[go: up one dir, main page]

ECSP18091593A - Anticuerpos antifactor de la coagulación xi - Google Patents

Anticuerpos antifactor de la coagulación xi

Info

Publication number
ECSP18091593A
ECSP18091593A ECSENADI201891593A ECDI201891593A ECSP18091593A EC SP18091593 A ECSP18091593 A EC SP18091593A EC SENADI201891593 A ECSENADI201891593 A EC SENADI201891593A EC DI201891593 A ECDI201891593 A EC DI201891593A EC SP18091593 A ECSP18091593 A EC SP18091593A
Authority
EC
Ecuador
Prior art keywords
antibodies
antifactor
coagulation
fxi
coagulation factor
Prior art date
Application number
ECSENADI201891593A
Other languages
English (en)
Inventor
Oldham Elizabeth
Seiffert Dietmar
P Ellsworth Kenneth
Ganti Vaishnavi
Tabrizifard Mohammad
Chen Zhu
Milligan James
Prinz Bianka
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ECSP18091593A publication Critical patent/ECSP18091593A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen anticuerpos que se unen al dominio apple 3 del factor de la coagulación humano XI e inhiben la activación del FXI por el factor de la coagulación XIIa, así como la activación del FXI por el FXa.
ECSENADI201891593A 2016-06-14 2018-12-11 Anticuerpos antifactor de la coagulación xi ECSP18091593A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662349888P 2016-06-14 2016-06-14

Publications (1)

Publication Number Publication Date
ECSP18091593A true ECSP18091593A (es) 2019-01-31

Family

ID=59078269

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201891593A ECSP18091593A (es) 2016-06-14 2018-12-11 Anticuerpos antifactor de la coagulación xi

Country Status (29)

Country Link
US (6) US10676536B2 (es)
EP (1) EP3469002A1 (es)
JP (2) JP7022081B2 (es)
KR (2) KR102379580B1 (es)
CN (2) CN109476758B (es)
AR (1) AR108717A1 (es)
AU (3) AU2017286432B2 (es)
BR (1) BR112018075858A2 (es)
CA (2) CA3025869C (es)
CL (2) CL2018003565A1 (es)
CO (1) CO2018013434A2 (es)
CR (1) CR20180583A (es)
DO (1) DOP2018000284A (es)
EA (1) EA201892716A1 (es)
EC (1) ECSP18091593A (es)
GE (2) GEAP202114983A (es)
IL (2) IL315266A (es)
JO (1) JOP20180121A1 (es)
MA (1) MA45234A (es)
MX (2) MX2018015757A (es)
MY (1) MY201852A (es)
NI (1) NI201800134A (es)
PE (1) PE20190416A1 (es)
PH (1) PH12018502586A1 (es)
SG (2) SG10202103120UA (es)
TN (1) TN2018000417A1 (es)
TW (2) TWI802193B (es)
UA (1) UA129793C2 (es)
WO (1) WO2017218371A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
IL315266A (en) * 2016-06-14 2024-10-01 Merck Sharp ַ& Dohme Llc Anti-coagulation factor xi antibodies
CN110325550B (zh) 2016-12-23 2024-03-08 诺华股份有限公司 因子xi抗体和使用方法
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
MX2022015959A (es) * 2020-07-02 2023-01-24 Beijing Tuo Jie Biopharmaceutical Co Ltd Anticuerpo anti-fxi/fxia, fragmento de union a antigeno del mismo y uso farmaceutico del mismo.
KR20230035079A (ko) * 2020-07-03 2023-03-10 수조우 알파맵 씨오., 엘티디. 응고인자 xi(fxi) 결합 단백질
CA3207703A1 (en) * 2021-02-09 2022-08-18 Jonas Hallen Anti-s100a4 humanized antibodies, uses and methods
CN116199782A (zh) * 2021-11-30 2023-06-02 苏州康宁杰瑞生物科技有限公司 预防和/或治疗血栓栓塞性疾病的方法
CN120858120A (zh) * 2022-12-30 2025-10-28 甘李药业股份有限公司 抗凝血因子XI和/或其活化形式因子XIa的抗体及其用途
WO2025130748A1 (zh) * 2023-12-22 2025-06-26 四川科伦博泰生物医药股份有限公司 一种抗凝血因子XI/XIa抗体制剂

