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ES8105248A1 - Procedimiento para preparar derivados de trifenilalqueno - Google Patents

Procedimiento para preparar derivados de trifenilalqueno

Info

Publication number
ES8105248A1
ES8105248A1 ES491512A ES491512A ES8105248A1 ES 8105248 A1 ES8105248 A1 ES 8105248A1 ES 491512 A ES491512 A ES 491512A ES 491512 A ES491512 A ES 491512A ES 8105248 A1 ES8105248 A1 ES 8105248A1
Authority
ES
Spain
Prior art keywords
triphenylalkene
procedure
derivatives
preparing
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491512A
Other languages
English (en)
Other versions
ES491512A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8105248A1 publication Critical patent/ES8105248A1/es
Publication of ES491512A0 publication Critical patent/ES491512A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE TRIFENILAQUENO. CONSISTE EN EFECTUAR ALGUNO DE LOS SIGUIENTES PROCEDIMIENTOS. 1. REACCION DE UN DERIVADO DE TRIFENILALQUENO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA R ELEVADO A 1 -X. 2. DESHIDRATACION DE UN COMPUESTO III, TRAS LO QUE SE PUEDE OBTENER UN DERIVADO TRIFENILALQUENO. 3. HIDROBORENACION DEL DERIVADO CORRESPONDIENTE DE TRIFENILALCANO O POR REDUCCION CON HIDRURO METALICO DEL CORRESPONDIENTE DERIVADO DE TRIFENILALQUENO. SE OBTIENEN DERIVADOS DE FORMULA GENERAL I. ACTIVIDAD ANTIESTROGENICA. *FORMULA* I
ES491512A 1979-05-15 1980-05-14 Procedimiento para preparar derivados de trifenilalqueno Granted ES491512A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7916860 1979-05-15

Publications (2)

Publication Number Publication Date
ES8105248A1 true ES8105248A1 (es) 1981-05-16
ES491512A0 ES491512A0 (es) 1981-05-16

Family

ID=10505167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491512A Granted ES491512A0 (es) 1979-05-15 1980-05-14 Procedimiento para preparar derivados de trifenilalqueno

Country Status (11)

Country Link
US (1) US4307111A (es)
EP (1) EP0019377B1 (es)
JP (1) JPS5629538A (es)
AT (1) ATE1418T1 (es)
AU (1) AU533169B2 (es)
CA (1) CA1150290A (es)
DE (1) DE3060722D1 (es)
ES (1) ES491512A0 (es)
IL (1) IL60006A (es)
NZ (1) NZ193584A (es)
ZA (1) ZA802569B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
US5204337A (en) * 1988-10-31 1993-04-20 Endorecherche Inc. Estrogen nucleus derivatives for use in inhibition of sex steroid activity
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
ZA924811B (en) * 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
EP0729363B1 (en) * 1994-06-27 2003-02-19 Neutron Therapies Inc. Boron-containing hormone analogs and methods of their use in imaging or killing cells having hormone receptors
ATE377418T1 (de) 1995-06-07 2007-11-15 Poniard Pharmaceuticals Inc Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
CA2301032C (en) 1997-08-15 2009-01-13 Duke University A method of preventing or treating estrogen-dependent diseases and disorders
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2301260A (en) * 1941-01-04 1942-11-10 Ici Ltd Medicinal compounds
US2346049A (en) * 1941-02-13 1944-04-04 Lilly Co Eli Method of producing dialkoxy stilbenes
GB567807A (en) * 1943-07-21 1945-03-05 Frederick Robert Basford Triphenylethylene derivatives
GB586493A (en) * 1944-10-26 1947-03-20 British Schering Res Lab Ltd New synthetic oestrogenic agents
GB916171A (en) * 1959-02-25 1963-01-23 Ferrosan Ab Improvements in or relating to diphenyl ethylene compounds having oestrogenic activity and processes for their preparation
US3320271A (en) * 1964-06-01 1967-05-16 Upjohn Co 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes
US3875242A (en) * 1968-01-02 1975-04-01 Upjohn Co Compounds and process for preparing the same
GB1289966A (es) * 1968-12-24 1972-09-20
US3712929A (en) * 1969-10-31 1973-01-23 Du Pont 1-perfluoroalkyl-1,2,2-triphenylethylenes
US3947520A (en) * 1970-11-12 1976-03-30 The Upjohn Company Compounds and process for preparing the same
FR2140270A1 (en) * 1971-06-07 1973-01-19 Aries Robert Organophosphorus insecticides - stabilized by styrenes

Also Published As

Publication number Publication date
AU533169B2 (en) 1983-11-03
IL60006A0 (en) 1980-07-31
EP0019377B1 (en) 1982-08-04
US4307111A (en) 1981-12-22
JPS5629538A (en) 1981-03-24
AU5799980A (en) 1980-11-20
EP0019377A1 (en) 1980-11-26
ATE1418T1 (de) 1982-08-15
NZ193584A (en) 1984-05-31
ES491512A0 (es) 1981-05-16
CA1150290A (en) 1983-07-19
DE3060722D1 (en) 1982-09-30
ZA802569B (en) 1981-04-29
IL60006A (en) 1983-03-31

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