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ES8107227A1 - Procedimiento para la preparacion de nuevas b-lactamas - Google Patents

Procedimiento para la preparacion de nuevas b-lactamas

Info

Publication number
ES8107227A1
ES8107227A1 ES493307A ES493307A ES8107227A1 ES 8107227 A1 ES8107227 A1 ES 8107227A1 ES 493307 A ES493307 A ES 493307A ES 493307 A ES493307 A ES 493307A ES 8107227 A1 ES8107227 A1 ES 8107227A1
Authority
ES
Spain
Prior art keywords
formula
radicals
lactams
procedure
formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493307A
Other languages
English (en)
Other versions
ES493307A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8107227A1 publication Critical patent/ES8107227A1/es
Publication of ES493307A0 publication Critical patent/ES493307A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BETA-LACTAMAS DE FORMULAS (I) O (II) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES CON BASES INORGANICAS U ORGANICAS, FORMULAS EN LAS QUE A PUEDE SER UNO DE VARIOS TIPOS DE RADICALES; R ES EL RADICAL DE FORMULA NH(CH2)NR1, EN LA QUE N VALE 0 O 1 Y R, ES UN RADICAL HETEROCICLICO DE 5 A 6 MIEMBROS, EVENTUALMENTE SUSTITUIDOS, Y X ES UNO DE LOS RADICALES DE FORMULA (III) O (IV), EN LAS QUE D PUEDE SER UNO DE VARIOS TIPOS DE RADICALES Y E ES HIDROGENO O UN GRUPO PROTECTOR. SE BASA EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (V) CON UN DERIVADO DE PRIMIDINA DE FORMULA (VI), EN AGUA, EN DISOLVENTES ACUO-ORGANICOS O EN DISOLVENTES ANHIDROS, A UN PH COMPRENDIDO ENTRE 2,0 Y 9,0 Y A UNA TEMPERATURA ENTRE -20 Y 50GC; B ES UNO DE LOS GRUPOS OCN=, C1OCNH-, BROCNH- O P-NO2C6H4-OOCNH-. *FORMULA*
ES493307A 1979-07-13 1980-07-11 Procedimiento para la preparacion de nuevas b-lactamas Granted ES493307A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792928344 DE2928344A1 (de) 1979-07-13 1979-07-13 Neue lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8107227A1 true ES8107227A1 (es) 1981-10-01
ES493307A0 ES493307A0 (es) 1981-10-01

Family

ID=6075645

Family Applications (3)

Application Number Title Priority Date Filing Date
ES493307A Granted ES493307A0 (es) 1979-07-13 1980-07-11 Procedimiento para la preparacion de nuevas b-lactamas
ES502528A Granted ES502528A0 (es) 1979-07-13 1981-05-27 Procedimiento para la preparacion de nuevas b-lactamas
ES502529A Expired ES8203903A1 (es) 1979-07-13 1981-05-27 Procedimiento para la preparacion de nuevas b-lactamas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES502528A Granted ES502528A0 (es) 1979-07-13 1981-05-27 Procedimiento para la preparacion de nuevas b-lactamas
ES502529A Expired ES8203903A1 (es) 1979-07-13 1981-05-27 Procedimiento para la preparacion de nuevas b-lactamas

Country Status (19)

Country Link
US (1) US4415566A (es)
EP (1) EP0022494B1 (es)
JP (1) JPS5615292A (es)
AT (1) ATE2621T1 (es)
AU (1) AU539009B2 (es)
CA (1) CA1146542A (es)
DD (1) DD151941A5 (es)
DE (2) DE2928344A1 (es)
DK (1) DK302580A (es)
ES (3) ES493307A0 (es)
FI (1) FI802227A7 (es)
GR (1) GR69686B (es)
HU (1) HU183177B (es)
IL (1) IL60547A (es)
NO (1) NO802086L (es)
NZ (1) NZ194314A (es)
PH (1) PH17846A (es)
PT (1) PT71531B (es)
ZA (1) ZA804203B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3007685A1 (de) 1980-02-29 1981-10-01 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephylosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3028451A1 (de) * 1980-07-26 1982-04-08 Dr. Karl Thomae Gmbh, 7950 Biberach Neue lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3038501A1 (de) * 1980-10-11 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
DE3042440A1 (de) * 1980-11-11 1982-06-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0053276A3 (de) * 1980-12-02 1983-08-03 Dr. Karl Thomae GmbH Neue Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0053693A1 (de) * 1980-12-05 1982-06-16 Dr. Karl Thomae GmbH Neue Penicilline, ihre Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3047082A1 (de) * 1980-12-13 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8318846D0 (en) * 1983-07-12 1983-08-10 Fujisawa Pharmaceutical Co Prophylactic/therapeutic agent against fish diseases
US4761410A (en) * 1985-01-14 1988-08-02 Fujisawa Pharmaceutical Co., Ltd. Cephem Compounds
JPS643597Y2 (es) * 1985-11-27 1989-01-31
US6403908B2 (en) 1999-02-19 2002-06-11 Bob Stardust Automated method and apparatus for playing card sequencing, with optional defect detection
WO2001014328A2 (en) * 1999-08-20 2001-03-01 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors
AU2003294161A1 (en) * 2003-03-20 2004-10-11 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
CN108191781B (zh) * 2018-01-08 2020-01-21 浙江大学 取代三氮唑类衍生物及其在制备抗肿瘤转移药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2450668A1 (de) * 1974-10-25 1976-04-29 Merck Patent Gmbh Ureidobenzylpenicilline und verfahren zu ihrer herstellung
US4063019A (en) * 1976-03-30 1977-12-13 E. R. Squibb & Sons, Inc. [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
JPS5344585A (en) * 1976-10-02 1978-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivatives and their preparation
PT67170B (de) * 1976-11-06 1979-03-21 Merck Patent Gmbh Lactame verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
DE2720580A1 (de) * 1977-05-07 1978-11-09 Bayer Ag Beta-lactam-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
ES477520A1 (es) * 1978-02-25 1979-06-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevas penicilinas.
DE2828261A1 (de) * 1978-06-28 1980-01-10 Thomae Gmbh Dr K Neue penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DK302580A (da) 1981-01-14
IL60547A0 (en) 1980-09-16
DE3062125D1 (en) 1983-03-31
ES502529A0 (es) 1982-04-01
PT71531A (de) 1980-08-01
NZ194314A (en) 1983-06-14
ATE2621T1 (de) 1983-03-15
US4415566A (en) 1983-11-15
GR69686B (es) 1982-07-08
PH17846A (en) 1985-01-09
EP0022494A1 (de) 1981-01-21
ES8203903A1 (es) 1982-04-01
EP0022494B1 (de) 1983-02-23
AU6036180A (en) 1981-01-15
DD151941A5 (de) 1981-11-11
NO802086L (no) 1981-01-14
AU539009B2 (en) 1984-09-06
DE2928344A1 (de) 1981-02-05
JPS5615292A (en) 1981-02-14
ES8203902A1 (es) 1982-04-01
ES493307A0 (es) 1981-10-01
ES502528A0 (es) 1982-04-01
ZA804203B (en) 1982-03-31
PT71531B (de) 1981-12-11
IL60547A (en) 1983-11-30
FI802227A7 (fi) 1981-01-01
HU183177B (en) 1984-04-28
CA1146542A (en) 1983-05-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001