ES555005A0 - Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral. - Google Patents

Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral.

Info

Publication number: ES555005A0
Authority: ES; Spain
Prior art keywords: amphotericin; preparing; procedure; emulsion formulation; parenteral administration
Prior art date: 1985-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES555005A

Other languages

English (en)

Other versions

ES8801578A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-17

Filing date

1986-05-16

Publication date

1988-02-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24956040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES555005(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-05-16 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1988-02-16 Publication of ES555005A0 publication Critical patent/ES555005A0/es

1988-02-16 Publication of ES8801578A1 publication Critical patent/ES8801578A1/es

Status Expired legal-status Critical Current

Links

238000009472 formulation Methods 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 4
239000000839 emulsion Substances 0.000 title abstract 3
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 title 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title 1
229960003942 amphotericin b Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000007911 parenteral administration Methods 0.000 title 1
229930182558 Sterol Natural products 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
210000000170 cell membrane Anatomy 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000007764 o/w emulsion Substances 0.000 abstract 1
239000002459 polyene antibiotic agent Substances 0.000 abstract 1
150000003432 sterols Chemical class 0.000 abstract 1
235000003702 sterols Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES555005A 1985-05-17 1986-05-16 Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral. Expired ES8801578A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/735,492 US4707470A (en)	1985-05-17	1985-05-17	Polyene antibiotic emulsion formulation

Publications (2)

Publication Number	Publication Date
ES555005A0 true ES555005A0 (es)	1988-02-16
ES8801578A1 ES8801578A1 (es)	1988-02-16

Family

ID=24956040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES555005A Expired ES8801578A1 (es)	1985-05-17	1986-05-16	Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral.

Country Status (11)

