[go: up one dir, main page]

EE200400022A - Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised - Google Patents

Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Info

Publication number
EE200400022A
EE200400022A EEP200400022A EEP200400022A EE200400022A EE 200400022 A EE200400022 A EE 200400022A EE P200400022 A EEP200400022 A EE P200400022A EE P200400022 A EEP200400022 A EE P200400022A EE 200400022 A EE200400022 A EE 200400022A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
thiadiazole derivatives
pyrrolidine oxadiazole
Prior art date
Application number
EEP200400022A
Other languages
English (en)
Estonian (et)
Inventor
Schwarz Matthias
Quattropani Anna
Page Patrick
J. Russell Thomas
Pomel Vincent
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200400022A publication Critical patent/EE200400022A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200400022A 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised EE200400022A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
EE200400022A true EE200400022A (et) 2004-04-15

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200400022A EE200400022A (et) 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Country Status (26)

Country Link
US (2) US7115639B2 (no)
EP (1) EP1444225B1 (no)
JP (1) JP4426284B2 (no)
KR (1) KR20040030678A (no)
CN (1) CN100564378C (no)
AR (1) AR036108A1 (no)
AU (1) AU2002319237B2 (no)
BG (1) BG108424A (no)
BR (1) BR0211030A (no)
CA (1) CA2449578C (no)
CZ (1) CZ20033475A3 (no)
EA (1) EA006212B1 (no)
EE (1) EE200400022A (no)
ES (1) ES2397305T3 (no)
HR (1) HRP20031017A2 (no)
HU (1) HUP0400238A2 (no)
IL (1) IL159219A0 (no)
MX (1) MXPA03011441A (no)
MY (1) MY128890A (no)
NO (1) NO20035399L (no)
PL (1) PL367275A1 (no)
RS (1) RS99503A (no)
SK (1) SK15552003A3 (no)
UA (1) UA75145C2 (no)
WO (1) WO2002102799A2 (no)
ZA (1) ZA200309402B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2397305T3 (es) 2001-06-18 2013-03-06 Merck Serono Sa Derivados de oxadiazol y tiadiazol-oxima de pirrolidina que son antagonistas del receptor oxitocina
DE602004024170D1 (de) 2003-02-27 2009-12-31 Merck Serono Sa Coinsins Pyrrolidin-derivate als oxytocin antagonisten
ES2296137T3 (es) * 2004-02-26 2008-04-16 Laboratoires Serono Sa Metodo para preparar pirrolidin-oximas.
BR122020016659B8 (pt) 2005-05-10 2021-07-27 Incyte Holdings Corp moduladores de 2,3-dioxigenase de indolamina e métodos de modulação de atividade de inibição e de imunossupressão
TWI382974B (zh) 2005-12-20 2013-01-21 英塞特公司 作為吲哚胺２，３-二氧化酶調節劑之ｎ-羥基甲脒基雜環化物
CA2663057C (en) 2006-09-19 2015-12-08 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
BR122019015876B8 (pt) 2008-07-08 2021-07-27 Incyte Holdings Corp compostos derivados de 1,2,5-oxadiazóis, composição, bem como seus usos
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
DK3066085T3 (da) 2013-11-08 2020-06-02 Incyte Holdings Corp Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EA201891873A1 (ru) 2014-07-02 2019-04-30 Обсева Са Кристаллический о-метилоксим (3z,5s)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-он, полезный в способах лечения состояний, связанных с активностью ot-r
TW202435864A (zh) 2023-02-09 2024-09-16 大陸商上海葆正醫藥科技有限公司 亞胺化合物及其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (en) 1995-01-24 1996-08-01 Peter D. Williams Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
CA2372176A1 (en) * 1999-05-05 2000-11-09 Merck & Co., Inc. Novel prolines as antimicrobial agents
EP1268419B1 (en) * 2000-03-27 2006-06-21 Applied Research Systems ARS Holding N.V. Pyrrolidine derivatives useful as bax inhibitors
AU5222201A (en) 2000-03-27 2001-10-15 Applied Research Systems Pharmaceutically active pyrrolidine derivatives as bax inhibitors
IL155333A0 (en) * 2000-10-17 2003-11-23 Applied Res Sulfanilide derivatives for use in medicine, certain such new derivatives and their preparation
IL157995A0 (en) * 2001-03-20 2004-03-28 Applied Research Systems The use of pyrrolidine ester derivatives in modulation of oxytoxin activity, some new such derivatives, their preparation and pharmaceutical compositions containing them
ES2397305T3 (es) 2001-06-18 2013-03-06 Merck Serono Sa Derivados de oxadiazol y tiadiazol-oxima de pirrolidina que son antagonistas del receptor oxitocina
IL162615A0 (en) * 2001-12-20 2005-11-20 Applied Research Systems Triazole derivatives, their preparation and pharmaceutical compositions containing them
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
UA75145C2 (en) 2006-03-15
ZA200309402B (en) 2004-12-03
JP4426284B2 (ja) 2010-03-03
CN100564378C (zh) 2009-12-02
HK1074204A1 (zh) 2005-11-04
US20060229343A1 (en) 2006-10-12
CA2449578C (en) 2011-12-13
RS99503A (sr) 2006-12-15
JP2004534804A (ja) 2004-11-18
BG108424A (en) 2005-03-31
KR20040030678A (ko) 2004-04-09
EP1444225B1 (en) 2012-10-10
MY128890A (en) 2007-02-28
WO2002102799A2 (en) 2002-12-27
IL159219A0 (en) 2004-06-01
HRP20031017A2 (en) 2004-04-30
CA2449578A1 (en) 2002-12-27
SK15552003A3 (sk) 2004-05-04
EP1444225A2 (en) 2004-08-11
WO2002102799A3 (en) 2003-04-03
BR0211030A (pt) 2004-06-22
MXPA03011441A (es) 2004-07-01
PL367275A1 (en) 2005-02-21
NO20035399L (no) 2004-02-17
CN1639155A (zh) 2005-07-13
AR036108A1 (es) 2004-08-11
EA006212B1 (ru) 2005-10-27
ES2397305T3 (es) 2013-03-06
AU2002319237B2 (en) 2008-01-03
US7115639B2 (en) 2006-10-03
HUP0400238A2 (hu) 2004-07-28
NO20035399D0 (no) 2003-12-04
CZ20033475A3 (en) 2004-05-12
EA200400049A1 (ru) 2004-08-26
US20040220238A1 (en) 2004-11-04

