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ES8502683A1 - Procedimiento para la preparacion de derivados de r- y s-carbazol - Google Patents

Procedimiento para la preparacion de derivados de r- y s-carbazol

Info

Publication number
ES8502683A1
ES8502683A1 ES532838A ES532838A ES8502683A1 ES 8502683 A1 ES8502683 A1 ES 8502683A1 ES 532838 A ES532838 A ES 532838A ES 532838 A ES532838 A ES 532838A ES 8502683 A1 ES8502683 A1 ES 8502683A1
Authority
ES
Spain
Prior art keywords
derivative
general formula
carbazole
preparation
carbazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532838A
Other languages
English (en)
Other versions
ES532838A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6199873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8502683(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES532838A0 publication Critical patent/ES532838A0/es
Publication of ES8502683A1 publication Critical patent/ES8502683A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE R- Y S-CARBAZOL.CONSISTE EN HACER REACCIONAR 4-HIDROXI-CARBAZOL CON UN DERIVADO DE S-EPOXIDO DE FORMULA (II) EN PRESENCIA DE UN DISOLVENTE ORGANICO Y UN MEDIO ALCALINO; EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON AMONIACO O UNA AMINA SUSTITUIDA Y A CONTINUACION SE TRANSFORMA EL COMPUESTO OBTENIDO EN UNA SAL FARMACOLOGICAMENTE COMPATIBLE DE FORMULA (I). EL RADICAL R1 SIGNIFICA UN DERIVADO DEL ACIDO SULFONICO SUSTITUIDO.LOS COMPUESTOS OBTENIDOS TIENEN UTILIDAD FARMACOLOGICAS TALES COMO TRATAMIENTO DE GLAUCOMA.
ES532838A 1983-05-26 1984-05-25 Procedimiento para la preparacion de derivados de r- y s-carbazol Expired ES8502683A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833319027 DE3319027A1 (de) 1983-05-26 1983-05-26 Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
ES532838A0 ES532838A0 (es) 1985-02-01
ES8502683A1 true ES8502683A1 (es) 1985-02-01

Family

ID=6199873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532838A Expired ES8502683A1 (es) 1983-05-26 1984-05-25 Procedimiento para la preparacion de derivados de r- y s-carbazol

Country Status (20)

