NO951133L - Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater - Google Patents

Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater

Info

Publication number: NO951133L
Authority: NO; Norway
Prior art keywords: amino; renin; oxoethyl; inhibiting; alkyl
Prior art date: 1992-09-25

Application number

NO951133A

Other languages

English (en)

Norwegian (no)

Other versions

NO951133D0 (no

Inventor

Pierre Lavallee

Bruno Simoneau

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1995-03-24

Publication date

1995-05-24

1995-03-24 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-03-24 Publication of NO951133D0 publication Critical patent/NO951133D0/no

1995-05-24 Publication of NO951133L publication Critical patent/NO951133L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

NO951133A 1992-09-25 1995-03-24 Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater NO951133L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95147892A	1992-09-25	1992-09-25
PCT/CA1993/000380 WO1994007846A1 (en)	1992-09-25	1993-09-15	Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives

Publications (2)

Publication Number	Publication Date
NO951133D0 NO951133D0 (no)	1995-03-24
NO951133L true NO951133L (no)	1995-05-24

Family

ID=25491725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951133A NO951133L (no)	1992-09-25	1995-03-24	Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater

Country Status (29)

Country	Link
US (2)	US5541163A (et)
EP (1)	EP0589445B1 (et)
JP (1)	JP3490442B2 (et)
KR (1)	KR950703520A (et)
CN (1)	CN1090278A (et)
AT (1)	ATE147720T1 (et)
AU (1)	AU680829B2 (et)
BG (1)	BG99542A (et)
BR (1)	BR9307110A (et)
CA (1)	CA2143300C (et)
CO (1)	CO4560549A1 (et)
CZ (1)	CZ74895A3 (et)
DE (1)	DE69307446T2 (et)
EE (1)	EE03083B1 (et)
FI (1)	FI951398L (et)
HU (2)	HUT70432A (et)
IL (1)	IL107092A (et)
LT (1)	LT3072B (et)
LV (1)	LV10945B (et)
MX (1)	MX9305918A (et)
NO (1)	NO951133L (et)
NZ (1)	NZ255301A (et)
PH (1)	PH30881A (et)
PL (1)	PL174454B1 (et)
RU (1)	RU95113586A (et)
SK (1)	SK37695A3 (et)
TW (1)	TW239117B (et)
WO (1)	WO1994007846A1 (et)
ZA (1)	ZA937079B (et)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994007845A1 (en) *	1992-09-25	1994-04-14	Bio-Mega/Boehringer Ingelheim Research Inc.	N-(hydroxyethyl)butanediamide derivatives as renin inhibitors
CA2165996C (en) *	1995-12-22	2002-01-29	Murray Douglas Bailey	Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) *	1997-09-19	2000-08-01	Georgetown University	Method for treating essential hypertension
US20050209141A1 (en) *	2003-10-17	2005-09-22	Silver Randi B	Mast cell-derived renin
US10517839B2 (en) *	2008-06-09	2019-12-31	Cornell University	Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en)	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US5006511A (en) *	1981-10-14	1991-04-09	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en)	1986-11-12	1990-05-23	Merck & Co. Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en)	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (en) *	1987-10-14	1990-05-09	Merck & Co. Inc.	Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5001113A (en)	1987-10-14	1991-03-19	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) *	1987-11-23	1994-05-17	Harold Norris Weller, Iii	N-heterocyclic alcohol derivatives
FI893212L (fi) *	1988-07-01	1990-01-02	Searle & Co	Antihypertensiva aminoalkylaminokarbo- nylaminodiolaminsyraderivat.
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
EP0417698B1 (de) *	1989-09-12	1996-03-13	Hoechst Aktiengesellschaft	Aminosäurederivate mit reninhemmenden Eigenschaften, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung
JPH0532602A (ja) *	1991-07-26	1993-02-09	Terumo Corp	ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

1993
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 FI FI951398A patent/FI951398L/fi not_active Application Discontinuation
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/et unknown
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU4940393A (en)	1994-04-26
ATE147720T1 (de)	1997-02-15
PL308180A1 (en)	1995-07-24
DE69307446T2 (de)	1997-05-15
HU211315A9 (en)	1995-11-28
NO951133D0 (no)	1995-03-24
WO1994007846A1 (en)	1994-04-14
CN1090278A (zh)	1994-08-03
HUT70432A (en)	1995-10-30
JP3490442B2 (ja)	2004-01-26
NZ255301A (en)	1997-05-26
TW239117B (et)	1995-01-21
BR9307110A (pt)	1999-03-30
AU680829B2 (en)	1997-08-14
MX9305918A (es)	1994-05-31
ZA937079B (en)	1994-06-06
LTIP1092A (en)	1994-05-15
BG99542A (bg)	1995-12-29
EP0589445B1 (en)	1997-01-15
US5541163A (en)	1996-07-30
RU95113586A (ru)	1997-01-10
CO4560549A1 (es)	1998-02-10
CA2143300A1 (en)	1994-04-14
CA2143300C (en)	1998-04-21
FI951398A7 (fi)	1995-03-24
DE69307446D1 (de)	1997-02-27
FI951398A0 (fi)	1995-03-24
FI951398L (fi)	1995-03-24
IL107092A0 (en)	1993-12-28
EE03083B1 (et)	1998-04-15
HU9500871D0 (en)	1995-05-29
CZ74895A3 (en)	1995-12-13
LT3072B (en)	1994-11-25
KR950703520A (ko)	1995-09-20
IL107092A (en)	1997-09-30
LV10945B (en)	1996-06-20
JPH08501567A (ja)	1996-02-20
LV10945A (lv)	1995-12-20
US5693619A (en)	1997-12-02
EP0589445A1 (en)	1994-03-30
PL174454B1 (pl)	1998-07-31
PH30881A (en)	1997-12-23
SK37695A3 (en)	1995-07-11

Publication	Publication Date	Title
NO986055D0 (no)	1998-12-22	Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
IL193244A0 (en)	2009-02-11	Amine derivatives useul for the synthesis of ceramide-like compounds and methods utilizing the same
AU6216686A (en)	1987-03-12	Heterocyclic-substituted indole
AU7607791A (en)	1991-11-14	4-(Piperazinyl, morpholinyl, or thiomorpholinyl) sulphonyl derivatives used as renin inhibitors, compositions and processes for their production
MX9800718A (es)	1998-04-30	Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida.
NO951133L (no)	1995-05-24	Renin-inhiberende N-(2-amino-2-oksoetyl)butan-diamidderivater
NO982927L (no)	1998-06-23	Biologisk aktive benzotiazolon etanaminer
DK491089D0 (da)	1989-10-05	Benzoxazepinon og fremgangsmaade til fremstilling deraf samt mellemprodukt til brug i fremgangsmaaden
NO941073L (no)	1994-09-27	Fenylglycinamid av heterocykliske, substituerte fenyleddiksyrederivater
AU718659B2 (en)	2000-04-20	Thiazole derivatives
NZ240404A (en)	1994-02-25	Oxysulphonyl (thio)carbamate derivatives and pharmaceutical
HU9500872D0 (en)	1995-05-29	N-(hydroxyethyl)butanediamide derivatives as renin inhibitors
FI953618A0 (fi)	1995-07-28	Kondensoituneita heterosyklisiä glutamiinijohdannaisia antiproliferatiivisina aineina
NO893039D0 (no)	1989-07-26	Bruk av imidazopyrazol-derivater som analgesiske og antiinflammatoriske midler.
DE3788955D1 (de)	1994-03-10	Pyridinyl-Derivate von 2-Aminoacetamid.
WO1996017843A3 (en)	1996-08-22	Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives