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EE03083B1 - Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim - Google Patents

Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim

Info

Publication number
EE03083B1
EE03083B1 EE9400334A EE9400334A EE03083B1 EE 03083 B1 EE03083 B1 EE 03083B1 EE 9400334 A EE9400334 A EE 9400334A EE 9400334 A EE9400334 A EE 9400334A EE 03083 B1 EE03083 B1 EE 03083B1
Authority
EE
Estonia
Prior art keywords
alkyl
amino
renin
oxyethyl
inhibiting
Prior art date
Application number
EE9400334A
Other languages
English (en)
Inventor
Lavalle Pierre
Simoneau Bruno
Original Assignee
Boehringer Ingelheim (Canada) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim (Canada) Ltd. filed Critical Boehringer Ingelheim (Canada) Ltd.
Publication of EE03083B1 publication Critical patent/EE03083B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EE9400334A 1992-09-25 1994-11-23 Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim EE03083B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95147892A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
EE03083B1 true EE03083B1 (et) 1998-04-15

Family

ID=25491725

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400334A EE03083B1 (et) 1992-09-25 1994-11-23 Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim

Country Status (29)

Country Link
US (2) US5541163A (et)
EP (1) EP0589445B1 (et)
JP (1) JP3490442B2 (et)
KR (1) KR950703520A (et)
CN (1) CN1090278A (et)
AT (1) ATE147720T1 (et)
AU (1) AU680829B2 (et)
BG (1) BG99542A (et)
BR (1) BR9307110A (et)
CA (1) CA2143300C (et)
CO (1) CO4560549A1 (et)
CZ (1) CZ74895A3 (et)
DE (1) DE69307446T2 (et)
EE (1) EE03083B1 (et)
FI (1) FI951398L (et)
HU (2) HUT70432A (et)
IL (1) IL107092A (et)
LT (1) LT3072B (et)
LV (1) LV10945B (et)
MX (1) MX9305918A (et)
NO (1) NO951133L (et)
NZ (1) NZ255301A (et)
PH (1) PH30881A (et)
PL (1) PL174454B1 (et)
RU (1) RU95113586A (et)
SK (1) SK37695A3 (et)
TW (1) TW239117B (et)
WO (1) WO1994007846A1 (et)
ZA (1) ZA937079B (et)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007845A1 (en) * 1992-09-25 1994-04-14 Bio-Mega/Boehringer Ingelheim Research Inc. N-(hydroxyethyl)butanediamide derivatives as renin inhibitors
CA2165996C (en) * 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
US20050209141A1 (en) * 2003-10-17 2005-09-22 Silver Randi B Mast cell-derived renin
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en) 1986-11-12 1990-05-23 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (en) * 1987-10-14 1990-05-09 Merck & Co. Inc. Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
FI893212L (fi) * 1988-07-01 1990-01-02 Searle & Co Antihypertensiva aminoalkylaminokarbo- nylaminodiolaminsyraderivat.
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
EP0417698B1 (de) * 1989-09-12 1996-03-13 Hoechst Aktiengesellschaft Aminosäurederivate mit reninhemmenden Eigenschaften, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung
JPH0532602A (ja) * 1991-07-26 1993-02-09 Terumo Corp ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

Also Published As

Publication number Publication date
AU4940393A (en) 1994-04-26
ATE147720T1 (de) 1997-02-15
PL308180A1 (en) 1995-07-24
DE69307446T2 (de) 1997-05-15
HU211315A9 (en) 1995-11-28
NO951133D0 (no) 1995-03-24
WO1994007846A1 (en) 1994-04-14
CN1090278A (zh) 1994-08-03
HUT70432A (en) 1995-10-30
JP3490442B2 (ja) 2004-01-26
NZ255301A (en) 1997-05-26
TW239117B (et) 1995-01-21
BR9307110A (pt) 1999-03-30
AU680829B2 (en) 1997-08-14
MX9305918A (es) 1994-05-31
ZA937079B (en) 1994-06-06
LTIP1092A (en) 1994-05-15
BG99542A (bg) 1995-12-29
EP0589445B1 (en) 1997-01-15
US5541163A (en) 1996-07-30
RU95113586A (ru) 1997-01-10
CO4560549A1 (es) 1998-02-10
CA2143300A1 (en) 1994-04-14
CA2143300C (en) 1998-04-21
FI951398A7 (fi) 1995-03-24
NO951133L (no) 1995-05-24
DE69307446D1 (de) 1997-02-27
FI951398A0 (fi) 1995-03-24
FI951398L (fi) 1995-03-24
IL107092A0 (en) 1993-12-28
HU9500871D0 (en) 1995-05-29
CZ74895A3 (en) 1995-12-13
LT3072B (en) 1994-11-25
KR950703520A (ko) 1995-09-20
IL107092A (en) 1997-09-30
LV10945B (en) 1996-06-20
JPH08501567A (ja) 1996-02-20
LV10945A (lv) 1995-12-20
US5693619A (en) 1997-12-02
EP0589445A1 (en) 1994-03-30
PL174454B1 (pl) 1998-07-31
PH30881A (en) 1997-12-23
SK37695A3 (en) 1995-07-11

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