ECSP18006878A - Proteínas inhibidoras de insectos novedosas - Google Patents
Proteínas inhibidoras de insectos novedosasInfo
- Publication number
- ECSP18006878A ECSP18006878A ECIEPI20186878A ECPI201806878A ECSP18006878A EC SP18006878 A ECSP18006878 A EC SP18006878A EC IEPI20186878 A ECIEPI20186878 A EC IEPI20186878A EC PI201806878 A ECPI201806878 A EC PI201806878A EC SP18006878 A ECSP18006878 A EC SP18006878A
- Authority
- EC
- Ecuador
- Prior art keywords
- tic5290
- nucleic acid
- recombinant nucleic
- lepidopteran
- methods
- Prior art date
Links
- 241000238631 Hexapoda Species 0.000 title 1
- 108091006086 inhibitor proteins Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 241000258937 Hemiptera Species 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/22—Bacillus
- A01N63/23—B. thuringiensis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Insects & Arthropods (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Botany (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Se describe una clase de proteína pesticida que presenta actividad tóxica contra especies de plagas de coleópteros, lepidópteros y hemípteros, e incluye, entre otros, TIC5290. Se proporcionan construcciones de ADN que contienen una secuencia de ácido nucleico recombinante que codifica TIC5290. Se proporcionan plantas, células de plantas, semillas y partes de plantas transgénicas que contienen secuencias de ácido nucleico recombinante que codifican TIC5290. También se proporcionan métodos para detectar la presencia de las secuencias de ácido nucleico recombinante o TIC5290 en una muestra biológica, y métodos para controlar plagas de especies de coleópteros, lepidópteros y hemípteros que utilizan TIC5290.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199024P | 2015-07-30 | 2015-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18006878A true ECSP18006878A (es) | 2018-04-30 |
Family
ID=57885446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI20186878A ECSP18006878A (es) | 2015-07-30 | 2018-01-29 | Proteínas inhibidoras de insectos novedosas |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10100330B2 (es) |
| EP (1) | EP3328187B1 (es) |
| JP (1) | JP6933641B2 (es) |
| CN (1) | CN107849571B (es) |
| AR (1) | AR105768A1 (es) |
| BR (1) | BR112018001379B1 (es) |
| CA (1) | CA2992084A1 (es) |
| CL (1) | CL2018000227A1 (es) |
| CO (1) | CO2018000801A2 (es) |
| CR (1) | CR20180060A (es) |
| EC (1) | ECSP18006878A (es) |
| ES (1) | ES2904255T3 (es) |
| HR (1) | HRP20211858T1 (es) |
| HU (1) | HUE057364T2 (es) |
| MX (1) | MX378742B (es) |
| NI (1) | NI201800013A (es) |
| PE (1) | PE20180775A1 (es) |
| RU (1) | RU2765310C2 (es) |
| SV (1) | SV2018005620A (es) |
| UA (1) | UA126327C2 (es) |
| WO (1) | WO2017019787A1 (es) |
| ZA (1) | ZA201800227B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211858T1 (hr) * | 2015-07-30 | 2022-03-04 | Monsanto Technology, Llc | Novi proteini za inhibiciju insekata |
| CR20240410A (es) * | 2016-10-10 | 2024-11-08 | Monsanto Technology Llc | PROTEÍNAS INHIBIDORAS DE INSECTOS NOVEDOSAS (Divisional Exp. 2019-0221) |
| CN111148432B (zh) * | 2017-10-02 | 2021-11-23 | 先正达参股股份有限公司 | 工程化的杀有害生物蛋白和控制植物有害生物的方法 |
| BR112020012763A2 (pt) * | 2017-12-22 | 2020-12-15 | AgBiome, Inc. | Genes pesticidas e métodos de uso |
