[go: up one dir, main page]

ZA937079B - Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives - Google Patents

Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives

Info

Publication number
ZA937079B
ZA937079B ZA937079A ZA937079A ZA937079B ZA 937079 B ZA937079 B ZA 937079B ZA 937079 A ZA937079 A ZA 937079A ZA 937079 A ZA937079 A ZA 937079A ZA 937079 B ZA937079 B ZA 937079B
Authority
ZA
South Africa
Prior art keywords
alkyl
amino
oxoethyl
cyclohexylmethyl
hydrogen
Prior art date
Application number
ZA937079A
Other languages
English (en)
Inventor
Pierre Lavalle
Bruno Simoneau
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of ZA937079B publication Critical patent/ZA937079B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ZA937079A 1992-09-25 1993-09-24 Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives ZA937079B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95147892A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
ZA937079B true ZA937079B (en) 1994-06-06

Family

ID=25491725

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA937079A ZA937079B (en) 1992-09-25 1993-09-24 Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives

Country Status (29)

Country Link
US (2) US5541163A (xx)
EP (1) EP0589445B1 (xx)
JP (1) JP3490442B2 (xx)
KR (1) KR950703520A (xx)
CN (1) CN1090278A (xx)
AT (1) ATE147720T1 (xx)
AU (1) AU680829B2 (xx)
BG (1) BG99542A (xx)
BR (1) BR9307110A (xx)
CA (1) CA2143300C (xx)
CO (1) CO4560549A1 (xx)
CZ (1) CZ74895A3 (xx)
DE (1) DE69307446T2 (xx)
EE (1) EE03083B1 (xx)
FI (1) FI951398A0 (xx)
HU (2) HUT70432A (xx)
IL (1) IL107092A (xx)
LT (1) LT3072B (xx)
LV (1) LV10945B (xx)
MX (1) MX9305918A (xx)
NO (1) NO951133L (xx)
NZ (1) NZ255301A (xx)
PH (1) PH30881A (xx)
PL (1) PL174454B1 (xx)
RU (1) RU95113586A (xx)
SK (1) SK37695A3 (xx)
TW (1) TW239117B (xx)
WO (1) WO1994007846A1 (xx)
ZA (1) ZA937079B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9307111A (pt) * 1992-09-25 1999-06-15 Boehringer Ingelheim Ca Ltd Derivados de n-(hidroxietil) butanodiamida como inibidores de renina
CA2165996C (en) * 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
WO2005037317A2 (en) * 2003-10-17 2005-04-28 Cornell Research Foundation, Inc. Mast cell-derived renin
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en) 1986-11-12 1990-05-23 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
EP0312283A3 (en) * 1987-10-14 1990-05-09 Merck & Co. Inc. Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
EP0349922A3 (en) * 1988-07-01 1991-08-21 G.D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
DE59010189D1 (de) * 1989-09-12 1996-04-18 Hoechst Ag Aminosäurederivate mit reninhemmenden Eigenschaften, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung
JPH0532602A (ja) * 1991-07-26 1993-02-09 Terumo Corp ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

Also Published As

Publication number Publication date
NO951133L (no) 1995-05-24
IL107092A (en) 1997-09-30
HU211315A9 (en) 1995-11-28
FI951398A7 (fi) 1995-03-24
IL107092A0 (en) 1993-12-28
FI951398L (fi) 1995-03-24
NZ255301A (en) 1997-05-26
CN1090278A (zh) 1994-08-03
LV10945B (en) 1996-06-20
US5541163A (en) 1996-07-30
BG99542A (bg) 1995-12-29
DE69307446T2 (de) 1997-05-15
PL308180A1 (en) 1995-07-24
US5693619A (en) 1997-12-02
CO4560549A1 (es) 1998-02-10
RU95113586A (ru) 1997-01-10
TW239117B (xx) 1995-01-21
LTIP1092A (en) 1994-05-15
DE69307446D1 (de) 1997-02-27
KR950703520A (ko) 1995-09-20
ATE147720T1 (de) 1997-02-15
BR9307110A (pt) 1999-03-30
PH30881A (en) 1997-12-23
HUT70432A (en) 1995-10-30
CA2143300C (en) 1998-04-21
JP3490442B2 (ja) 2004-01-26
FI951398A0 (fi) 1995-03-24
AU680829B2 (en) 1997-08-14
MX9305918A (es) 1994-05-31
EE03083B1 (et) 1998-04-15
WO1994007846A1 (en) 1994-04-14
PL174454B1 (pl) 1998-07-31
JPH08501567A (ja) 1996-02-20
EP0589445A1 (en) 1994-03-30
HU9500871D0 (en) 1995-05-29
NO951133D0 (no) 1995-03-24
AU4940393A (en) 1994-04-26
CZ74895A3 (en) 1995-12-13
SK37695A3 (en) 1995-07-11
EP0589445B1 (en) 1997-01-15
LV10945A (lv) 1995-12-20
CA2143300A1 (en) 1994-04-14
LT3072B (en) 1994-11-25

Similar Documents

Publication Publication Date Title
IL135537A0 (en) Substituted fused heterocyclic compounds
EP0628311A4 (en) ANTIDEPRESSOR.
NO159656C (no) Analogifremgangsm te til fremstilling av terapeutisk aktive karbapenemderivater.
AU5577598A (en) Pyrrolidine derivatives having phospholipase a2 inhibitory activity
ZA937079B (en) Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives
AU7624394A (en) Optically active imidazolidinone derivative and process for producing the same
TW221429B (xx)
AU4187996A (en) Thiazolidinone compounds or angina pectoris remedy or preventive containing the same as active ingredient
HU9500872D0 (en) N-(hydroxyethyl)butanediamide derivatives as renin inhibitors
PH24636A (en) Method of treating heart failure
ATE201877T1 (de) Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel
IE900585L (en) Peptides having renin inhibitory activity, their preparation¹and use
MX9703363A (es) Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano.
CA2058603A1 (en) Renin Inhibiting Polyhydroxymonoamides