GB2006771A - Substituted Heterocyclic Compounds, their Preparation and Pharmaceutical Compositions Containing them - Google Patents
Substituted Heterocyclic Compounds, their Preparation and Pharmaceutical Compositions Containing themInfo
- Publication number
- GB2006771A GB2006771A GB7840125A GB7840125A GB2006771A GB 2006771 A GB2006771 A GB 2006771A GB 7840125 A GB7840125 A GB 7840125A GB 7840125 A GB7840125 A GB 7840125A GB 2006771 A GB2006771 A GB 2006771A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- image
- carbon atoms
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to compounds of the general formula <IMAGE> and physiologically acceptable salts and N-oxides, hydrates and bioprecursors thereof, in which R1 and R2 which may be the same or different each represent hydrogen, C1-8 alkyl, C4-8 cycloalkyl, C3-6 alkenyl, aralkyl with 1 to 4 carbon atoms in the alkyl residue or C1-8 alkyl interrupted by an oxygen atom or a group <IMAGE> in which R5 represents hydrogen or C1-8 alkyl, or R1 and R2 may together with the nitrogen atom to which they are attached, form a saturated monocyclic 5 to 7 membered heterocyclic ring which may additionally contain the heterofunction 0 or <IMAGE> R3 represents straight or branched chain C1-8 alkyl, alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue, C1-8 hydroxyalkyl, C1-8 alkoxycarbonyl, alkyl thioalkyl with 1 to 8 carbon atoms in each alkyl residue, halogen or aryl; R4 represents hydrogen, C1-8 alkyl, C3-6 alkenyl or alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue; X represents -O- or -S-; Y represents =S, =O, =NR6 or =CHNO2 where R6 represents hydrogen, nitro, cyano, C1-8 alkyl, aryl, C1-8 alkylsulphonyl or arylsulphonyl; m represents an integer from 2 to 4 inclusive; and n represents an integer which is 1 or 2, or additionally when X is -S- n may also be zero. The invention also relates to processes for the production of such compounds, pharmaceutical compositions containing them and certain novel intermediates used in their production, i.e. amines of the formula <IMAGE> and alcohols of the formula <IMAGE> The compounds of formula (I) show pharmacological activity as selective histamine H2-antagonists.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7840125A GB2006771B (en) | 1977-10-11 | 1978-10-11 | Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4225677 | 1977-10-11 | ||
| GB7840125A GB2006771B (en) | 1977-10-11 | 1978-10-11 | Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2006771A true GB2006771A (en) | 1979-05-10 |
| GB2006771B GB2006771B (en) | 1982-10-20 |
Family
ID=26264870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7840125A Expired GB2006771B (en) | 1977-10-11 | 1978-10-11 | Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2006771B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491586A (en) * | 1980-06-05 | 1985-01-01 | Glaxo Group Limited | Amine derivatives |
| EP0454469A1 (en) * | 1990-04-26 | 1991-10-30 | Glaxo Group Limited | Carboxylic acid derivatives |
| FR2728793A1 (en) * | 1994-12-28 | 1996-07-05 | Oreal | USE OF A HISTAMINE ANTAGONIST, AN INTERLEUKIN 1 ANTAGONIST AND / OR A TNF-ALPHA ANTAGONIST IN A COSMETIC, PHARMACEUTICAL OR DERMATOLOGICAL COMPOSITION AND COMPOSITION OBTAINED |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9206083D0 (en) * | 1992-03-20 | 1992-05-06 | Glaxo Group Ltd | Medicaments |
-
1978
- 1978-10-11 GB GB7840125A patent/GB2006771B/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491586A (en) * | 1980-06-05 | 1985-01-01 | Glaxo Group Limited | Amine derivatives |
| EP0454469A1 (en) * | 1990-04-26 | 1991-10-30 | Glaxo Group Limited | Carboxylic acid derivatives |
| US5229418A (en) * | 1990-04-26 | 1993-07-20 | Glaxo Group Limited | Carboxylic acid derivatives |
| FR2728793A1 (en) * | 1994-12-28 | 1996-07-05 | Oreal | USE OF A HISTAMINE ANTAGONIST, AN INTERLEUKIN 1 ANTAGONIST AND / OR A TNF-ALPHA ANTAGONIST IN A COSMETIC, PHARMACEUTICAL OR DERMATOLOGICAL COMPOSITION AND COMPOSITION OBTAINED |
| EP0729750A1 (en) * | 1994-12-28 | 1996-09-04 | L'oreal | Use of an interleukin-1 antagonist and/or alpha-TNF antagonist in a cosmetic, pharmaceutical or dermatological composition, and the composition therefrom, possibly used in combination with a histamine antagonist |
| US5658581A (en) * | 1994-12-28 | 1997-08-19 | L'oreal | Histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist in a cosmetic, pharmaceutical or dermatological composition and composition obtained |
| US6277387B1 (en) | 1994-12-28 | 2001-08-21 | L'oreal | Use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF αantagonist in a cosmetic, pharmaceutical or dermatological composition and composition obtained |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2006771B (en) | 1982-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 7732 | Case decided by the comptroller ** patent revoked (sect. 73(2)/1977) |