EE04589B1 - Vähivastaste ühendite valmistamise protsessid ja vaheühendid - Google Patents

Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Info

Publication number: EE04589B1
Authority: EE; Estonia
Prior art keywords: intermediates; processes; preparation; anticancer compounds; anticancer
Prior art date: 1999-03-31

Application number

EEP200000255A

Other languages

English (en)

Estonian (et)

Inventor

Shelton Lehner Richard

Norris Timothy

Paul Santafianos Dinos

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-31

Filing date

2000-03-30

Publication date

2006-02-15

2000-03-30 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2000-12-15 Publication of EE200000255A publication Critical patent/EE200000255A/xx

2006-02-15 Publication of EE04589B1 publication Critical patent/EE04589B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B15/00—Obtaining copper
- C22B15/0002—Preliminary treatment
- C22B15/0004—Preliminary treatment without modification of the copper constituent
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B15/00—Obtaining copper
- C22B15/0063—Hydrometallurgy
- C22B15/0065—Leaching or slurrying
- C22B15/0067—Leaching or slurrying with acids or salts thereof
- C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Mechanical Engineering (AREA)
Manufacturing & Machinery (AREA)
Metallurgy (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200000255A 1999-03-31 2000-03-30 Vähivastaste ühendite valmistamise protsessid ja vaheühendid EE04589B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12707299P	1999-03-31	1999-03-31

Publications (2)

Publication Number	Publication Date
EE200000255A EE200000255A (et)	2000-12-15
EE04589B1 true EE04589B1 (et)	2006-02-15

Family

ID=22428179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000255A EE04589B1 (et)	1999-03-31	2000-03-30	Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Country Status (49)

