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ES8203376A1 - Procedimiento para obtener acidos 6-cloro- o 6-bromo-1,2-di-hidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos y sus derivados - Google Patents

Procedimiento para obtener acidos 6-cloro- o 6-bromo-1,2-di-hidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos y sus derivados

Info

Publication number
ES8203376A1
ES8203376A1 ES502855A ES502855A ES8203376A1 ES 8203376 A1 ES8203376 A1 ES 8203376A1 ES 502855 A ES502855 A ES 502855A ES 502855 A ES502855 A ES 502855A ES 8203376 A1 ES8203376 A1 ES 8203376A1
Authority
ES
Spain
Prior art keywords
bromo
derivatives
pyrrolo
pyrrole
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502855A
Other languages
English (en)
Other versions
ES502855A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES502855A0 publication Critical patent/ES502855A0/es
Publication of ES8203376A1 publication Critical patent/ES8203376A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 6-CLORO O 6-BROMO-1,2-DIHIDRO-3H-PIRROLO (1,2-A)PIRROL-1-CARBOXILICOS Y SUS DERIVADOS. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA GENERAL (I) CON UNA AMIDA (II) O CON UN CLORURO DE ACIDO (III) PARA OBTENER EL COMPUESTO (IV). OPCIONALMENTE PUEDE HIDROLIZARSE EL ESTER ALCOHILICO OBTENIDO PARA OBTENER EL ACIDO LIBRE O UNA SAL DEL MISMO; PUEDE TAMBIEN ESTERIFICARSE EL ACIDO (IV) O CONVERTIRLO EN UNA SAL NO TOXICA FARMACEUTICAMENTE ACEPTABLE O PUEDE CONVERTIRSE UNA SAL DE UN COMPUESTO IV EN EL CORRESPONDIENTE ACIDO LIBRE.
ES502855A 1980-06-09 1981-06-08 Procedimiento para obtener acidos 6-cloro- o 6-bromo-1,2-di-hidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos y sus derivados Expired ES8203376A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,719 US4344943A (en) 1980-06-09 1980-06-09 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof

Publications (2)

Publication Number Publication Date
ES502855A0 ES502855A0 (es) 1982-04-01
ES8203376A1 true ES8203376A1 (es) 1982-04-01

Family

ID=22564979

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502855A Expired ES8203376A1 (es) 1980-06-09 1981-06-08 Procedimiento para obtener acidos 6-cloro- o 6-bromo-1,2-di-hidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos y sus derivados

Country Status (19)

Country Link
US (1) US4344943A (es)
EP (1) EP0041711B1 (es)
JP (1) JPS5714591A (es)
KR (1) KR850000609B1 (es)
AT (1) ATE12771T1 (es)
AU (1) AU546012B2 (es)
CA (1) CA1178277A (es)
DE (1) DE3169956D1 (es)
DK (1) DK249781A (es)
ES (1) ES8203376A1 (es)
GR (1) GR74615B (es)
HU (1) HU185430B (es)
IE (1) IE51523B1 (es)
IL (1) IL63047A (es)
NZ (1) NZ197331A (es)
PT (1) PT73154B (es)
SU (1) SU1217260A3 (es)
YU (2) YU43235B (es)
ZA (1) ZA813829B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4612325A (en) * 1982-06-08 1986-09-16 Syntex (U.S.A) Inc. 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4849526A (en) * 1987-01-14 1989-07-18 Syntex (U.S.A.) Inc. Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
US5082950A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
WO1995001767A1 (en) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
MXPA02007080A (es) * 2000-01-19 2003-09-25 Cadila Healthcare Ltd Compuestos novedosos que tienen actividades hipolidemicas e hipocolesterolemicas, proceso para su preparacion y composiciones farmaceuticas que los contienen.
WO2002062341A1 (en) * 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids

Also Published As

Publication number Publication date
CA1178277A (en) 1984-11-20
YU142381A (en) 1983-12-31
PT73154B (en) 1982-07-16
IE811269L (en) 1981-12-09
NZ197331A (en) 1985-05-31
SU1217260A3 (ru) 1986-03-07
US4344943A (en) 1982-08-17
AU7143881A (en) 1981-12-17
ZA813829B (en) 1983-01-26
YU137083A (en) 1983-12-31
HU185430B (en) 1985-02-28
EP0041711A1 (en) 1981-12-16
AU546012B2 (en) 1985-08-08
ES502855A0 (es) 1982-04-01
DE3169956D1 (en) 1985-05-23
DK249781A (da) 1981-12-10
PT73154A (en) 1981-07-01
IE51523B1 (en) 1987-01-07
EP0041711B1 (en) 1985-04-17
KR830006289A (ko) 1983-09-20
KR850000609B1 (ko) 1985-05-01
GR74615B (es) 1984-06-29
JPS5714591A (en) 1982-01-25
YU43235B (en) 1989-06-30
IL63047A (en) 1984-07-31
ATE12771T1 (de) 1985-05-15
IL63047A0 (en) 1981-09-13

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