EE04149B1 - Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine - Google Patents

Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine

Info

Publication number: EE04149B1
Authority: EE; Estonia
Prior art keywords: preparation; nitric oxide; oxide synthase; synthase inhibitors; inhibitors
Prior art date: 1998-05-30

Application number

EEP200000716A

Other languages

English (en)

Inventor

John Beswick Paul

Kleanthous Savvas

John Young Robert

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-30

Filing date

1999-05-27

Publication date

2003-10-15

1999-05-27 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2002-04-15 Publication of EE200000716A publication Critical patent/EE200000716A/et

2003-10-15 Publication of EE04149B1 publication Critical patent/EE04149B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP200000716A 1998-05-30 1999-05-27 Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine EE04149B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9811599.1A GB9811599D0 (en)	1998-05-30	1998-05-30	Nitric oxide synthase inhibitors
PCT/EP1999/003583 WO1999062875A1 (en)	1998-05-30	1999-05-27	Nitric oxide synthase inhibitors

Publications (2)

Publication Number	Publication Date
EE200000716A EE200000716A (et)	2002-04-15
EE04149B1 true EE04149B1 (et)	2003-10-15

Family

ID=10832929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000716A EE04149B1 (et)	1998-05-30	1999-05-27	Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine

Country Status (30)

Country	Link
US (2)	US6355689B1 (et)
EP (1)	EP1084104B1 (et)
JP (1)	JP3839256B2 (et)
KR (1)	KR20010043920A (et)
CN (1)	CN1218940C (et)
AP (1)	AP1382A (et)
AT (1)	ATE245142T1 (et)
AU (1)	AU757042B2 (et)
BR (1)	BR9910849A (et)
CA (1)	CA2333322C (et)
CZ (1)	CZ297473B6 (et)
DE (1)	DE69909625T2 (et)
DK (1)	DK1084104T3 (et)
EA (1)	EA003026B1 (et)
EE (1)	EE04149B1 (et)
ES (1)	ES2203147T3 (et)
GB (1)	GB9811599D0 (et)
HU (1)	HUP0102472A3 (et)
ID (1)	ID26790A (et)
IL (1)	IL139697A (et)
IS (1)	IS2442B (et)
NO (1)	NO20006044L (et)
NZ (1)	NZ508222A (et)
PL (1)	PL194784B1 (et)
PT (1)	PT1084104E (et)
RS (1)	RS49984B (et)
SK (1)	SK18052000A3 (et)
TR (1)	TR200003539T2 (et)
WO (1)	WO1999062875A1 (et)
ZA (1)	ZA200006847B (et)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1265860E (pt) *	2000-03-24	2005-10-31	Pharmacia Corp	Compostos amidino uteis como inibidores de sintase de oxido nitrico
US7012098B2 (en)	2001-03-23	2006-03-14	Pharmacia Corporation	Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
WO2003022309A1 (fr) *	2001-09-10	2003-03-20	Ono Pharmaceutical Co., Ltd.	Remedes pour maladies allergiques
US20030109522A1 (en) *	2001-09-24	2003-06-12	Manning Pamela T.	Ophthalmologic treatment methods using selective iNOS inhibitors
IL164826A0 (en) *	2002-05-16	2005-12-18	Pharmacia Corp	Methods for the treatment of respiratory diseases and conditions using a selective inos inhibitor
BR0310061A (pt) *	2002-05-16	2005-03-01	Pharmacia Corp	Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições
EP1528921A2 (en) *	2002-08-02	2005-05-11	Pharmacia Corporation	Methods for treatment and prevention of gastrointestinal conditions
EP1562975A2 (en) *	2002-10-25	2005-08-17	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
WO2004050084A2 (en) *	2002-11-29	2004-06-17	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Ace-inhibitors having antioxidant and nitricoxid-donor activity
TWI328009B (en)	2003-05-21	2010-08-01	Glaxo Group Ltd	Quinoline derivatives as phosphodiesterase inhibitors
GB0316212D0 (en) *	2003-07-10	2003-08-13	Glaxo Group Ltd	Novel compounds
GB0316290D0 (en)	2003-07-11	2003-08-13	Glaxo Group Ltd	Novel compounds
WO2005025620A2 (en) *	2003-08-13	2005-03-24	Pharmacia Corporation	Combination therapy with inhibitors of inducible nitric oxide synthase and alkylating agents
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
TWI307630B (en)	2004-07-01	2009-03-21	Glaxo Group Ltd	Immunoglobulins
GB0418045D0 (en)	2004-08-12	2004-09-15	Glaxo Group Ltd	Compounds
EP1841780B1 (en)	2005-01-10	2011-07-27	Glaxo Group Limited	Androstane 17-alpha-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
PE20100741A1 (es)	2005-03-25	2010-11-25	Glaxo Group Ltd	COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38
TWI389690B (zh)	2005-03-25	2013-03-21	Glaxo Group Ltd	新穎化合物（一）
WO2007000884A1 (ja) *	2005-06-29	2007-01-04	National University Corporation Kanazawa University	骨・関節疾患の予防・治療剤およびそのスクリーニング方法
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
PE20071068A1 (es)	2005-12-20	2007-12-13	Glaxo Group Ltd	Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3
EA200801997A1 (ru)	2006-04-20	2009-04-28	Глаксо Груп Лимитед	Новые соединения
GB0611587D0 (en)	2006-06-12	2006-07-19	Glaxo Group Ltd	Novel compounds
SI2046787T1 (sl)	2006-08-01	2011-07-29	Glaxo Group Ltd	Pirazolo(3,4-b)piridinske spojine in njihova uporaba kot PDE4 inhibitorji
US20080114021A1 (en) *	2006-11-09	2008-05-15	University Of Maryland Baltimore	Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
US20110160249A1 (en)	2008-05-23	2011-06-30	Schaab Kevin Murray	5-lipoxygenase-activating protein inhibitor
