ECSP20029142A - Ligandos de psma para la formación de imágenes y endorradioterapia - Google Patents
Ligandos de psma para la formación de imágenes y endorradioterapiaInfo
- Publication number
- ECSP20029142A ECSP20029142A ECSENADI202029142A ECDI202029142A ECSP20029142A EC SP20029142 A ECSP20029142 A EC SP20029142A EC SENADI202029142 A ECSENADI202029142 A EC SENADI202029142A EC DI202029142 A ECDI202029142 A EC DI202029142A EC SP20029142 A ECSP20029142 A EC SP20029142A
- Authority
- EC
- Ecuador
- Prior art keywords
- psma
- imaging
- endorradiotherapy
- links
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nuclear Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente divulgación se refiere a la formación de imágenes y endorradioterapia de enfermedades que implican antígeno de membrana específico de próstata (PSMA). Se proporcionan compuestos que unen o inhiben PSMA y adicionalmente llevan al menos una fracción que es susceptible de radiomarcaje. También se porporcionan usos médicos de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17206510 | 2017-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20029142A true ECSP20029142A (es) | 2020-09-30 |
Family
ID=60654872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202029142A ECSP20029142A (es) | 2017-12-11 | 2020-06-03 | Ligandos de psma para la formación de imágenes y endorradioterapia |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US11497819B2 (es) |
| EP (3) | EP4464341A3 (es) |
| JP (3) | JP7317375B2 (es) |
| KR (1) | KR102815791B1 (es) |
| CN (2) | CN116617421A (es) |
| AU (2) | AU2018382479B2 (es) |
| BR (1) | BR112020011727A2 (es) |
| CA (1) | CA3078104A1 (es) |
| CL (1) | CL2020001542A1 (es) |
| CR (1) | CR20200241A (es) |
| CU (1) | CU24677B1 (es) |
| CY (1) | CY1125376T1 (es) |
| DK (2) | DK3723815T3 (es) |
| EC (1) | ECSP20029142A (es) |
| ES (2) | ES2997266T3 (es) |
| FI (1) | FI4008359T3 (es) |
| HR (2) | HRP20241453T1 (es) |
| HU (2) | HUE069034T2 (es) |
| IL (3) | IL274072B2 (es) |
| JO (1) | JOP20200135A1 (es) |
| LT (2) | LT4008359T (es) |
| MX (2) | MX2020005430A (es) |
| PE (1) | PE20210456A1 (es) |
| PL (1) | PL3723815T3 (es) |
| PT (2) | PT3723815T (es) |
| RS (2) | RS66086B1 (es) |
| SG (1) | SG11202002965WA (es) |
| SI (2) | SI3723815T1 (es) |
| SM (1) | SMT202400439T1 (es) |
| TN (1) | TN2020000072A1 (es) |
| UA (1) | UA126413C2 (es) |
| WO (1) | WO2019115547A1 (es) |
| ZA (1) | ZA202003472B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3658194T3 (pl) * | 2017-07-28 | 2025-09-15 | Technische Universität München | Radioznacznik i środki radioterapeutyczne o podwójnym trybie działania |
| PT3723815T (pt) * | 2017-12-11 | 2022-05-30 | Univ Muenchen Tech | Ligandos psma para imagiologia e endorradioterapia |
| US12377176B2 (en) * | 2019-01-30 | 2025-08-05 | Technische Universität München | Cancer diagnostic imaging agents |
| CA3128401A1 (en) * | 2019-01-30 | 2020-08-06 | Technische Universitat Munchen | Psma binding dual mode radiotracer and -therapeutics |
| CA3136979A1 (en) | 2019-04-17 | 2020-10-22 | Provincial Health Services Authority | Radiolabelled compounds for diagnosis or treatment of prostate-spe cific membrane antigen-expressing cancer |
