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ES8104289A1 - Procedimiento para la produccion de derivados de feobromina. - Google Patents

Procedimiento para la produccion de derivados de feobromina.

Info

Publication number
ES8104289A1
ES8104289A1 ES489184A ES489184A ES8104289A1 ES 8104289 A1 ES8104289 A1 ES 8104289A1 ES 489184 A ES489184 A ES 489184A ES 489184 A ES489184 A ES 489184A ES 8104289 A1 ES8104289 A1 ES 8104289A1
Authority
ES
Spain
Prior art keywords
theobromine
derivatives
substituted
theobromine derivatives
homopiperazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489184A
Other languages
English (en)
Other versions
ES489184A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8104289A1 publication Critical patent/ES8104289A1/es
Publication of ES489184A0 publication Critical patent/ES489184A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE DERIVADOS DE TEOBROMINA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES, DONDE Z PUEDEN SER DISTINTOS TIPOS DE RADICALES; N ES UN NUMERO ENTERO DE 3 A 8. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA GENERAL HZ; X ES UN ATOMO DE HALOGENO O UN GRUPO P-TOLUENSULFONILOXI. LA REACCION PUEDE LLEVARSE A CABO EN PRESENCIA DE UN DISOLVENTE SELECCIONADO ENTRE LOS QUE NO PARTICIPAN EN LA REACCION. LA REACCION SE REALIZA CON MAS SUAVIDAD EN PRESENCIA DE AGENTES ACEPTORES DE ACIDOS COMO TRIETILAMINA, BICARBONATOS DE METALES ALCALINOS, ETC. ESTOS DERIVADOS TIENE APLICACION PARA MEJORAR EL FLUJO SANGUINEO EN EL CEREBRO Y EN LA ARTERIA CORONARIA. *FORMULA*
ES489184A 1979-03-05 1980-03-04 Procedimiento para la produccion de derivados de feobromina. Granted ES489184A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2457079A JPS55118488A (en) 1979-03-05 1979-03-05 Theobromine derivative and its preparation

Publications (2)

Publication Number Publication Date
ES8104289A1 true ES8104289A1 (es) 1981-03-16
ES489184A0 ES489184A0 (es) 1981-03-16

Family

ID=12141814

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489184A Granted ES489184A0 (es) 1979-03-05 1980-03-04 Procedimiento para la produccion de derivados de feobromina.

Country Status (12)

Country Link
US (1) US4493837A (es)
JP (1) JPS55118488A (es)
BE (1) BE882044A (es)
CA (1) CA1139750A (es)
CH (1) CH642659A5 (es)
DE (1) DE3008318A1 (es)
ES (1) ES489184A0 (es)
FR (1) FR2450831A1 (es)
GB (1) GB2046741B (es)
IT (1) IT1130292B (es)
NL (1) NL8001304A (es)
SE (1) SE447994B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618983A (en) * 1979-07-25 1981-02-23 Eisai Co Ltd Theophylline derivative and its preapration
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
US4374837A (en) * 1981-07-31 1983-02-22 Laroche Navarron, S.A. Piperazine derivatives of theobromine
JPS58148820A (ja) * 1982-02-26 1983-09-05 Eisai Co Ltd テオブロミン誘導体を有効成分とする脳循環代謝改善剤
FR2531085A1 (fr) * 1982-07-28 1984-02-03 Adir Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1215251B (it) * 1985-03-14 1990-01-31 Ellem Ind Farmaceutica Farmaceutiche che li contengono. composti ad attivita'antiaggregante piastrinica, procedimento per la loro preparazione e composizioni
US4810706A (en) * 1985-12-20 1989-03-07 Recherche Syntex Piperazine derivatives of theophylline and theobromine
US4716165A (en) * 1986-09-24 1987-12-29 American Home Products Corporation Histamine H1 antagonists
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
USRE49128E1 (en) 2014-10-09 2022-07-12 Guangdong Raynovent Biotech Co., Ltd. Hydroxyl purine compounds and applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620576A1 (de) * 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
DE2401254A1 (de) * 1974-01-11 1975-11-27 Boehringer Mannheim Gmbh Neue derivate von n hoch 6-substituierten adeninen

Also Published As

Publication number Publication date
DE3008318A1 (de) 1980-09-18
JPS55118488A (en) 1980-09-11
SE8001682L (sv) 1980-09-06
SE447994B (sv) 1987-01-12
CA1139750A (en) 1983-01-18
BE882044A (fr) 1980-09-04
FR2450831B1 (es) 1983-07-08
FR2450831A1 (fr) 1980-10-03
NL8001304A (nl) 1980-09-09
IT1130292B (it) 1986-06-11
CH642659A5 (fr) 1984-04-30
IT8020358A0 (it) 1980-03-05
GB2046741A (en) 1980-11-19
US4493837A (en) 1985-01-15
GB2046741B (en) 1983-06-15
ES489184A0 (es) 1981-03-16

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