[go: up one dir, main page]

ES8504778A1 - Un procedimiento para la preparacion de derivados de fenil-piperazina - Google Patents

Un procedimiento para la preparacion de derivados de fenil-piperazina

Info

Publication number
ES8504778A1
ES8504778A1 ES527319A ES527319A ES8504778A1 ES 8504778 A1 ES8504778 A1 ES 8504778A1 ES 527319 A ES527319 A ES 527319A ES 527319 A ES527319 A ES 527319A ES 8504778 A1 ES8504778 A1 ES 8504778A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
phenyl
piperazine derivatives
recristalization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527319A
Other languages
English (en)
Other versions
ES527319A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of ES527319A0 publication Critical patent/ES527319A0/es
Publication of ES8504778A1 publication Critical patent/ES8504778A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paper (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE FENILPIPERAZINA, DE FORMULA (I), DONDE R1 ES ALQUILO, SATURADO O INSATURADO, SUSTITUIDO O NO; Y R2 ES HIDROGENO, HALOGENO, ALQUILO INFERIOR O SULFAMOILO.MEDIANTE REACCION DE UN COMPUESTO DE FORMULA (II) CON UN HALURO DE ALQUILO R1,X DONDE X ES HALOGENO Y R1, R2 SON LOS ANTERIORMENTE INDICADOS. EL COMPUESTO FINAL SE AISLA POR TECNICAS CONVENCIONALES COMO ADICION DE AGUA, FILTRACION Y RECRISTALIZACION O EXTRACCION CON DISOLVENTE ORGANICO, DESTILACION DEL DISOLVENTE Y RECRISTALIZACION O CROMATOGRAFIA EN COLUMNA.DE APLICACION COMO ANTIHIPERTENSIVOS Y VASODILATADORES DE LAS VENAS PERIFERICAS.
ES527319A 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenil-piperazina Expired ES8504778A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57040904A JPS58159480A (ja) 1982-03-17 1982-03-17 新規なフエニルピペラジン誘導体

Publications (2)

Publication Number Publication Date
ES527319A0 ES527319A0 (es) 1985-05-01
ES8504778A1 true ES8504778A1 (es) 1985-05-01

Family

ID=12593492

Family Applications (3)

Application Number Title Priority Date Filing Date
ES520693A Expired ES8404347A1 (es) 1982-03-17 1983-03-16 Un procedimiento para la preparacion de derivados de fenilpiperazina.
ES527319A Expired ES8504778A1 (es) 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenil-piperazina
ES527318A Granted ES527318A0 (es) 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenilpiperazina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES520693A Expired ES8404347A1 (es) 1982-03-17 1983-03-16 Un procedimiento para la preparacion de derivados de fenilpiperazina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES527318A Granted ES527318A0 (es) 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenilpiperazina

Country Status (12)

Country Link
US (1) US4578465A (es)
EP (1) EP0089065B1 (es)
JP (1) JPS58159480A (es)
KR (1) KR900004125B1 (es)
AT (1) ATE27817T1 (es)
CA (1) CA1248102A (es)
DE (2) DE3372095D1 (es)
DK (1) DK156064C (es)
ES (3) ES8404347A1 (es)
FI (1) FI77456C (es)
MX (1) MX7157E (es)
ZA (1) ZA831674B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
JPS60169467A (ja) * 1984-02-10 1985-09-02 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
US4711883A (en) * 1985-09-30 1987-12-08 Ortho Pharmaceutical Corporation Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
GB8524663D0 (en) * 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
JPS62135464A (ja) * 1985-12-10 1987-06-18 Nippon Kayaku Co Ltd フエニルピペラジン誘導体
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
CA2753599C (en) * 2009-02-26 2017-03-14 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
BRPI1003506B1 (pt) 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
KR102132078B1 (ko) * 2018-09-20 2020-07-08 원광대학교산학협력단 방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274194A (en) * 1963-03-29 1966-09-20 Miles Lab Quinazolinedione derivatives
US3322766A (en) * 1964-11-13 1967-05-30 Shulton Inc 3-beta-(4-pyridyl) ethyl-2, 3-dihydro-4(1h)-quinazolinones
AT269143B (de) * 1966-06-30 1969-03-10 Miles Lab Verfahren zur Herstellung von neuen Chinazolindionderivaten und ihrer Säureadditionssalze bzw. ihrer entsprechenden Piperaziniumverbindungen
GB1227936A (es) * 1968-02-29 1971-04-15
DE1934037A1 (de) * 1969-07-04 1971-01-07 Cassella Farbwerke Mainkur Ag Basisch substituierte Derivate des 2,4-(1H,3H)-Chinazolindions
US3726979A (en) * 1971-04-09 1973-04-10 E Hong Method of producing serotonin antagonism
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
EP0040793B1 (en) * 1980-05-22 1985-08-28 Masayuki Ishikawa Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Also Published As