Country	Link
US (1)	US6476040B1 (xx)
EP (1)	EP1044969B1 (xx)
JP (2)	JP3420549B2 (xx)
KR (2)	KR100430210B1 (xx)
CN (2)	CN100351242C (xx)
AP (2)	AP1265A (xx)
AR (1)	AR018705A1 (xx)
AT (1)	ATE348098T1 (xx)
AU (2)	AU781402B2 (xx)
BG (1)	BG65194B1 (xx)
BR (1)	BRPI0001486B8 (xx)
CA (2)	CA2427221C (xx)
CO (1)	CO5160273A1 (xx)
CR (1)	CR6165A (xx)
CZ (1)	CZ299426B6 (xx)
DE (1)	DE60032275T2 (xx)
DK (1)	DK1044969T3 (xx)
DZ (1)	DZ3030A1 (xx)
EA (3)	EA004654B1 (xx)
EE (1)	EE04589B1 (xx)
EG (1)	EG22506A (xx)
ES (1)	ES2278578T3 (xx)
GE (1)	GEP20022653B (xx)
GT (1)	GT200000037A (xx)
HR (1)	HRP20000182B1 (xx)
HU (1)	HU227698B1 (xx)
ID (1)	ID25427A (xx)
IL (2)	IL168036A (xx)
IS (1)	IS2468B (xx)
MA (1)	MA25087A1 (xx)
MY (1)	MY136270A (xx)
NO (2)	NO321952B1 (xx)
NZ (2)	NZ512818A (xx)
OA (1)	OA11335A (xx)
PA (1)	PA8491901A1 (xx)
PE (1)	PE20001599A1 (xx)
PL (1)	PL339330A1 (xx)
PT (1)	PT1044969E (xx)
RS (1)	RS49836B (xx)
SG (2)	SG121687A1 (xx)
SK (1)	SK287339B6 (xx)
SV (1)	SV2002000047A (xx)
TN (1)	TNSN00064A1 (xx)
TR (1)	TR200000837A2 (xx)
TW (1)	TW553939B (xx)
UA (2)	UA70928C2 (xx)
UY (1)	UY26086A1 (xx)
YU (1)	YU13200A (xx)
ZA (1)	ZA200001586B (xx)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6706721B1 (en)	1998-04-29	2004-03-16	Osi Pharmaceuticals, Inc.	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
UA74803C2 (uk) *	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en)	1999-11-11	2006-08-08	Osi Pharmaceuticals, Inc.	Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
EP1415987B1 (en)	2000-10-20	2007-02-28	Eisai R&D Management Co., Ltd.	Nitrogenous aromatic ring compounds as anti cancer agents
AU2002350105A1 (en)	2001-06-21	2003-01-08	Ariad Pharmaceuticals, Inc.	Novel quinazolines and uses thereof
US7078409B2 (en)	2002-03-28	2006-07-18	Beta Pharma, Inc.	Fused quinazoline derivatives useful as tyrosine kinase inhibitors
US7576074B2 (en)	2002-07-15	2009-08-18	Rice Kenneth D	Receptor-type kinase modulators and methods of use
US7148231B2 (en) *	2003-02-17	2006-12-12	Hoffmann-La Roche Inc.	[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
ATE508747T1 (de)	2003-03-10	2011-05-15	Eisai R&D Man Co Ltd	C-kit kinase-hemmer
US8309562B2 (en) *	2003-07-03	2012-11-13	Myrexis, Inc.	Compounds and therapeutical use thereof
CN1984660B (zh)	2003-07-03	2010-12-15	美瑞德生物工程公司	作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
ES2305844T3 (es)	2003-09-16	2008-11-01	Astrazeneca Ab	Derivados de quinazolina como inhibidores de tirosina cinasa.
PL2392565T3 (pl)	2003-09-26	2014-08-29	Exelixis Inc	Modulatory c-Met i sposoby stosowania
WO2005044788A1 (ja)	2003-11-11	2005-05-19	Eisai Co., Ltd.	ウレア誘導体およびその製造方法
SI1746999T1 (sl)	2004-05-06	2012-01-31	Warner Lambert Co	4-fenilamino-kinazolin-6-il-amidi
AU2005283422C1 (en)	2004-09-17	2017-02-02	Eisai R & D Management Co., Ltd.	Medicinal composition
CA2592900A1 (en)	2005-01-03	2006-07-13	Myriad Genetics Inc.	Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en)	2005-01-03	2012-09-04	Myrexis, Inc.	Method of treating brain cancer
