ES2012927A6 - Procedimiento para preparar derivados de adenosina. - Google Patents
Procedimiento para preparar derivados de adenosina.Info
- Publication number
- ES2012927A6 ES2012927A6 ES8803906A ES8803906A ES2012927A6 ES 2012927 A6 ES2012927 A6 ES 2012927A6 ES 8803906 A ES8803906 A ES 8803906A ES 8803906 A ES8803906 A ES 8803906A ES 2012927 A6 ES2012927 A6 ES 2012927A6
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- derivatives
- adenosine derivatives
- protected derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003835 adenosine derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101100037762 Caenorhabditis elegans rnh-2 gene Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ADENOSINA DE FORMULA FORMULA DONDE R REPRESENTA CICLOPENTILO SUSTITUIDO CON HIDROXI Y, OPCIONALMENTE, CON ALQUILO C1-C6. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA: FORMULA DONDE L ES UN GRUPO LABIL, O UN DERIVADO PROTEGIDO DEL MISMO, CON UN COMPUESTO DE FORMULA RNH2, DONDE R ES COMO ANTES, O UNA SAL O DERIVADO PROTEGIDO DEL MISMO, EN CONDICIONES BASICAS, SEGUIDO EVENTUALMENTE POR ELIMINACION DE GRUPOS PROTECTORES. HAY OTRAS FORMAS DE OBTENER TALES DERIVADOS QUE SE DESCRIBEN EN LA MEMORIA. EL INVENTO ES UTIL EN MEDICAMENTOS CON ACCION ANTILIPOLITICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878729994A GB8729994D0 (en) | 1987-12-23 | 1987-12-23 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2012927A6 true ES2012927A6 (es) | 1990-04-16 |
Family
ID=10628947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8803906A Expired - Fee Related ES2012927A6 (es) | 1987-12-23 | 1988-12-22 | Procedimiento para preparar derivados de adenosina. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US5032583A (es) |
| EP (1) | EP0322242B1 (es) |
| JP (1) | JP2736088B2 (es) |
| KR (1) | KR890009967A (es) |
| CN (1) | CN1024198C (es) |
| AT (1) | ATA315488A (es) |
| AU (2) | AU612747B2 (es) |
| BE (1) | BE1002167A5 (es) |
| CA (1) | CA1320195C (es) |
| CH (1) | CH677495A5 (es) |
| CZ (1) | CZ403991A3 (es) |
| DE (2) | DE3856154T2 (es) |
| DK (1) | DK170894B1 (es) |
| ES (1) | ES2012927A6 (es) |
| FI (1) | FI90429C (es) |
| FR (1) | FR2629715B1 (es) |
| GB (2) | GB8729994D0 (es) |
| GR (1) | GR1000307B (es) |
| HK (1) | HK1009650A1 (es) |
| HU (1) | HU203364B (es) |
| IE (1) | IE61302B1 (es) |
| IL (1) | IL88765A (es) |
| IT (1) | IT1224840B (es) |
| LU (1) | LU87414A1 (es) |
| MX (1) | MX14331A (es) |
| NL (1) | NL8803140A (es) |
| NO (1) | NO171506C (es) |
| NZ (1) | NZ227485A (es) |
| PH (1) | PH25932A (es) |
| PL (1) | PL158800B1 (es) |
| PT (1) | PT89328B (es) |
| RU (2) | RU1826971C (es) |
| SE (1) | SE8804609L (es) |
| SG (1) | SG44701A1 (es) |
| YU (1) | YU234188A (es) |
| ZA (1) | ZA889593B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
| FR2665362B1 (fr) * | 1990-08-03 | 1994-12-09 | Cepbepe | Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application. |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| DE69123974T2 (de) * | 1990-09-25 | 1997-05-07 | Rhone-Poulenc Rorer International (Holdings) Inc., Greenville, Del. | Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen |
| GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
| DK62692D0 (es) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
| US5672588A (en) * | 1992-05-20 | 1997-09-30 | Novo Nordisk A/S | Purine derivatives |
| US5443836A (en) * | 1993-03-15 | 1995-08-22 | Gensia, Inc. | Methods for protecting tissues and organs from ischemic damage |
| HUT75338A (en) * | 1994-05-10 | 1997-05-28 | Sandoz Ag | Adenosine derivatives, their preparation and use, and pharmaceutical preparations containing them |
| GB9421133D0 (en) * | 1994-10-20 | 1994-12-07 | Glaxo Group Ltd | Medicaments |
| WO1997033591A1 (en) * | 1996-03-13 | 1997-09-18 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
| WO1997033590A1 (en) * | 1996-03-13 | 1997-09-18 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
| US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| TR200003513T2 (tr) | 1998-06-02 | 2001-06-21 | Osi Pharmaceuticals, Inc. | Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları |
| US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6784165B1 (en) | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
| GB9930083D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
| GB9930077D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| GB0106867D0 (en) * | 2001-03-20 | 2001-05-09 | Glaxo Group Ltd | Process |
| EP1258247A1 (en) * | 2001-05-14 | 2002-11-20 | Aventis Pharma Deutschland GmbH | Adenosine analogues for the treatment of insulin resistance syndrome and diabetes |
| ATE446298T1 (de) | 2001-11-30 | 2009-11-15 | Osi Pharm Inc | Verbindungen, die für adenosin a1 und a3 rezeptoren spezifisch sind, und deren anwendungen |
| US20030229067A1 (en) | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
