ES417471A1 - Acylated n6-aralkyl-adenosine derivatives - Google Patents
Acylated n6-aralkyl-adenosine derivativesInfo
- Publication number
- ES417471A1 ES417471A1 ES417471A ES417471A ES417471A1 ES 417471 A1 ES417471 A1 ES 417471A1 ES 417471 A ES417471 A ES 417471A ES 417471 A ES417471 A ES 417471A ES 417471 A1 ES417471 A1 ES 417471A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- adenosine derivatives
- formula
- meanings
- alcoholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of acylated N (6) -aralkoxy-adenosine derivatives of the general formula I **(See formula)** wherein R1 and R2 signify hydrogen, halogen, an alcoholic group, alkoxy or alcoholmercapto, R3 means halogen, an alcoholic group, alkoxy to alcoholmercapto and R4 means an alcoholic or aryl group or a heterocyclic radical, as well as their pharmacologically compatible salts, characterized because in a manner known per se a) N (6) substituted adenosine derivatives of general formula II are reacted **(See formula)** in which R1, R2, and R3 have the meanings mentioned above, with an acid of the general formula III r4-coOh (III), in which R4 has the aforementioned meanings, or with a reactive derivative thereof; or b) compounds of the general formula IV are reacted **(See formula)** in which R4 has the meanings mentioned above and X means a reactive radical, with an amine of the general formula V **(See formula)** in which R1, R2 and R3 have the indicated meanings, and the compounds obtained are eventually transformed into their pharmacologically compatible salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2238923A DE2238923A1 (en) | 1972-08-08 | 1972-08-08 | ACYLATED N (6) ARALKYL ADENOSINE DERIVATIVES AND METHOD FOR PREPARING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES417471A1 true ES417471A1 (en) | 1976-03-01 |
Family
ID=5852971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417471A Expired ES417471A1 (en) | 1972-08-08 | 1973-08-01 | Acylated n6-aralkyl-adenosine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS4945095A (en) |
| AT (1) | AT325784B (en) |
| AU (1) | AU470398B2 (en) |
| CA (1) | CA1003411A (en) |
| CH (1) | CH579587A5 (en) |
| DE (1) | DE2238923A1 (en) |
| ES (1) | ES417471A1 (en) |
| FR (1) | FR2195434B1 (en) |
| GB (1) | GB1384518A (en) |
| NL (1) | NL7310870A (en) |
| SE (1) | SE400086B (en) |
| ZA (1) | ZA735331B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5519950A (en) * | 1978-07-29 | 1980-02-13 | Katsukio Akiyama | Power generator using cooling gas |
| US4214170A (en) * | 1978-10-12 | 1980-07-22 | Carrier Corporation | Power generation-refrigeration system |
| AU582359B2 (en) * | 1984-04-18 | 1989-03-23 | Nelson Research & Development Company | N-6 substituted adenosine derivatives as cardiac vasodilators |
| WO1988003147A1 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
| US5066655A (en) * | 1987-04-24 | 1991-11-19 | Whitby Research, Inc. | N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists |
| US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
-
1972
- 1972-08-08 DE DE2238923A patent/DE2238923A1/en active Pending
-
1973
- 1973-07-31 CA CA177,826A patent/CA1003411A/en not_active Expired
- 1973-08-01 ES ES417471A patent/ES417471A1/en not_active Expired
- 1973-08-01 GB GB3648973A patent/GB1384518A/en not_active Expired
- 1973-08-02 AU AU58857/73A patent/AU470398B2/en not_active Expired
- 1973-08-03 CH CH1130773A patent/CH579587A5/xx not_active IP Right Cessation
- 1973-08-06 FR FR7328648A patent/FR2195434B1/fr not_active Expired
- 1973-08-06 ZA ZA735331A patent/ZA735331B/en unknown
- 1973-08-07 SE SE7310808A patent/SE400086B/en unknown
- 1973-08-07 NL NL7310870A patent/NL7310870A/xx not_active Application Discontinuation
- 1973-08-07 AT AT691873A patent/AT325784B/en active
- 1973-08-08 JP JP48089161A patent/JPS4945095A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1003411A (en) | 1977-01-11 |
| GB1384518A (en) | 1975-02-19 |
| DE2238923A1 (en) | 1974-02-14 |
| ZA735331B (en) | 1974-08-28 |
| SE400086B (en) | 1978-03-13 |
| AU5885773A (en) | 1975-02-06 |
| FR2195434B1 (en) | 1977-02-25 |
| CH579587A5 (en) | 1976-09-15 |
| JPS4945095A (en) | 1974-04-27 |
| AU470398B2 (en) | 1976-03-11 |
| ATA691873A (en) | 1975-01-15 |
| AT325784B (en) | 1975-11-10 |
| NL7310870A (en) | 1974-02-12 |
| FR2195434A1 (en) | 1974-03-08 |
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