Country	Link
US (1)	US4707470A (es)
EP (1)	EP0202837B1 (es)
JP (1)	JPS61268625A (es)
AT (1)	ATE47312T1 (es)
AU (1)	AU589961B2 (es)
DE (1)	DE3666347D1 (es)
DK (1)	DK223686A (es)
ES (1)	ES8801578A1 (es)
GR (1)	GR861225B (es)
PT (1)	PT82564B (es)
ZA (1)	ZA863639B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4831018A (en) *	1985-05-17	1989-05-16	Smithkline Beckman Corporation	Polyene antibiotic emulsion formulation
US4784845A (en) *	1985-09-16	1988-11-15	American Cyanamid Company	Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
US4826822A (en) *	1986-04-22	1989-05-02	Ecolab Inc.	Liquid suspensions of polyene antibiotics and use thereof for slime control in industrial waters
US4822777A (en) *	1987-02-27	1989-04-18	Liposome Technology, Inc.	Amphotericin B/cholesterol sulfate composition
US6406713B1 (en)	1987-03-05	2002-06-18	The Liposome Company, Inc.	Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) *	1987-03-05	1997-04-01	The Liposome Company, Inc.	Low toxicity drug-lipid systems
GB8714652D0 (en) *	1987-06-23	1987-07-29	Davis S S	Drug emulsion
US4981690A (en) *	1987-10-27	1991-01-01	Board Of Regents, The University Of Texas System	Liposome-incorporated mepartricin
DK0393890T3 (da) *	1989-04-11	1992-09-28	Pfizer	Injicerbart præparat indeholdende 25-cyclohexyl-avermectin B1
GB8919172D0 (en) *	1989-08-23	1989-10-04	Univ Nottingham	Useful composition
AU6461090A (en) *	1989-10-30	1991-05-02	Abbott Laboratories	Injectable formulation for lipophilic drugs
US5054995A (en) *	1989-11-06	1991-10-08	Ingersoll-Rand Company	Apparatus for controlling a fluid compression system
ATE140622T1 (de) *	1989-11-27	1996-08-15	Nippon Shinyaku Co Ltd	Fettemulsion
US5210226A (en) *	1990-02-02	1993-05-11	Xechem Inc.	Method for separating and purifying polyene macrolide antibiotics
US5258519A (en) *	1990-11-13	1993-11-02	Glaxo Inc.	Dihydropyridine vasodilators agents
US5622649A (en) *	1991-06-27	1997-04-22	Emory University	Multiple emulsions and methods of preparation
SG49652A1 (en) *	1992-03-30	1998-06-15	American Home Prod	Rapamycin formulation for iv injection
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
US5980945A (en) *	1996-01-16	1999-11-09	Societe De Conseils De Recherches Et D'applications Scientifique S.A.	Sustained release drug formulations
GB9601120D0 (en)	1996-01-19	1996-03-20	Sandoz Ltd	Organic compounds
IN188843B (es) *	2000-06-22	2002-11-09	Vinod Daftary Gautam Dr
DE10036871A1 (de) *	2000-07-28	2002-02-14	Pharmasol Gmbh	Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
WO2009102814A2 (en) *	2008-02-11	2009-08-20	Accentia Biopharmaceuticals, Inc.	Mucosally non-irritative liquid amphotericin b formulations and methods for treating non-invasive fungus-induced mucositis
US8993625B2 (en)	2009-03-11	2015-03-31	Stable Solutions Llc	Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US9034389B2 (en) *	2009-03-11	2015-05-19	Stable Solutions Llc	Omega-3 enriched fish oil-in-water parenteral nutrition emulsions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3096249A (en) *	1960-05-10	1963-07-02	Samuel J Prigal	Emulsion composition
GB1148801A (en) *	1965-06-09	1969-04-16	Miles Lab	Stabilised antibiotic compositions
GB1171125A (en) *	1966-06-08	1969-11-19	Glaxo Lab Ltd	Improvements in or relating to Injectable Preparations
US3651218A (en) *	1970-06-03	1972-03-21	Miles Lab	Antifungal compositions
US4148891A (en) *	1974-07-03	1979-04-10	Gist-Brocades N.V.	Antifungal preparations
US4073943A (en) *	1974-09-11	1978-02-14	Apoteksvarucentralen Vitrum Ab	Method of enhancing the administration of pharmalogically active agents
US4025620A (en) *	1975-10-22	1977-05-24	Leo Pharmaceutical Products Ltd., A/S	Treatment of canine otitis and composition therefor
US4100271A (en) *	1976-02-26	1978-07-11	Cooper Laboratories, Inc.	Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4168308A (en) *	1976-03-12	1979-09-18	Apoteksvarucentralen Vitrum Ab	Composition for enhancing the administration of pharmacologically active agents
DE3071101D1 (en) *	1980-11-27	1985-10-24	Chinoin Gyogyszer Es Vegyeszet	Antimycotic synergistic pharmaceutical compositions and process for the preparation thereof
DE3210138A1 (de) *	1982-03-19	1983-09-22	Röhm Pharma GmbH, 6100 Darmstadt	Antimykotische, therapeutische zubereitungen auf creme- und salbenbasis
FR2553661B1 (fr) *	1983-10-19	1985-12-20	Rhone Poulenc Sante	Nouvelles microemulsions pharmaceutiquement acceptables
US4542020A (en) *	1984-08-17	1985-09-17	E. R. Squibb & Sons, Inc.	Long-lasting adhesive antifungal suppositories

1985
- 1985-05-17 US US06/735,492 patent/US4707470A/en not_active Expired - Fee Related
1986
- 1986-05-12 PT PT82564A patent/PT82564B/pt unknown
- 1986-05-12 AU AU57333/86A patent/AU589961B2/en not_active Ceased
- 1986-05-12 DE DE8686303594T patent/DE3666347D1/de not_active Expired
- 1986-05-12 AT AT86303594T patent/ATE47312T1/de not_active IP Right Cessation
- 1986-05-12 EP EP86303594A patent/EP0202837B1/en not_active Expired
- 1986-05-12 GR GR861225A patent/GR861225B/el unknown
- 1986-05-14 JP JP61111753A patent/JPS61268625A/ja active Pending
- 1986-05-14 DK DK223686A patent/DK223686A/da not_active Application Discontinuation
- 1986-05-16 ES ES555005A patent/ES8801578A1/es not_active Expired
- 1986-05-16 ZA ZA863639A patent/ZA863639B/xx unknown