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
WO1989012463A1 (en) 1988-06-21 1989-12-28 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
WO1993011161A1 (en) 1991-11-25 1993-06-10 Enzon, Inc. Multivalent antigen-binding proteins
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
JPH0656382A (ja) 1992-08-04 1994-03-01 Kawasaki Steel Corp コークス乾式消火装置のバケット巻上機の吊ビーム装置
MA24512A1 (fr) 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
JP2002531466A (ja) 1998-12-01 2002-09-24 プロテイン デザイン ラブス， インコーポレイテッド γ−インターフェロンに対するヒト化抗体
WO2001066754A1 (en) 2000-03-03 2001-09-13 Cambridge Antibody Technology Limited Human antibodies against eotaxin and their use
CA2492671C (en) 2002-03-22 2012-04-17 Aprogen, Inc. Humanized antibody and process for preparing same
GEP20104887B (en) 2003-07-15 2010-02-10 Medarex Inc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
CN101120087A (zh) 2004-12-21 2008-02-06 森托科尔公司 抗-il-12抗体、表位、组合物、方法和用途
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
PL1960434T3 (pl) 2005-12-08 2012-12-31 Squibb & Sons Llc Ludzkie przeciwciała monoklonalne przeciw fozylowi-gm1 i sposoby zastosowania antyfukozylu-gm1
EA017812B1 (ru) 2005-12-08 2013-03-29 Медарекс, Инк. Выделенное моноклональное антитело или его антигенсвязывающий участок, которые связываются с протеинтирозинкиназой 7 ( ptk7) человека, и их применение
US7960518B2 (en) 2006-06-06 2011-06-14 Crucell Holland B.V. Human binding molecules having killing activity against enterococci and uses thereof
CN103524619B (zh) 2006-08-03 2016-10-05 阿斯利康(瑞典)有限公司 针对αVβ6的抗体及其应用
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
EP2134749B1 (en) 2007-03-22 2013-11-06 The Regents of the University of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
GB0708585D0 (en) 2007-05-03 2007-06-13 Queen Mary & Westfield College Novel antibody and use in diagnosis and therapy of arthropathies
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
CN101855242B (zh) 2007-09-14 2014-07-30 阿迪马布有限责任公司 合理设计的合成抗体文库及其用途
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
PL2207809T3 (pl) 2007-09-26 2014-02-28 U3 Pharma Gmbh Białka wiążące wiążący heparynę czynnik wzrostu podobny do naskórkowego czynnika wzrostu jako antygen
HUE046564T2 (hu) 2007-11-21 2020-03-30 Univ Oregon Health & Science XI-es faktor elleni monoklonális antitestek és eljárások az alkalmazásukra
AU2016203944A1 (en) 2007-11-21 2016-07-07 Oregon Health & Science University Anti-factor xi monoclonal antibodies and methods of use thereof
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
US20110159006A1 (en) * 2008-06-19 2011-06-30 Erik Hack Use of anti-factor xi antibodies for prevention of thrombus formation
EP2313434A4 (en) 2008-07-31 2013-03-27 Univ California ANTIBODIES FOR NEUTRALIZING BOTULINE NEUROTOXINES
HUE031756T2 (en) 2008-10-31 2017-07-28 Janssen Biotech Inc TLR3 antagonists
JP2012508017A (ja) 2008-11-07 2012-04-05 ファブラス エルエルシー 抗ｄｌｌ４抗体及びその使用
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
LT2373691T (lt) 2008-12-18 2019-05-27 Oregon Health & Science University Anti-fxi antikūnai ir jų panaudojimo būdai
