ES407933A2 - Nitrofuran and nitrothiophene derivatives - Google Patents
Nitrofuran and nitrothiophene derivativesInfo
- Publication number
- ES407933A2 ES407933A2 ES407933A ES407933A ES407933A2 ES 407933 A2 ES407933 A2 ES 407933A2 ES 407933 A ES407933 A ES 407933A ES 407933 A ES407933 A ES 407933A ES 407933 A2 ES407933 A2 ES 407933A2
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- group
- het
- meanings
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Improvements introduced in the main patent object 392,284 by process for the preparation of nitrofuran derivatives, characterized in that for the preparation of compounds of the general formula I' **(See formula)** where X represents an oxygen or sulfur atom, Het represents a triazolopyridazine or thiadiazole system and R represents a dialkohilamino group, an acylated amino group, an acylated aminoalkoxy group, a carboalkoxyalkoxy group, a morpholino group or a cycloalkoxy group, piperidino or piperazinyl optionally substituted in position 4 by hydroxyl, alcoholic or hydroxyalkoxy, as well as their pharmacologically compatible salts, it is established that: a) compounds of the general formula II are reacted **(See formula)** wherein X and Het have the above-mentioned meanings and R1 means a lower alcohol group or their salts, with compounds H-R, where R has the above-mentioned meanings, or b) compounds of the general formula III are condensed **(See formula)** where X and Het have the meanings indicated above, with compounds Z = CH-R where R has the meanings mentioned above and Z means an oxygen or sulfur atom or with a reactive derivative thereof; or c) compounds of the general formula IV are nitrated **(See formula)** in which X, Het and R have the meanings mentioned above, and if desired, the compounds I'obtained are transformed into their pharmacologically compatible salts, or the group R is modified. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2153902A DE2153902A1 (en) | 1971-10-29 | 1971-10-29 | ANTIMICROBIALLY EFFECTIVE NITROFURA DERIVATIVES AND METHOD FOR PRODUCING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES407933A2 true ES407933A2 (en) | 1975-11-01 |
Family
ID=5823698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES407933A Expired ES407933A2 (en) | 1971-10-29 | 1972-10-24 | Nitrofuran and nitrothiophene derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4852769A (en) |
| AR (3) | AR197008A1 (en) |
| AT (5) | AT327882B (en) |
| AU (1) | AU467712B2 (en) |
| DD (1) | DD102387A5 (en) |
| DE (1) | DE2153902A1 (en) |
| ES (1) | ES407933A2 (en) |
| FR (1) | FR2158313B2 (en) |
| GB (1) | GB1348088A (en) |
| HU (1) | HU164715B (en) |
| IL (1) | IL40639A0 (en) |
| NL (1) | NL7214621A (en) |
| PL (1) | PL82632B1 (en) |
| SU (2) | SU509235A3 (en) |
| ZA (1) | ZA727504B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2222834A1 (en) * | 1972-05-10 | 1973-11-29 | Boehringer Mannheim Gmbh | NITROFURYL AMIDINE DERIVATIVES AND METHOD FOR PREPARING THE SAME |
| US7268136B2 (en) * | 2002-12-18 | 2007-09-11 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1527537A (en) * | 1966-06-18 | 1968-05-31 | Boehringer & Soehne Gmbh | Process for the preparation of new derivatives of 5-nitrofuran and 5-nitrothiophene |
-
1971
- 1971-10-29 DE DE2153902A patent/DE2153902A1/en active Pending
-
1972
- 1972-10-22 IL IL40639A patent/IL40639A0/en unknown
- 1972-10-23 ZA ZA727504A patent/ZA727504B/en unknown
- 1972-10-23 DD DD166425A patent/DD102387A5/xx unknown
- 1972-10-24 GB GB4893772A patent/GB1348088A/en not_active Expired
- 1972-10-24 ES ES407933A patent/ES407933A2/en not_active Expired
- 1972-10-25 AR AR244808A patent/AR197008A1/en active
- 1972-10-27 AT AT61774*7A patent/AT327882B/en not_active IP Right Cessation
- 1972-10-27 FR FR7238198A patent/FR2158313B2/fr not_active Expired
- 1972-10-27 AT AT917072A patent/AT320628B/en not_active IP Right Cessation
- 1972-10-27 AU AU48277/72A patent/AU467712B2/en not_active Expired
- 1972-10-27 AT AT61774*A patent/ATA61774A/en not_active IP Right Cessation
- 1972-10-27 HU HUBO1401A patent/HU164715B/hu unknown
- 1972-10-27 AT AT61874*7A patent/AT327883B/en not_active IP Right Cessation
- 1972-10-27 NL NL7214621A patent/NL7214621A/xx unknown
- 1972-10-27 AT AT61874*A patent/ATA61874A/en not_active IP Right Cessation
- 1972-10-28 PL PL1972158524A patent/PL82632B1/pl unknown
- 1972-10-30 JP JP47108772A patent/JPS4852769A/ja active Pending
-
1973
- 1973-07-30 AR AR249345A patent/AR197054A1/en active
- 1973-07-30 AR AR249346A patent/AR197055A1/en active
-
1974
- 1974-04-19 SU SU2018983A patent/SU509235A3/en active
- 1974-04-19 SU SU2018982A patent/SU511006A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SU511006A3 (en) | 1976-04-15 |
| HU164715B (en) | 1974-04-11 |
| FR2158313B2 (en) | 1976-04-23 |
| IL40639A0 (en) | 1972-12-29 |
| AT320628B (en) | 1975-02-25 |
| FR2158313A2 (en) | 1973-06-15 |
| AR197008A1 (en) | 1974-03-08 |
| AU467712B2 (en) | 1975-12-11 |
| AU4827772A (en) | 1974-05-16 |
| ZA727504B (en) | 1973-08-29 |
| AR197054A1 (en) | 1974-03-08 |
| AR197055A1 (en) | 1974-03-08 |
| AT327883B (en) | 1976-02-25 |
| SU509235A3 (en) | 1976-03-30 |
| ATA61874A (en) | 1975-05-15 |
| GB1348088A (en) | 1974-03-13 |
| PL82632B1 (en) | 1975-10-31 |
| JPS4852769A (en) | 1973-07-24 |
| DD102387A5 (en) | 1973-12-12 |
| ATA61774A (en) | 1975-05-15 |
| AT327882B (en) | 1976-02-25 |
| DE2153902A1 (en) | 1973-05-03 |
| NL7214621A (en) | 1973-05-02 |
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