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ES470836A1 - A procedure for the preparation of aminoalquilfurans (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of aminoalquilfurans (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES470836A1
ES470836A1 ES470836A ES470836A ES470836A1 ES 470836 A1 ES470836 A1 ES 470836A1 ES 470836 A ES470836 A ES 470836A ES 470836 A ES470836 A ES 470836A ES 470836 A1 ES470836 A1 ES 470836A1
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
procedure
aminoalquilfurans
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470836A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES470836(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB32465/76A external-priority patent/GB1565966A/en
Priority claimed from KR7701808A external-priority patent/KR810000355B1/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of ES470836A1 publication Critical patent/ES470836A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un procedimiento para la producción de aminoalquilfurano de fórmula general (I): **(Fórmula 1)** y sales del mismo fisiológicamente aceptables del mismo y N-óxidos e hidratos en el cual R1 y R2 que pueden ser iguales o diferentes representan hidrógeno, alquilo inferior, cicloalquilo, alquenilo inferior, aralquilo o alquilo inferior interrumpido por un átomo de oxígeno o un grupo -N-R4 en el que R4 representa hidrógeno o alquilo inferior o R1 y R2 pueden formar, conjuntamente con el átomo de hidrógeno al cual están unidos, un anillo heterocíclico que puede contener otros heteroátomos seleccionados de O y -N-R4; R3 es hidrógeno, alquilo inferior, alquenilo inferior, o alcoxialquilo; X es S; Y representa =S, =O, =NR5 o =CH6; Alq representa una cadena alquilénica de cadena lineal o ramificada de 1 a 6 átomos de carbono; R5 es H, nitro, ciano, alquilo inferior, arilo, alquilsulfonilo o arilsulfonilo; R6 representa nitro, arilsulfonilo o alquilsulfonilo; m es un número entero de 2 a 4; y n es 1; y cuando R1 y R2 son hidrógeno Y no es =CHNO2.A procedure for the production of aminoalkylphuran of general formula (I): **(Formula 1)** and physiologically acceptable salts thereof and N-oxides and hydrates in which R1 and R2 which may be the same or different represent hydrogen , lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group -N-R4 in which R4 represents hydrogen or lower alkyl or R1 and R2 can form, together with the hydrogen atom to which are attached, a heterocyclic ring that may contain other heteroatoms selected from O and -N-R4; R3 is hydrogen, lower alkyl, lower alkenyl, or alkoxyalkyl; X is S; Y represents =S, =O, =NR5 or =CH6; Alk represents a straight or branched chain alkylene chain of 1 to 6 carbon atoms; R5 is H, nitro, cyano, lower alkyl, aryl, alkylsulfonyl or arylsulfonyl; R6 represents nitro, arylsulfonyl or alkylsulfonyl; m is an integer from 2 to 4; and n is 1; and when R1 and R2 are hydrogen Y is not =CHNO2.

ES470836A 1976-08-04 1978-06-15 A procedure for the preparation of aminoalquilfurans (Machine-translation by Google Translate, not legally binding) Expired ES470836A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB32465/76A GB1565966A (en) 1976-08-04 1976-08-04 Aminoalkyl furan derivatives
GB5068576 1976-12-06
GB2018777 1977-05-13
KR7701808A KR810000355B1 (en) 1977-05-13 1977-08-04 Preparation for pharmacologically active compounds

Publications (1)

Publication Number Publication Date
ES470836A1 true ES470836A1 (en) 1979-02-16

Family

ID=27448487

Family Applications (2)

Application Number Title Priority Date Filing Date
ES461334A Expired ES461334A1 (en) 1976-08-04 1977-08-03 A procedure for the preparation of aminoalquilfurans. (Machine-translation by Google Translate, not legally binding)
ES470836A Expired ES470836A1 (en) 1976-08-04 1978-06-15 A procedure for the preparation of aminoalquilfurans (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES461334A Expired ES461334A1 (en) 1976-08-04 1977-08-03 A procedure for the preparation of aminoalquilfurans. (Machine-translation by Google Translate, not legally binding)

Country Status (16)

Country Link
AT (1) AT375931B (en)
CH (2) CH642072A5 (en)
CY (1) CY1077A (en)
DE (2) DE2760097C2 (en)
DK (2) DK148258C (en)
ES (2) ES461334A1 (en)
FI (1) FI72318C (en)
HK (1) HK55780A (en)
IE (1) IE45456B1 (en)
IT (2) IT1126759B (en)
KE (1) KE3080A (en)
NZ (2) NZ191383A (en)
PH (1) PH13540A (en)
PT (1) PT66874B (en)
SE (3) SE437373B (en)
YU (2) YU40006B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203909A (en) * 1978-09-26 1980-05-20 Bristol-Myers Company Furan compounds
YU52598A (en) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj Procedure for synthesis of n-[2[[[5-[ (dialkylamino)methyl] -2-furanil]methyl]thi0]etyl]-n'-alkyl-2-nitro 1,1 alkendiamine and its hydrochloride

Also Published As

Publication number Publication date
CH642072A5 (en) 1984-03-30
FI772264A7 (en) 1978-02-05
SE454882B (en) 1988-06-06
YU200082A (en) 1983-01-21
PH13540A (en) 1980-06-26
PT66874B (en) 1979-01-23
SE8206556D0 (en) 1982-11-17
NZ184759A (en) 1980-09-12
DE2759959C2 (en) 1988-08-04
PT66874A (en) 1977-09-01
KE3080A (en) 1980-10-03
IE45456L (en) 1978-02-04
DE2760097C2 (en) 1989-08-17
DK148258B (en) 1985-05-20
SE8206556L (en) 1982-11-17
DK337977A (en) 1978-02-05
CY1077A (en) 1980-12-27
IT1126759B (en) 1986-05-21
SE8205533L (en) 1982-09-28
SE8205533D0 (en) 1982-09-28
ATA574077A (en) 1984-02-15
FI72318C (en) 1987-05-11
SE7708521L (en) 1978-02-05
YU40088B (en) 1985-06-30
ES461334A1 (en) 1979-05-16
SE437373B (en) 1985-02-25
SE454883B (en) 1988-06-06
DK148258C (en) 1985-10-14
DK416384D0 (en) 1984-08-30
DK149952B (en) 1986-11-03
IT1221058B (en) 1990-06-21
NZ191383A (en) 1980-09-12
FI72318B (en) 1987-01-30
YU191177A (en) 1983-01-21
IE45456B1 (en) 1982-08-25
DK149952C (en) 1987-07-06
DK416384A (en) 1984-08-30
YU40006B (en) 1985-06-30
IT8548437A0 (en) 1985-08-01
AT375931B (en) 1984-09-25
CH641176A5 (en) 1984-02-15
HK55780A (en) 1980-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990121