| CR20210149A (es) * | 2018-09-25 | 2021-06-24 | Monsanto Technology Llc | Proteínas inhibidoras de insectos novedosas |
| CR20220534A (es) | 2020-04-24 | 2023-02-17 | Monsanto Technology Llc | Evento de maíz transgénico mon95275, métodos para su detección y usos de este |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849870A (en) * | 1993-03-25 | 1998-12-15 | Novartis Finance Corporation | Pesticidal proteins and strains |
| EP0938562A2 (en) * | 1996-10-30 | 1999-09-01 | Mycogen Corporation | Pesticidal toxins and nucleotide sequences which encode these toxins |
| US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
| US7304162B2 (en) * | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| MXPA06000293A (es) * | 2003-07-07 | 2006-04-07 | Monsanto Technology Llc | Proteinas insecticidas secretadas a partir de bacillus thuringiensis y usos para las mismas. |
| DE602004030044D1 (de) * | 2003-12-16 | 2010-12-23 | Monsanto Technology Llc | Bacillus thuringiensis und deren verwendungen |
| EP1818405B2 (en) | 2004-04-09 | 2025-03-19 | Monsanto Technology, LLC | Compositions and methods for control of insect infestations in plants |
| US9121035B2 (en) * | 2005-08-31 | 2015-09-01 | Monsanto Technology Llc | Insecticidal compositions and methods for making insect-resistant transgenic plants |
| US7521235B2 (en) | 2006-07-21 | 2009-04-21 | Pioneer Hi-Bred International, Inc. | Unique novel Bacillus thuringiensis gene with Lepidopteran activity |
| CL2007002136A1 (es) | 2006-07-21 | 2008-03-14 | Pioneer Hi Bred Int | Acido nucleico de bacillus thuringiensis que codifican polipeptidos con actividad plaguicida; construccion de adn y celula huesped que lo comprenden; metodo de proteccion de una planta contra una plaga; polipeptidos y metodo de produccion; y composic |
| US7772465B2 (en) | 2007-06-26 | 2010-08-10 | Pioneer Hi-Bred International, Inc. | Bacillus thuringiensis gene with lepidopteran activity |
| US8283524B2 (en) | 2008-05-15 | 2012-10-09 | Pioneer Hi-Bred International, Inc | Bacillus thuringiensis gene with lepidopteran activity |
| CA2727614A1 (en) | 2008-06-11 | 2009-12-17 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| US8445749B2 (en) | 2008-09-19 | 2013-05-21 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
| US20100077507A1 (en) | 2008-09-22 | 2010-03-25 | Pioneer Hi-Bred International, Inc. | Novel Bacillus Thuringiensis Gene with Lepidopteran Activity |
| CA2749298C (en) | 2009-01-23 | 2018-02-13 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| AR075634A1 (es) * | 2009-02-27 | 2011-04-20 | Athenix Corp | Proteinas pesticidas y metodos de uso de las mismas |
| CA2780540A1 (en) | 2009-11-12 | 2011-05-19 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| WO2011084324A2 (en) | 2009-12-21 | 2011-07-14 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| CN103154247A (zh) | 2010-08-19 | 2013-06-12 | 先锋国际良种公司 | 对鳞翅目昆虫具有活性的新苏云金杆菌基因 |
| US8822762B2 (en) | 2010-12-28 | 2014-09-02 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
| WO2012109430A2 (en) * | 2011-02-11 | 2012-08-16 | Monsanto Technology Llc | Pesticidal nucleic acids and proteins and uses thereof |