Similar Documents

Publication Publication Date Title
EE200000707A (et) Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE04779B1 (et) 1,3-dihüdro-2H-indool-2-ooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
NO20024175L (no) Azetidinderivater, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene
EE200300054A (et) Kinaasi inhibiitoritena toimivad bitsüklopürasoolid, nende valmistamismeetod, kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
EE200200486A (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, uued derivaadid ja nende valmistamismeetodid
EE200100484A (et) Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid,ja nende valmistamise meetodid
IL164798A0 (en) Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
HUP0402161A3 (en) Nicotin-or isonicotin benzothiazole derivatives, process for their preparation and pharmaceutical compositions containing them
NO20016038D0 (no) Benzenderivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
EE200300254A (et) Heterotsüklilised ühendid, millel on antibakteriaalne toime, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP0401747A3 (en) Piridazine derivatives of hydrazono-malonitriles, their use, process for preparation of the compounds and pharmaceutical compositions containing the compounds
EE200400022A (et) Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised
HUP0400156A3 (en) Pyrrolidine derivatives as factor xa inhibitors, their preparation and pharmaceutical compositions containing them
PL356911A1 (en) Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
EE05004B1 (et) Aminotiasooli derivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
HUP0204001A3 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives, process for their preparation and pharmaceutical compositions containing them
SI1118610T1 (en) Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0303361A3 (en) Substituted 1-aminobutan-3-ol derivatives, process for their preparation and pharmaceutical compositions containing them
EE04778B1 (et) Hargnenud ahelaga asendatud 3-amino-1-fenüül-1H-[1,2,4]triasooli aminoderivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP0303105A3 (en) Novel aminocyclohexane derivatives, process for their preparation, pharmaceutical compositions containing them and their use
EE200300553A (et) Piperidiinkarboksamiidi derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
EE200100499A (et) Uued morfoliini derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
AU2002306687A1 (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
EE04437B1 (et) (1-fenatsüül-3-fenüül-3-piperidinüületüül)piperidiini derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
SI1241169T1 (en) Isoindoloindolone derivatives, process for their preparation and pharmaceutical compositions containing them