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SV2019005838A - Derivado de triazolopirazinona útil como un inhibidor de pde1 humana - Google Patents

Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Info

Publication number
SV2019005838A
SV2019005838A SV2019005838A SV2019005838A SV2019005838A SV 2019005838 A SV2019005838 A SV 2019005838A SV 2019005838 A SV2019005838 A SV 2019005838A SV 2019005838 A SV2019005838 A SV 2019005838A SV 2019005838 A SV2019005838 A SV 2019005838A
Authority
SV
El Salvador
Prior art keywords
triazolopirazinone
derived
useful
pde1 inhibitor
human pde1
Prior art date
Application number
SV2019005838A
Other languages
English (en)
Inventor
Mark David Rekhter
Qing Shi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2019005838A publication Critical patent/SV2019005838A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA I: (VER FÓRMULA) O UNA SAL DEL MISMO FARMACÉUTICAMENTE ACEPTABLE, PARA USO COMO UN INHIBIDOR DE PDE1 HUMANA.
SV2019005838A 2016-08-25 2019-02-19 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana SV2019005838A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662379372P 2016-08-25 2016-08-25

Publications (1)

Publication Number Publication Date
SV2019005838A true SV2019005838A (es) 2019-04-04

Family

ID=59762063

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2019005838A SV2019005838A (es) 2016-08-25 2019-02-19 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Country Status (37)

Country Link
US (1) US10138244B2 (es)
EP (1) EP3504208B1 (es)
JP (1) JP6633246B2 (es)
KR (1) KR20190028544A (es)
CN (1) CN109641902B (es)
AR (1) AR109328A1 (es)
AU (1) AU2017317111A1 (es)
BR (1) BR112019000988A2 (es)
CA (1) CA3034828A1 (es)
CL (1) CL2019000487A1 (es)
CO (1) CO2019001644A2 (es)
CR (1) CR20190078A (es)
CY (1) CY1123406T1 (es)
DK (1) DK3504208T3 (es)
DO (1) DOP2019000021A (es)
EA (1) EA201990313A1 (es)
EC (1) ECSP19013196A (es)
ES (1) ES2800433T3 (es)
HR (1) HRP20201187T1 (es)
HU (1) HUE050419T2 (es)
JO (1) JOP20170164A1 (es)
LT (1) LT3504208T (es)
MA (1) MA46039B1 (es)
MD (1) MD3504208T2 (es)
ME (1) ME03791B (es)
MX (1) MX2019002065A (es)
PE (1) PE20190452A1 (es)
PH (1) PH12019500370A1 (es)
PL (1) PL3504208T3 (es)
PT (1) PT3504208T (es)
RS (1) RS60442B1 (es)
SG (1) SG11201901311WA (es)
SI (1) SI3504208T1 (es)
SV (1) SV2019005838A (es)
TN (1) TN2019000038A1 (es)
TW (1) TWI651323B (es)
WO (1) WO2018039051A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112457A1 (es) * 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
US20220280517A1 (en) * 2019-08-22 2022-09-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2025059641A1 (en) 2023-09-14 2025-03-20 Eli Lilly And Company Pde1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
ES2599054T3 (es) * 2006-12-13 2017-01-31 Aska Pharmaceutical Co., Ltd. Derivados de quinoxalina
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
CA2810659A1 (en) 2010-09-07 2012-03-15 Astellas Pharma Inc. Quinoxaline compound
IN2015DN00334A (es) 2012-06-18 2015-06-12 Dart Neuroscience Cayman Ltd
US9938284B2 (en) * 2014-08-07 2018-04-10 Intra-Cellular Therapies, Inc. Organic compounds
US20160083400A1 (en) * 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
AR107456A1 (es) 2016-02-12 2018-05-02 Lilly Co Eli Inhibidor de pde1

Also Published As

Publication number Publication date
PH12019500370A1 (en) 2019-10-21
CL2019000487A1 (es) 2019-07-12
RS60442B1 (sr) 2020-07-31
HUE050419T2 (hu) 2020-12-28
CR20190078A (es) 2019-04-05
TWI651323B (zh) 2019-02-21
ECSP19013196A (es) 2019-03-29
AU2017317111A1 (en) 2019-01-31
CY1123406T1 (el) 2021-12-31
US20180057494A1 (en) 2018-03-01
EA201990313A1 (ru) 2019-07-31
AR109328A1 (es) 2018-11-21
PL3504208T3 (pl) 2020-11-16
EP3504208B1 (en) 2020-06-10
US10138244B2 (en) 2018-11-27
ES2800433T3 (es) 2020-12-30
TW201819379A (zh) 2018-06-01
SG11201901311WA (en) 2019-03-28
PE20190452A1 (es) 2019-03-29
CA3034828A1 (en) 2018-03-01
MX2019002065A (es) 2019-06-03
PT3504208T (pt) 2020-08-31
ME03791B (me) 2021-04-20
MA46039B1 (fr) 2020-09-30
LT3504208T (lt) 2020-08-10
JP2019526567A (ja) 2019-09-19
HRP20201187T1 (hr) 2020-11-13
CN109641902A (zh) 2019-04-16
DOP2019000021A (es) 2019-02-28
JP6633246B2 (ja) 2020-01-22
WO2018039051A1 (en) 2018-03-01
TN2019000038A1 (en) 2020-07-15
SI3504208T1 (sl) 2020-08-31
CN109641902B (zh) 2021-06-08
CO2019001644A2 (es) 2019-05-21
MD3504208T2 (ro) 2020-08-31
BR112019000988A2 (pt) 2019-05-14
KR20190028544A (ko) 2019-03-18
DK3504208T3 (da) 2020-07-27
JOP20170164A1 (ar) 2019-01-30
EP3504208A1 (en) 2019-07-03

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