| EA007468B1 (ru) | 2001-12-20 | 2006-10-27 | Оси Фармасьютикалз, Инк. | Пиримидиновые соединения, относящиеся к a-селективным антагонистам, их синтез и применение |
| CA2523746A1 (en) * | 2003-04-24 | 2004-11-25 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
| TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
| WO2005025545A2 (en) * | 2003-09-17 | 2005-03-24 | Aderis Pharmaceuticals, Inc. | Pharmaceutical formulation for controlled release of selodenoson |
| US7732424B2 (en) * | 2005-11-30 | 2010-06-08 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
| CN101712709A (zh) * | 2008-10-06 | 2010-05-26 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷及其调血脂的用途 |
| PL2473492T3 (pl) * | 2009-08-31 | 2016-03-31 | Lonza Ag | Sposób wytwarzania (1S,4R)-2-oksa-3-azabicyklo[2.2.1]-hept-5-enów |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130136C (es) * | 1966-10-20 | |||
| NL6717061A (es) * | 1966-12-21 | 1968-06-24 | ||
| DE2052596A1 (de) * | 1970-10-27 | 1972-05-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten |
| NL7203984A (es) * | 1971-04-10 | 1972-10-12 | ||
| BE788958A (fr) * | 1971-09-18 | 1973-03-19 | Schering Ag | Derives d'adenosine et leur procede de preparation |
| DE2148838A1 (de) * | 1971-09-30 | 1973-04-05 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
| DE2157036A1 (de) * | 1971-11-17 | 1973-05-24 | Boehringer Mannheim Gmbh | Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung |
| DE2244328A1 (de) * | 1972-09-09 | 1974-03-21 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
| DE2338705A1 (de) * | 1973-07-31 | 1975-02-13 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
| DE2338963A1 (de) * | 1973-08-01 | 1975-02-13 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
| DE2426682A1 (de) * | 1974-06-01 | 1975-12-11 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
| AU579412B2 (en) * | 1984-10-26 | 1988-11-24 | Warner-Lambert Company | N` - substituted adenosines |
| ZA857998B (en) * | 1984-10-26 | 1986-05-28 | Warner Lambert Co | N6-substituted adenosines |
-
1987
- 1987-12-23 GB GB878729994A patent/GB8729994D0/en active Pending
-
1988
- 1988-12-21 SE SE8804609A patent/SE8804609L/xx not_active Application Discontinuation
- 1988-12-21 DK DK713488A patent/DK170894B1/da not_active IP Right Cessation
- 1988-12-22 DE DE3856154T patent/DE3856154T2/de not_active Expired - Lifetime
- 1988-12-22 NZ NZ227485A patent/NZ227485A/en unknown
- 1988-12-22 FI FI885943A patent/FI90429C/fi not_active IP Right Cessation
- 1988-12-22 GR GR880100856A patent/GR1000307B/el unknown
- 1988-12-22 ZA ZA889593A patent/ZA889593B/xx unknown
- 1988-12-22 NO NO885719A patent/NO171506C/no unknown
- 1988-12-22 IL IL88765A patent/IL88765A/xx not_active IP Right Cessation
- 1988-12-22 HU HU886569A patent/HU203364B/hu not_active IP Right Cessation
- 1988-12-22 RU SU884613189A patent/RU1826971C/ru active
- 1988-12-22 IE IE384588A patent/IE61302B1/en not_active IP Right Cessation
- 1988-12-22 PT PT89328A patent/PT89328B/pt not_active IP Right Cessation
- 1988-12-22 EP EP88312231A patent/EP0322242B1/en not_active Expired - Lifetime
- 1988-12-22 GB GB8829983A patent/GB2212498B/en not_active Expired - Lifetime
- 1988-12-22 SG SG1996005914A patent/SG44701A1/en unknown
- 1988-12-22 ES ES8803906A patent/ES2012927A6/es not_active Expired - Fee Related
- 1988-12-22 BE BE8801427A patent/BE1002167A5/fr not_active IP Right Cessation
- 1988-12-22 CA CA000586787A patent/CA1320195C/en not_active Expired - Lifetime
- 1988-12-22 NL NL8803140A patent/NL8803140A/nl not_active Application Discontinuation
- 1988-12-23 IT IT8848714A patent/IT1224840B/it active
- 1988-12-23 KR KR1019880017330A patent/KR890009967A/ko not_active Withdrawn
- 1988-12-23 AT AT0315488A patent/ATA315488A/de not_active Application Discontinuation
- 1988-12-23 PH PH37978A patent/PH25932A/en unknown
- 1988-12-23 FR FR888817132A patent/FR2629715B1/fr not_active Expired - Lifetime
- 1988-12-23 PL PL1988276697A patent/PL158800B1/pl unknown
- 1988-12-23 CH CH4777/88A patent/CH677495A5/de not_active IP Right Cessation
- 1988-12-23 JP JP63323836A patent/JP2736088B2/ja not_active Expired - Lifetime
- 1988-12-23 DE DE3843609A patent/DE3843609A1/de not_active Withdrawn
- 1988-12-23 LU LU87414A patent/LU87414A1/fr unknown
- 1988-12-23 CN CN88108757A patent/CN1024198C/zh not_active Expired - Fee Related
- 1988-12-23 AU AU27401/88A patent/AU612747B2/en not_active Expired
- 1988-12-23 MX MX1433188A patent/MX14331A/es unknown
- 1988-12-23 YU YU02341/88A patent/YU234188A/xx unknown
-
1989
- 1989-11-03 US US07/431,089 patent/US5032583A/en not_active Expired - Lifetime
-
1991
- 1991-10-16 AU AU85894/91A patent/AU8589491A/en not_active Abandoned
- 1991-12-23 CZ CS914039A patent/CZ403991A3/cs unknown
-
1992
- 1992-02-24 RU SU925010893A patent/RU2060996C1/ru active
-
1998
- 1998-09-01 HK HK98110345A patent/HK1009650A1/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-12-22 |
|
| FD1A | Patent lapsed |
Effective date: 20081223 |