ES8505993A1 - Un metodo para preparar un derivado de 3-indolcarboxamida - Google Patents
Un metodo para preparar un derivado de 3-indolcarboxamidaInfo
- Publication number
- ES8505993A1 ES8505993A1 ES535826A ES535826A ES8505993A1 ES 8505993 A1 ES8505993 A1 ES 8505993A1 ES 535826 A ES535826 A ES 535826A ES 535826 A ES535826 A ES 535826A ES 8505993 A1 ES8505993 A1 ES 8505993A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- indolcarboxamide
- reaction
- value
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3-INDOLCARBOXAMIDA, DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES Y/O SUS HIDRATOS, DE FORMULA (I), EN LA QUE A Y R1-R5 PUEDEN SER VARIOS RADICALES, M VALE 0 O 1; Y N VALE 0, 1 O 2.CONSISTE EN LA REACCION DE UN ACIDO CARBOXILICO, DE FORMULA (II), CON UNA AMINA, DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE CONDENSACION, A TEMPERATURA AMBIENTE O SUPERIOR.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58170061A JPS6084281A (ja) | 1983-09-14 | 1983-09-14 | ３−インド−ルカルボキサミド類 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES535826A0 ES535826A0 (es) | 1985-06-16 |
| ES8505993A1 true ES8505993A1 (es) | 1985-06-16 |
Family
ID=15897899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535826A Expired ES8505993A1 (es) | 1983-09-14 | 1984-09-11 | Un metodo para preparar un derivado de 3-indolcarboxamida |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4576940A (es) |
| EP (1) | EP0137163A3 (es) |
| JP (1) | JPS6084281A (es) |
| KR (1) | KR850002268A (es) |
| AU (1) | AU563515B2 (es) |
| CA (1) | CA1230332A (es) |
| ES (1) | ES8505993A1 (es) |
| GR (1) | GR80371B (es) |
| PT (1) | PT79199B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3604949A1 (de) * | 1986-02-17 | 1987-08-20 | Merck Patent Gmbh | Hydroxyindolester |
| US5036067A (en) * | 1990-03-14 | 1991-07-30 | Merck & Co., Inc. | Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
| JPH0764841B2 (ja) * | 1990-10-03 | 1995-07-12 | ファイザー製薬株式会社 | インドール誘導体およびその用途 |
| US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5827875A (en) * | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068259B (es) * | 1954-04-28 | 1959-11-05 | ||
| US3238215A (en) * | 1963-10-17 | 1966-03-01 | Sterling Drug Inc | 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines |
| GB1345872A (en) * | 1970-09-03 | 1974-02-06 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and hydropyridine derivatives |
| US3869463A (en) * | 1973-01-17 | 1975-03-04 | Wyeth John & Brother Ltd | N-phenyl derivatives of alkanoylamido piperidines |
| FR2334358A1 (fr) * | 1975-12-12 | 1977-07-08 | Sogeras | Nouveaux medicaments derives de l'indole |
| DE2557342A1 (de) * | 1975-12-19 | 1977-06-30 | Hoechst Ag | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
-
1983
- 1983-09-14 JP JP58170061A patent/JPS6084281A/ja active Granted
-
1984
- 1984-07-26 EP EP84108884A patent/EP0137163A3/en not_active Withdrawn
- 1984-07-28 KR KR1019840004499A patent/KR850002268A/ko not_active Withdrawn
- 1984-08-10 CA CA000460799A patent/CA1230332A/en not_active Expired
- 1984-08-10 US US06/639,292 patent/US4576940A/en not_active Expired - Fee Related
- 1984-09-11 ES ES535826A patent/ES8505993A1/es not_active Expired
- 1984-09-13 PT PT79199A patent/PT79199B/pt unknown
- 1984-09-14 GR GR80371A patent/GR80371B/el unknown
- 1984-09-14 AU AU33045/84A patent/AU563515B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU3304584A (en) | 1985-03-21 |
| US4576940A (en) | 1986-03-18 |
| ES535826A0 (es) | 1985-06-16 |
| PT79199A (en) | 1984-10-01 |
| CA1230332A (en) | 1987-12-15 |
| JPS6084281A (ja) | 1985-05-13 |
| GR80371B (en) | 1985-01-15 |
| EP0137163A3 (en) | 1987-04-15 |
| PT79199B (en) | 1986-08-14 |
| EP0137163A2 (en) | 1985-04-17 |
| KR850002268A (ko) | 1985-05-10 |
| JPS6320824B2 (es) | 1988-04-30 |
| AU563515B2 (en) | 1987-07-09 |
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