RO82216B - Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului - Google Patents
Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazoluluiInfo
- Publication number
- RO82216B RO82216B RO105346A RO10534681A RO82216B RO 82216 B RO82216 B RO 82216B RO 105346 A RO105346 A RO 105346A RO 10534681 A RO10534681 A RO 10534681A RO 82216 B RO82216 B RO 82216B
- Authority
- RO
- Romania
- Prior art keywords
- carbon atoms
- general formula
- aryl
- hydrogen
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului cu formula generala I: (vezi formula) în care R reprezinta hidrogen, halogen, o grupa amino, hidroxi sai alchilamino cu 1...4 atomi de carbon Ar reprezinta fenil, piridil, tienil sau: (vezi formula) în care R1, R2 si R3 reprezinta hidrogen, halogen, grupe haloalchil cu 1...4 atomi de carbon, alcoxi cu 1...4 atomi de carbon, alchil cu 1...4 atomi de carbon, sau R1 si R2 si R3 luati împreuna reprezinta un radical alchilendioxi cu 1...4 atomi de carbon cu exceptia cazului în care R reprezinta hidrogen sau brom, si Ar reprezinta fenil, constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R si Ar au semnificatiile de mai sus si Qreprezinta un radical ales dintre (vezi formula) în care R4 si R5 sunt identici sau diferiti si reprezinta hidrogen sau alchil cu 1...3 atomi de carbon si R6 reprezinta alchil cu 1...4 atomi de carbon se hidrolizeaza în prezenta unui hidroxid de met al alcalin, în mediu apos, la o temperatura cuprinsa între 0 si 110 degree C, iar acidul cu formula generala I poate fi, eventual, transformat, prin metode în sine cunoscute, într-o sare sau ester acceptabile farmaceutic.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/189,435 US4346094A (en) | 1980-09-22 | 1980-09-22 | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO82216B true RO82216B (ro) | 1983-06-30 |
| RO82216A RO82216A (ro) | 1983-07-07 |
Family
ID=22697314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO81105346A RO82216A (ro) | 1980-09-22 | 1981-09-21 | Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4346094A (ro) |
| EP (1) | EP0048615B1 (ro) |
| JP (1) | JPS5785379A (ro) |
| KR (1) | KR830007597A (ro) |
| AR (1) | AR229103A1 (ro) |
| AT (1) | ATE7657T1 (ro) |
| AU (1) | AU7551681A (ro) |
| CS (1) | CS228536B2 (ro) |
| DD (1) | DD201790A5 (ro) |
| DE (1) | DE3163900D1 (ro) |
| DK (1) | DK417981A (ro) |
| ES (1) | ES505678A0 (ro) |
| FI (1) | FI812940A7 (ro) |
| GB (1) | GB2084573B (ro) |
| GR (1) | GR75046B (ro) |
| IL (1) | IL63890A0 (ro) |
| NO (1) | NO813208L (ro) |
| PL (1) | PL130497B1 (ro) |
| PT (1) | PT73711B (ro) |
| RO (1) | RO82216A (ro) |
| YU (1) | YU227181A (ro) |
| ZA (1) | ZA816549B (ro) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4428956A (en) | 1980-12-29 | 1984-01-31 | Merck & Co., Inc. | 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis |
| US4431652A (en) * | 1980-12-29 | 1984-02-14 | Merck & Co., Inc. | 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis |
| US4539328A (en) * | 1983-03-25 | 1985-09-03 | Fmc Corporation | Nematicidal isothiazole derivatives |
| US4620865A (en) * | 1983-11-07 | 1986-11-04 | Eli Lilly And Company | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides |
| IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
| ZW21687A1 (en) * | 1986-12-12 | 1988-07-20 | Hoffmann La Roche | Triazine derivatives |
| DE69122084T2 (de) * | 1990-11-30 | 1997-04-03 | Teijin Ltd., Osaka | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| US5294630A (en) * | 1992-07-07 | 1994-03-15 | Eli Lilly And Company | Treatment of inflammatory bowel disease |
| US5436258A (en) * | 1992-09-09 | 1995-07-25 | Eli Lilly And Company | Prevention of bone resorption |
| MY117352A (en) * | 1995-10-31 | 2004-06-30 | Ciba Sc Holding Ag | Oximesulfonic acid esters and the use thereof as latent sulfonic acids. |
| ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| AU1520699A (en) | 1997-11-07 | 1999-05-31 | Johns Hopkins University, The | Methods for treatment of disorders of cardiac contractility |
| TW575792B (en) * | 1998-08-19 | 2004-02-11 | Ciba Sc Holding Ag | New unsaturated oxime derivatives and the use thereof as latent acids |
| SG78412A1 (en) | 1999-03-31 | 2001-02-20 | Ciba Sc Holding Ag | Oxime derivatives and the use thereof as latent acids |
| EP1472576B1 (en) | 2002-02-06 | 2013-04-24 | Basf Se | Sulfonate derivatives and the use therof as latent acids |
| MX2007002160A (es) * | 2004-08-27 | 2007-05-10 | Astellas Pharma Inc | Derivado de 2-fenilpiridina. |