| US9238678B2 (en) | 2011-04-07 | 2016-01-19 | Monsanto Technology Llc | Insect inhibitory toxin family active against hemipteran and/or lepidopteran insects |
| US20130227743A1 (en) * | 2011-08-19 | 2013-08-29 | Christopher J. Grandlic | Integrated method for high-throughput identification of novel pesticidal compositions and uses therefor |
| AR097292A1 (es) * | 2013-08-09 | 2016-03-02 | Monsanto Technology Llc | Toxina pesticida activa contra insectos coleópteros y/o hemípteros |
| HRP20211858T1 (hr) * | 2015-07-30 | 2022-03-04 | Monsanto Technology, Llc | Novi proteini za inhibiciju insekata |
-
2016
- 2016-07-27 HR HRP20211858TT patent/HRP20211858T1/hr unknown
- 2016-07-27 EP EP16831304.7A patent/EP3328187B1/en active Active
- 2016-07-27 RU RU2018107162A patent/RU2765310C2/ru active
- 2016-07-27 MX MX2018001258A patent/MX378742B/es unknown
- 2016-07-27 CN CN201680043100.XA patent/CN107849571B/zh active Active
- 2016-07-27 CA CA2992084A patent/CA2992084A1/en active Pending
- 2016-07-27 BR BR112018001379-0A patent/BR112018001379B1/pt active IP Right Grant
- 2016-07-27 PE PE2018000135A patent/PE20180775A1/es unknown
- 2016-07-27 US US15/221,544 patent/US10100330B2/en active Active
- 2016-07-27 UA UAA201802018A patent/UA126327C2/uk unknown
- 2016-07-27 HU HUE16831304A patent/HUE057364T2/hu unknown
- 2016-07-27 JP JP2018504868A patent/JP6933641B2/ja active Active
- 2016-07-27 ES ES16831304T patent/ES2904255T3/es active Active
- 2016-07-27 WO PCT/US2016/044296 patent/WO2017019787A1/en not_active Ceased
- 2016-07-27 CR CR20180060A patent/CR20180060A/es unknown
- 2016-07-29 AR ARP160102316A patent/AR105768A1/es unknown
-
2018
- 2018-01-12 ZA ZA2018/00227A patent/ZA201800227B/en unknown
- 2018-01-26 SV SV2018005620A patent/SV2018005620A/es unknown
- 2018-01-26 CL CL2018000227A patent/CL2018000227A1/es unknown
- 2018-01-26 CO CONC2018/0000801A patent/CO2018000801A2/es unknown
- 2018-01-26 NI NI201800013A patent/NI201800013A/es unknown
- 2018-01-29 EC ECIEPI20186878A patent/ECSP18006878A/es unknown
- 2018-06-07 US US16/002,994 patent/US20180346925A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2018000227A1 (es) | 2018-04-27 |
| CN107849571B (zh) | 2022-04-19 |
| RU2018107162A3 (es) | 2020-01-28 |
| AR105768A1 (es) | 2017-11-08 |
| PE20180775A1 (es) | 2018-05-07 |
| ES2904255T3 (es) | 2022-04-04 |
| US10100330B2 (en) | 2018-10-16 |
| UA126327C2 (uk) | 2022-09-21 |
| ZA201800227B (en) | 2018-12-19 |
| EP3328187A4 (en) | 2019-01-09 |
| US20180346925A1 (en) | 2018-12-06 |
| CA2992084A1 (en) | 2017-02-02 |
| BR112018001379A2 (pt) | 2018-09-11 |
| CO2018000801A2 (es) | 2018-04-10 |
| RU2018107162A (ru) | 2019-08-28 |
| RU2765310C2 (ru) | 2022-01-28 |
| MX2018001258A (es) | 2018-04-20 |
| HRP20211858T1 (hr) | 2022-03-04 |
| JP6933641B2 (ja) | 2021-09-08 |
| CR20180060A (es) | 2018-07-09 |
| WO2017019787A1 (en) | 2017-02-02 |
| JP2018525987A (ja) | 2018-09-13 |
| MX378742B (es) | 2025-03-10 |
| NI201800013A (es) | 2018-06-12 |
| EP3328187B1 (en) | 2021-11-10 |
| CN107849571A (zh) | 2018-03-27 |
| BR112018001379B1 (pt) | 2024-04-30 |
| US20170044568A1 (en) | 2017-02-16 |
| HUE057364T2 (hu) | 2022-05-28 |
| SV2018005620A (es) | 2018-08-31 |
| EP3328187A1 (en) | 2018-06-06 |
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