US7625911B2 (en) *	2005-01-12	2009-12-01	Mai De Ltd.	Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
CN101163468A (zh)	2005-02-28	2008-04-16	卫材R&D管理有限公司	磺酰胺化合物的新联合用途
EP1925941B1 (en) *	2005-08-01	2012-11-28	Eisai R&D Management Co., Ltd.	Method for prediction of the efficacy of vascularization inhibitor
EP2281901B1 (en)	2005-08-02	2013-11-27	Eisai R&D Management Co., Ltd.	Anti-tumour pharmaceutical composition with angiogenesis inhibitors
CA2627598C (en)	2005-11-07	2013-06-25	Eisai R & D Management Co., Ltd.	Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
WO2007061127A1 (ja) *	2005-11-22	2007-05-31	Eisai R & D Management Co., Ltd.	多発性骨髄腫に対する抗腫瘍剤
WO2007136103A1 (ja) *	2006-05-18	2007-11-29	Eisai R & D Management Co., Ltd.	甲状腺癌に対する抗腫瘍剤
EP2044939A1 (en) *	2006-06-29	2009-04-08	Eisai R&D Management Co., Ltd.	Therapeutic agent for liver fibrosis
CN101547910A (zh)	2006-07-28	2009-09-30	合成纤维有限公司	结晶埃罗替尼
WO2008026748A1 (en)	2006-08-28	2008-03-06	Eisai R & D Management Co., Ltd.	Antitumor agent for undifferentiated gastric cancer
US8372856B2 (en) *	2006-10-27	2013-02-12	Synthon Bv	Hydrates of erlotinib hydrochloride
EP2116246A1 (en)	2007-01-19	2009-11-11	Eisai R&D Management Co., Ltd.	Composition for treatment of pancreatic cancer
EP2119707B1 (en)	2007-01-29	2015-01-14	Eisai R&D Management Co., Ltd.	Composition for treatment of undifferentiated-type of gastric cancer
WO2008102369A1 (en) *	2007-02-21	2008-08-28	Natco Pharma Limited	Novel polymorphs of erlotinib hydrochloride and method of preparation
KR20140069232A (ko)	2007-04-04	2014-06-09	시플라 리미티드	에르로티닙 및 그의 약학적으로 허용가능한 염의 제조방법
US20090012295A1 (en) *	2007-06-25	2009-01-08	Ales Gavenda	Amorphous Erlotinib, processes for the preparation thereof, and processes to prepare additional forms of Erlotinib
US8389531B2 (en)	2007-07-11	2013-03-05	Hetero Drugs Limited	Process for erlotinib hydrochloride
MX2010002081A (es) *	2007-08-23	2010-06-01	Plus Chemicals Sa	Procesos para la preparacion de formas a, b cristalinas y de la forma a cristalina pura de erlotinib hc1.
US20090124642A1 (en) *	2007-08-23	2009-05-14	Augusto Canavesi	Crystalline forms of Erlotinib HCI and formulations thereof
US20090076042A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched erlotinib
CA2704000C (en)	2007-11-09	2016-12-13	Eisai R&D Management Co., Ltd.	Combination of anti-angiogenic substance and anti-tumor platinum complex
KR101506062B1 (ko) *	2008-01-29	2015-03-25	에자이 알앤드디 매니지먼트 가부시키가이샤	혈관 저해 물질과 탁산의 병용
US20090269354A1 (en) *	2008-03-28	2009-10-29	Concert Pharmaceuticals, Inc.	Quinazoline derivatives and methods of treatment
EP2307386A1 (en) *	2008-07-07	2011-04-13	Plus Chemicals S.A.	Crystalline forms of erlotinib base and erlotinib hcl
KR101132937B1 (ko)	2008-10-01	2012-04-06	주식회사종근당	Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
WO2010040212A1 (en) *	2008-10-08	2010-04-15	Apotex Pharmachem Inc.	Processes for the preparation of erlotinib hydrochloride