Publication number Publication date
ZA831674B (en) 1984-04-25
ES8504777A1 (es) 1985-05-01
US4578465A (en) 1986-03-25
ES527318A0 (es) 1985-05-01
DE3372095D1 (en) 1987-07-23
JPS58159480A (ja) 1983-09-21
FI77456B (fi) 1988-11-30
FI830893L (fi) 1983-09-18
CA1248102A (en) 1989-01-03
EP0089065A3 (en) 1984-05-23
ES527319A0 (es) 1985-05-01
ES520693A0 (es) 1984-05-01
DK156064B (da) 1989-06-19
FI830893A0 (fi) 1983-03-17
DK120483A (da) 1983-09-18
JPH033669B2 (es) 1991-01-21
ES8404347A1 (es) 1984-05-01
EP0089065B1 (en) 1987-06-16
KR840004104A (ko) 1984-10-06
KR900004125B1 (ko) 1990-06-16
EP0089065A2 (en) 1983-09-21
DK156064C (da) 1989-11-06
FI77456C (fi) 1989-03-10
DE89065T1 (de) 1985-04-11
MX7157E (es) 1987-11-27
DK120483D0 (da) 1983-03-15
ATE27817T1 (de) 1987-07-15

Similar Documents

Publication Publication Date Title
ES8504778A1 (es) Un procedimiento para la preparacion de derivados de fenil-piperazina
ES2061660T3 (es) Eteres azabiciclicos.
ES2072939T3 (es) Nuevos derivados de esteroides.
BE863414A (fr) Compositions de resines organiques durcissables par la lumiere ultra-violette
AR241474A1 (es) Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina.
AR241019A2 (es) "procedimiento para separar el grupo alilo de compuestos de carba-penem-carboxilatos de alilo para formar los correspondientes compuestos con el grupo carboxilo libre".
ES8305752A1 (es) Procedimiento para preparar esteres de acidos quinolina-car boxilicos.
ES8703460A1 (es) Un procedimiento para preparar aminoacil-ladanos
DK51488A (da) Fremgangsmaade til hydrogenering af en umaettet organisk forbindelse
ES8300729A1 (es) Un procedimiento para la produccion de un derivado de pripe-razina.
DK557281A (da) Fremgangsmaade til indfoering af alkoxy- og aralkyloxygrupper i organiske forbindelser
ES8502980A1 (es) Procedimiento para la obtencion de azoles 2,4,5-trisustituidos. (como desglose y con prioridad de la patente espanola no.510.504, presentada el 17 de marzo de 1.982)
ES2040856T3 (es) Un procedimiento para preparar un compuesto de tiofeno.
IT1127300B (it) Procedimento per il recupero di composti del molibdeno
ES2128554T3 (es) Nuevos derivados del acido glutamico, procedimiento para su preparacion y su utilizacion como medicamentos para el aumento de la memoria y aprendizaje.
SE8306740D0 (sv) 2-thiacephems and (5r) penems derivatives
ES8702379A1 (es) Un procedimiento para la produccion de 1h-tetrazol-5-carboxamidas-n-sustituidas.
ES8403132A1 (es) Un procedimiento para la preparacion de bis-esteres de metanodiol.
ES2039257T3 (es) Derivados del acido isocianurico.
ES2108691T3 (es) Compuestos y composiciones absorbentes de uv.
ES2032461T3 (es) Procedimiento para preparar derivados de indol.
ES8104806A1 (es) Un procedimiento para la preparacion de octahidro-1h-pirro- lo-(2,3g)isoquinolinas
DK539079A (da) Fremgangsmaade til fremstilling af isoxazolderivater
SE8502973L (sv) Framstellning av aminderivat
ES8301872A1 (es) Un procedimiento para la preparacion de nuevos derivados de 4-2-hidroxi-4(sustituido) fenil-naftalen-2-1h-onas y 2-oles.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401