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ES484111A1 - Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina - Google Patents

Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina

Info

Publication number
ES484111A1
ES484111A1 ES484111A ES484111A ES484111A1 ES 484111 A1 ES484111 A1 ES 484111A1 ES 484111 A ES484111 A ES 484111A ES 484111 A ES484111 A ES 484111A ES 484111 A1 ES484111 A1 ES 484111A1
Authority
ES
Spain
Prior art keywords
formula
dichlorophenyl
procedure
derivatives
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484111A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES484111A1 publication Critical patent/ES484111A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para la obtención de derivados de 1-benicl-1, 2, 3, 6- tetrahidropiridina de fórmula: **(Fórmula -1)** en donde el anillo benceno A es un radical 3, 4-diclorofenilo, 3, 5-diclorofenilo, 4-cloro- 3-hidroxifenilo, 3, 4-dihidroxifenilo o 4-hidroxifenilo; o una sal de adición de ácido farmacéuticamente aceptable del mismo, caracterizado porque comprende reaccionar 1, 2, 3, 6- tetrahidropiridina con un haluro de bencilo de la siguiente fórmula: **(Fórmula-2)** donde Hal. Es un átomo de cloro, bromo ó yodo, y el anillo benceno B es un radical 3, 4-diclorofenilo, 3,5-diclorofenilo, 4-cloro-3-acetoxifenilo, 3,4-diacetoxifenilo o 4-acetoxifenilo; tras lo cual, cuando se requiere una sal de adición de ácido farmacéuticamente aceptable, se reacciona un compuesto de fórmula I con un ácido adecuado.
ES484111A 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina Expired ES484111A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1432378 1978-04-12
GB7840272 1978-10-12

Publications (1)

Publication Number Publication Date
ES484111A1 true ES484111A1 (es) 1980-04-16

Family

ID=26250483

Family Applications (3)

Application Number Title Priority Date Filing Date
ES479561A Expired ES479561A1 (es) 1978-04-12 1979-04-11 Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.
ES484111A Expired ES484111A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina
ES484112A Expired ES484112A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES479561A Expired ES479561A1 (es) 1978-04-12 1979-04-11 Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES484112A Expired ES484112A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina

Country Status (17)

Country Link
US (1) US4645771A (es)
EP (1) EP0004727B1 (es)
AT (1) AT371443B (es)
AU (1) AU528873B2 (es)
CA (1) CA1118778A (es)
DE (1) DE2960612D1 (es)
DK (1) DK152979A (es)
ES (3) ES479561A1 (es)
FI (1) FI791189A7 (es)
GR (1) GR68387B (es)
HU (1) HU178589B (es)
IL (1) IL57249A (es)
NO (1) NO152558C (es)
NZ (1) NZ190092A (es)
PH (1) PH14565A (es)
PT (1) PT69489A (es)
ZW (1) ZW7179A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
US5229385A (en) * 1986-01-30 1993-07-20 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
HU209573B (en) * 1990-12-13 1994-08-29 Richter Gedeon Vegyeszet Process for producing of 1,2,3,6-tetrahydropyridine derivatives and pharmaceutical compositions comprising these substances
US5136040A (en) * 1991-02-26 1992-08-04 Eli Lilly And Company Preparation of substituted tetrahydropyridines
AU2320400A (en) * 1999-02-08 2000-08-25 Shionogi & Co., Ltd. Cyclic amine derivatives and uses thereof
WO2002012191A1 (en) 2000-08-08 2002-02-14 Shionogi & Co., Ltd. Cyclic amine derivatives and use thereof
US20020147193A1 (en) * 2001-01-23 2002-10-10 Mu-Iii Lim Novel couplers for use in oxidative hair dyeing
CN101376627B (zh) * 2008-09-26 2012-05-09 上海应用技术学院 4-羟基苯甲酰氯的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA778383A (en) * 1968-02-13 Marxer Adrian N-phenyl-lower alkyl-pyridinium compounds and process for preparing same
US3125488A (en) * 1964-03-17 Method of inducing analgesia by
US2609270A (en) * 1949-11-15 1952-09-02 Inst Textile Tech Mildewproof cellulose produced by reaction with chlord-benzyl quaternary ammonium salts
GB754372A (en) * 1953-05-11 1956-08-08 Schering Corp Pyridine and piperidine derivatives
US2967182A (en) * 1957-08-16 1961-01-03 Lilly Co Eli Novel substituted tetrahydropyridines
DE1445560C3 (de) * 1961-02-27 1974-05-16 Ciba-Geigy Ag, Basel (Schweiz) N-Dichlorbenzyl-4-alkyl-pyridiniumsalze und Verfahren zu ihrer Herstellung.
US3284457A (en) * 1964-01-17 1966-11-08 Degussa 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts
US3632767A (en) * 1968-02-12 1972-01-04 Mallinckrodt Chemical Works Treatment of depression with 4-substituted piperidines
DE2101998A1 (en) * 1971-01-16 1972-08-03 Bayer Ag Tetrahydropyridines prepn - from 1-benzyl-tetrahydropyridines
DE2101997A1 (en) * 1971-01-16 1972-08-03 Farbenfabriken Bayer AG, 509öfLeverkusen 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals
US3758483A (en) * 1971-05-28 1973-09-11 Hoffmann La Roche Tetrahydropyridine derivatives
ES425971A1 (es) * 1974-05-04 1976-09-16 Made Labor Sa Procedimiento para la preparacion de 1,3,4 - trimetil - 2- (3,4,5-trimetoxibencil)- 1,2,5,6-tetrahidropiridina.
US4028371A (en) * 1974-05-04 1977-06-07 Laboratorios Made, S.A. The compound 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride
EP0004726B1 (en) * 1978-04-12 1981-01-28 Imperial Chemical Industries Plc Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture

Also Published As

Publication number Publication date
CA1118778A (en) 1982-02-23
HU178589B (en) 1982-05-28
AU4581779A (en) 1979-10-18
DK152979A (da) 1979-10-13
PH14565A (en) 1981-09-24
EP0004727B1 (en) 1981-08-12
ES484112A1 (es) 1980-04-16
NO791237L (no) 1979-10-15
AT371443B (de) 1983-06-27
IL57249A0 (en) 1979-09-30
US4645771A (en) 1987-02-24
IL57249A (en) 1982-12-31
AU528873B2 (en) 1983-05-19
EP0004727A2 (en) 1979-10-17
NO152558C (no) 1985-10-16
EP0004727A3 (en) 1979-10-31
ES479561A1 (es) 1979-12-01
PT69489A (en) 1979-05-01
GR68387B (es) 1981-12-28
NZ190092A (en) 1981-05-15
NO152558B (no) 1985-07-08
ZW7179A1 (en) 1980-11-26
ATA275379A (de) 1982-11-15
FI791189A7 (fi) 1981-01-01
DE2960612D1 (en) 1981-11-12

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