[go: up one dir, main page]

ES8101074A1 - Procedimiento para la preparacion de derivados de xantina - Google Patents

Procedimiento para la preparacion de derivados de xantina

Info

Publication number
ES8101074A1
ES8101074A1 ES491915A ES491915A ES8101074A1 ES 8101074 A1 ES8101074 A1 ES 8101074A1 ES 491915 A ES491915 A ES 491915A ES 491915 A ES491915 A ES 491915A ES 8101074 A1 ES8101074 A1 ES 8101074A1
Authority
ES
Spain
Prior art keywords
compound
procedure
derivatives
xantina
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491915A
Other languages
English (en)
Other versions
ES491915A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES491915A0 publication Critical patent/ES491915A0/es
Publication of ES8101074A1 publication Critical patent/ES8101074A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE XANTINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I), EN QUE UNO DE LOS RADICALES R''1, R''2 SIGNIFICA EL GRUPO METILO, Y EL OTRO, UN ATOMO DE HIDROGENO, CON UN COMPUESTO DE FORMULA X-CH2-CH2-CH2-Y, EN QUE X E Y SIGNIFICAN RADICALES REACTIVOS, *FORMULA* Y CON UN COMPUESTO (II), OBTENIENDOSE EL COMPUESTO DE FORMULA GENERAL (III). LA REACCION SE EFECTUA EN MEDIO ALCALINO, PREFERIBLEMENTE EN UN ALCOHOL INFERIOR TAL COMO EL ISOPROPANOL EN PRESENCIA DE ISOPROPANOLATO SODICO. EFECTO ANTIINFLAMATORIO, ANTIALERGICO, ANTIEDEMATOSO.
ES491915A 1979-05-31 1980-05-28 Procedimiento para la preparacion de derivados de xantina Expired ES8101074A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792922159 DE2922159A1 (de) 1979-05-31 1979-05-31 Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES491915A0 ES491915A0 (es) 1980-12-16
ES8101074A1 true ES8101074A1 (es) 1980-12-16

Family

ID=6072153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491915A Expired ES8101074A1 (es) 1979-05-31 1980-05-28 Procedimiento para la preparacion de derivados de xantina

Country Status (13)

Country Link
US (1) US4284633A (es)
EP (1) EP0021103B1 (es)
JP (1) JPS55162785A (es)
AT (1) ATE3549T1 (es)
AU (1) AU529812B2 (es)
CA (1) CA1128040A (es)
DD (1) DD151168A5 (es)
DE (2) DE2922159A1 (es)
ES (1) ES8101074A1 (es)
HU (1) HU184291B (es)
IL (1) IL60176A (es)
SU (1) SU1079176A3 (es)
ZA (1) ZA803245B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426383A (en) 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
CH648559A5 (de) * 1981-07-20 1985-03-29 Siegfried Ag Theophyllinderivate und verfahren zu deren herstellung.
FR2558162B1 (fr) * 1984-01-17 1986-04-25 Adir Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US7550468B2 (en) * 2000-07-28 2009-06-23 Ing-Jun Chen Theophylline and 3-isobutyl-1 methylxanthine based N-7 substituted derivatives displaying inhibitory activities on PDE-5 phospodiesterase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE2401254A1 (de) * 1974-01-11 1975-11-27 Boehringer Mannheim Gmbh Neue derivate von n hoch 6-substituierten adeninen
DE2550000A1 (de) * 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh Neue purin-derivate und verfahren zu ihrer herstellung
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
DE2804416A1 (de) * 1978-02-02 1979-08-09 Boehringer Mannheim Gmbh Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
EP0011399A1 (en) * 1978-11-11 1980-05-28 FISONS plc N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA1128040A (en) 1982-07-20
DE3063450D1 (en) 1983-07-07
DE2922159A1 (de) 1980-12-04
EP0021103B1 (de) 1983-05-25
AU5878780A (en) 1980-12-04
ES491915A0 (es) 1980-12-16
HU184291B (en) 1984-07-30
ZA803245B (en) 1981-06-24
AU529812B2 (en) 1983-06-23
SU1079176A3 (ru) 1984-03-07
EP0021103A1 (de) 1981-01-07
IL60176A0 (en) 1980-07-31
IL60176A (en) 1983-06-15
ATE3549T1 (de) 1983-06-15
DD151168A5 (de) 1981-10-08
JPS55162785A (en) 1980-12-18
US4284633A (en) 1981-08-18

Similar Documents

Publication Publication Date Title
MY102774A (en) Process for the preparation of 1-triazolylethyl ether derivatives
ES481729A1 (es) Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
ES8604179A1 (es) Procedimiento para la preparacion de nuevos derivados tiazo-lidinicos
ES8504738A1 (es) Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol
ES8105248A1 (es) Procedimiento para preparar derivados de trifenilalqueno
ES8404671A1 (es) Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico.
ES2106936T5 (es) Derivados de carbazolona y procedimientos para su preparacion.
ES470787A1 (es) Procedimiento para preparar derivados de benzoquinolicina
ES8101074A1 (es) Procedimiento para la preparacion de derivados de xantina
SE7704616L (sv) Sett att framstella nya 11-desoxi-prostaglandin-fÿ2-derivat
ES463971A1 (es) Perfeccionamientos en o relacionados con compuestos organi- cos.
ES484255A1 (es) Un procedimiento para la preparacion de derivados de n-ben- cilnalocetamida.
ES377662A1 (es) Procedimiento para la preparacion de nuevos compuestos de derivados de dialcohil-xantina.
ES432714A1 (es) Procedimiento para preparar derivados de triazina.
ES8503945A1 (es) Un procedimiento para la preparacion de derivados de pirazolona utiles como inhibidores de lipoxigenasa.
ES8100304A1 (es) Un procedimiento para preparar derivados de indol policiclicos
ES467408A1 (es) Un procedimiento para la produccion de derivados de 2-hidro-xi-n-propilamina
ES8202003A1 (es) Un procedimiento para la preparacion de derivados de ergoli-na
ES447751A1 (es) Procedimiento para preparar derivados de imidazolilquinazo- lina.
ES8800262A1 (es) Procedimiento de preparacion de 21-hidroxi-20-ceto-delta16-esteroides
FR2393797A1 (fr) Preparation de sels quaternaires sulfoalkyle
ES467861A1 (es) Procedimiento de preparacion de espiro-oxazolidinas esteroi-des y sus esteroisomeros.
ES394972A1 (es) Procedimiento para la preparacion de nuevos 3 - alcohil - ariloximetilisoxazoles.
ES463164A1 (es) Procedimiento para la obtencion de derivados de ferroceno.
ES454299A1 (es) Procedimiento para la preparacion de derivados de 3-nitropi-razol.