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ES470214A1 - Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos - Google Patents

Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos

Info

Publication number
ES470214A1
ES470214A1 ES470214A ES470214A ES470214A1 ES 470214 A1 ES470214 A1 ES 470214A1 ES 470214 A ES470214 A ES 470214A ES 470214 A ES470214 A ES 470214A ES 470214 A1 ES470214 A1 ES 470214A1
Authority
ES
Spain
Prior art keywords
give
formula
carbon atoms
preparation
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470214A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES470214(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES470214A1 publication Critical patent/ES470214A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de ácidos pirrol-l-carboxílicos de fórmula: **(Fórmula)** o sus ácidos isoméricos individuales (1) y (d) y los ésteres y sales no tóxicos, farmaceúticamente aceptables de los mismos, donde R representa hidrógeno o un grupo alquilo inferior que tiene de 1 a 4 átomos de carbono y R1 representa hidrógeno, un grupo alquilo inferior que tiene de 1 a 4 átomos de carbono, un grupo alcoxi inferior que tiene de 1 a 4 átomos de carbono, cloro, flúor o bromo, estando la sustitución R1 en las posiciones orto, meta o para del grupo aroílo, cuyo procedimiento se caracteriza porque comprende: a) hidrolizar un éster de un compuesto de la fórmula anterior para dar la correspondiente sal o ácido libre; b) convertir una sal de un compuesto de la fórmula anterior para dar el correspondiente ácido libre; c) esterificar un ácido libre de la fórmula anterior para dar un éster correspondiente; o d) convertir un ácido libre de la fórmula anterior para dar unasal correspondiente.
ES470214A 1976-07-14 1978-05-24 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos Expired ES470214A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (1)

Publication Number Publication Date
ES470214A1 true ES470214A1 (es) 1979-09-16

Family

ID=27107410

Family Applications (2)

Application Number Title Priority Date Filing Date
ES460706A Expired ES460706A1 (es) 1976-07-14 1977-07-13 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos.
ES470214A Expired ES470214A1 (es) 1976-07-14 1978-05-24 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES460706A Expired ES460706A1 (es) 1976-07-14 1977-07-13 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos.

Country Status (27)

Country Link
JP (1) JPS539788A (es)
AR (1) AR224997A1 (es)
CA (1) CA1102809A (es)
CH (3) CH641458A5 (es)
CS (1) CS204954B2 (es)
DE (2) DE2731678A1 (es)
DK (1) DK151886C (es)
ES (2) ES460706A1 (es)
FI (1) FI63406C (es)
FR (2) FR2358406A1 (es)
GB (1) GB1554075A (es)
GR (1) GR61111B (es)
HK (1) HK15981A (es)
HU (1) HU174224B (es)
IE (1) IE45253B1 (es)
IL (2) IL52493A (es)
IT (1) IT1117313B (es)
MX (1) MX163202B (es)
MY (1) MY8100357A (es)
NL (2) NL186318C (es)
NO (1) NO147564C (es)
NZ (1) NZ184610A (es)
PL (4) PL109390B1 (es)
PT (1) PT66780B (es)
SE (1) SE434643B (es)
SU (1) SU695558A3 (es)
YU (1) YU40816B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
ES2136093T3 (es) * 1991-11-11 1999-11-16 Hisamitsu Pharmaceutical Co Fomentacion que contiene cetorolac.
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置
KR20230131182A (ko) * 2020-12-16 2023-09-12 뉴 프런티어 랩스 엘엘씨 진통 효과를 유도하기 위한 디카르복실산 에스테르

Also Published As

Publication number Publication date
PL124711B1 (en) 1983-02-28
CA1102809A (en) 1981-06-09
PL109390B1 (en) 1980-05-31
IL52493A0 (en) 1977-10-31
AU2697577A (en) 1979-01-18
CH646972A5 (en) 1984-12-28
ES460706A1 (es) 1978-12-01
IT1117313B (it) 1986-02-17
PL124444B1 (en) 1983-01-31
FI63406C (fi) 1983-06-10
DE2731678C2 (es) 1989-06-08
GB1554075A (en) 1979-10-17
FR2358406A1 (fr) 1978-02-10
NZ184610A (en) 1979-03-28
PL124445B1 (en) 1983-01-31
AR224997A1 (es) 1982-02-15
MX163202B (es) 1992-02-20
DK307577A (da) 1978-01-15
NO147564C (no) 1983-05-18
YU40816B (en) 1986-06-30
NL930021I1 (nl) 1993-05-03
FR2358406B1 (es) 1981-04-17
NL930021I2 (nl) 1997-03-03
DK151886C (da) 1988-06-06
JPS539788A (en) 1978-01-28
JPS6254109B2 (es) 1987-11-13
AU513384B2 (en) 1980-11-27
PT66780A (fr) 1977-08-01
IE45253B1 (en) 1982-07-14
SU695558A3 (ru) 1979-10-30
MY8100357A (en) 1981-12-31
IL58779A0 (en) 1980-02-29
HU174224B (hu) 1979-11-28
CS204954B2 (en) 1981-04-30
NL186318C (nl) 1990-11-01
FI772153A7 (es) 1978-01-15
YU172177A (en) 1983-09-30
FR2375234B1 (es) 1980-11-07
IL52493A (en) 1982-02-28
DE2760330C2 (es) 1989-06-15
PT66780B (fr) 1978-12-18
CH641458A5 (en) 1984-02-29
NL186318B (nl) 1990-06-01
DK151886B (da) 1988-01-11
GR61111B (en) 1978-09-12
SE7708141L (sv) 1978-01-15
NO147564B (no) 1983-01-24
FR2375234A1 (fr) 1978-07-21
PL199603A1 (pl) 1978-04-24
FI63406B (fi) 1983-02-28
DE2731678A1 (de) 1978-03-16
SE434643B (sv) 1984-08-06
IE45253L (en) 1978-01-14
HK15981A (en) 1981-05-01
NO772494L (no) 1978-01-17
CH646973A5 (en) 1984-12-28
NL7707651A (nl) 1978-01-17

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