EE9600117A - Antifungaalsed sordariini derivaadid - Google Patents

Antifungaalsed sordariini derivaadid

Info

Publication number: EE9600117A
Authority: EE; Estonia
Prior art keywords: herrine; antifungal; derivatives; herrine derivatives; antifungal herrine
Prior art date: 1994-11-08

Application number

EE9600117A

Other languages

English (en)

Estonian (et)

Inventor

Maria Bueno Calderon Jose

Castro Pichel Julia

Carlos Cueva Zurita Juan

Luis Lavandera Diaz Jose

Ramon Ruiz Gomez Jose

Garcia-Ochoa Dorado Silvestre

Teresa Fraile Gabaldon Maria

Fiandor Roman Jose

Garsallo Viola Domingo

Huss Sophie

Original Assignee

Glaxo Wellcome S.A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-08

Filing date

1995-11-06

Publication date

1997-04-15

1994-11-08 Priority claimed from EP94500175A external-priority patent/EP0711784A1/en

1994-11-08 Priority claimed from EP94500173A external-priority patent/EP0712859A1/en

1995-11-06 Application filed by Glaxo Wellcome S.A filed Critical Glaxo Wellcome S.A

1997-04-15 Publication of EE9600117A publication Critical patent/EE9600117A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

EE9600117A 1994-11-08 1995-11-06 Antifungaalsed sordariini derivaadid EE9600117A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94500175A EP0711784A1 (en)	1994-11-08	1994-11-08	Antifungal Sordarin derivatives
EP94500173A EP0712859A1 (en)	1994-11-08	1994-11-08	Antifungal Sordarin derivatives
PCT/EP1995/004331 WO1996014326A1 (en)	1994-11-08	1995-11-06	Antifungal sordaridin derivatives

Publications (1)

Publication Number	Publication Date
EE9600117A true EE9600117A (et)	1997-04-15

Family

ID=26137608

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600117A EE9600117A (et)	1994-11-08	1995-11-06	Antifungaalsed sordariini derivaadid

Country Status (34)

Country	Link
US (2)	US5854280A (es)
EP (1)	EP0753001B1 (es)
JP (1)	JPH09508144A (es)
KR (1)	KR100391401B1 (es)
CN (1)	CN1056849C (es)
AP (1)	AP614A (es)
AR (1)	AR013815A1 (es)
AT (1)	ATE184284T1 (es)
AU (1)	AU704405B2 (es)
BG (1)	BG62620B1 (es)
BR (1)	BR9506473A (es)
CA (1)	CA2179403A1 (es)
CO (1)	CO4520226A1 (es)
CZ (1)	CZ202796A3 (es)
DE (1)	DE69512041T2 (es)
DK (1)	DK0753001T3 (es)
EE (1)	EE9600117A (es)
ES (1)	ES2137549T3 (es)
FI (1)	FI962773L (es)
GR (1)	GR3031677T3 (es)
HU (1)	HU218611B (es)
IL (1)	IL115905A0 (es)
IS (1)	IS4352A (es)
MX (1)	MX9602563A (es)
NO (1)	NO307092B1 (es)
NZ (1)	NZ296091A (es)
OA (1)	OA10303A (es)
PE (1)	PE49696A1 (es)
RU (1)	RU2152398C1 (es)
SI (1)	SI0753001T1 (es)
SK (1)	SK88496A3 (es)
TW (1)	TW321644B (es)
WO (1)	WO1996014326A1 (es)
ZA (1)	ZA959362B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0901493A1 (en) *	1996-05-08	1999-03-17	Glaxo Wellcome S.A.	Process for the preparation of an indacene compound
US6436395B1 (en) *	1996-09-18	2002-08-20	Merck & Co., Inc.	Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) *	1996-10-07	2000-03-21	Merck & Co., Inc.	Sordarin derivatives
US6096511A (en) *	1997-06-10	2000-08-01	Merck & Co., Inc.	Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5965612A (en) *	1997-08-22	1999-10-12	Merck & Co., Inc.	4-cyano-4-deformylsordaricin derivatives
EP1007031B1 (en) *	1997-08-22	2003-06-04	Merck & Co., Inc.	4-cyano-4-deformylsordarin derivatives
US5972996A (en) *	1997-08-22	1999-10-26	Merck & Co., Inc.	4-cyano-4-deformylsordarin derivatives
US6136853A (en) *	1997-10-03	2000-10-24	Merck & Co., Inc.	Sordarin derivatives
FI974385A0 (fi) *	1997-12-01	1997-12-01	Xyrofin Oy	Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) *	1998-04-14	2006-07-04	Zhenhua Yang	Small molecule anticancer compounds and related production process
MA26628A1 (fr) *	1998-05-11	2004-12-20	Glaxo Wellcome Sa	Morpholino ethers
EP1124813B1 (en)	1998-10-26	2003-12-03	Merck & Co., Inc.	Microbial transformation product
AU5871000A (en)	1999-06-11	2001-01-02	Paul G. Abrams	High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en)	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
AU1520601A (en) *	1999-11-11	2001-06-06	Glaxo Wellcome S.A.	Antifungal sordaricin derivatives
WO2002022567A1 (en) *	2000-09-15	2002-03-21	Bristol-Myers Squibb Company	Novel thio derivatives of sordarin as antifungal agents
JP2004536034A (ja)	2001-01-08	2004-12-02	ネオルクスコーポレイション	治療的および診断的化合物、組成物および方法
WO2003007878A2 (en)	2001-07-18	2003-01-30	Merck & Co., Inc.	Antifungal agents of sordarin derivatives
RU2223093C2 (ru) *	2001-11-19	2004-02-10	Открытое акционерное общество "Биосинтез"	Фармацевтическая композиция для лечения грибковых заболеваний
EP1458416A1 (en)	2001-12-13	2004-09-22	Dow Global Technologies Inc.	Treatment of osteomyelitis with radiopharmaceuticals
DE60218341D1 (de) *	2001-12-14	2007-04-05	Merck & Co Inc	Neues, aus kulturfermentierungen isoliertes sordarinderivat und wirkungen als antipilzmittel
RU2201230C1 (ru) *	2001-12-24	2003-03-27	Закрытое акционерное общество "Брынцалов-А"	Лекарственное средство флузол, обладающее противогрибковым действием
RU2207842C1 (ru) *	2002-02-18	2003-07-10	Акционерное Курганское общество медицинских препаратов и изделий "Синтез"	Противогрибковое средство в виде мази и способ его получения
TW200503781A (en) *	2002-12-31	2005-02-01	Nektar Therapeutics	Aerosolizable pharmaceutical formulation for fungal infection therapy
US9314524B2 (en)	2007-12-31	2016-04-19	Calla Therapeutics Llc	Topical formulations of Flucytosine
US8419948B2 (en) *	2009-11-22	2013-04-16	United Laboratories International, Llc	Wastewater treatment
WO2012033427A1 (ru) *	2010-09-08	2012-03-15	Dalin Mikhail Viktorovich	Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) *	2016-02-25	2017-09-07	Жанна Владимировна Вараткова	Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH465771A (de) *	1965-12-06	1968-11-30	Sandoz Ag	Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) *	1985-08-14	1994-03-02	三共株式会社	抗生物質ゾフイマリン
JP3189443B2 (ja) *	1992-11-20	2001-07-16	萬有製薬株式会社	抗真菌性物質ｂｅ−３１４０５
CA2265824C (en) *	1996-09-12	2004-11-09	Merck & Co., Inc.	Antifungal combination therapy