TW201920110A (zh)	2009-01-16	2019-06-01	美商艾克塞里克斯公司	包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
EP2411373B1 (en)	2009-03-26	2015-10-21	Ranbaxy Laboratories Limited	Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
UA108618C2 (uk)	2009-08-07	2015-05-25		Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
ES2564797T3 (es)	2009-08-19	2016-03-29	Eisai R&D Management Co., Ltd.	Composición farmacéutica con contenido en un derivado de quinolina
US20120302749A1 (en)	2009-11-12	2012-11-29	Ranbaxy Laboratories Limited	Processes for the preparation of erlotinib hydrochloride form a and erlotinib hydrochloride form b
WO2011068404A2 (en)	2009-12-02	2011-06-09	Ultimorphix Technologies B.V.	Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
RU2560683C2 (ru)	2010-06-25	2015-08-20	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации
NZ606042A (en)	2010-07-23	2015-05-29	Generics Uk Ltd	Process for the preparation of erlotinib and salts thereof
IT1402029B1 (it) *	2010-10-14	2013-08-28	Italiana Sint Spa	Procedimento per la preparazione di erlotinib
MX2013009931A (es)	2011-04-18	2013-10-01	Eisai R&D Man Co Ltd	Agentes terapeuticos contra tumores.
ES2705950T3 (es)	2011-06-03	2019-03-27	Eisai R&D Man Co Ltd	Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
CN102267952B (zh) *	2011-06-21	2013-12-11	天津市汉康医药生物技术有限公司	喹唑啉类化合物、其制备方法和用途
CN103420924B (zh) *	2012-05-25	2016-08-31	浙江九洲药业股份有限公司	一种盐酸埃罗替尼晶型a的制备方法
WO2014037961A1 (en)	2012-09-04	2014-03-13	Shilpa Medicare Limited	Crystalline erlotinib hydrochloride process
WO2014098176A1 (ja)	2012-12-21	2014-06-26	エーザイ・アール・アンド・ディー・マネジメント株式会社	キノリン誘導体のアモルファス及びその製造方法
WO2014118737A1 (en)	2013-01-31	2014-08-07	Ranbaxy Laboratories Limited	Erlotinib salts
RU2658601C2 (ru)	2013-05-14	2018-06-21	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
CN103333124B (zh) *	2013-05-28	2015-03-25	埃斯特维华义制药有限公司	一种制备盐酸厄洛替尼晶型f的方法
ES2926687T3 (es)	2014-08-28	2022-10-27	Eisai R&D Man Co Ltd	Derivado de quinolina muy puro y método para su producción
CA2908441A1 (en)	2014-10-28	2016-04-28	Cerbios-Pharma Sa	Process for the preparation of erlotinib
RS65049B1 (sr)	2015-02-25	2024-02-29	Eisai R&D Man Co Ltd	Metoda za suzbijanje gorčine derivata kinolina
AU2015384801B2 (en)	2015-03-04	2022-01-06	Eisai R&D Management Co., Ltd.	Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
CA2988707C (en)	2015-06-16	2023-10-10	Eisai R&D Management Co., Ltd.	Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
ES2887426T3 (es)	2015-08-20	2021-12-22	Eisai R&D Man Co Ltd	Lenvatinib combinado con etopósido e ifosfamida para su uso en el tratamiento de un tumor
CN105884653A (zh) *	2016-06-08	2016-08-24	浙江汇能生物股份有限公司	一种埃罗替尼衍生物及其制备方法
CN106279585A (zh) *	2016-08-26	2017-01-04	宁波圣达精工智能科技有限公司	一种阻燃智能密集书架的制备方法
JP6581320B2 (ja)	2017-02-08	2019-09-25	エーザイ・アール・アンド・ディー・マネジメント株式会社	腫瘍治療用医薬組成物
RU2019134940A (ru)	2017-05-16	2021-06-16	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Лечение гепатоцеллюлярной карциномы

