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EE200400022A - Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised - Google Patents

Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Info

Publication number
EE200400022A
EE200400022A EEP200400022A EEP200400022A EE200400022A EE 200400022 A EE200400022 A EE 200400022A EE P200400022 A EEP200400022 A EE P200400022A EE P200400022 A EEP200400022 A EE P200400022A EE 200400022 A EE200400022 A EE 200400022A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
thiadiazole derivatives
pyrrolidine oxadiazole
Prior art date
Application number
EEP200400022A
Other languages
English (en)
Inventor
Schwarz Matthias
Quattropani Anna
Page Patrick
J. Russell Thomas
Pomel Vincent
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200400022A publication Critical patent/EE200400022A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200400022A 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised EE200400022A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
EE200400022A true EE200400022A (et) 2004-04-15

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200400022A EE200400022A (et) 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Country Status (26)

Country Link
US (2) US7115639B2 (et)
EP (1) EP1444225B1 (et)
JP (1) JP4426284B2 (et)
KR (1) KR20040030678A (et)
CN (1) CN100564378C (et)
AR (1) AR036108A1 (et)
AU (1) AU2002319237B2 (et)
BG (1) BG108424A (et)
BR (1) BR0211030A (et)
CA (1) CA2449578C (et)
CZ (1) CZ20033475A3 (et)
EA (1) EA006212B1 (et)
EE (1) EE200400022A (et)
ES (1) ES2397305T3 (et)
HR (1) HRP20031017A2 (et)
HU (1) HUP0400238A2 (et)
IL (1) IL159219A0 (et)
MX (1) MXPA03011441A (et)
MY (1) MY128890A (et)
NO (1) NO20035399L (et)
PL (1) PL367275A1 (et)
RS (1) RS99503A (et)
SK (1) SK15552003A3 (et)
UA (1) UA75145C2 (et)
WO (1) WO2002102799A2 (et)
ZA (1) ZA200309402B (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400238A2 (hu) 2001-06-18 2004-07-28 Applied Research Systems Ars Holding N.V. Pirrolidin-oxadiazol- és tiadiazolszármazékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
ATE449067T1 (de) * 2003-02-27 2009-12-15 Merck Serono Sa Pyrrolidin-derivate als oxytocin antagonisten
AU2005217153A1 (en) * 2004-02-26 2005-09-09 Merck Serono Sa Method for preparing pyrrolidine oximes
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
ES2540561T3 (es) 2005-12-20 2015-07-10 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa
US20080125470A1 (en) 2006-09-19 2008-05-29 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
HRP20141094T1 (hr) 2008-07-08 2015-01-16 Incyte Corporation 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze
EP2845850A1 (en) * 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
JP6461953B2 (ja) 2013-11-08 2019-01-30 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ インドールアミン２，３−ジオキシゲナーゼ阻害剤の合成のためのプロセス
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
CA2953722C (en) 2014-07-02 2022-09-13 ObsEva SA Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same
TW202435864A (zh) 2023-02-09 2024-09-16 大陸商上海葆正醫藥科技有限公司 亞胺化合物及其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
WO1996022775A1 (en) 1995-01-24 1996-08-01 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE319446T1 (de) * 1999-05-05 2006-03-15 Merck & Co Inc Neue prolinverbindungen als mikrobizide mittel
HRP20020705A2 (en) * 2000-03-27 2004-12-31 Applied Research Systems Pharmaceutically active pyrrolidine derivatives
IL151911A0 (en) 2000-03-27 2003-04-10 Applied Research Systems Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them
CA2423933A1 (en) * 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Pharmaceutically active sulfanilide derivatives
CA2440002A1 (en) * 2001-03-20 2002-09-26 Applied Research Systems Ars Holding N.V. Pyrrolidine ester derivatives with oxytocin modulating activity
HUP0400238A2 (hu) 2001-06-18 2004-07-28 Applied Research Systems Ars Holding N.V. Pirrolidin-oxadiazol- és tiadiazolszármazékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
SI1458381T1 (sl) * 2001-12-20 2006-04-30 Applied Research Systems Triazoli kot oksitocinski antagonisti
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
CN100564378C (zh) 2009-12-02
US20040220238A1 (en) 2004-11-04
CZ20033475A3 (en) 2004-05-12
WO2002102799A2 (en) 2002-12-27
US20060229343A1 (en) 2006-10-12
NO20035399L (no) 2004-02-17
BR0211030A (pt) 2004-06-22
EA200400049A1 (ru) 2004-08-26
EP1444225B1 (en) 2012-10-10
MXPA03011441A (es) 2004-07-01
AU2002319237B2 (en) 2008-01-03
BG108424A (en) 2005-03-31
ES2397305T3 (es) 2013-03-06
SK15552003A3 (sk) 2004-05-04
HUP0400238A2 (hu) 2004-07-28
CA2449578A1 (en) 2002-12-27
US7115639B2 (en) 2006-10-03
CA2449578C (en) 2011-12-13
KR20040030678A (ko) 2004-04-09
MY128890A (en) 2007-02-28
CN1639155A (zh) 2005-07-13
HRP20031017A2 (en) 2004-04-30
NO20035399D0 (no) 2003-12-04
JP2004534804A (ja) 2004-11-18
JP4426284B2 (ja) 2010-03-03
PL367275A1 (en) 2005-02-21
EA006212B1 (ru) 2005-10-27
RS99503A (sr) 2006-12-15
WO2002102799A3 (en) 2003-04-03
IL159219A0 (en) 2004-06-01
ZA200309402B (en) 2004-12-03
AR036108A1 (es) 2004-08-11
EP1444225A2 (en) 2004-08-11
UA75145C2 (en) 2006-03-15
HK1074204A1 (zh) 2005-11-04

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