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NO307092B1 - Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding - Google Patents

Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding

Info

Publication number
NO307092B1
NO307092B1 NO962856A NO962856A NO307092B1 NO 307092 B1 NO307092 B1 NO 307092B1 NO 962856 A NO962856 A NO 962856A NO 962856 A NO962856 A NO 962856A NO 307092 B1 NO307092 B1 NO 307092B1
Authority
NO
Norway
Prior art keywords
sordaridine
derivatives
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
NO962856A
Other languages
English (en)
Norwegian (no)
Other versions
NO962856D0 (no
NO962856L (no
Inventor
Jose Ramon Ruiz Gomez
Jose Maria Bueno Calderon
Silvestre Garcia-Ochoa Dorado
Maria Teresa Fraile Gabaldon
Julia Castro Pichel
Jose Fiandor Roman
Domingo Gargallo Viola
Juan Carlos Cuevas Zurita
Jose Luis Lavandera Diaz
Sophie Huss
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/en
Priority claimed from EP94500173A external-priority patent/EP0712859A1/en
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Publication of NO962856D0 publication Critical patent/NO962856D0/no
Publication of NO962856L publication Critical patent/NO962856L/no
Publication of NO307092B1 publication Critical patent/NO307092B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO962856A 1994-11-08 1996-07-05 Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding NO307092B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
EP94500173A EP0712859A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
PCT/EP1995/004331 WO1996014326A1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Publications (3)

Publication Number Publication Date
NO962856D0 NO962856D0 (no) 1996-07-05
NO962856L NO962856L (no) 1996-09-05
NO307092B1 true NO307092B1 (no) 2000-02-07

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962856A NO307092B1 (no) 1994-11-08 1996-07-05 Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding

Country Status (34)

Country Link
US (2) US5854280A (es)
EP (1) EP0753001B1 (es)
JP (1) JPH09508144A (es)
KR (1) KR100391401B1 (es)
CN (1) CN1056849C (es)
AP (1) AP614A (es)
AR (1) AR013815A1 (es)
AT (1) ATE184284T1 (es)
AU (1) AU704405B2 (es)
BG (1) BG62620B1 (es)
BR (1) BR9506473A (es)
CA (1) CA2179403A1 (es)
CO (1) CO4520226A1 (es)
CZ (1) CZ202796A3 (es)
DE (1) DE69512041T2 (es)
DK (1) DK0753001T3 (es)
EE (1) EE9600117A (es)
ES (1) ES2137549T3 (es)
FI (1) FI962773L (es)
GR (1) GR3031677T3 (es)
HU (1) HU218611B (es)
IL (1) IL115905A0 (es)
IS (1) IS4352A (es)
MX (1) MX9602563A (es)
NO (1) NO307092B1 (es)
NZ (1) NZ296091A (es)
OA (1) OA10303A (es)
PE (1) PE49696A1 (es)
RU (1) RU2152398C1 (es)
SI (1) SI0753001T1 (es)
SK (1) SK88496A3 (es)
TW (1) TW321644B (es)
WO (1) WO1996014326A1 (es)
ZA (1) ZA959362B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901493A1 (en) * 1996-05-08 1999-03-17 Glaxo Wellcome S.A. Process for the preparation of an indacene compound
US6436395B1 (en) * 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
EP1007031B1 (en) * 1997-08-22 2003-06-04 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) * 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
EP1124813B1 (en) 1998-10-26 2003-12-03 Merck & Co., Inc. Microbial transformation product
AU5871000A (en) 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
AU1520601A (en) * 1999-11-11 2001-06-06 Glaxo Wellcome S.A. Antifungal sordaricin derivatives
WO2002022567A1 (en) * 2000-09-15 2002-03-21 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
RU2223093C2 (ru) * 2001-11-19 2004-02-10 Открытое акционерное общество "Биосинтез" Фармацевтическая композиция для лечения грибковых заболеваний
EP1458416A1 (en) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
DE60218341D1 (de) * 2001-12-14 2007-04-05 Merck & Co Inc Neues, aus kulturfermentierungen isoliertes sordarinderivat und wirkungen als antipilzmittel
RU2201230C1 (ru) * 2001-12-24 2003-03-27 Закрытое акционерное общество "Брынцалов-А" Лекарственное средство флузол, обладающее противогрибковым действием
RU2207842C1 (ru) * 2002-02-18 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Противогрибковое средство в виде мази и способ его получения
TW200503781A (en) * 2002-12-31 2005-02-01 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
CA2265824C (en) * 1996-09-12 2004-11-09 Merck & Co., Inc. Antifungal combination therapy

Also Published As

Publication number Publication date
DK0753001T3 (da) 2000-05-08
AP9600824A0 (en) 1996-07-31
KR100391401B1 (ko) 2003-12-31
ZA959362B (en) 1996-05-08
CN1056849C (zh) 2000-09-27
HK1004222A1 (en) 1998-11-20
NO962856D0 (no) 1996-07-05
FI962773A0 (fi) 1996-07-05
PE49696A1 (es) 1996-12-05
WO1996014326A1 (en) 1996-05-17
IL115905A0 (en) 1996-01-31
BG100699A (bg) 1997-02-28
SI0753001T1 (en) 1999-12-31
IS4352A (is) 1996-06-10
CO4520226A1 (es) 1997-10-15
CN1143965A (zh) 1997-02-26
US5854280A (en) 1998-12-29
CZ202796A3 (en) 1997-02-12
AU3980995A (en) 1996-05-31
FI962773A7 (fi) 1996-08-26
OA10303A (en) 1997-10-07
DE69512041D1 (de) 1999-10-14
JPH09508144A (ja) 1997-08-19
BR9506473A (pt) 1997-10-07
AU704405B2 (en) 1999-04-22
RU2152398C1 (ru) 2000-07-10
NO962856L (no) 1996-09-05
NZ296091A (en) 1998-06-26
ES2137549T3 (es) 1999-12-16
HU218611B (hu) 2000-10-28
BG62620B1 (bg) 2000-03-31
GR3031677T3 (en) 2000-02-29
HUT76292A (en) 1997-07-28
US5952334A (en) 1999-09-14
SK88496A3 (en) 1997-04-09
ATE184284T1 (de) 1999-09-15
EP0753001A1 (en) 1997-01-15
CA2179403A1 (en) 1996-05-17
AP614A (en) 1997-09-05
HU9601865D0 (en) 1996-11-28
FI962773L (fi) 1996-08-26
EE9600117A (et) 1997-04-15
AR013815A1 (es) 2001-01-31
MX9602563A (es) 1997-05-31
DE69512041T2 (de) 2000-02-03
EP0753001B1 (en) 1999-09-08
TW321644B (es) 1997-12-01

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Legal Events

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN MAY 2002