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4747498A (en) *	1986-06-27	1988-05-31	Sunbeam Plastics Corporation	Safety dispensing closure-container package
AU661533B2 (en)	1992-01-20	1995-07-27	Astrazeneca Ab	Quinazoline derivatives
JP2657760B2 (ja) *	1992-07-15	1997-09-24	小野薬品工業株式会社	４−アミノキナゾリン誘導体およびそれを含有する医薬品
ES2332984T3 (es) *	1995-03-30	2010-02-16	Pfizer Products Inc.	Derivados de quinazolinas.
US5747498A (en) *	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines
BR9707495A (pt)	1996-02-13	1999-07-27	Zeneca Ltd	Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
AU719327B2 (en)	1996-03-05	2000-05-04	Astrazeneca Ab	4-anilinoquinazoline derivatives
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
US6225499B1 (en)	1997-07-14	2001-05-01	Catalytica Pharmaceuticals, Inc.	Process for preparing aminoarylacetylenes
MEP42008A (en)	1998-04-29	2011-02-10	Osi Farmaceuticals Inc	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

2000
- 2000-03-03 RS YUP-132/00A patent/RS49836B/sr unknown
- 2000-03-03 YU YU13200A patent/YU13200A/sh unknown
- 2000-03-10 OA OA1200000071A patent/OA11335A/en unknown
- 2000-03-14 CR CR6165A patent/CR6165A/es unknown
- 2000-03-17 PA PA20008491901A patent/PA8491901A1/es unknown
- 2000-03-20 ES ES00302256T patent/ES2278578T3/es not_active Expired - Lifetime
- 2000-03-20 AT AT00302256T patent/ATE348098T1/de not_active IP Right Cessation
- 2000-03-20 EP EP00302256A patent/EP1044969B1/en not_active Expired - Lifetime
- 2000-03-20 DK DK00302256T patent/DK1044969T3/da active
- 2000-03-20 PT PT00302256T patent/PT1044969E/pt unknown
- 2000-03-20 DE DE60032275T patent/DE60032275T2/de not_active Expired - Lifetime
- 2000-03-21 IS IS5411A patent/IS2468B/is unknown
- 2000-03-22 CO CO00020444A patent/CO5160273A1/es unknown
- 2000-03-23 IL IL168036A patent/IL168036A/en not_active IP Right Cessation
- 2000-03-23 IL IL13524500A patent/IL135245A0/xx not_active IP Right Cessation
- 2000-03-27 ID IDP20000240A patent/ID25427A/id unknown
- 2000-03-27 BR BRPI0001486A patent/BRPI0001486B8/pt not_active IP Right Cessation
- 2000-03-27 UA UA2000031727A patent/UA70928C2/uk unknown
- 2000-03-27 UA UA20040503766A patent/UA80955C2/uk unknown
- 2000-03-27 EG EG20000364A patent/EG22506A/xx active
- 2000-03-27 TW TW089105605A patent/TW553939B/zh not_active IP Right Cessation
- 2000-03-27 SK SK444-2000A patent/SK287339B6/sk not_active IP Right Cessation
- 2000-03-27 SG SG200001746A patent/SG121687A1/en unknown
- 2000-03-27 SG SG200302185A patent/SG115536A1/en unknown
- 2000-03-28 AU AU22620/00A patent/AU781402B2/en not_active Expired
- 2000-03-28 BG BG104278A patent/BG65194B1/bg unknown
- 2000-03-29 CA CA002427221A patent/CA2427221C/en not_active Expired - Lifetime
- 2000-03-29 MY MYPI20001252A patent/MY136270A/en unknown
- 2000-03-29 AR ARP000101413A patent/AR018705A1/es active IP Right Grant
- 2000-03-29 DZ DZ000059A patent/DZ3030A1/xx active
- 2000-03-29 CA CA002302965A patent/CA2302965C/en not_active Expired - Lifetime
- 2000-03-29 MA MA25940A patent/MA25087A1/fr unknown
- 2000-03-29 JP JP2000091300A patent/JP3420549B2/ja not_active Expired - Lifetime
- 2000-03-29 UY UY26086A patent/UY26086A1/es not_active Application Discontinuation
- 2000-03-29 AP APAP/P/2000/001778A patent/AP1265A/en active
- 2000-03-29 AP APAP/P/2003/002757D patent/AP1655A/en active
- 2000-03-29 ZA ZA200001586A patent/ZA200001586B/xx unknown
- 2000-03-29 TN TNTNSN00064A patent/TNSN00064A1/fr unknown
- 2000-03-30 HU HU0001353A patent/HU227698B1/hu unknown
- 2000-03-30 NZ NZ512818A patent/NZ512818A/xx not_active IP Right Cessation
- 2000-03-30 EA EA200000274A patent/EA004654B1/ru not_active IP Right Cessation
- 2000-03-30 KR KR1020000016386A patent/KR100430210B1/ko not_active Expired - Lifetime
- 2000-03-30 US US09/538,635 patent/US6476040B1/en not_active Expired - Lifetime
- 2000-03-30 NZ NZ503683A patent/NZ503683A/en not_active IP Right Cessation
- 2000-03-30 TR TR2000/00837A patent/TR200000837A2/xx unknown
