[go: up one dir, main page]

ES474234A1 - Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina sustituidos en posicion 6 - Google Patents

Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina sustituidos en posicion 6

Info

Publication number
ES474234A1
ES474234A1 ES474234A ES474234A ES474234A1 ES 474234 A1 ES474234 A1 ES 474234A1 ES 474234 A ES474234 A ES 474234A ES 474234 A ES474234 A ES 474234A ES 474234 A1 ES474234 A1 ES 474234A1
Authority
ES
Spain
Prior art keywords
dihydropyridine derivatives
compounds
formula
image
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474234A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES474234A1 publication Critical patent/ES474234A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de compuestos de 1,4-dihidropiridina sustituidos en posición 6. Más particularmente, se refiere a un procedimiento para la preparación de nuevos compuestos de 1,4-dihidropiridina sustituidos en posición 6 que tiene actividad vasodilatadora y anti-hipertensora. Respecto a los estados de las técnicas en este campo, el compuesto siguiente es conocido por el público en la bibliografía. **(Fórmula)**
ES474234A 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina sustituidos en posicion 6 Expired ES474234A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (1)

Publication Number Publication Date
ES474234A1 true ES474234A1 (es) 1979-04-01

Family

ID=10465031

Family Applications (3)

Application Number Title Priority Date Filing Date
ES465137A Expired ES465137A1 (es) 1976-12-17 1977-12-16 Un procedimiento para preparar compuestos de 6-hidroxialco- hil-1,4-dihidropiridina
ES474234A Expired ES474234A1 (es) 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina sustituidos en posicion 6
ES474233A Expired ES474233A1 (es) 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES465137A Expired ES465137A1 (es) 1976-12-17 1977-12-16 Un procedimiento para preparar compuestos de 6-hidroxialco- hil-1,4-dihidropiridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES474233A Expired ES474233A1 (es) 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina

Country Status (15)

Country Link
JP (1) JPS5948828B2 (es)
AR (2) AR221478A1 (es)
AT (1) AT367401B (es)
AU (1) AU518206B2 (es)
BE (1) BE861964A (es)
CH (1) CH633266A5 (es)
DE (1) DE2756226A1 (es)
DK (2) DK563377A (es)
ES (3) ES465137A1 (es)
FR (1) FR2374307A1 (es)
GB (1) GB1591089A (es)
HU (1) HU176454B (es)
NL (1) NL7714066A (es)
SE (2) SE7714374L (es)
ZA (1) ZA777532B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
HU197881B (en) * 1982-08-06 1989-06-28 Banyu Pharma Co Ltd Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
FI862343A7 (fi) 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
DE3675747D1 (de) * 1985-08-21 1991-01-03 Glaxo Spa 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung.
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN103951608B (zh) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 尼伐地平晶型及其制备方法
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH607848A5 (es) * 1974-06-04 1978-11-30 Bayer Ag
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
ES474233A1 (es) 1979-11-01
DK172182A (da) 1982-04-16
FR2374307B1 (es) 1981-02-13
NL7714066A (nl) 1978-06-20
SE7714374L (sv) 1978-06-18
AR221478A1 (es) 1981-02-13
CH633266A5 (en) 1982-11-30
ATA901877A (de) 1981-11-15
AR221887A1 (es) 1981-03-31
JPS5395977A (en) 1978-08-22
AU3165777A (en) 1979-06-21
ZA777532B (en) 1978-10-25
HU176454B (en) 1981-03-28
GB1591089A (en) 1981-06-10
JPS5948828B2 (ja) 1984-11-29
AT367401B (de) 1982-07-12
DK563377A (da) 1978-06-18
FR2374307A1 (fr) 1978-07-13
AU518206B2 (en) 1981-09-17
BE861964A (fr) 1978-06-16
DE2756226A1 (de) 1978-06-29
SE8204312D0 (sv) 1982-07-13
ES465137A1 (es) 1979-01-01
SE8204312L (sv) 1982-07-13

Similar Documents

Publication Publication Date Title
ES474233A1 (es) Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina
JPS5278848A (en) Preparation of novel propionic acid ester derivatives
JPS5212109A (en) Process for preparation of alkylglycerylether
JPS5283380A (en) Synthesis of thiocarbostyril derivatives
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
JPS525755A (en) Process for preparation of 3-amino-4-homotwistane and its acid salts
JPS527946A (en) Preparation of indanylpropionic acid derivatives
JPS51145548A (en) Stabilizers for polymeric materials
JPS51146474A (en) Process for preparing piperidylbenzimidazole derivatives
JPS5217441A (en) Process for preparation of p-cyanophenylester of 4-substituted- benzoi c acid
JPS52130820A (en) Production of tetrachloronaphthalic acid derivative
JPS51131879A (en) A process for preparing piperidyl benzimidazole derivatives
JPS5217442A (en) Process for preparation of benzoylhydrazone derivatives
JPS51136673A (en) Process for preparation of piperidylbenzimidazole derivatives
JPS51136698A (en) Process for preparing new pyridone carboxylic acid derivatives
JPS51128961A (en) Process for preparing 8-azaprostanoic acid derivatives
JPS5246019A (en) Process for preparation of alkyl-3-(2,2-dihalovinyl)-4-methyl-4-penten oate and its derivatives
JPS51115918A (en) Germicides for the porposes withowt medical treatment and method for p reparing them
JPS5436252A (en) Novel propano-anthracene derivatives and their preparation
JPS5242892A (en) Preparation of 1beta h, 13alpha h-9-oxabicyclo 11,3,0 hexadeca-3-ene derivative s
JPS51136643A (en) Process for preparation of aromatic ester derivatives
JPS5365882A (en) 1,4-dihydro-4-oxonicotinic acids and process for preparation of the same
JPS5248640A (en) Process for preparation of alpha-substituted-phenyl-alkane-carboxylic acids their derivatives
JPS51136682A (en) Process for preparing 5-alkanoylcarbostyril derivatives.
JPS5246073A (en) Process for preparation of novel 3-substituted pyrrolidine derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201