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ES8105252A1 - Un procedimiento para la preparacion de derivados de acido citrico - Google Patents

Un procedimiento para la preparacion de derivados de acido citrico

Info

Publication number
ES8105252A1
ES8105252A1 ES492727A ES492727A ES8105252A1 ES 8105252 A1 ES8105252 A1 ES 8105252A1 ES 492727 A ES492727 A ES 492727A ES 492727 A ES492727 A ES 492727A ES 8105252 A1 ES8105252 A1 ES 8105252A1
Authority
ES
Spain
Prior art keywords
water
procedure
acid
acid derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492727A
Other languages
English (en)
Other versions
ES492727A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/973,504 external-priority patent/US4312885A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES492727A0 publication Critical patent/ES492727A0/es
Publication of ES8105252A1 publication Critical patent/ES8105252A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/295—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE ACIDO CITRICO. CONSISTE EN DISOCIAR ACIDO EPOXIACONITICO CON UN CLORURO DE METAL ALCALINO O ALCALINOTERREO EN UN DISOLVENTE ACUOSO EN PRESENCIA DE UN ACIDO. OPCIONALMENTE SE PUEDE RESOLVER UN DERIVADO DE ACIDO (+-)-TREO O (+-)-ERITROCITICO EN SUS ANTIPODAS OPTICAMENTE ACTIVOS. EL COMPUESTO OBTENIDO PUEDE AISLAR EN FORMA DE LA SAL RESPECTIVA LOS DISOLVENTES ACUOSOS QUE INCLUYEN AGUA Y MEZCLAS DE AGUA Y UN ALCANOL INFERIOR AGUA Y UN ETER, TAL COMO DIMETOXIETANO, TETRAHIDROFURANO O DIOXANO Y AGUA Y UN DISOLVENTE APORTICO POLAR TAL COMO DIMETILACETAMIDA, DIMEDITILFORMAMIDA, SULFOXIDO DE DIMETILO O HEXAMETILFOSFORAMIDA. AGENTES ANORECTICOS. D
ES492727A 1978-12-26 1980-06-25 Un procedimiento para la preparacion de derivados de acido citrico Expired ES8105252A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/973,504 US4312885A (en) 1978-12-26 1978-12-26 Chlorocitric acids
CH1058079 1979-11-28

Publications (2)

Publication Number Publication Date
ES492727A0 ES492727A0 (es) 1981-06-01
ES8105252A1 true ES8105252A1 (es) 1981-06-01

Family

ID=25706941

Family Applications (2)

Application Number Title Priority Date Filing Date
ES79487247A Expired ES8100243A1 (es) 1978-12-26 1979-12-24 Un procedimiento para la preparacion de derivados de acido tro-clorocitrico
ES492727A Expired ES8105252A1 (es) 1978-12-26 1980-06-25 Un procedimiento para la preparacion de derivados de acido citrico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES79487247A Expired ES8100243A1 (es) 1978-12-26 1979-12-24 Un procedimiento para la preparacion de derivados de acido tro-clorocitrico

Country Status (16)

Country Link
EP (1) EP0016867B1 (es)
AR (1) AR222201A1 (es)
AU (1) AU527139B2 (es)
CA (1) CA1138470A (es)
DE (1) DE2965783D1 (es)
DK (1) DK154641C (es)
ES (2) ES8100243A1 (es)
FI (1) FI67073C (es)
HU (1) HU179987B (es)
IE (1) IE49341B1 (es)
IL (1) IL59015A (es)
MC (1) MC1299A1 (es)
NO (1) NO153491C (es)
NZ (1) NZ192423A (es)
PH (1) PH14915A (es)
PT (1) PT70628A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500800B1 (de) 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356721A (en) * 1962-03-21 1967-12-05 Richard H Wiley Citric acid manufacture
US3764692A (en) * 1970-09-30 1973-10-09 Hoffmann La Roche Method of treating obesity
US3901915A (en) * 1973-10-10 1975-08-26 Hoffmann La Roche Optical resolution of organic carboxylic acids
US4123458A (en) * 1975-12-22 1978-10-31 Lever Brothers Company Preparation of cis and trans aconitic acids and their salts

Also Published As

Publication number Publication date
ES487247A0 (es) 1980-11-01
DK154641B (da) 1988-12-05
DE2965783D1 (en) 1983-07-28
PT70628A (en) 1980-01-01
FI793976A7 (fi) 1980-06-27
IL59015A (en) 1983-10-31
ES492727A0 (es) 1981-06-01
NO794232L (no) 1980-06-27
FI67073C (fi) 1985-01-10
AU5400979A (en) 1980-07-03
MC1299A1 (fr) 1980-10-03
PH14915A (en) 1982-01-29
IE49341B1 (en) 1985-09-18
AR222201A1 (es) 1981-04-30
NZ192423A (en) 1981-12-15
HU179987B (en) 1983-01-28
NO153491C (no) 1986-04-02
EP0016867B1 (de) 1983-06-22
AU527139B2 (en) 1983-02-17
EP0016867A1 (de) 1980-10-15
DK554079A (da) 1980-06-27
ES8100243A1 (es) 1980-11-01
IL59015A0 (en) 1980-03-31
DK154641C (da) 1989-05-08
NO153491B (no) 1985-12-23
IE792501L (en) 1980-06-26
CA1138470A (en) 1982-12-28
FI67073B (fi) 1984-09-28

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