| JPWO2006022375A1 (ja) * | 2004-08-27 | 2008-05-08 | アステラス製薬株式会社 | ２−フェニルチオフェン誘導体 |
| EP1932832B1 (en) | 2005-10-07 | 2010-12-01 | Astellas Pharma Inc. | Triarylcarboxylic acid derivative |
| KR20080097456A (ko) | 2006-02-24 | 2008-11-05 | 아스텔라스세이야쿠 가부시키가이샤 | 소화관 궤양의 치료제 또는 예방제 |
| GB2450975B (en) | 2007-07-12 | 2010-02-24 | Ciba Holding Inc | Yellow radiation curing inks |
| EP2668953A1 (en) * | 2008-05-22 | 2013-12-04 | Bristol-Myers Squibb Company | Pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate and/or an inhibitor of uric acid synthesis |
| PL2404908T3 (pl) | 2009-02-27 | 2014-12-31 | Teijin Ltd | Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego |
| KR20110137821A (ko) | 2009-03-30 | 2011-12-23 | 바스프 에스이 | Ｕｖ-조사량 인디케이터 필름 |
| HUE030166T2 (en) | 2010-08-27 | 2017-05-29 | Teijin Pharma Ltd | Process for the preparation of a phenyl-substituted heterocyclic derivative by coupling using a palladium compound |
| KR101897842B1 (ko) | 2011-01-28 | 2018-09-12 | 바스프 에스이 | 열 경화제로서 옥심 술포네이트를 포함하는 중합성 조성물 |
| CN105189476B (zh) | 2013-03-29 | 2017-07-07 | 帝人制药株式会社 | 吡唑衍生物 |
| CN106604912A (zh) | 2014-08-29 | 2017-04-26 | 巴斯夫欧洲公司 | 肟磺酸酯衍生物 |
| CA2984044A1 (en) | 2015-04-29 | 2016-11-03 | Bsn Medical Gmbh | Steady-state no production via ph control |
| AU2016256577B2 (en) | 2015-04-29 | 2019-04-04 | Bsn Medical Gmbh | Medical bathing device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1178604A (en) * | 1966-03-21 | 1970-01-21 | American Cyanamid Co | Novel Pyridinium Salts and Methods for Preparing Same |
| US3464999A (en) * | 1967-07-27 | 1969-09-02 | R & L Molecular Research Ltd | Thiadiazolylisothiazoles |
| GB1180268A (en) * | 1967-09-26 | 1970-02-04 | Ici Ltd | Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives |
| GB1192701A (en) * | 1968-03-22 | 1970-05-20 | Ici Ltd | Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same |
| US3681498A (en) * | 1970-10-19 | 1972-08-01 | American Cyanamid Co | Isothiazolyl pyridinium salts as hypoglycemic agents |
-
1980
- 1980-09-22 US US06/189,435 patent/US4346094A/en not_active Expired - Lifetime
-
1981
- 1981-09-19 PL PL1981233103A patent/PL130497B1/pl unknown
- 1981-09-20 IL IL63890A patent/IL63890A0/xx unknown
- 1981-09-21 ZA ZA816549A patent/ZA816549B/xx unknown
- 1981-09-21 GB GB8128465A patent/GB2084573B/en not_active Expired
- 1981-09-21 GR GR66108A patent/GR75046B/el unknown
- 1981-09-21 RO RO81105346A patent/RO82216A/ro unknown
- 1981-09-21 YU YU02271/81A patent/YU227181A/xx unknown
- 1981-09-21 DE DE8181304325T patent/DE3163900D1/de not_active Expired
- 1981-09-21 AU AU75516/81A patent/AU7551681A/en not_active Abandoned
- 1981-09-21 AR AR286818A patent/AR229103A1/es active
- 1981-09-21 EP EP81304325A patent/EP0048615B1/en not_active Expired
- 1981-09-21 PT PT73711A patent/PT73711B/pt unknown
- 1981-09-21 DK DK417981A patent/DK417981A/da not_active Application Discontinuation
- 1981-09-21 AT AT81304325T patent/ATE7657T1/de not_active IP Right Cessation
- 1981-09-21 NO NO813208A patent/NO813208L/no unknown
- 1981-09-21 ES ES505678A patent/ES505678A0/es active Granted
- 1981-09-21 FI FI812940A patent/FI812940A7/fi not_active Application Discontinuation
- 1981-09-22 CS CS816978A patent/CS228536B2/cs unknown
- 1981-09-22 KR KR1019810003537A patent/KR830007597A/ko not_active Abandoned
- 1981-09-22 JP JP56150483A patent/JPS5785379A/ja active Pending
- 1981-09-22 DD DD81233487A patent/DD201790A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0048615A1 (en) | 1982-03-31 |
| DE3163900D1 (en) | 1984-07-05 |
| PT73711A (en) | 1981-10-01 |
| ZA816549B (en) | 1983-04-27 |
| PT73711B (en) | 1982-12-20 |
| YU227181A (en) | 1983-10-31 |
| DD201790A5 (de) | 1983-08-10 |
| ES8301225A1 (es) | 1982-12-01 |
| KR830007597A (ko) | 1983-11-04 |
| US4346094A (en) | 1982-08-24 |
| JPS5785379A (en) | 1982-05-28 |
| NO813208L (no) | 1982-03-23 |
| CS228536B2 (en) | 1984-05-14 |
| PL130497B1 (en) | 1984-08-31 |
| PL233103A1 (ro) | 1982-12-20 |
| ATE7657T1 (de) | 1984-06-15 |
| AR229103A1 (es) | 1983-06-15 |
| IL63890A0 (en) | 1981-12-31 |
| FI812940L (fi) | 1982-03-23 |
| RO82216A (ro) | 1983-07-07 |
| GB2084573B (en) | 1984-09-12 |
| ES505678A0 (es) | 1982-12-01 |
| GR75046B (ro) | 1984-07-12 |
| FI812940A7 (fi) | 1982-03-23 |
| DK417981A (da) | 1982-03-23 |
| AU7551681A (en) | 1982-04-01 |
| EP0048615B1 (en) | 1984-05-30 |
| GB2084573A (en) | 1982-04-15 |
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