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EE04962B1 - Kinoliini ühend, seda sisaldav farmatseutiline kompositsioon, ühendi kasutamine ravimina ning meetod ühendi ja kompositsiooni valmistamiseks - Google Patents

Kinoliini ühend, seda sisaldav farmatseutiline kompositsioon, ühendi kasutamine ravimina ning meetod ühendi ja kompositsiooni valmistamiseks

Info

Publication number
EE04962B1
EE04962B1 EEP200100318A EEP200100318A EE04962B1 EE 04962 B1 EE04962 B1 EE 04962B1 EE P200100318 A EEP200100318 A EE P200100318A EE P200100318 A EEP200100318 A EE P200100318A EE 04962 B1 EE04962 B1 EE 04962B1
Authority
EE
Estonia
Prior art keywords
compound
medicament
preparation
quinoline
pharmaceutical composition
Prior art date
Application number
EEP200100318A
Other languages
English (en)
Inventor
Ren� Angibaud Patrick
Gaston Venet Marc
Marc Bourdrez Xavier
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100318A publication Critical patent/EE200100318A/et
Publication of EE04962B1 publication Critical patent/EE04962B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
EEP200100318A 1998-12-23 1999-12-17 Kinoliini ühend, seda sisaldav farmatseutiline kompositsioon, ühendi kasutamine ravimina ning meetod ühendi ja kompositsiooni valmistamiseks EE04962B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204444 1998-12-23
PCT/EP1999/010214 WO2000039082A2 (en) 1998-12-23 1999-12-17 1,2-annelated quinoline derivatives

Publications (2)

Publication Number Publication Date
EE200100318A EE200100318A (et) 2002-10-15
EE04962B1 true EE04962B1 (et) 2008-02-15

Family

ID=8234557

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100318A EE04962B1 (et) 1998-12-23 1999-12-17 Kinoliini ühend, seda sisaldav farmatseutiline kompositsioon, ühendi kasutamine ravimina ning meetod ühendi ja kompositsiooni valmistamiseks

Country Status (32)

Country Link
US (2) US6458800B1 (et)
EP (1) EP1140935B1 (et)
JP (1) JP4725940B2 (et)
KR (2) KR100818541B1 (et)
CN (1) CN1178938C (et)
AR (1) AR021995A1 (et)
AT (1) ATE240327T1 (et)
AU (1) AU765437B2 (et)
BG (1) BG65124B1 (et)
BR (1) BR9916827A (et)
CA (1) CA2355717C (et)
CZ (1) CZ302374B6 (et)
DE (1) DE69907964T2 (et)
DK (1) DK1140935T3 (et)
EA (1) EA004542B1 (et)
EE (1) EE04962B1 (et)
ES (1) ES2200591T3 (et)
HK (1) HK1038746B (et)
HR (1) HRP20010454B1 (et)
HU (1) HU229404B1 (et)
ID (1) ID29241A (et)
IL (2) IL143859A0 (et)
NO (1) NO318922B1 (et)
PL (1) PL199080B1 (et)
PT (1) PT1140935E (et)
SI (1) SI1140935T1 (et)
SK (1) SK286072B6 (et)
TR (1) TR200101961T2 (et)
TW (1) TW531533B (et)
UA (1) UA71592C2 (et)
WO (1) WO2000039082A2 (et)
ZA (1) ZA200105136B (et)

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CA2397657A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica Inc. Farnesyl protein transferase inhibitor combinations with platinum compounds
WO2001064246A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with an her2 antibody
AU2001239275A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
WO2001064199A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with taxane compounds
US20030186925A1 (en) * 2000-02-29 2003-10-02 Palmer Peter Albert Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
AU2001244166A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with further anti-cancer agents
JP2003525236A (ja) * 2000-02-29 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ビンカアルカロイドとのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤
CA2397253A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
WO2001064218A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations
US20030078281A1 (en) * 2000-02-29 2003-04-24 Rybak Mary Ellen Margaret Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
AU2001240658A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with camptothecin compounds
JO2361B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
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US7196094B2 (en) 2000-09-25 2007-03-27 Janssen Pharmaceutica, N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
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US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
JP4537710B2 (ja) 2001-12-19 2010-09-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ファルネシルトランスフェラーゼ阻害剤としての炭素連結トリアゾールで置換されている１，８−アネル化キノリン誘導体
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Also Published As

Publication number Publication date
WO2000039082A2 (en) 2000-07-06
TW531533B (en) 2003-05-11
KR100818541B1 (ko) 2008-04-02
NO20013088D0 (no) 2001-06-21
EP1140935A2 (en) 2001-10-10
CA2355717A1 (en) 2000-07-06
SK286072B6 (sk) 2008-02-05
UA71592C2 (uk) 2004-12-15
PL199080B1 (pl) 2008-08-29
HUP0104582A2 (hu) 2002-04-29
HU229404B1 (en) 2013-12-30
EP1140935B1 (en) 2003-05-14
KR20010087396A (ko) 2001-09-15
ES2200591T3 (es) 2004-03-01
ID29241A (id) 2001-08-16
HK1038746A1 (en) 2002-03-28
PL349504A1 (en) 2002-07-29
NO318922B1 (no) 2005-05-23
DK1140935T3 (da) 2003-09-01
EA004542B1 (ru) 2004-06-24
US6914066B2 (en) 2005-07-05
KR100712226B1 (ko) 2007-04-27
TR200101961T2 (tr) 2001-12-21
HUP0104582A3 (en) 2002-12-28
HK1038746B (en) 2003-09-05
IL143859A (en) 2008-04-13
CZ20012142A3 (cs) 2002-01-16
WO2000039082A3 (en) 2000-10-26
IL143859A0 (en) 2002-04-21
NO20013088L (no) 2001-06-21
EA200100708A1 (ru) 2001-12-24
AR021995A1 (es) 2002-09-04
SK8732001A3 (en) 2002-02-05
AU2795300A (en) 2000-07-31
EE200100318A (et) 2002-10-15
DE69907964T2 (de) 2004-02-19
AU765437B2 (en) 2003-09-18
BR9916827A (pt) 2001-10-16
CA2355717C (en) 2011-02-08
US6458800B1 (en) 2002-10-01
HRP20010454A2 (en) 2002-06-30
CZ302374B6 (cs) 2011-04-20
JP2002533435A (ja) 2002-10-08
DE69907964D1 (de) 2003-06-18
JP4725940B2 (ja) 2011-07-13
SI1140935T1 (en) 2003-10-31
CN1178938C (zh) 2004-12-08
HRP20010454B1 (en) 2004-06-30
BG105631A (en) 2002-02-28
KR20060117380A (ko) 2006-11-16
BG65124B1 (bg) 2007-03-30
ZA200105136B (en) 2002-06-21
ATE240327T1 (de) 2003-05-15
PT1140935E (pt) 2003-10-31
CN1331693A (zh) 2002-01-16
US20030119843A1 (en) 2003-06-26

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