US8163743B2 (en)	2008-06-05	2012-04-24	GlaxoGroupLimited	4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases
US8765743B2 (en)	2008-06-05	2014-07-01	Glaxosmithkline Intellectual Property Development Limited	Compounds
WO2010094643A1 (en)	2009-02-17	2010-08-26	Glaxo Group Limited	Quinoline derivatives and their uses for rhinitis and urticaria
US8524751B2 (en)	2009-03-09	2013-09-03	GlaxoSmithKline Intellecutual Property Development	4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases
EP2406249A1 (en)	2009-03-10	2012-01-18	Glaxo Group Limited	Indole derivatives as ikk2 inhibitors
US20120058984A1 (en)	2009-03-17	2012-03-08	Catherine Mary Alder	Pyrimidine derivatives used as itk inhibitors
US20120016011A1 (en)	2009-03-19	2012-01-19	Merck Sharp & Dohme Corp.	RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
EP2408915A2 (en)	2009-03-19	2012-01-25	Merck Sharp&Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
MX2011009724A (es)	2009-03-19	2011-10-14	Merck Sharp & Dohme	Inhibicion mediada por interferencia de acido ribonucleico de la expresion del gen del factor de transcripcion basico de cierre de leucina 1 de homologia de btb y cnc 1, usando el listado de secuencias de acido nucleico corto de interferencia.
US20120035247A1 (en)	2009-03-19	2012-02-09	Merck Sharp & Dohme Corp.	RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
WO2010111490A2 (en)	2009-03-27	2010-09-30	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
MX2011010072A (es)	2009-03-27	2011-10-06	Merck Sharp & Dohme	Inhibicion mediada por interferencia de acido ribonucleico de la expresion del gen de la molecula de adhesion intercelular 1 usando acido nucleico corto de interferencia.
EP2411018A2 (en)	2009-03-27	2012-02-01	Merck Sharp&Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
JP2012521760A (ja)	2009-03-27	2012-09-20	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたアポトーシスシグナル調節キナーゼ１（ＡＳＫ１）遺伝子発現のＲＮＡ干渉媒介性阻害
EP2411019A2 (en)	2009-03-27	2012-02-01	Merck Sharp&Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2010122088A1 (en)	2009-04-24	2010-10-28	Glaxo Group Limited	Pyrazole and triazole carboxamides as crac channel inhibitors
UY32571A (es)	2009-04-24	2010-11-30	Glaxo Group Ltd	Compuestos derivados de pirazol amida
WO2010125082A1 (en)	2009-04-30	2010-11-04	Glaxo Group Limited	Oxazole substituted indazoles as pi3-kinase inhibitors
JP2013512880A (ja)	2009-12-03	2013-04-18	グラクソグループリミテッド	Ｐｉ３−キナーゼ阻害剤としてのインダゾール誘導体
EP2507223A1 (en)	2009-12-03	2012-10-10	Glaxo Group Limited	Benzpyrazole derivatives as inhibitors of p13 kinases
EP2507226A1 (en)	2009-12-03	2012-10-10	Glaxo Group Limited	Novel compounds
WO2011084316A2 (en)	2009-12-16	2011-07-14	3M Innovative Properties Company	Formulations and methods for controlling mdi particle size delivery
TWI375671B (en) *	2010-03-01	2012-11-01	Univ China Medical	Pharmaceutical compositions containing brazilin for inhibiting expression of cytokines of t helper cell type ii and/or inhibiting expression of chemokines and uses of the same
WO2011110575A1 (en)	2010-03-11	2011-09-15	Glaxo Group Limited	Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases
GB201007203D0 (en)	2010-04-29	2010-06-16	Glaxo Group Ltd	Novel compounds
WO2012032065A1 (en)	2010-09-08	2012-03-15	Glaxo Group Limited	Indazole derivatives for use in the treatment of influenza virus infection
DK2614058T3 (en)	2010-09-08	2015-09-28	Glaxosmithkline Ip Dev Ltd	Polymorphs, and the salts of N- [5- [4- (5 - {[(2R, 6S) -2,6-dimethyl-4-morpholinyl] methyl} -1,3-oxazol-2-yl) -1H-indazole -6-yl] -2- (methyloxy) -3-pyridinyl] methanesulfonamide.
WO2012035055A1 (en)	2010-09-17	2012-03-22	Glaxo Group Limited	Novel compounds
WO2012052458A1 (en)	2010-10-21	2012-04-26	Glaxo Group Limited	Pyrazole compounds acting against allergic, immune and inflammatory conditions
EP2630127A1 (en)	2010-10-21	2013-08-28	Glaxo Group Limited	Pyrazole compounds acting against allergic, inflammatory and immune disorders
GB201018124D0 (en)	2010-10-27	2010-12-08	Glaxo Group Ltd	Polymorphs and salts
GB201104153D0 (en)	2011-03-11	2011-04-27	Glaxo Group Ltd	Novel compounds
EP2683716A1 (en)	2011-03-11	2014-01-15	Glaxo Group Limited	Pyrido[3,4-b]pyrazine derivatives as syk inhibitors
AU2014321419B2 (en)	2013-09-22	2017-06-15	Sunshine Lake Pharma Co., Ltd.	Substituted aminopyrimidine compounds and methods of use
EP3122729A4 (en)	2014-03-28	2017-11-15	Calitor Sciences, LLC	Substituted heteroaryl compounds and methods of use
AU2015260841A1 (en)	2014-05-12	2016-12-01	Glaxosmithkline Intellectual Property (No. 2) Limited	Pharmaceutical compositions comprising danirixin for treating infectious diseases
EP3347097B1 (en)	2015-09-11	2021-02-24	Sunshine Lake Pharma Co., Ltd.	Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
US10683297B2 (en)	2017-11-19	2020-06-16	Calitor Sciences, Llc	Substituted heteroaryl compounds and methods of use
US10751339B2 (en)	2018-01-20	2020-08-25	Sunshine Lake Pharma Co., Ltd.	Substituted aminopyrimidine compounds and methods of use
BR112022019245A2 (pt)	2020-03-26	2022-11-16	Glaxosmithkline Ip Dev Ltd	Inibidores de catepsina para prevenir ou tratar infecções virais

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2049582A (en)	1931-11-04	1936-08-04	Rohm & Haas	Amidines
US4085217A (en)	1964-01-29	1978-04-18	L'oreal	Process and cosmetic compositions for the treatment of skin and scalp
US4085218A (en)	1975-10-30	1978-04-18	Sandoz Ltd.	Elevating mood in geriatric patients
US4512979A (en)	1981-03-23	1985-04-23	Merck & Co., Inc.	Dipeptides containing thialysine and related amino acids as antihypertensives
DE3260831D1 (en)	1981-06-05	1984-10-31	Merck & Co Inc	Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
US4594341A (en)	1982-04-06	1986-06-10	Merck & Co., Inc.	Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives
FI832053L (fi)	1982-06-10	1983-12-11	Syntex Inc	Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
DE3514450A1 (de)	1985-04-22	1986-10-23	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von imidaten sowie neue arylsubstituierte imidate
US5028627A (en)	1989-09-13	1991-07-02	Cornell Research Foundation, Inc.	Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
GB8929076D0 (en)	1989-12-22	1990-02-28	Scras	Treatment of shock by blocking agents of edrf effect or formation
CA2036770C (en)	1990-02-26	2003-09-09	Jeffrey P. Whitten	Inhibitors of nitric oxide biosynthesis
GB9127376D0 (en)	1991-12-24	1992-02-19	Wellcome Found	Amidino derivatives
DE4310202A1 (de)	1992-03-30	1993-10-07	Ciba Geigy	µ-Ketoimidoester als Stabilisatoren für chlorhaltige Polymerisate
US5281627A (en)	1992-05-28	1994-01-25	Cornell Research Foundation, Inc.	Substituted arginines and substituted homoarginines and use thereof
US5585402A (en)	1992-12-23	1996-12-17	Glaxo Wellcome Inc.	Nitric oxide synthase inhibitors
US5364881A (en)	1993-11-15	1994-11-15	The Medical College Of Wisconsin Research Foundation, Inc.	S-alkyl-isothioureido-amino acids and use thereof
ES2189322T3 (es)	1994-06-15	2003-07-01	Wellcome Found	Intermediarios utiles en la preparacion de inhibidores de encimas.
FR2727111B1 (fr)	1994-11-21	1997-01-17	Hoechst Lab	Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
MY117948A (en) *	1997-01-13	2004-08-30	Glaxo Group Ltd	Nitride oxide synthase inhibitors.

