) |
| DE (1) | DE3464910D1 (es) |
| DK (1) | DK158726C (es) |
| EG (1) | EG17794A (es) |
| ES (1) | ES531498A0 (es) |
| FI (1) | FI84348C (es) |
| FR (1) | FR2544312B1 (es) |
| GB (1) | GB8309813D0 (es) |
| GR (1) | GR79890B (es) |
| HU (1) | HU192548B (es) |
| IE (1) | IE57321B1 (es) |
| IL (1) | IL71515A (es) |
| IN (1) | IN161291B (es) |
| IT (1) | IT1177658B (es) |
| LU (1) | LU85296A1 (es) |
| MA (1) | MA20092A1 (es) |
| MX (1) | MX159632A (es) |
| NO (1) | NO170928C (es) |
| NZ (1) | NZ207802A (es) |
| PH (1) | PH24131A (es) |
| PL (1) | PL144481B1 (es) |
| PT (1) | PT78400B (es) |
| RO (1) | RO89141A (es) |
| SU (1) | SU1380611A3 (es) |
| UA (1) | UA7040A1 (es) |
| YU (1) | YU45607B (es) |
| ZA (1) | ZA842687B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9002890D0 (en) * | 1990-02-08 | 1990-04-04 | Sapos Sa | Process for preparing pyrimidinetrione derivatives |
| JPH0436236A (ja) * | 1990-05-30 | 1992-02-06 | Mitsui Pharmaceut Inc | 脳神経障害及び脳循環代謝障害の改善治療剤 |
| RU2141322C1 (ru) * | 1997-08-12 | 1999-11-20 | Голощапов Николай Михайлович | Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения |
| RU2188196C2 (ru) * | 1998-05-26 | 2002-08-27 | Ашкинази Римма Ильинична | N-замещенные производные 5-оксииминобарбитуровой кислоты |
| US7074925B1 (en) * | 1998-05-26 | 2006-07-11 | Rimma Lliinichna Ashkinazi | N-substituted derivatives of 5-oxyiminobarbituric acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075983A (en) * | 1963-01-29 | -oconh | ||
| CA873891A (en) * | 1971-06-22 | Melkonian Diran | Barbituric acid derivatives | |
| GB1193438A (en) * | 1966-10-26 | 1970-06-03 | Phillipe Gold-Aubert | Barbituric Acid Derivatives, preparation thereof and Pharmaceutical Compositions containing them |
| GB1581834A (en) * | 1976-11-01 | 1980-12-31 | Sapos Sa | Complexes of barbituric acid derivatives |
| FR2424262A1 (fr) * | 1978-04-24 | 1979-11-23 | Sapos Sa | Nouveaux complexes tetrameres de derives de la malonyl-uree a action psychotrope et procede de preparation |
-
1983
- 1983-04-12 GB GB838309813A patent/GB8309813D0/en active Pending
-
1984
- 1984-04-11 RO RO84114230A patent/RO89141A/ro unknown
- 1984-04-11 IE IE890/84A patent/IE57321B1/en not_active IP Right Cessation
- 1984-04-11 ZA ZA842687A patent/ZA842687B/xx unknown
- 1984-04-11 EP EP84302489A patent/EP0125046B1/en not_active Expired
- 1984-04-11 NO NO841438A patent/NO170928C/no unknown
- 1984-04-11 DK DK186784A patent/DK158726C/da not_active IP Right Cessation
- 1984-04-11 IL IL71515A patent/IL71515A/xx not_active IP Right Cessation
- 1984-04-11 PL PL1984247174A patent/PL144481B1/pl unknown
- 1984-04-11 BE BE0/212734A patent/BE899385A/fr not_active IP Right Cessation
- 1984-04-11 IN IN318/DEL/84A patent/IN161291B/en unknown
- 1984-04-11 NZ NZ207802A patent/NZ207802A/en unknown
- 1984-04-11 AU AU26749/84A patent/AU554056B2/en not_active Ceased
- 1984-04-11 AT AT0122084A patent/AT388917B/de not_active IP Right Cessation
- 1984-04-11 CA CA000451688A patent/CA1247619A/en not_active Expired
- 1984-04-11 FI FI841430A patent/FI84348C/fi not_active IP Right Cessation
- 1984-04-11 IT IT48019/84A patent/IT1177658B/it active
- 1984-04-11 UA UA3723552A patent/UA7040A1/uk unknown
- 1984-04-11 CS CS842762A patent/CS276389B6/cs unknown
- 1984-04-11 EG EG238/84A patent/EG17794A/xx active
- 1984-04-11 YU YU66484A patent/YU45607B/sh unknown
- 1984-04-11 DD DD84261877A patent/DD222018A5/de not_active IP Right Cessation
- 1984-04-11 HU HU841424A patent/HU192548B/hu not_active IP Right Cessation
- 1984-04-11 US US06/598,969 patent/US4611057A/en not_active Expired - Fee Related
- 1984-04-11 LU LU85296A patent/LU85296A1/fr unknown
- 1984-04-11 JP JP59071048A patent/JPS59205370A/ja active Granted
- 1984-04-11 MX MX8203A patent/MX159632A/es unknown
- 1984-04-11 MA MA20313A patent/MA20092A1/fr unknown
- 1984-04-11 BG BG65031A patent/BG65031A/xx unknown
- 1984-04-11 ES ES531498A patent/ES531498A0/es active Granted
- 1984-04-11 DE DE8484302489T patent/DE3464910D1/de not_active Expired
- 1984-04-11 CH CH1826/84A patent/CH658653A5/de not_active IP Right Cessation
- 1984-04-11 FR FR8405750A patent/FR2544312B1/fr not_active Expired
- 1984-04-11 GR GR74381A patent/GR79890B/el unknown
- 1984-04-11 BR BR8401679A patent/BR8401679A/pt unknown
- 1984-04-11 PT PT78400A patent/PT78400B/pt not_active IP Right Cessation
- 1984-04-11 AR AR296253A patent/AR240317A1/es active
- 1984-04-11 SU SU843723552A patent/SU1380611A3/ru active
- 1984-04-12 PH PH30536A patent/PH24131A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |