ES479561A1 - Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. - Google Patents
Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.Info
- Publication number
- ES479561A1 ES479561A1 ES479561A ES479561A ES479561A1 ES 479561 A1 ES479561 A1 ES 479561A1 ES 479561 A ES479561 A ES 479561A ES 479561 A ES479561 A ES 479561A ES 479561 A1 ES479561 A1 ES 479561A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- radical
- ring
- hydrogen
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedimiento para la obtención de derivados de l- bencil-1,2,3,6-tetrahidropiridina, de fórmula: **(Fórmula-01)** en donde R1 es hidrógeno o un radial alquilo C1-4; uno de R2, R3, R4, R5 y R6 es halógeno, alquilo C1-4, alcoxi C1-4, hidroxi, nitro, ciano, carbonilo (alcoxi C-1-4), alcanoilamino C1-4 o alquilsulfonamido C1-4; otro de R2, R3, R4, R5 y R6 es hidrógeno o un halógeno, hidroxi, nitro un radical alquilo c1-4 ó un radical alcoxi C1-4, y el resto de R2. R3, R4, R5 y R6 es hidrógeno; pero el anillo bencénico A es distinto a un radical 2- clorofenilo, 3,4-diclorofenilo, 3,5-diclorofenilo, 4-cloro-3-hidroxifenilo, 3,4-dihidrocxifenilo o 4- hidroxifenil, cuando R1 es hidrógeno; o una sal de adición de ácido farmaceúticamente aceptable de los mismos, caracterizado porque comprende reaccionar una 1,2,3,6-tetrahidropiridina de fórmula: **(Fórmula-02)** en la que R1 se define como anteriormente, con un haluro de bencilo de fórmula: **(Fórmula-03)** donde Hal es un átomo de cloro, bromo o yodo, y R2, R3, R4, R5 y R6 en el anillo B tienen los valores dados anteriormente para los del anillo A, excepto que cuando el anillo A lleva una radical hidroxi, el anillo B lleva un radical alcanoiloxi (1-4C) en la misma posición; tras lo cual cuando se desea una sal de adición de ácido farmaceúticamente aceptable, se hace reaccionar un compuesto de fórmula I con un ácido apropiado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1432378 | 1978-04-12 | ||
| GB7840272 | 1978-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES479561A1 true ES479561A1 (es) | 1979-12-01 |
Family
ID=26250483
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479561A Expired ES479561A1 (es) | 1978-04-12 | 1979-04-11 | Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. |
| ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
| ES484112A Expired ES484112A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
| ES484112A Expired ES484112A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4645771A (es) |
| EP (1) | EP0004727B1 (es) |
| AT (1) | AT371443B (es) |
| AU (1) | AU528873B2 (es) |
| CA (1) | CA1118778A (es) |
| DE (1) | DE2960612D1 (es) |
| DK (1) | DK152979A (es) |
| ES (3) | ES479561A1 (es) |
| FI (1) | FI791189A7 (es) |
| GR (1) | GR68387B (es) |
| HU (1) | HU178589B (es) |
| IL (1) | IL57249A (es) |
| NO (1) | NO152558C (es) |
| NZ (1) | NZ190092A (es) |
| PH (1) | PH14565A (es) |
| PT (1) | PT69489A (es) |
| ZW (1) | ZW7179A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL81264A (en) * | 1986-01-30 | 1990-11-05 | Takeda Chemical Industries Ltd | Quinone derivatives,their production and pharmaceutical compositions containing them |
| US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| HU209573B (en) * | 1990-12-13 | 1994-08-29 | Richter Gedeon Vegyeszet | Process for producing of 1,2,3,6-tetrahydropyridine derivatives and pharmaceutical compositions comprising these substances |
| US5136040A (en) * | 1991-02-26 | 1992-08-04 | Eli Lilly And Company | Preparation of substituted tetrahydropyridines |
| AU2320400A (en) * | 1999-02-08 | 2000-08-25 | Shionogi & Co., Ltd. | Cyclic amine derivatives and uses thereof |
| WO2002012191A1 (en) | 2000-08-08 | 2002-02-14 | Shionogi & Co., Ltd. | Cyclic amine derivatives and use thereof |
| US20020147193A1 (en) * | 2001-01-23 | 2002-10-10 | Mu-Iii Lim | Novel couplers for use in oxidative hair dyeing |
