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ES8405001A1 - Un procedimiento para la preparacion de un derivado de carbostirilo. - Google Patents

Un procedimiento para la preparacion de un derivado de carbostirilo.

Info

Publication number
ES8405001A1
ES8405001A1 ES521473A ES521473A ES8405001A1 ES 8405001 A1 ES8405001 A1 ES 8405001A1 ES 521473 A ES521473 A ES 521473A ES 521473 A ES521473 A ES 521473A ES 8405001 A1 ES8405001 A1 ES 8405001A1
Authority
ES
Spain
Prior art keywords
group
substituted
activity
carbostyril
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521473A
Other languages
English (en)
Other versions
ES521473A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56137984A external-priority patent/JPS5838258A/ja
Priority claimed from JP56210368A external-priority patent/JPS58110568A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8405001A1 publication Critical patent/ES8405001A1/es
Publication of ES521473A0 publication Critical patent/ES521473A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO, DE FORMULA (I), EN LA QUE A ES ALQUILENO INFERIOR; R Y R PUEDEN SER VARIOS TIPOS DE RADICALES Y LA LINEA DISCONTINUA SIGNIFICA UN ENLACE SENCILLO O DOBLE.CONSISTE EN LA REACCION DE UN DERIVADO DE CARBOSTIRILO, DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X ES UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACIDO DE LEWIS, A TEMPERATURAS ENTRE 0JC Y 120JC.ESTOSCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS.
ES521473A 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo. Granted ES521473A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56137984A JPS5838258A (ja) 1981-09-01 1981-09-01 カルボスチリル誘導体
JP56210368A JPS58110568A (ja) 1981-12-25 1981-12-25 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
ES8405001A1 true ES8405001A1 (es) 1984-05-16
ES521473A0 ES521473A0 (es) 1984-05-16

Family

ID=26471144

Family Applications (5)

Application Number Title Priority Date Filing Date
ES514992A Expired ES8401058A1 (es) 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo.
ES521472A Granted ES521472A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521471A Expired ES8500933A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521473A Granted ES521473A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES536982A Granted ES536982A0 (es) 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES514992A Expired ES8401058A1 (es) 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo.
ES521472A Granted ES521472A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521471A Expired ES8500933A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES536982A Granted ES536982A0 (es) 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo

Country Status (21)

Country Link
US (1) US4514401A (es)
KR (1) KR860000135B1 (es)
AR (2) AR241905A1 (es)
AT (1) AT383592B (es)
AU (1) AU532361B2 (es)
BE (1) BE894105A (es)
CA (1) CA1205807A (es)
CH (1) CH650783A5 (es)
DE (1) DE3230209C2 (es)
DK (1) DK166877B1 (es)
ES (5) ES8401058A1 (es)
FI (1) FI78688C (es)
FR (1) FR2512019B1 (es)
GB (1) GB2108109B (es)
IT (1) IT1156490B (es)
NL (1) NL8203225A (es)
NO (1) NO159591C (es)
PH (1) PH18055A (es)
PT (1) PT75424B (es)
SE (1) SE452984B (es)
SU (1) SU1356962A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
EP0255134B1 (en) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same
US5098477A (en) * 1988-12-14 1992-03-24 Ciba-Geigy Corporation Inks, particularly for ink printing
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CN1890225A (zh) * 2003-12-10 2007-01-03 詹森药业有限公司 作为多聚(adp－核糖)聚合酶抑制剂的被取代的6－环己基烷基取代的2－喹啉酮和2－喹喔啉酮
HRP20171415T4 (hr) 2009-06-25 2023-03-03 Alkermes Pharma Ireland Limited Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja
CA2797708C (en) 2010-05-04 2016-08-16 Alkermes Pharma Ireland Limited Process for synthesizing oxidized lactam compounds
RU2448698C2 (ru) * 2010-06-21 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) Способ восстановления синусового ритма при трепетании предсердий i типа
ES2691671T3 (es) 2010-06-24 2018-11-28 Alkermes Pharma Ireland Limited Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5118771A (ja) * 1974-08-07 1976-02-14 Akimitsu Takeya Bantaioshigatanitaisuru keshoshiitotenchakuho
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS597707B2 (ja) * 1975-06-23 1984-02-20 オオツカセイヤク カブシキガイシヤ カルボスチリルユウドウタイノ セイゾウホウ
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
JPS5585520A (en) * 1978-12-22 1980-06-27 Otsuka Pharmaceut Co Ltd Remedy for peptic ulcer
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Also Published As

Publication number Publication date
IT8268020A0 (it) 1982-08-16
NO822749L (no) 1983-03-02
AT383592B (de) 1987-07-27
SE8204677D0 (sv) 1982-08-13
ES521471A0 (es) 1984-11-01
AU532361B2 (en) 1983-09-29
IT8268020A1 (it) 1984-02-16
AR240918A2 (es) 1991-03-27
BE894105A (fr) 1983-02-14
ES8506302A1 (es) 1985-07-01
CA1205807A (en) 1986-06-10
SE452984B (sv) 1988-01-04
FI78688B (fi) 1989-05-31
FI822803A0 (fi) 1982-08-11
ES514992A0 (es) 1983-11-16
FI78688C (fi) 1989-09-11
IT1156490B (it) 1987-02-04
AR240918A1 (es) 1991-03-27
PT75424A (en) 1982-09-01
DK361982A (da) 1983-03-02
PT75424B (en) 1985-01-04
KR840001157A (ko) 1984-03-28
US4514401A (en) 1985-04-30
DE3230209A1 (de) 1983-03-10
PH18055A (en) 1985-03-18
NO159591C (no) 1989-01-18
KR860000135B1 (ko) 1986-02-26
CH650783A5 (de) 1985-08-15
ES8401058A1 (es) 1983-11-16
FI822803L (fi) 1983-03-02
ES536982A0 (es) 1985-07-01
GB2108109B (en) 1985-05-09
SU1356962A3 (ru) 1987-11-30
DE3230209C2 (de) 1985-08-22
ES8405000A1 (es) 1984-05-16
GB2108109A (en) 1983-05-11
ES521473A0 (es) 1984-05-16
ES521472A0 (es) 1984-05-16
ES8500933A1 (es) 1984-11-01
FR2512019B1 (fr) 1986-01-03
NO159591B (no) 1988-10-10
ATA310682A (de) 1986-12-15
DK166877B1 (da) 1993-07-26
AR241905A1 (es) 1993-01-29
SE8204677L (sv) 1983-03-02
NL8203225A (nl) 1983-04-05
AU8698082A (en) 1983-04-14
FR2512019A1 (fr) 1983-03-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401