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ECSP13012764A - COMPUESTO DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO COMO INHIBIDOR DUAL DE CINASA PI3/mTOR - Google Patents

COMPUESTO DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO COMO INHIBIDOR DUAL DE CINASA PI3/mTOR

Info

Publication number
ECSP13012764A
ECSP13012764A ECSP13012764A ECSP13012764A EC SP13012764 A ECSP13012764 A EC SP13012764A EC SP13012764 A ECSP13012764 A EC SP13012764A EC SP13012764 A ECSP13012764 A EC SP13012764A
Authority
EC
Ecuador
Prior art keywords
mtor
quinolin
ona
kinase
dual inhibitor
Prior art date
Application number
Other languages
English (en)
Inventor
David Anthony Barda
Mary Margaret Mader
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP13012764A publication Critical patent/ECSP13012764A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto de imidazo[4,5-c]quinolin-2-ona, o una sal del mismo farmacéuticamente aceptable, que inhibe tanto PI3K como mTOR y, por lo tanto, es útil en el tratamiento de cáncer.
ECSP13012764 2011-01-14 2013-07-12 COMPUESTO DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO COMO INHIBIDOR DUAL DE CINASA PI3/mTOR ECSP13012764A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161432958P 2011-01-14 2011-01-14

Publications (1)

Publication Number Publication Date
ECSP13012764A true ECSP13012764A (es) 2013-09-30

Family

ID=45531593

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012764 ECSP13012764A (es) 2011-01-14 2013-07-12 COMPUESTO DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO COMO INHIBIDOR DUAL DE CINASA PI3/mTOR

Country Status (39)

Country Link
US (2) US8440829B2 (es)
EP (1) EP2663564B1 (es)
JP (1) JP5891247B2 (es)
KR (1) KR101561360B1 (es)
CN (1) CN103282364B (es)
AR (1) AR084551A1 (es)
AU (1) AU2012205619B2 (es)
BR (1) BR112013017672A2 (es)
CA (1) CA2824760C (es)
CL (1) CL2013002005A1 (es)
CO (1) CO6731133A2 (es)
CR (1) CR20130289A (es)
CY (1) CY1116007T1 (es)
DK (1) DK2663564T3 (es)
DO (1) DOP2013000158A (es)
EA (1) EA022163B1 (es)
EC (1) ECSP13012764A (es)
ES (1) ES2531891T3 (es)
GT (1) GT201300180A (es)
HR (1) HRP20150135T1 (es)
HU (1) HUE024426T2 (es)
IL (1) IL227165A (es)
JO (1) JO3003B1 (es)
ME (1) ME02019B (es)
MX (1) MX2013008185A (es)
MY (1) MY164705A (es)
PE (1) PE20140864A1 (es)
PH (1) PH12013501493A1 (es)
PL (1) PL2663564T3 (es)
PT (1) PT2663564E (es)
RS (1) RS53828B1 (es)
SG (1) SG191744A1 (es)
SI (1) SI2663564T1 (es)
SV (1) SV2013004496A (es)
TN (1) TN2013000237A1 (es)
TW (1) TWI518086B (es)
UA (1) UA109921C2 (es)
WO (1) WO2012097039A1 (es)
ZA (1) ZA201304757B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3003B1 (ar) 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
US20160264570A1 (en) * 2013-11-15 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Method of blocking transmission of malarial parasite
TWI609687B (zh) 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
TW201703769A (zh) 2015-05-08 2017-02-01 美國禮來大藥廠 用於癌症的組合療法
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
KR20180081580A (ko) * 2015-12-15 2018-07-16 일라이 릴리 앤드 캄파니 암에 대한 조합 요법
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
KR102418765B1 (ko) * 2016-04-12 2022-07-08 일라이 릴리 앤드 캄파니 암 치료를 위한 Notch 및 CDK4/6 억제제의 조합 요법
CN109310685B (zh) * 2016-04-12 2021-10-29 伊莱利利公司 用于治疗癌症的notch和pi3k/mtor抑制剂的组合疗法
CN109475629A (zh) 2016-05-20 2019-03-15 伊莱利利公司 用notch和pd-1或pd-l1抑制剂的组合治疗
WO2018017410A1 (en) 2016-07-22 2018-01-25 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of breast cancer
WO2018063873A1 (en) * 2016-09-27 2018-04-05 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of pancreatic cancer
CA3039405A1 (en) 2016-10-12 2018-04-19 Eli Lilly And Company Targeted treatment of mature t-cell lymphoma
ES2949364T3 (es) 2017-02-17 2023-09-28 Fred Hutchinson Cancer Center Terapias de combinación para el tratamiento de cánceres y trastornos autoinmunitarios relacionados con BCMA
US12193994B2 (en) 2017-11-06 2025-01-14 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
EP4302827A3 (en) 2018-06-15 2024-03-13 JANSSEN Pharmaceutica NV Rapamycin analogs and uses thereof
WO2020081329A1 (en) * 2018-10-18 2020-04-23 Camp4 Therapeutics Corporation Methods and compositions for modulating pcsk9 and angptl3 expression
MX2022006807A (es) 2019-12-05 2022-09-12 Anakuria Therapeutics Inc Análogos de rapamicina y usos de estos.
WO2022060377A1 (en) * 2020-09-21 2022-03-24 Wei Zhong Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
JP2025500409A (ja) 2021-12-22 2025-01-09 キャンプ４ セラピューティクス コーポレイション 調節ｒｎａを標的とするアンチセンスオリゴヌクレオチドを用いた遺伝子転写の調節方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
AR046845A1 (es) * 2003-11-21 2005-12-28 Novartis Ag Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas
CA2546117A1 (en) 2003-11-21 2005-06-16 Novartis Ag 1h-imidazoquinoline derivatives as protein kinase inhibitors
AU2006216798A1 (en) * 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Hydroxyalkyl substituted imidazoquinoline compounds and methods
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CA2628131C (en) 2005-11-04 2012-03-20 Coley Pharmaceutical Group, Inc. Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods
WO2007106854A2 (en) 2006-03-15 2007-09-20 Coley Pharmaceutical Group, Inc. Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods
CA2735932C (en) * 2008-09-30 2013-07-09 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
KR101445458B1 (ko) 2009-06-04 2014-10-07 노파르티스 아게 １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체
EP2438063A1 (en) 2009-06-04 2012-04-11 Novartis AG 1h-imidazo[4,5-c]quinolinone compounds, useful for the treatment of proliferative diseases
JP2012532187A (ja) * 2009-06-30 2012-12-13 ピラマル・ライフ・サイエンシーズ・リミテッド イミダゾ［４，５−ｃ］キノリン誘導体ならびに腫瘍および／または炎症の治療におけるそれらの使用
WO2012077031A1 (en) * 2010-12-06 2012-06-14 Piramal Life Sciences Limited Substituted imidazoquinoline derivatives
JO3003B1 (ar) 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor

Also Published As

Publication number Publication date
CO6731133A2 (es) 2013-08-15
CN103282364B (zh) 2015-06-17
EP2663564B1 (en) 2014-12-17
TN2013000237A1 (en) 2014-11-10
RS53828B1 (sr) 2015-06-30
US8658668B2 (en) 2014-02-25
EA022163B1 (ru) 2015-11-30
DOP2013000158A (es) 2013-11-30
ZA201304757B (en) 2014-12-23
UA109921C2 (uk) 2015-10-26
EA201390823A1 (ru) 2013-12-30
IL227165A (en) 2016-06-30
CA2824760A1 (en) 2012-07-19
PH12013501493A1 (en) 2021-06-02
DK2663564T3 (en) 2015-01-12
WO2012097039A1 (en) 2012-07-19
BR112013017672A2 (pt) 2018-09-18
KR101561360B1 (ko) 2015-10-16
TWI518086B (zh) 2016-01-21
MY164705A (en) 2018-01-30
PT2663564E (pt) 2015-02-24
MX2013008185A (es) 2013-08-21
CL2013002005A1 (es) 2013-12-27
PE20140864A1 (es) 2014-07-19
CR20130289A (es) 2013-10-07
HUE024426T2 (en) 2016-01-28
HK1188454A1 (en) 2014-05-02
GT201300180A (es) 2014-04-08
CY1116007T1 (el) 2017-01-25
CA2824760C (en) 2016-03-15
SV2013004496A (es) 2017-11-07
JO3003B1 (ar) 2016-09-05
HRP20150135T1 (xx) 2015-03-13
AU2012205619A1 (en) 2013-06-27
NZ611541A (en) 2015-02-27
AR084551A1 (es) 2013-05-22
KR20130116302A (ko) 2013-10-23
JP5891247B2 (ja) 2016-03-22
SG191744A1 (en) 2013-08-30
US20130237562A1 (en) 2013-09-12
ES2531891T3 (es) 2015-03-20
CN103282364A (zh) 2013-09-04
SI2663564T1 (sl) 2015-01-30
ME02019B (me) 2015-05-20
EP2663564A1 (en) 2013-11-20
AU2012205619B2 (en) 2015-05-21
JP2014502638A (ja) 2014-02-03
US8440829B2 (en) 2013-05-14
TW201307343A (zh) 2013-02-16
US20120184577A1 (en) 2012-07-19
PL2663564T3 (pl) 2015-05-29

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