1998
- 1998-05-30 GB GBGB9811599.1A patent/GB9811599D0/en not_active Ceased
1999
- 1999-05-27 EA EA200001122A patent/EA003026B1/ru not_active IP Right Cessation
- 1999-05-27 EE EEP200000716A patent/EE04149B1/et not_active IP Right Cessation
- 1999-05-27 RS YUP-746/00A patent/RS49984B/sr unknown
- 1999-05-27 DK DK99926397T patent/DK1084104T3/da active
- 1999-05-27 WO PCT/EP1999/003583 patent/WO1999062875A1/en not_active Ceased
- 1999-05-27 CA CA002333322A patent/CA2333322C/en not_active Expired - Fee Related
- 1999-05-27 AU AU43671/99A patent/AU757042B2/en not_active Ceased
- 1999-05-27 PT PT99926397T patent/PT1084104E/pt unknown
- 1999-05-27 JP JP2000552087A patent/JP3839256B2/ja not_active Expired - Fee Related
- 1999-05-27 ES ES99926397T patent/ES2203147T3/es not_active Expired - Lifetime
- 1999-05-27 BR BR9910849-6A patent/BR9910849A/pt not_active Application Discontinuation
- 1999-05-27 ID IDW20002495A patent/ID26790A/id unknown
- 1999-05-27 IL IL13969799A patent/IL139697A/xx not_active IP Right Cessation
- 1999-05-27 SK SK1805-2000A patent/SK18052000A3/sk unknown
- 1999-05-27 NZ NZ508222A patent/NZ508222A/xx unknown
- 1999-05-27 CZ CZ20004450A patent/CZ297473B6/cs not_active IP Right Cessation
- 1999-05-27 TR TR2000/03539T patent/TR200003539T2/xx unknown
- 1999-05-27 CN CNB998068578A patent/CN1218940C/zh not_active Expired - Fee Related
- 1999-05-27 AT AT99926397T patent/ATE245142T1/de not_active IP Right Cessation
- 1999-05-27 HU HU0102472A patent/HUP0102472A3/hu unknown
- 1999-05-27 US US09/701,473 patent/US6355689B1/en not_active Expired - Lifetime
- 1999-05-27 DE DE69909625T patent/DE69909625T2/de not_active Expired - Lifetime
- 1999-05-27 PL PL344368A patent/PL194784B1/pl unknown
- 1999-05-27 AP APAP/P/2000/001998A patent/AP1382A/en active
- 1999-05-27 KR KR1020007013451A patent/KR20010043920A/ko not_active Ceased
- 1999-05-27 EP EP99926397A patent/EP1084104B1/en not_active Expired - Lifetime
2000
- 2000-11-21 IS IS5723A patent/IS2442B/is unknown
- 2000-11-22 ZA ZA200006847A patent/ZA200006847B/en unknown
- 2000-11-29 NO NO20006044A patent/NO20006044L/no not_active Application Discontinuation
2001
- 2001-11-26 US US09/994,969 patent/US6495606B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IS5723A (is)	2000-11-21
DE69909625D1 (en)	2003-08-21
CN1303367A (zh)	2001-07-11
GB9811599D0 (en)	1998-07-29
ZA200006847B (en)	2001-11-22
TR200003539T2 (tr)	2001-06-21
IS2442B (is)	2008-11-15
CZ20004450A3 (en)	2001-05-16
RS49984B (sr)	2008-09-29
CA2333322A1 (en)	1999-12-09
ID26790A (id)	2001-02-08
IL139697A (en)	2005-12-18
EP1084104A1 (en)	2001-03-21
CN1218940C (zh)	2005-09-14
NO20006044L (no)	2001-01-29
AP1382A (en)	2005-04-01
ES2203147T3 (es)	2004-04-01
EP1084104B1 (en)	2003-07-16
JP2002516901A (ja)	2002-06-11
NZ508222A (en)	2003-02-28
EA003026B1 (ru)	2002-12-26
HUP0102472A3 (en)	2002-12-28
DK1084104T3 (da)	2003-10-27
HUP0102472A2 (hu)	2002-03-28
JP3839256B2 (ja)	2006-11-01
KR20010043920A (ko)	2001-05-25
WO1999062875A1 (en)	1999-12-09
PL344368A1 (en)	2001-11-05
AU4367199A (en)	1999-12-20
DE69909625T2 (de)	2004-06-24
NO20006044D0 (no)	2000-11-29
PT1084104E (pt)	2003-11-28
EE200000716A (et)	2002-04-15
CA2333322C (en)	2008-01-22
BR9910849A (pt)	2001-02-20
YU74600A (sh)	2002-12-10
US6355689B1 (en)	2002-03-12
IL139697A0 (en)	2002-02-10
HK1034241A1 (en)	2001-10-19
SK18052000A3 (sk)	2001-06-11
AP2000001998A0 (en)	2000-12-31
US6495606B1 (en)	2002-12-17
CZ297473B6 (cs)	2006-12-13
ATE245142T1 (de)	2003-08-15
EA200001122A1 (ru)	2001-06-25
AU757042B2 (en)	2003-01-30
PL194784B1 (pl)	2007-07-31

Publication	Publication Date	Title
EE04149B1 (et)	2003-10-15	Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine
IS5094A (is)	1999-06-25	Nituroxíð sýntasa latar, notkun og aðferð til framleiðslu þeirra, ásamt lyfjasamsetningum
IS5053A (is)	1999-05-18	6-Fenýlpýridýl-2-amín afleiður nytsamlegar sem nituroxíð sýntasa tálmar
EE200200175A (et)	2003-04-15	Asendatud 2-tio-3,5-ditsüano-4-arüül-6-aminopüridiinid ja nende kasutamine
NO20032835L (no)	2003-08-15	Nitrogenoksyd-syntase-inhibitor-fosfatsalt
FI965039L (fi)	1997-02-14	Uusia trombiini-inhibiittoreita, niiden valmistus ja käyttö
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE200000621A (et)	2002-06-17	Pikornaviirusevastased ühendid, nende valmistamine ja kasutamine
EE200100391A (et)	2002-10-15	Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon
MXPA03002207A (es)	2003-06-24	Derivados de acido 2-amino-2-alquil-5-heptenoico y -heptinoico utiles como inhibidores de la oxido nitrico sintasa.
EE200000519A (et)	2002-02-15	Lämmastikoksiidi süntaasi inhibiitoritena toimivad halogeenitud amidinoaminohappederivaadid
MXPA03002271A (es)	2003-06-06	Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa.
AU8473398A (en)	1999-02-16	1,3-diaza- heterocycles and their use as nitric oxide synthase inhibitors
EE9900474A (et)	2000-06-15	Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena
GB9810299D0 (en)	1998-07-15	Use of nitric oxide synthase inhibitors
NO20006479D0 (no)	2000-12-19	Tienopyridinforbindelser, deres fremstilling og anvendelse
NO996156L (no)	2000-06-15	Substituerte cykloheptener, deres fremstilling og anvendelse
EE200000179A (et)	2001-04-16	1-oxa, aza ja tianaftaleen-2-1 biseetrid fosfolambaani inhibiitoritena
MXPA03002211A (es)	2003-06-24	Derivados de acido 2-amino-2-alquil-4-heptenoico y heptinoico utiles como inhibidores de la oxido nitrico sintasa.
MXPA03002272A (es)	2003-06-06	Derivados de acido 2-amino-2-alquil-3-heptenoico y 2-amino-2-alquil-3-heptenoico utiles como inhibidores de oxido nitrico sintasa.
HRP980381B1 (en)	2002-02-28	Nitric oxide synthase inhibitors
SE0003877D0 (sv)	2000-10-25	New composition, method and use
SI0958277T1 (en)	2002-06-30	Nitric oxide synthase inhibitors
GB0031177D0 (en)	2001-01-31	Nitric oxide synthase inhibitors

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090527