Country Link
US (4) US4697022A (es)
EP (1) EP0127099B1 (es)
JP (2) JPS59222473A (es)
KR (1) KR860001761B1 (es)
AT (1) ATE27273T1 (es)
AU (1) AU551116B2 (es)
CA (1) CA1259071A (es)
DE (2) DE3319027A1 (es)
DK (2) DK169331B1 (es)
ES (1) ES8502683A1 (es)
FI (1) FI80018C (es)
GR (1) GR81577B (es)
HU (1) HU193011B (es)
IE (1) IE57533B1 (es)
IL (1) IL71876A (es)
NO (1) NO164537C (es)
NZ (1) NZ208254A (es)
PH (1) PH22749A (es)
PT (1) PT78633B (es)
ZA (1) ZA843976B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
DE3540149A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
ES2050425T3 (es) * 1988-12-26 1994-05-16 Kowa Co Produccion de un eter glicidilico.
WO1994020096A1 (en) * 1993-03-05 1994-09-15 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited Method of employing carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5308862A (en) * 1993-03-05 1994-05-03 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US6075040A (en) * 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
WO1998002157A1 (de) * 1996-07-13 1998-01-22 Roche Diagnostics Gmbh Topisch einsetzbare pharmazeutische formulierungen enthaltend als wirkstoff ein carbazolyl-(4)-oxy-propanolamin-derivat
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
EP0893440A1 (en) * 1997-07-22 1999-01-27 Roche Diagnostics GmbH Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
US6730326B2 (en) 1997-07-22 2004-05-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it
ZA989365B (en) * 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
HU227441B1 (en) * 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof
HU9702209D0 (en) * 1997-11-24 1998-01-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical product
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
US6664284B2 (en) * 1998-07-23 2003-12-16 Roche Diagnostics Gmbh Stabilized carvedilol injection solution
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
EP1272180B1 (en) * 2000-04-03 2004-09-29 F. Hoffmann-La Roche Ag Concentrated solutions of carvedilol
HUP0301802A3 (en) 2000-06-28 2009-04-28 Teva Pharma Process for producing carvedilol, crystalline carvedilol, process for producing it and pharmaceutical composition containing it
KR100342659B1 (en) 2000-12-15 2002-07-04 Rstech Co Ltd Chiral polymer salene catalyst and process for preparing chiral compounds from racemic epoxide using the same
JP2005507899A (ja) * 2001-09-28 2005-03-24 エフ．ホフマン−ラ　ロシュ　アーゲー カルベジロールの疑似多形形態
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US6710184B2 (en) 2002-01-15 2004-03-23 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
US20050148779A1 (en) * 2002-04-30 2005-07-07 Wei Chen Carvedilol monocitrate monohydrate
EP1539140A4 (en) * 2002-06-27 2005-12-07 Sb Pharmco Inc CARVEDILOLHYDOBROMID
AU2003248746B2 (en) * 2002-06-27 2009-01-08 Smithkline Beecham (Cork) Limited Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
SK285547B6 (sk) 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
EP1615888A1 (en) * 2003-04-21 2006-01-18 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
US7482471B2 (en) * 2003-06-20 2009-01-27 Sun Pharmaceutical Industries Limited Process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(-methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
JP5072364B2 (ja) * 2003-11-25 2012-11-14 スミスクライン ビーチャム （コーク） リミテッド カルベジロール遊離塩基、カルベジロール塩、無水形態またはその溶媒和物、対応する医薬組成物、制御放出処方および治療またはデリバリー方法
EP1686986A4 (en) * 2003-11-25 2009-05-27 Sb Pharmco Inc CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT
EP1686967A4 (en) * 2003-11-25 2012-08-08 Smithkline Beecham Cork Ltd CARVEDILOL-FREE BASE, SALTS, WATER-FREE FORMS OR SOLVATES THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULAS AND TREATMENT OR DISPOSAL PROCEDURES
EP1723107A2 (en) 2004-02-23 2006-11-22 Cadila Healthcare Ltd. Process for manufacture of racemic carvedilol
WO2005115981A2 (en) * 2004-04-22 2005-12-08 Usv Limited A process for the preparation of 1-(9h-carbazol-4-yloxy)-3-2-(-methoxyphenoxy)-ethyl amino-propan-2-ol
GB0411273D0 (en) * 2004-05-20 2004-06-23 Cipla Ltd Process and product
JP2008523025A (ja) * 2004-12-09 2008-07-03 ザック システム エス．ピー．エー． カルベジロール及びそのエナンチオマーの調製プロセス
US20070043099A1 (en) * 2005-06-09 2007-02-22 Igor Lifshitz Crystalline forms of carvedilol and processes for their preparation
WO2007077111A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
WO2008002683A2 (en) * 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
WO2008038301A1 (en) * 2006-09-26 2008-04-03 Morepen Laboratories Limited A process for the preparation of carvedilol
EP2114881A1 (en) * 2007-02-26 2009-11-11 Teva Pharmaceutical Industries Ltd. Process for the purification of carvedilol or its salts thereof
CN102285910B (zh) * 2011-07-04 2013-06-19 南京工业大学 一种制备(s)-卡维地洛的方法
CN102617368B (zh) * 2012-02-27 2014-07-09 华中科技大学 一种α/β受体双重抑制剂及其盐的制备方法
US10749118B2 (en) 2014-06-26 2020-08-18 Samsung Display Co., Ltd. Heterocyclic compound and organic light-emitting device including the same
WO2022126236A1 (en) * 2020-09-17 2022-06-23 Uti Limited Partnership Methods of treating and/or preventing alzheimer's disease with r-carvedilol
CN116041248B (zh) * 2023-04-03 2023-06-06 成都摩诃大龙医药科技有限公司 一种具有抗癌活性的咔唑衍生物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB1369580A (en) * 1972-08-18 1974-10-09 Boehringer Mannheim Gmbh Tricyclic diphenylamine derivatives
GB1458392A (en) * 1973-11-09 1976-12-15 Ici Ltd Optically-active 1-aryloxy-2,3-epoxypropane derivatives
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
CH641147A5 (de) * 1979-01-17 1984-02-15 Sandoz Ag 3-amino-2-hydroxypropoxyaryl-derivat, seine herstellung und dieses enthaltende heilmittel.
DE3011808A1 (de) * 1980-03-27 1981-10-01 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung von n-hydroxyalkylcarbazol
US4400383A (en) * 1981-12-11 1983-08-23 Burroughs Wellcome Co. Treatment of anxiety
DE3300933A1 (de) * 1983-01-13 1984-07-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von d,l- und d-carazolol als antiglaukommittel sowie arzneimittel, die diese stoffe enthalten

Also Published As

Publication number Publication date
IL71876A (en) 1987-10-30
KR860001761B1 (ko) 1986-10-21
FI842046A0 (fi) 1984-05-22
PH22749A (en) 1988-11-28
AU551116B2 (en) 1986-04-17
IE841295L (en) 1984-11-26
US5071868A (en) 1991-12-10
AU2848084A (en) 1984-11-29
PT78633A (de) 1984-06-01
DK255184A (da) 1984-11-27
GR81577B (es) 1984-12-11
ES532838A0 (es) 1985-02-01
FI80018C (fi) 1990-04-10
DK169331B1 (da) 1994-10-10
IE57533B1 (en) 1993-03-24
ZA843976B (en) 1985-01-30
PT78633B (de) 1986-06-18
US4985454A (en) 1991-01-15
US4697022A (en) 1987-09-29
CA1259071A (en) 1989-09-05
EP0127099A1 (de) 1984-12-05
DK91393A (da) 1993-08-06
IL71876A0 (en) 1984-09-30
JPS59222473A (ja) 1984-12-14
KR840009088A (ko) 1984-12-24
HU193011B (en) 1987-08-28
NO164537B (no) 1990-07-09
NO164537C (no) 1990-10-17
DK91393D0 (da) 1993-08-06
FI80018B (fi) 1989-12-29
JPH0527622B2 (es) 1993-04-21
JPH0613508B2 (ja) 1994-02-23
ATE27273T1 (de) 1987-06-15
EP0127099B1 (de) 1987-05-20
DE3319027A1 (de) 1984-11-29
NZ208254A (en) 1988-11-29
JPH05208957A (ja) 1993-08-20
US4824963A (en) 1989-04-25
DK169333B1 (da) 1994-10-10
DK255184D0 (da) 1984-05-24
NO842084L (no) 1984-11-27
DE3463768D1 (en) 1987-06-25
FI842046L (fi) 1984-11-27
HUT34160A (en) 1985-02-28

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