| KR20220024595A (ko) | 2019-06-21 | 2022-03-03 | 프로빈셜 헬스 서비시즈 오쏘리티 | 전립선-특이적 막 항원을 표적으로 하는 방사성표지 화합물 |
| CN112321673B (zh) * | 2020-11-04 | 2022-09-20 | 北京市肿瘤防治研究所 | 一种前列腺特异性膜抗原靶向抑制剂及应用和探针 |
| CN113354707A (zh) * | 2021-06-07 | 2021-09-07 | 苏州思萃同位素技术研究所有限公司 | 一种针对前列腺癌的三功能诊疗一体化药物前体的合成方法及其产品 |
| WO2023173074A2 (en) * | 2022-03-10 | 2023-09-14 | The Research Foundation For The State University Of New York | Immunostimulant-cytotoxic conjugate composition and methods for cancer treatment |
| CN115010629B (zh) * | 2022-06-07 | 2024-02-23 | 西南医科大学附属医院 | 前列腺特异性膜抗原抑制剂、其核素标记物及制法和应用 |
| CN120282804A (zh) | 2022-09-23 | 2025-07-08 | 核素迪姆股份公司 | 高纯度铜放射性药物组合物及其诊断和治疗用途 |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| WO2025022285A2 (en) | 2023-07-21 | 2025-01-30 | Novartis Ag | Psma-targeting radioligand treatment regimen |
| JP2025538914A (ja) | 2023-07-31 | 2025-12-03 | キュリウム ユーエス エルエルシー | ［１７７ｌｕ］ルテチウム－ｐｓｍａ ｉ＆ｔ組成物及び線量測定、キット、それを作製する方法、並びにそれを使用する方法 |
| WO2025147677A1 (en) * | 2024-01-05 | 2025-07-10 | Point Biopharma, Inc. | Preparation of psma-targeted radiopharmaceutical |
| CN119101006B (zh) * | 2024-09-05 | 2025-11-07 | 西南医科大学附属医院 | 前列腺特异性膜抗原抑制剂、其放射性标记物及制法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1888581A2 (en) | 2005-05-16 | 2008-02-20 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| HRP20171133T1 (hr) * | 2008-08-01 | 2017-10-20 | The Johns Hopkins University | Psma-vezujući agensi i njihove uporabe |
| WO2010135431A2 (en) * | 2009-05-19 | 2010-11-25 | The Regents Of The University Of California | Compositions, devices, and methods related to prostate-specific membrane antigen |
| EP3415489A1 (en) * | 2013-10-18 | 2018-12-19 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| CA2950892C (en) | 2014-05-06 | 2023-10-24 | The Johns Hopkins University | Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy |
| US10688200B2 (en) | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| DK3925952T3 (da) | 2016-03-22 | 2024-02-05 | Univ Johns Hopkins | Prostataspecifik membranantigen-målrettede højaffinitetsmidler til endoradioterapi af prostatacancer / Prostate-Specific Membrane Antigen Targeted High-Affinity Agents For Endoradiotherapy Of Prostate Cancer |
| PT3723815T (pt) | 2017-12-11 | 2022-05-30 | Univ Muenchen Tech | Ligandos psma para imagiologia e endorradioterapia |
| CN111683934B (zh) | 2017-12-11 | 2024-01-23 | 赫尔森保健股份公司 | (r)-3-(1-(2,3-二氯-4-(吡嗪-2-基)苯基)-2,2,2-三氟乙基)-1-甲基-1-(1-甲基哌啶-4-基)脲的延胡索酸盐、制备方法及其用途 |
| TW201930265A (zh) | 2017-12-11 | 2019-08-01 | 西班牙商阿爾米雷爾有限公司 | 作為acc抑制劑的吡咯衍生物 |
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2018
- 2018-12-11 PT PT188122154T patent/PT3723815T/pt unknown
- 2018-12-11 CR CR20200241A patent/CR20200241A/es unknown
- 2018-12-11 IL IL274072A patent/IL274072B2/en unknown
- 2018-12-11 UA UAA202003533A patent/UA126413C2/uk unknown
- 2018-12-11 HR HRP20241453TT patent/HRP20241453T1/hr unknown
- 2018-12-11 DK DK18812215.4T patent/DK3723815T3/da active
- 2018-12-11 PL PL18812215.4T patent/PL3723815T3/pl unknown