EP2379595A2 (en) 2008-12-23 2011-10-26 AstraZeneca AB Targeted binding agents directed to 5 1 and uses thereof
WO2010108154A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Selective and potent peptide inhibitors of kv1.3
US8722860B2 (en) 2009-04-16 2014-05-13 Abbvie Biotherapeutics Inc. Anti-TNF-α antibodies and their uses
EP2426148B1 (en) 2009-04-27 2015-08-05 Kyowa Hakko Kirin Co., Ltd. Anti-il-3ra antibody for use in treatment of blood tumor
US8435516B2 (en) 2009-10-12 2013-05-07 Pfizer Inc. Cancer treatment
JP6007420B2 (ja) 2009-11-04 2016-10-12 ファブラス エルエルシー 親和性成熟に基づく抗体最適化方法
EP2516624B1 (en) 2009-12-23 2020-02-05 Merck Sharp & Dohme Corp. Cell line 3m
EP2532151A2 (en) * 2010-02-03 2012-12-12 Trilogy IP Holdings, Inc. Mobile communication plan offerings
DK2593594T3 (en) 2010-07-16 2017-12-11 Adimab Llc ANTIBODY LIBRARIES
CA2815154A1 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment
KR101919170B1 (ko) 2010-11-19 2018-11-15 에자이 알앤드디 매니지먼트 가부시키가이샤 중화 항-ccl20 항체
CN103635489B (zh) 2011-01-06 2016-04-13 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
EP2694553B1 (en) 2011-04-01 2017-10-11 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2
ES2929575T3 (es) 2011-06-06 2022-11-30 Novo Nordisk As Anticuerpos terapéuticos
US8765385B2 (en) 2011-10-27 2014-07-01 Ravindra Kumar Method of detection of neutralizing anti-actriib antibodies
EP2650310B1 (en) 2012-04-13 2016-06-08 Rottapharm Biotech S.r.l. Anti-ADAMTS-5 antibody, derivatives and uses thereof
WO2013167669A1 (en) 2012-05-10 2013-11-14 Bayer Pharma Aktiengesellschaft Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof
JP6441792B2 (ja) 2012-05-17 2018-12-19 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｅｇｆｒに結合する抗原結合蛋白質
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
WO2015049280A1 (en) 2013-10-01 2015-04-09 Medimmune Limited Methods of treating and diagnosing alpha-v-beta-6 overexpressing cancer
JPWO2015141826A1 (ja) 2014-03-20 2017-04-13 国立感染症研究所長 Ｃ型肝炎ウイルスに対する感染阻害活性を有する抗体
NZ726911A (en) 2014-06-03 2023-01-27 Xbiotech Inc Compositions and methods for treating and preventing staphylococcus aureus infections
EP3177322A4 (en) 2014-08-08 2018-07-18 Alector LLC Anti-trem2 antibodies and methods of use thereof
US9139653B1 (en) 2015-04-30 2015-09-22 Kymab Limited Anti-human OX40L antibodies and methods of treatment
CA2981851A1 (en) 2015-04-07 2016-10-13 Alector Llc Anti-sortilin antibodies and methods of use thereof
HK1252675A1 (zh) 2015-06-12 2019-05-31 Alector Llc 抗cd33抗体及其使用方法
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
US11066481B2 (en) 2015-07-23 2021-07-20 The Regents Of The University Of California Antibodies to coagulation factor XIa and uses thereof
JP7628764B2 (ja) 2015-09-29 2025-02-12 アムジエン・インコーポレーテツド Ａｓｇｒ阻害剤
BR112018014810A2 (pt) 2016-01-22 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-fator xi de coagulação
IL315266A (en) 2016-06-14 2024-10-01 Merck Sharp ַ& Dohme Llc Anti-coagulation factor xi antibodies
RU2758160C2 (ru) 2016-09-20 2021-10-26 Байер Фарма Акциенгезельшафт Новые антитела против фактора xi и их применения

Also Published As

Publication number Publication date
GEP20227382B (en) 2022-05-25
JOP20180121A1 (ar) 2018-12-12
TW202214702A (zh) 2022-04-16
AU2017286432B2 (en) 2020-09-24
CA3172367A1 (en) 2017-12-21
KR20190018504A (ko) 2019-02-22
IL315266A (en) 2024-10-01
CA3025869A1 (en) 2017-12-21
CR20180583A (es) 2019-07-02
TWI802193B (zh) 2023-05-11
IL263272A (en) 2018-12-31
NZ786442A (en) 2025-06-27
MA45234A (fr) 2019-04-17
US11512142B2 (en) 2022-11-29
CO2018013434A2 (es) 2018-12-28
SG10202103120UA (en) 2021-05-28
MY201852A (en) 2024-03-20
US11485794B2 (en) 2022-11-01
AU2017286432A1 (en) 2018-12-06
KR102379580B1 (ko) 2022-03-29
KR102218714B1 (ko) 2021-02-24
TWI752964B (zh) 2022-01-21
AR108717A1 (es) 2018-09-19
JP2019521978A (ja) 2019-08-08
KR20210021124A (ko) 2021-02-24
PE20190416A1 (es) 2019-03-19
US20200317811A1 (en) 2020-10-08
EA201892716A1 (ru) 2019-05-31
CL2024000367A1 (es) 2024-08-23
JP7277500B2 (ja) 2023-05-19
US11479615B2 (en) 2022-10-25
IL263272B2 (en) 2025-07-01
CN109476758A (zh) 2019-03-15
MX2023012740A (es) 2024-02-23
NZ786443A (en) 2025-06-27
WO2017218371A1 (en) 2017-12-21
AU2024201084A1 (en) 2024-03-14
CN109476758B (zh) 2023-05-23
BR112018075858A2 (pt) 2019-04-02
TN2018000417A1 (en) 2020-06-15
EP3469002A1 (en) 2019-04-17
CA3025869C (en) 2025-10-07
NZ786444A (en) 2025-06-27
IL263272B1 (en) 2025-03-01
NZ786447A (en) 2025-06-27
PH12018502586A1 (en) 2019-10-07
SG11201810763TA (en) 2018-12-28
CN116425879A (zh) 2023-07-14
US11661460B2 (en) 2023-05-30
US20200308302A1 (en) 2020-10-01
US20200255542A1 (en) 2020-08-13
US20200270364A1 (en) 2020-08-27
NI201800134A (es) 2019-03-05
AU2020210233A1 (en) 2020-08-20
US12275800B2 (en) 2025-04-15
MX2018015757A (es) 2019-05-30
AU2020210233B2 (en) 2024-03-07
CL2018003565A1 (es) 2019-03-22
US10676536B2 (en) 2020-06-09
US20230287141A1 (en) 2023-09-14
UA129793C2 (uk) 2025-08-06
NZ786448A (en) 2025-06-27
TW201802120A (zh) 2018-01-16
NZ748743A (en) 2025-06-27
JP7022081B2 (ja) 2022-02-17
US20170355780A1 (en) 2017-12-14
GEAP202114983A (en) 2021-12-10
DOP2018000284A (es) 2019-01-31
JP2021101720A (ja) 2021-07-15

Similar Documents

Publication Publication Date Title
CL2024000367A1 (es) Anticuerpos antifactor de la coagulación xi.
MX2018008939A (es) Anticuerpos anti-factor de la coagulacion xi.
CY1125327T1 (el) Anti-pd-1 αντισωματα και συνθεσεις
CY1124663T1 (el) Αντιιικα παραγωγα ν4-υδροξυκυτιδινης
CY1124215T1 (el) Μκ2 αναστολεις και χρησεις αυτων
EA202091540A1 (ru) Антитела к lilrb2
CL2018001478A1 (es) Agonistas del receptor de apelina y métodos de uso
JOP20190194A1 (ar) مركبات نيوكليوتيدات ثنائية حلقية لعلاج السرطان
MX385915B (es) Anticuerpos anti-tigit, anticuerpos anti-pvrig y combinaciones de estos
EA202092435A3 (ru) Моноклональные антитела против bcma
EA201791485A1 (ru) Анти-cd47-антитела и их применения
UY35417A (es) Anticuerpos dirigidos contra il-33 y sus usos.
DOP2015000269A (es) Composiciones y métodos para alterar la señalización del segundo mensajero
TR201808169T3 (tr) Rekombinant probiyotik bakteriler .
CY1124338T1 (el) Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτων
EA201691610A1 (ru) Анти-jagged1 антитела и способы применения
EA201692091A1 (ru) Хиноксалиновые соединения и их применение
SA518400237B1 (ar) SIRPa أجسم مضادة لـ جديدة وتطبيقاتها العلاجية
MX373818B (es) Composiciones de apilimod y métodos para usar las mismas.
EA201991997A1 (ru) Комбинированная терапия
MX377663B (es) Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados.
EP3602547C0 (en) TARGET SAMPLE GENERATION
EA201692028A1 (ru) Применение замещенных оксотетрагидрохинолинилсульфонамидов или их солей для повышения стрессоустойчивости растений
MX374286B (es) Compuestos organolepticos novedosos.
MX380297B (es) Compuestos organolépticos novedosos.