1995
- 1995-11-06 PE PE1995283875A patent/PE49696A1/es not_active Application Discontinuation
- 1995-11-06 CA CA002179403A patent/CA2179403A1/en not_active Abandoned
- 1995-11-06 SI SI9530311T patent/SI0753001T1/xx not_active IP Right Cessation
- 1995-11-06 CN CN95192028A patent/CN1056849C/zh not_active Expired - Fee Related
- 1995-11-06 EE EE9600117A patent/EE9600117A/xx unknown
- 1995-11-06 DK DK95938406T patent/DK0753001T3/da active
- 1995-11-06 RU RU96115273/04A patent/RU2152398C1/ru active
- 1995-11-06 AP APAP/P/1996/000824A patent/AP614A/en active
- 1995-11-06 KR KR1019960703661A patent/KR100391401B1/ko not_active Expired - Fee Related
- 1995-11-06 CZ CZ962027A patent/CZ202796A3/cs unknown
- 1995-11-06 EP EP95938406A patent/EP0753001B1/en not_active Expired - Lifetime
- 1995-11-06 AT AT95938406T patent/ATE184284T1/de not_active IP Right Cessation
- 1995-11-06 JP JP8515051A patent/JPH09508144A/ja not_active Ceased
- 1995-11-06 ES ES95938406T patent/ES2137549T3/es not_active Expired - Lifetime
- 1995-11-06 HU HU9701865A patent/HU218611B/hu not_active IP Right Cessation
- 1995-11-06 MX MX9602563A patent/MX9602563A/es not_active IP Right Cessation
- 1995-11-06 WO PCT/EP1995/004331 patent/WO1996014326A1/en not_active Ceased
- 1995-11-06 NZ NZ296091A patent/NZ296091A/en unknown
- 1995-11-06 US US08/669,441 patent/US5854280A/en not_active Expired - Fee Related
- 1995-11-06 DE DE69512041T patent/DE69512041T2/de not_active Expired - Fee Related
- 1995-11-06 ZA ZA959362A patent/ZA959362B/xx unknown
- 1995-11-06 SK SK884-96A patent/SK88496A3/sk unknown
- 1995-11-06 AU AU39809/95A patent/AU704405B2/en not_active Ceased
- 1995-11-06 FI FI962773A patent/FI962773L/fi not_active IP Right Cessation
- 1995-11-06 BR BR9506473A patent/BR9506473A/pt not_active IP Right Cessation
- 1995-11-07 AR ARP950100073A patent/AR013815A1/es unknown
- 1995-11-07 CO CO95052481A patent/CO4520226A1/es unknown
- 1995-11-07 IL IL11590595A patent/IL115905A0/xx unknown
- 1995-11-18 TW TW084112259A patent/TW321644B/zh active
1996
- 1996-06-10 IS IS4352A patent/IS4352A/is unknown
- 1996-07-03 OA OA60855A patent/OA10303A/en unknown
- 1996-07-05 BG BG100699A patent/BG62620B1/xx unknown
- 1996-07-05 NO NO962856A patent/NO307092B1/no not_active IP Right Cessation
1998
- 1998-05-19 US US09/081,090 patent/US5952334A/en not_active Expired - Fee Related
1999
- 1999-10-27 GR GR990402767T patent/GR3031677T3/el unknown

