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ECSP11010809A - Derivados de pirazolo[3,4-d]pirimidin-4-il y sus usos en el tratamiento de diabetes y obesidad - Google Patents

Derivados de pirazolo[3,4-d]pirimidin-4-il y sus usos en el tratamiento de diabetes y obesidad

Info

Publication number
ECSP11010809A
ECSP11010809A EC2011010809A ECSP11010809A ECSP11010809A EC SP11010809 A ECSP11010809 A EC SP11010809A EC 2011010809 A EC2011010809 A EC 2011010809A EC SP11010809 A ECSP11010809 A EC SP11010809A EC SP11010809 A ECSP11010809 A EC SP11010809A
Authority
EC
Ecuador
Prior art keywords
treatment
pirazolo
pirimidin
obesity
diabetes
Prior art date
Application number
EC2011010809A
Other languages
English (en)
Inventor
Michael James Waring
Robert Davies
Leonie Campbell
Roger John Butlin
Graeme Richard Robb
Stuart Norman Lile Bennett
Peter Gustaf Bonn
Mikael Dan Brink
Jonas Rickard Fagerhag
Ulrik Jurva
Helen Claire Pointon
Rolf Peter Walker
Christer Ralf Westerlund
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP11010809A publication Critical patent/ECSP11010809A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de fórmula (I), es útil en el tratamiento o prevención de una enfermedad o afección médica mediada por glucoquinasa (GLK o GK), que conduce a una reducción del umbral de glucosa para la secreción de insulina
EC2011010809A 2008-08-04 2011-02-04 Derivados de pirazolo[3,4-d]pirimidin-4-il y sus usos en el tratamiento de diabetes y obesidad ECSP11010809A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8591908P 2008-08-04 2008-08-04
US16804809P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
ECSP11010809A true ECSP11010809A (es) 2011-03-31

Family

ID=41563374

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010809A ECSP11010809A (es) 2008-08-04 2011-02-04 Derivados de pirazolo[3,4-d]pirimidin-4-il y sus usos en el tratamiento de diabetes y obesidad

Country Status (23)

Country Link
US (1) US8143263B2 (es)
EP (1) EP2324028A2 (es)
JP (1) JP2011529955A (es)
KR (1) KR20110052676A (es)
CN (1) CN102171213A (es)
AR (1) AR072900A1 (es)
AU (1) AU2009278929B2 (es)
BR (1) BRPI0917589A2 (es)
CA (1) CA2732165A1 (es)
CL (1) CL2011000249A1 (es)
CO (1) CO6351730A2 (es)
CR (1) CR20110065A (es)
DO (1) DOP2011000047A (es)
EA (1) EA201100097A1 (es)
EC (1) ECSP11010809A (es)
IL (1) IL210778A0 (es)
MX (1) MX2011001333A (es)
PE (1) PE20110568A1 (es)
SV (1) SV2011003829A (es)
TW (1) TW201011026A (es)
UY (1) UY32032A (es)
WO (1) WO2010015849A2 (es)
ZA (1) ZA201101663B (es)

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CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
WO2010116177A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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CN106749265A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106749263A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106361753A (zh) * 2016-11-13 2017-02-01 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
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GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form

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