[go: up one dir, main page]

EE9900474A - Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena - Google Patents

Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena

Info

Publication number
EE9900474A
EE9900474A EEP199900474A EEP9900474A EE9900474A EE 9900474 A EE9900474 A EE 9900474A EE P199900474 A EEP199900474 A EE P199900474A EE P9900474 A EEP9900474 A EE P9900474A EE 9900474 A EE9900474 A EE 9900474A
Authority
EE
Estonia
Prior art keywords
nitric oxide
oxide synthase
synthase inhibitors
amidine derivatives
amidine
Prior art date
Application number
EEP199900474A
Other languages
English (en)
Inventor
Macdonald James
Matz James
Shakespeare William
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9900474A publication Critical patent/EE9900474A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP199900474A 1997-05-05 1998-04-28 Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena EE9900474A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
EE9900474A true EE9900474A (et) 2000-06-15

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900474A EE9900474A (et) 1997-05-05 1998-04-28 Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena

Country Status (25)

Country Link
US (1) US6489322B1 (et)
EP (1) EP0983268B1 (et)
JP (1) JP2001523262A (et)
KR (1) KR20010012228A (et)
CN (1) CN1255131A (et)
AR (1) AR012601A1 (et)
AT (1) ATE221065T1 (et)
AU (1) AU734391B2 (et)
BR (1) BR9809218A (et)
CA (1) CA2288333A1 (et)
DE (1) DE69806750T2 (et)
EE (1) EE9900474A (et)
HU (1) HUP0001873A3 (et)
ID (1) ID22885A (et)
IL (1) IL132678A0 (et)
IS (1) IS5236A (et)
MX (1) MXPA99009882A (et)
NO (1) NO995403L (et)
NZ (1) NZ500675A (et)
PL (1) PL336853A1 (et)
SE (1) SE9701681D0 (et)
SK (1) SK140599A3 (et)
TR (1) TR199902720T2 (et)
WO (1) WO1998050382A1 (et)
ZA (1) ZA983736B (et)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
JPWO2006118104A1 (ja) * 2005-04-26 2008-12-18 株式会社東芝 白色ｌｅｄおよびそれを用いたバックライト並びに液晶表示装置
JP2009501705A (ja) * 2005-07-05 2009-01-22 アストラゼネカ・アクチエボラーグ 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような５−ｈｔ６介在疾患の治療におけるそれらの使用
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
EP2077846B1 (en) * 2006-11-02 2011-10-12 Piramal Life Sciences Limited Benzoxazepine compounds, their preparation and use
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
US8648066B2 (en) * 2009-05-22 2014-02-11 Exelixis, Inc. Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713483B1 (en) 1993-08-12 2003-01-15 AstraZeneca AB Amidine derivatives with nitric oxide synthetase activities
AU7705694A (en) 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
KR100342275B1 (ko) 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체
US5807886A (en) * 1994-05-07 1998-09-15 Astra Aktiebolag Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase
TW397812B (en) 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
SK281442B6 (sk) * 1995-08-10 2001-03-12 Astra Aktiebolag Bicyklické amidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
TW458978B (en) 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
CN1255131A (zh) 2000-05-31
ID22885A (id) 1999-12-16
NO995403D0 (no) 1999-11-04
AU7459898A (en) 1998-11-27
JP2001523262A (ja) 2001-11-20
KR20010012228A (ko) 2001-02-15
EP0983268B1 (en) 2002-07-24
AU734391B2 (en) 2001-06-14
BR9809218A (pt) 2000-06-27
MXPA99009882A (es) 2005-11-22
NO995403L (no) 2000-01-05
CA2288333A1 (en) 1998-11-12
US6489322B1 (en) 2002-12-03
PL336853A1 (en) 2000-07-17
AR012601A1 (es) 2000-11-08
DE69806750D1 (de) 2002-08-29
IL132678A0 (en) 2001-03-19
SK140599A3 (en) 2000-06-12
DE69806750T2 (de) 2003-03-06
SE9701681D0 (sv) 1997-05-05
WO1998050382A1 (en) 1998-11-12
TR199902720T2 (xx) 2000-02-21
EP0983268A1 (en) 2000-03-08
ZA983736B (en) 1998-11-05
HUP0001873A2 (hu) 2001-01-29
HUP0001873A3 (en) 2001-12-28
NZ500675A (en) 2001-05-25
IS5236A (is) 1999-11-01
ATE221065T1 (de) 2002-08-15

Similar Documents

Publication Publication Date Title
EE04013B1 (et) Lämmastikoksiidi süntaasi inhibiitorid
EE200000716A (et) Lämmastikoksiidi süntaasi inhibiitorid
IS5053A (is) 6-Fenýlpýridýl-2-amín afleiður nytsamlegar sem nituroxíð sýntasa tálmar
NO20032835L (no) Nitrogenoksyd-syntase-inhibitor-fosfatsalt
NO20002121D0 (no) Benzotiazol-protein-tyrosin-kinaseinhibitorer
EE200000519A (et) Lämmastikoksiidi süntaasi inhibiitoritena toimivad halogeenitud amidinoaminohappederivaadid
PT1181017E (pt) Inibidores de metaloproteases
DE60008527D1 (de) Zellproliferation inhibitoren
DK0958287T3 (da) Sulfamidmetalloprotease-inhibitorer
FI964463A7 (fi) Bisykliset amidiinijohdannaiset typpioksidinsyntetaasin inhibiittorein a
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
EE9900474A (et) Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena
ATE262517T1 (de) Thiopyranderivate as mmp-inhibitoren
MA24854A1 (fr) Inhibiteurs d'oxyde nitrique synthase
AU2417601A (en) Amidine derivatives which are inhibitors of nitric oxide synthase
AU4446500A (en) 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors
AU2563601A (en) Amidine derivatives which are inhibitors of nitric oxide synthase
HK1025772A (en) Amidine derivatives as inhibitors of nitric oxide synthase
SI0958277T1 (en) Nitric oxide synthase inhibitors
AU2001282829A1 (en) Amidine derivatives which are inhibitors of nitric oxide synthase
HRP980381B1 (en) Nitric oxide synthase inhibitors
SI1084104T1 (en) Nitric oxide synthase inhibitors
ZA971944B (en) Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
DK1062201T3 (da) Halogenerede amidinoaminosyrederivater anvendelige som nitrogenoxidsynthaseinhibitirer