Also Published As

Publication number	Publication date
US4707470A (en)	1987-11-17
AU5733386A (en)	1986-11-20
ZA863639B (en)	1987-06-24
DE3666347D1 (en)	1989-11-23
PT82564B (en)	1987-12-14
GR861225B (en)	1986-09-10
EP0202837A1 (en)	1986-11-26
DK223686D0 (da)	1986-05-14
PT82564A (en)	1986-06-01
ES8801578A1 (es)	1988-02-16
ATE47312T1 (de)	1989-11-15
AU589961B2 (en)	1989-10-26
DK223686A (da)	1986-11-18
JPS61268625A (ja)	1986-11-28
EP0202837B1 (en)	1989-10-18

Publication	Publication Date	Title
ES555005A0 (es)	1988-02-16	Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral.
AU2342284A (en)	1984-06-04	Tetracycline activity enhancement
ES2104731T3 (es)	1997-10-16	Micobacterium utilizado como adyuvante para antigenos.
WO1987004076A1 (en)	1987-07-16	Low dosage of interferon to enhance vaccine efficiency
ES2010226A6 (es)	1989-11-01	Un procedimiento para producir una preparacion farmaceutica estable que contiene un factor estimulante de colonias de granulocitos
ES2167611T3 (es)	2002-05-16	Formulaciones de gel que contienen factores de crecimiento.
ATE5508T1 (de)	1983-12-15	Praeparate zur parenteralen verabreichung fettloeslicher wirkstoffe.
ES2152483T3 (es)	2001-02-01	Aplicacion terapeutica en anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de celulas b.
AU601957B2 (en)	1990-09-27	Immunostimulant agents
FI894888A7 (fi)	1989-10-16	Astaksantiinia tuottavia hiivasoluja, menetelmiä niiden valmistamiseks i ja niiden käyttö
EP1238677A3 (en)	2003-01-22	Parenteral fat emulsions comprising edetate as preservative
MX27046A (es)	1994-01-31	5-arilalquil-4-alcoxy-2(5h)-furanonas, productos intermedios y procedimiento para su preparacion asi como su aplicacion como sustancia activa terapeutica.
DE3880593D1 (de)	1993-06-03	Arzneizubereitungen mit retardierter wirkstofffreisetzung.
DK0806941T3 (da)	2003-07-21	Liposomalt antibakterielt præparat med lav fasthed
DK0904067T3 (da)	2005-03-14	Transdermalt indgivet dextromethorpan som hostestillende middel
ES8105149A1 (es)	1981-05-16	Un procedimiento para la preparacion de la mezcla antibioti-ca a-42355
IE45415L (en)	1977-11-13	Long acting preparation of cefalexin
ES2067520T3 (es)	1995-04-01	Antibioticos y procedimiento para su produccion.
ES2106032T3 (es)	1997-11-01	Vacuna para inmunizar gatos contra el desprendimiento de oocistos de toxoplasma.
PT859613E (pt)	2006-06-30	Utilizacao de flupirtina para a profilaxia e o tratamento de doencas associadas a uma alteracao do sistema celular hematopoietico
EA199900750A1 (ru)	2000-04-24	Водная фармацевтическая композиция, включающая активный ингредиент, в высшей степени нерастворимый в воде
ES2054777T3 (es)	1994-08-16	Metodo para la preparacion de o-carboxiarilimidazolinonas.
DE59410457D1 (de)	2008-10-02	Mittel zur beeinflussung von hyperaktivierten immunologischen effektorzellen
ES284914U (es)	1985-08-01	Dispositivo para la administracion percutanea de un principio activo.
ATE101044T1 (de)	1994-02-15	Gefluegelcolibacillose-vakzin.