- 2000-03-30 PE PE2000000277A patent/PE20001599A1/es not_active Application Discontinuation
- 2000-03-30 PL PL00339330A patent/PL339330A1/xx not_active Application Discontinuation
- 2000-03-30 CZ CZ20001155A patent/CZ299426B6/cs not_active IP Right Cessation
- 2000-03-30 GT GT200000037A patent/GT200000037A/es unknown
- 2000-03-30 SV SV2000000047A patent/SV2002000047A/es not_active Application Discontinuation
- 2000-03-30 NO NO20001648A patent/NO321952B1/no not_active IP Right Cessation
- 2000-03-30 EE EEP200000255A patent/EE04589B1/xx not_active IP Right Cessation
- 2000-03-30 EA EA200201245A patent/EA005892B1/ru not_active IP Right Cessation
- 2000-03-30 EA EA200201244A patent/EA005561B1/ru not_active IP Right Cessation
- 2000-03-31 HR HR20000182A patent/HRP20000182B1/xx not_active IP Right Cessation
- 2000-03-31 CN CNB2005100763600A patent/CN100351242C/zh not_active Expired - Lifetime
- 2000-03-31 GE GEAP20005284A patent/GEP20022653B/en unknown
- 2000-03-31 CN CNB001045954A patent/CN1215061C/zh not_active Expired - Lifetime
2002
- 2002-07-29 KR KR10-2002-0044610A patent/KR100430209B1/ko not_active Expired - Lifetime
- 2002-12-12 JP JP2002360742A patent/JP4074509B2/ja not_active Expired - Lifetime
2005
- 2005-04-08 AU AU2005201494A patent/AU2005201494B2/en not_active Expired
- 2005-10-13 NO NO20054715A patent/NO324745B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
GEP20022653B (en)	2002-03-25
NO324745B1 (no)	2007-12-03
TNSN00064A1 (fr)	2005-11-10
DZ3030A1 (fr)	2004-03-27
AP1655A (en)	2006-09-01
NO20001648L (no)	2000-10-02
JP2003176274A (ja)	2003-06-24
IS2468B (is)	2008-12-15
CZ20001155A3 (cs)	2001-03-14
EA200000274A3 (ru)	2003-02-27
NZ512818A (en)	2003-01-31
DE60032275T2 (de)	2007-07-12
CN1699350A (zh)	2005-11-23
BR0001486A (pt)	2001-05-02
CN1215061C (zh)	2005-08-17
GT200000037A (es)	2001-09-21
EP1044969B1 (en)	2006-12-13
KR20020084903A (ko)	2002-11-13
ZA200001586B (en)	2001-10-01
TR200000837A2 (tr)	2000-11-21
SV2002000047A (es)	2002-01-23
MA25087A1 (fr)	2000-10-01
AU781402B2 (en)	2005-05-19
CA2427221C (en)	2008-09-16
NO321952B1 (no)	2006-07-24
HRP20000182A2 (en)	2001-04-30
EA005892B1 (ru)	2005-06-30
US6476040B1 (en)	2002-11-05
YU13200A (sh)	2002-10-18
RS49836B (sr)	2008-08-07
UA70928C2 (uk)	2004-11-15
PA8491901A1 (es)	2001-12-14
CO5160273A1 (es)	2002-05-30
MY136270A (en)	2008-09-30
BG65194B1 (bg)	2007-06-29
BG104278A (en)	2001-08-31
CR6165A (es)	2008-10-10
ATE348098T1 (de)	2007-01-15
CZ299426B6 (cs)	2008-07-23
SG115536A1 (en)	2005-10-28
EA200000274A2 (ru)	2000-10-30
DE60032275D1 (de)	2007-01-25
EA200201245A1 (ru)	2003-04-24
CA2302965C (en)	2004-02-17
NO20054715L (no)	2000-10-02
BRPI0001486B8 (pt)	2021-05-25
ES2278578T3 (es)	2007-08-16
EA005561B1 (ru)	2005-04-28
IS5411A (is)	2000-10-02
ID25427A (id)	2000-10-05
EG22506A (en)	2003-03-31
EP1044969A2 (en)	2000-10-18
JP4074509B2 (ja)	2008-04-09
IL135245A0 (en)	2001-05-20
HUP0001353A3 (en)	2002-01-28
CN100351242C (zh)	2007-11-28
EP1044969A3 (en)	2000-11-29
HK1029790A1 (en)	2001-04-12
JP3420549B2 (ja)	2003-06-23
CN1276370A (zh)	2000-12-13
AU2005201494B2 (en)	2008-02-07
UA80955C2 (en)	2007-11-26
AU2005201494A1 (en)	2005-05-05
CA2427221A1 (en)	2000-09-30
NZ503683A (en)	2001-09-28
OA11335A (en)	2003-12-10
KR100430209B1 (ko)	2004-05-03
NO20001648D0 (no)	2000-03-30
KR100430210B1 (ko)	2004-05-03
PE20001599A1 (es)	2001-01-18
EA200201244A1 (ru)	2003-04-24
PL339330A1 (en)	2000-10-09
SK287339B6 (sk)	2010-07-07
SK4442000A3 (en)	2000-10-09
AP1265A (en)	2004-03-26
HRP20000182B1 (en)	2007-10-31
IL168036A (en)	2006-12-10
HUP0001353A2 (hu)	2001-05-28
DK1044969T3 (da)	2007-04-23
HU227698B1 (en)	2011-12-28
CA2302965A1 (en)	2000-09-30
BRPI0001486B1 (pt)	2019-01-29
KR20010014658A (ko)	2001-02-26
PT1044969E (pt)	2007-05-31
AP2000001778A0 (en)	2000-03-31
AU2262000A (en)	2000-10-05
EA004654B1 (ru)	2004-06-24
UY26086A1 (es)	2000-10-31
TW553939B (en)	2003-09-21
JP2000290262A (ja)	2000-10-17
SG121687A1 (en)	2006-05-26
AR018705A1 (es)	2001-11-28
HU0001353D0 (en)	2000-06-28
EE200000255A (et)	2000-12-15

Publication	Publication Date	Title
EE04589B1 (et)	2006-02-15	Vähivastaste ühendite valmistamise protsessid ja vaheühendid
NO20015017D0 (no)	2001-10-15	Fremgangsmåte for fremstilling av citalopram
NO20010318D0 (no)	2001-01-19	Fremgangsmåte for fremstilling av Citalopram
NO20010319L (no)	2001-02-23	Fremgangsmate for fremstilling av Citalopram
FI20000564A0 (fi)	2000-03-10	Menetelmä nanolaminaattien valmistamiseksi
PT1210113E (pt)	2006-07-31	Composicoes de vacinas de combinacao
NO20042680L (no)	2004-06-25	Fremgangsmater for fremstilling av O-demetylvenflaxine
NO20013369D0 (no)	2001-07-06	Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
EE200100259A (et)	2002-12-16	Moksifloksatsiini farmatseutiline preparaat
EE04747B1 (et)	2006-12-15	Amiini-plaatina komplekside valmistamismeetod
FI20011622A0 (fi)	2001-08-09	Menetelmä sitalopraamin valmistamiseksi
NO20013818L (no)	2001-10-03	Mikrobiell fremgangsmåte for fremstilling av pravastatin
NO20016151D0 (no)	2001-12-17	Fremstilling av substituerte piperidin-4-oner
NO20003454L (no)	2000-07-04	FremgangsmÕte for fremstilling av (-)cis-3-hydroksy-1-metyl-4-
NO996432D0 (no)	1999-12-23	Fremgangsmåte for fremstilling av 4-substituert-1H-indol-3- glykosamider
EE200000537A (et)	2001-06-15	Pürasolo[4,3-d]pürimidiin-7-oon-3-püridüülsulfonüülühendite ja nende vaheühendite valmistamise protsess
PT1175417E (pt)	2004-04-30	Compostos substituidos de benzolactamas
ITMI992048A0 (it)	1999-10-01	Procedimento stereoselettivo per la preparazione di endo-3-amminoazabi cicloalcani
DK1177165T3 (da)	2004-08-30	Fremgangsmåde til fremstilling af pesticidmellemprodukter
NO20022956D0 (no)	2002-06-19	Fremgangsmåte for fremstilling av nitroguanidin
NO20000805D0 (no)	2000-02-18	Fremgangsmåte for fremstilling av organiske azider
EE200100333A (et)	2002-08-15	Meetod 2-halo-3-nitro-4-aminopüridiini valmistamiseks ja selleks vajalike vaheühendite saamine
NO20020328D0 (no)	2002-01-22	Fremgangsmåte for fremstilling av 4-cyano-2-aminometyltiazol
NO20020327D0 (no)	2002-01-22	Fremgangsmåte for fremstilling av 2-aminometyl-4-cyano-tiazol
NO994557D0 (no)	1999-09-20	Fremgangsmaate for fremstilling av arylaminotriazolopyridiner

Legal Events

Date	Code	Title	Description
2004-12-15	GB1A	Change in the ownership or in the address of the owner
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20110330