- 2018-12-11 WO PCT/EP2018/084399 patent/WO2019115547A1/en not_active Ceased
- 2018-12-11 EP EP24198677.7A patent/EP4464341A3/en active Pending
- 2018-12-11 DK DK21218180.4T patent/DK4008359T3/da active
- 2018-12-11 HU HUE21218180A patent/HUE069034T2/hu unknown
- 2018-12-11 KR KR1020207014036A patent/KR102815791B1/ko active Active
- 2018-12-11 JP JP2020526146A patent/JP7317375B2/ja active Active
- 2018-12-11 CN CN202310801735.3A patent/CN116617421A/zh active Pending
- 2018-12-11 MX MX2020005430A patent/MX2020005430A/es unknown
- 2018-12-11 AU AU2018382479A patent/AU2018382479B2/en active Active
- 2018-12-11 CU CU2020000052A patent/CU24677B1/es unknown
- 2018-12-11 RS RS20241176A patent/RS66086B1/sr unknown
- 2018-12-11 ES ES21218180T patent/ES2997266T3/es active Active
- 2018-12-11 SI SI201830691T patent/SI3723815T1/sl unknown
- 2018-12-11 HU HUE18812215A patent/HUE059083T2/hu unknown
- 2018-12-11 CN CN201880056196.2A patent/CN111182927B/zh active Active
- 2018-12-11 EP EP21218180.4A patent/EP4008359B1/en active Active
- 2018-12-11 IL IL319022A patent/IL319022A/en unknown
- 2018-12-11 LT LTEP21218180.4T patent/LT4008359T/lt unknown
- 2018-12-11 ES ES18812215T patent/ES2914832T3/es active Active
- 2018-12-11 IL IL313103A patent/IL313103B2/en unknown
- 2018-12-11 TN TNP/2020/000072A patent/TN2020000072A1/en unknown
- 2018-12-11 RS RS20220527A patent/RS63279B1/sr unknown
- 2018-12-11 FI FIEP21218180.4T patent/FI4008359T3/fi active
- 2018-12-11 LT LTEPPCT/EP2018/084399T patent/LT3723815T/lt unknown
- 2018-12-11 SM SM20240439T patent/SMT202400439T1/it unknown
- 2018-12-11 BR BR112020011727-7A patent/BR112020011727A2/pt unknown
- 2018-12-11 PE PE2020000552A patent/PE20210456A1/es unknown
- 2018-12-11 CA CA3078104A patent/CA3078104A1/en active Pending
- 2018-12-11 EP EP18812215.4A patent/EP3723815B1/en active Active
- 2018-12-11 HR HRP20220764TT patent/HRP20220764T1/hr unknown
- 2018-12-11 PT PT212181804T patent/PT4008359T/pt unknown
- 2018-12-11 SI SI201831155T patent/SI4008359T1/sl unknown
- 2018-12-11 JO JOP/2020/0135A patent/JOP20200135A1/ar unknown
- 2018-12-11 US US16/765,729 patent/US11497819B2/en active Active
- 2018-12-11 SG SG11202002965WA patent/SG11202002965WA/en unknown
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2020
- 2020-06-03 EC ECSENADI202029142A patent/ECSP20029142A/es unknown
- 2020-06-10 ZA ZA2020/03472A patent/ZA202003472B/en unknown
- 2020-06-10 CL CL2020001542A patent/CL2020001542A1/es unknown
- 2020-07-13 MX MX2023005053A patent/MX2023005053A/es unknown
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2022
- 2022-07-15 US US17/866,034 patent/US20230122957A1/en active Pending
- 2022-07-20 CY CY20221100496T patent/CY1125376T1/el unknown
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2023
- 2023-07-11 JP JP2023113523A patent/JP7572080B2/ja active Active
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2024
- 2024-10-03 JP JP2024173980A patent/JP2025011169A/ja active Pending
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2025
- 2025-02-07 AU AU2025200837A patent/AU2025200837A1/en active Pending
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