| CN101376627B (zh) * | 2008-09-26 | 2012-05-09 | 上海应用技术学院 | 4-羟基苯甲酰氯的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA778383A (en) * | 1968-02-13 | Marxer Adrian | N-phenyl-lower alkyl-pyridinium compounds and process for preparing same | |
| US3125488A (en) * | 1964-03-17 | Method of inducing analgesia by | ||
| US2609270A (en) * | 1949-11-15 | 1952-09-02 | Inst Textile Tech | Mildewproof cellulose produced by reaction with chlord-benzyl quaternary ammonium salts |
| GB754372A (en) * | 1953-05-11 | 1956-08-08 | Schering Corp | Pyridine and piperidine derivatives |
| US2967182A (en) * | 1957-08-16 | 1961-01-03 | Lilly Co Eli | Novel substituted tetrahydropyridines |
| DE1445560C3 (de) * | 1961-02-27 | 1974-05-16 | Ciba-Geigy Ag, Basel (Schweiz) | N-Dichlorbenzyl-4-alkyl-pyridiniumsalze und Verfahren zu ihrer Herstellung. |
| US3284457A (en) * | 1964-01-17 | 1966-11-08 | Degussa | 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts |
| US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
| DE2101998A1 (en) * | 1971-01-16 | 1972-08-03 | Bayer Ag | Tetrahydropyridines prepn - from 1-benzyl-tetrahydropyridines |
| DE2101997A1 (en) * | 1971-01-16 | 1972-08-03 | Farbenfabriken Bayer AG, 509öfLeverkusen | 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals |
| US3758483A (en) * | 1971-05-28 | 1973-09-11 | Hoffmann La Roche | Tetrahydropyridine derivatives |
| ES425971A1 (es) * | 1974-05-04 | 1976-09-16 | Made Labor Sa | Procedimiento para la preparacion de 1,3,4 - trimetil - 2- (3,4,5-trimetoxibencil)- 1,2,5,6-tetrahidropiridina. |
| US4028371A (en) * | 1974-05-04 | 1977-06-07 | Laboratorios Made, S.A. | The compound 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride |
| EP0004726B1 (en) * | 1978-04-12 | 1981-01-28 | Imperial Chemical Industries Plc | Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture |
-
1979
- 1979-03-21 EP EP79300447A patent/EP0004727B1/en not_active Expired
- 1979-03-21 DE DE7979300447T patent/DE2960612D1/de not_active Expired
- 1979-03-31 GR GR58753A patent/GR68387B/el unknown
- 1979-04-02 NZ NZ190092A patent/NZ190092A/xx unknown
- 1979-04-03 CA CA000324750A patent/CA1118778A/en not_active Expired
- 1979-04-04 AU AU45817/79A patent/AU528873B2/en not_active Ceased
- 1979-04-10 PH PH22373A patent/PH14565A/en unknown
- 1979-04-10 ZW ZW71/79A patent/ZW7179A1/xx unknown
- 1979-04-11 NO NO791237A patent/NO152558C/no unknown
- 1979-04-11 DK DK152979A patent/DK152979A/da not_active IP Right Cessation
- 1979-04-11 ES ES479561A patent/ES479561A1/es not_active Expired
- 1979-04-11 FI FI791189A patent/FI791189A7/fi not_active Application Discontinuation
- 1979-04-11 HU HU79IE872A patent/HU178589B/hu unknown
- 1979-04-12 AT AT0275379A patent/AT371443B/de not_active IP Right Cessation
- 1979-04-12 PT PT69489A patent/PT69489A/pt unknown
- 1979-05-10 IL IL57249A patent/IL57249A/xx unknown
- 1979-09-12 ES ES484111A patent/ES484111A1/es not_active Expired
- 1979-09-12 ES ES484112A patent/ES484112A1/es not_active Expired
-
1982
- 1982-09-30 US US06/428,822 patent/US4645771A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1118778A (en) | 1982-02-23 |
| HU178589B (en) | 1982-05-28 |
| AU4581779A (en) | 1979-10-18 |
| DK152979A (da) | 1979-10-13 |
| PH14565A (en) | 1981-09-24 |
| EP0004727B1 (en) | 1981-08-12 |
| ES484112A1 (es) | 1980-04-16 |
| NO791237L (no) | 1979-10-15 |
| AT371443B (de) | 1983-06-27 |
| IL57249A0 (en) | 1979-09-30 |
| US4645771A (en) | 1987-02-24 |
| IL57249A (en) | 1982-12-31 |
| AU528873B2 (en) | 1983-05-19 |
| EP0004727A2 (en) | 1979-10-17 |
| NO152558C (no) | 1985-10-16 |
| EP0004727A3 (en) | 1979-10-31 |
| PT69489A (en) | 1979-05-01 |
| GR68387B (es) | 1981-12-28 |
| NZ190092A (en) | 1981-05-15 |
| ES484111A1 (es) | 1980-04-16 |
| NO152558B (no) | 1985-07-08 |
| ZW7179A1 (en) | 1980-11-26 |
| ATA275379A (de) | 1982-11-15 |
| FI791189A7 (fi) | 1981-01-01 |
| DE2960612D1 (en) | 1981-11-12 |
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