Also Published As

Publication number	Publication date
DK0753001T3 (da)	2000-05-08
AP9600824A0 (en)	1996-07-31
KR100391401B1 (ko)	2003-12-31
ZA959362B (en)	1996-05-08
NO307092B1 (no)	2000-02-07
CN1056849C (zh)	2000-09-27
HK1004222A1 (en)	1998-11-20
NO962856D0 (no)	1996-07-05
FI962773A0 (fi)	1996-07-05
PE49696A1 (es)	1996-12-05
WO1996014326A1 (en)	1996-05-17
IL115905A0 (en)	1996-01-31
BG100699A (bg)	1997-02-28
SI0753001T1 (en)	1999-12-31
IS4352A (is)	1996-06-10
CO4520226A1 (es)	1997-10-15
CN1143965A (zh)	1997-02-26
US5854280A (en)	1998-12-29
CZ202796A3 (en)	1997-02-12
AU3980995A (en)	1996-05-31
FI962773A7 (fi)	1996-08-26
OA10303A (en)	1997-10-07
DE69512041D1 (de)	1999-10-14
JPH09508144A (ja)	1997-08-19
BR9506473A (pt)	1997-10-07
AU704405B2 (en)	1999-04-22
RU2152398C1 (ru)	2000-07-10
NO962856L (no)	1996-09-05
NZ296091A (en)	1998-06-26
ES2137549T3 (es)	1999-12-16
HU218611B (hu)	2000-10-28
BG62620B1 (bg)	2000-03-31
GR3031677T3 (en)	2000-02-29
HUT76292A (en)	1997-07-28
US5952334A (en)	1999-09-14
SK88496A3 (en)	1997-04-09
ATE184284T1 (de)	1999-09-15
EP0753001A1 (en)	1997-01-15
CA2179403A1 (en)	1996-05-17
AP614A (en)	1997-09-05
HU9601865D0 (en)	1996-11-28
FI962773L (fi)	1996-08-26
AR013815A1 (es)	2001-01-31
MX9602563A (es)	1997-05-31
DE69512041T2 (de)	2000-02-03
EP0753001B1 (en)	1999-09-08
TW321644B (es)	1997-12-01

Publication	Publication Date	Title
DE69512041D1 (de)	1999-10-14	Antifungale sordaridin-derivate
NO304430B1 (no)	1998-12-14	Antifungale midler
FI954829L (fi)	1996-04-15	Aroyylipiperidiinijohdannaiset
NO952854D0 (no)	1995-07-18	1-arylpyrimidin-derivater
DE59508427D1 (de)	2000-07-06	3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
EP0708091A3 (en)	1996-07-17	Indoloyl-guanidines derivatives
FI971510A7 (fi)	1997-04-11	Atsolijohdannainen
DE69430587D1 (de)	2002-06-13	Pyrimidin-acyclonukleosid-derivate
BR9509793A (pt)	1997-09-30	Derivados de tiofeneno
FI971227L (fi)	1997-05-23	Pyramidinyylipyratsolijohdannaisia
FI960367L (fi)	1996-01-26	Uusia dialkoksipyridinyylibentsimidatsolijohdannaisia
DE69527786D1 (de)	2002-09-19	Diaminomethyliden-derivate
FI964853A7 (fi)	1997-02-07	Deasetoksitaksolijohdannaiset
NO970144D0 (no)	1997-01-14	Trifluormetylkinolinkarboksylsyre-derivat
KR950033309U (ko)	1995-12-16	줄연장
DE69510792D1 (de)	1999-08-19	Naphtochinonderivate
DE59509209D1 (de)	2001-05-23	Diphenyloxazolin-derivate
FI955026L (fi)	1996-04-23	Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
BR9509877A (pt)	1997-09-30	Novos derivados de pirimidinilóxi-e piridimidinilamino- etilfenil-dioxolano
FI963122A7 (fi)	1996-08-09	Karbamoyylimetyyliureajohdannaiset
BR9506613A (pt)	1997-09-16	Derivados de feniltio-oxazolinas
DK0755927T3 (da)	2001-10-29	Dimethylfurancarboxyanilidderivat
BR9508450A (pt)	1997-11-25	Derivados de n-alcóxi-amidina
FI952000A7 (fi)	1995-10-27	Tiadiatsinonijohdannaisia
SE9400156L (sv)	1995-07-22	Ställning