ES8106727A1 - Procedimiento de preparacion de derivados 15-hidroxiimino-e-homoeburnanos,de sus sales de adicion acidas y de sus deri- vados opticamente activos - Google Patents
Procedimiento de preparacion de derivados 15-hidroxiimino-e-homoeburnanos,de sus sales de adicion acidas y de sus deri- vados opticamente activosInfo
- Publication number
- ES8106727A1 ES8106727A1 ES493336A ES493336A ES8106727A1 ES 8106727 A1 ES8106727 A1 ES 8106727A1 ES 493336 A ES493336 A ES 493336A ES 493336 A ES493336 A ES 493336A ES 8106727 A1 ES8106727 A1 ES 8106727A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- optically active
- procedure
- homoeburnan
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000002378 acidificating effect Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- -1 POTASSIUM NITRILE Chemical class 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 15-HIDROXIIMINO-E-HOMOEBURNANO DE FORMULA (I), DE SUS SALES DE ADICION DE ACIDO Y DE LOS DERIVADOS OPTICAMENTE ACTIVOS, EN LA QUE A ES HALOGENO E HIDROGENO CONJUNTAMENTE, O ES NOH; X1 ES HIDROGENO O HALOGENO, Y R ES UN RADICAL ALQUILO C1-6. SE BASA EN LA REACCION DE UN DERIVADO 15-HIDROXI-E-HOMOEBURNANO OPTICAMENTE ACTIVO O RACEMICO DE FORMULA (II), EN LA QUE X1 Y R TIENEN LA SIGNIFICACION ANTERIOR, CON UN AGENTE HALOGENANTE, EN UN DISOLVENTE ORGANICO INERTE, A LA TEMPERATURA DE EBULLICION DE LA MEZCLA, SEGUIDA DE LA REACCION CON NITRILO SODICO O POTASICO EN MEDIO ACIDO Y A LA TEMPERATURA AMBIENTE. EL PRODUCTO SE SEPARA Y PURIFICA POR METODOS CONVENCIONALES O, SI SE DESEA, SE PUEDE TRANSFORMAR EN UNA SAL POR TRATAMIENTO CON UN ACIDO EN UN DISOLVENTE ADECUADO. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79RI719A HU180927B (en) | 1979-07-13 | 1979-07-13 | Process for producing 1k-hydroximino-e-homoe-eburane de rivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8106727A1 true ES8106727A1 (es) | 1981-09-01 |
| ES493336A0 ES493336A0 (es) | 1981-09-01 |
Family
ID=11001102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493336A Granted ES493336A0 (es) | 1979-07-13 | 1980-07-11 | Procedimiento de preparacion de derivados 15-hidroxiimino-e-homoeburnanos,de sus sales de adicion acidas y de sus deri- vados opticamente activos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4314939A (es) |
| JP (2) | JPS595595B2 (es) |
| AT (1) | AT375939B (es) |
| AU (1) | AU534308B2 (es) |
| BE (1) | BE884228A (es) |
| CA (1) | CA1137083A (es) |
| CH (1) | CH644122A5 (es) |
| DE (1) | DE3026602A1 (es) |
| DK (1) | DK156574C (es) |
| ES (1) | ES493336A0 (es) |
| FI (1) | FI70020C (es) |
| FR (1) | FR2460951A1 (es) |
| GB (1) | GB2055368B (es) |
| HU (1) | HU180927B (es) |
| IL (1) | IL60445A (es) |
| IT (1) | IT1132528B (es) |
| NL (1) | NL8003822A (es) |
| NO (1) | NO802101L (es) |
| NZ (1) | NZ194316A (es) |
| PH (1) | PH15654A (es) |
| SE (1) | SE438504B (es) |
| SU (1) | SU982541A3 (es) |
| ZA (1) | ZA803952B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU181496B (en) * | 1979-08-13 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for preparing 10-bromo-15-hydroxy-e-homo-eburnanes |
| HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
| HU186891B (en) * | 1981-06-12 | 1985-10-28 | Richter Gedeon Vegyeszet | Process for producing esters of apovincaminic acid |
| HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
| HU185172B (en) * | 1981-12-30 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for the preparation of hydroxy-imino-e-homo-eburnanes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU180514B (hu) * | 1977-05-26 | 1983-03-28 | Richter Gedeon Vegyeszet | Eljárás apovinkaminsav-észterek, illetve vinkaminsav-észterek és apovinkaminsavészterek egyidejű előállítására |
| HU180928B (en) * | 1979-08-06 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives |
| HU181496B (en) * | 1979-08-13 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for preparing 10-bromo-15-hydroxy-e-homo-eburnanes |
-
1979
- 1979-07-13 HU HU79RI719A patent/HU180927B/hu not_active IP Right Cessation
-
1980
- 1980-06-30 IL IL60445A patent/IL60445A/xx unknown
- 1980-07-01 ZA ZA00803952A patent/ZA803952B/xx unknown
- 1980-07-02 NL NL8003822A patent/NL8003822A/nl not_active Application Discontinuation
- 1980-07-07 FI FI802175A patent/FI70020C/fi not_active IP Right Cessation
- 1980-07-09 BE BE1/9892A patent/BE884228A/fr not_active IP Right Cessation
- 1980-07-09 PH PH24262A patent/PH15654A/en unknown
- 1980-07-10 GB GB8022561A patent/GB2055368B/en not_active Expired
- 1980-07-10 FR FR8015361A patent/FR2460951A1/fr active Granted
- 1980-07-10 AT AT0358880A patent/AT375939B/de not_active IP Right Cessation
- 1980-07-11 SU SU802949854A patent/SU982541A3/ru active
- 1980-07-11 DK DK302280A patent/DK156574C/da not_active IP Right Cessation
- 1980-07-11 IT IT23404/80A patent/IT1132528B/it active
- 1980-07-11 CH CH534080A patent/CH644122A5/de not_active IP Right Cessation
- 1980-07-11 AU AU60350/80A patent/AU534308B2/en not_active Ceased
- 1980-07-11 SE SE8005127A patent/SE438504B/sv not_active IP Right Cessation
- 1980-07-11 NO NO802101A patent/NO802101L/no unknown
- 1980-07-11 CA CA000355991A patent/CA1137083A/en not_active Expired
- 1980-07-11 ES ES493336A patent/ES493336A0/es active Granted
- 1980-07-11 NZ NZ194316A patent/NZ194316A/xx unknown
- 1980-07-12 JP JP55094575A patent/JPS595595B2/ja not_active Expired
- 1980-07-14 US US06/168,560 patent/US4314939A/en not_active Expired - Lifetime
- 1980-07-14 DE DE19803026602 patent/DE3026602A1/de active Granted
-
1983
- 1983-07-01 JP JP58120151A patent/JPS59116285A/ja active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |