EA201070437A3 - Способ получения 2'-дезокси -5-азацитидина (децитабина) - Google Patents
Способ получения 2'-дезокси -5-азацитидина (децитабина)Info
- Publication number
- EA201070437A3 EA201070437A3 EA201070437A EA201070437A EA201070437A3 EA 201070437 A3 EA201070437 A3 EA 201070437A3 EA 201070437 A EA201070437 A EA 201070437A EA 201070437 A EA201070437 A EA 201070437A EA 201070437 A3 EA201070437 A3 EA 201070437A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- formula
- decitabine
- deoxy
- azacitidine
- Prior art date
Links
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 title abstract 4
- 229960003603 decitabine Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 3
- -1 trimethylsilyl (TMS) residue Chemical group 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Способ получения 2'-дезокси-5-азацитидина (децитабина) путем предоставления соединения формулы (I), в которой R представляет собой удаляемый заместитель, известный per se; a Rпредставляет собой удаляемый заместитель; далее, предоставления силилированного основания формулы (II), в которой Rпредставляет собой защитную группу, предпочтительно триметилсилильный (TMS) остаток; осуществления взаимодействия соединения формулы (I) и соединения формулы (II) в подходящем безводном растворителе и в присутствии подходящего катализатора; и удаления заместителей R из полученного соединения с получением указанного соединения, представляющего собой 2'-дезокси-5-азацитидин (децитабин), при этом указанный катализатор выбирают из группы, включающей соль алифатической сульфокислоты или соль сильной неорганической кислоты.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07019826A EP2050757A1 (en) | 2007-10-10 | 2007-10-10 | Method of producing 2' -deoxy-5-azacytidine (Decitabine) |
| PCT/EP2008/063581 WO2009047313A2 (en) | 2007-10-10 | 2008-10-10 | Method of producing 2' -deoxy-5-azacytidine (decitabine) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201070437A2 EA201070437A2 (ru) | 2010-08-30 |
| EA201070437A3 true EA201070437A3 (ru) | 2011-02-28 |
| EA018924B1 EA018924B1 (ru) | 2013-11-29 |
Family
ID=39496166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201070437A EA018924B1 (ru) | 2007-10-10 | 2008-10-10 | Способ получения 2'-дезокси-5-азацитидина (децитабина) |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20100222565A1 (ru) |
| EP (2) | EP2050757A1 (ru) |
| JP (1) | JP5453279B2 (ru) |
| KR (1) | KR101551779B1 (ru) |
| CN (1) | CN102037003B (ru) |
| AP (1) | AP2719A (ru) |
| AU (1) | AU2008309552B2 (ru) |
| BR (1) | BRPI0818595B1 (ru) |
| CA (1) | CA2703560C (ru) |
| CO (1) | CO6270260A2 (ru) |
| CY (1) | CY1116540T1 (ru) |
| DK (1) | DK2201020T3 (ru) |
| EA (1) | EA018924B1 (ru) |
| EC (1) | ECSP10010091A (ru) |
| ES (1) | ES2512591T3 (ru) |
| GT (1) | GT201000076A (ru) |
| HN (1) | HN2010000654A (ru) |
| HR (1) | HRP20140856T1 (ru) |
| IL (1) | IL204918A0 (ru) |
| MX (1) | MX2010003887A (ru) |
| MY (1) | MY150047A (ru) |
| NI (1) | NI201000049A (ru) |
| NZ (1) | NZ584373A (ru) |
| PL (1) | PL2201020T3 (ru) |
| PT (1) | PT2201020E (ru) |
| SI (1) | SI2201020T1 (ru) |
| SV (1) | SV2010003523A (ru) |
| UA (1) | UA101482C2 (ru) |
| UY (1) | UY31388A1 (ru) |
| WO (1) | WO2009047313A2 (ru) |
| ZA (1) | ZA201002517B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2048151A1 (en) * | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
| US8586729B2 (en) * | 2008-10-03 | 2013-11-19 | Scinopharm Taiwan Ltd. | Synthesis of decitabine |
| EP2424845A4 (en) * | 2009-04-27 | 2014-03-05 | Reddys Lab Ltd Dr | PREPARATION OF DECITABIN |
| IT1399195B1 (it) * | 2010-03-30 | 2013-04-11 | Chemi Spa | Processo per la sintesi di azacitidina e decitabina |
| CN101948493A (zh) * | 2010-06-28 | 2011-01-19 | 江苏奥赛康药业有限公司 | 一种高纯度地西他滨的工业化生产方法 |
| KR101241321B1 (ko) * | 2010-08-05 | 2013-03-11 | 케이피엑스 라이프사이언스 주식회사 | 수율 및 순도가 개선된 데시타빈의 제조방법 |
| CN102391338A (zh) * | 2011-09-30 | 2012-03-28 | 重庆泰濠制药有限公司 | 一种地西他滨中间体粗品的纯化方法 |
| CN104211743A (zh) * | 2013-05-29 | 2014-12-17 | 南京工业大学 | 一种地西他宾的合成 |
| CN103601768B (zh) * | 2013-11-13 | 2015-09-30 | 齐鲁天和惠世制药有限公司 | 一种阿米卡星的制备方法 |
| CA3007357C (en) | 2015-12-03 | 2023-12-05 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| CN109912672B (zh) * | 2019-04-02 | 2021-07-27 | 江西师范大学 | 一种以邻炔基苯酚醚作为离去基的碱基糖苷化的方法 |
| CN112209976B (zh) * | 2019-07-10 | 2023-05-26 | 鲁南制药集团股份有限公司 | 一种地西他滨中间体化合物ⅴ |
| CN112209977B (zh) * | 2019-07-10 | 2023-05-26 | 鲁南制药集团股份有限公司 | 一种地西他滨中间体化合物ⅵ |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2012888C3 (de) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2508312A1 (de) * | 1975-02-24 | 1976-09-02 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| DE2757365A1 (de) * | 1977-12-20 | 1979-06-21 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
| US5426183A (en) * | 1992-06-22 | 1995-06-20 | Eli Lilly And Company | Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5606048A (en) | 1992-06-22 | 1997-02-25 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| WO1995012593A1 (en) * | 1993-11-05 | 1995-05-11 | The Noguchi Institute | 5-0-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, process for producing the same, and use thereof |
| CA2235598A1 (en) * | 1995-11-02 | 1997-05-09 | Hoe Joo Son | Novel nucleoside derivatives and process for preparing the same |
| PT1104415E (pt) * | 1998-08-12 | 2005-03-31 | Univ Emory | Metodo de preparacao de nucleosidos de 1,3-oxatiolano |
-
2007
- 2007-10-10 EP EP07019826A patent/EP2050757A1/en not_active Withdrawn
-
2008
- 2008-10-10 AP AP2010005226A patent/AP2719A/xx active
- 2008-10-10 CA CA2703560A patent/CA2703560C/en active Active
- 2008-10-10 WO PCT/EP2008/063581 patent/WO2009047313A2/en not_active Ceased
- 2008-10-10 AU AU2008309552A patent/AU2008309552B2/en active Active
- 2008-10-10 US US12/682,293 patent/US20100222565A1/en not_active Abandoned
- 2008-10-10 KR KR1020107009760A patent/KR101551779B1/ko active Active
- 2008-10-10 BR BRPI0818595-6A patent/BRPI0818595B1/pt active IP Right Grant
- 2008-10-10 UY UY31388A patent/UY31388A1/es active IP Right Grant
- 2008-10-10 PL PL08805203T patent/PL2201020T3/pl unknown
- 2008-10-10 EP EP08805203.0A patent/EP2201020B1/en active Active
- 2008-10-10 SI SI200831289T patent/SI2201020T1/sl unknown
- 2008-10-10 CN CN200880111108.0A patent/CN102037003B/zh active Active
- 2008-10-10 ES ES08805203.0T patent/ES2512591T3/es active Active
- 2008-10-10 PT PT88052030T patent/PT2201020E/pt unknown
- 2008-10-10 HR HRP20140856AT patent/HRP20140856T1/hr unknown
- 2008-10-10 EA EA201070437A patent/EA018924B1/ru unknown
- 2008-10-10 DK DK08805203.0T patent/DK2201020T3/da active
- 2008-10-10 MY MYPI2010001611A patent/MY150047A/en unknown
- 2008-10-10 UA UAA201004166A patent/UA101482C2/ru unknown
- 2008-10-10 JP JP2010528403A patent/JP5453279B2/ja active Active
- 2008-10-10 MX MX2010003887A patent/MX2010003887A/es active IP Right Grant
- 2008-10-10 NZ NZ584373A patent/NZ584373A/en unknown
-
2010
- 2010-04-05 CO CO10037834A patent/CO6270260A2/es active IP Right Grant
- 2010-04-06 GT GT201000076A patent/GT201000076A/es unknown
- 2010-04-08 IL IL204918A patent/IL204918A0/en active IP Right Grant
- 2010-04-09 SV SV2010003523A patent/SV2010003523A/es unknown
- 2010-04-09 ZA ZA2010/02517A patent/ZA201002517B/en unknown
- 2010-04-09 HN HN2010000654A patent/HN2010000654A/es unknown
- 2010-04-09 EC EC2010010091A patent/ECSP10010091A/es unknown
- 2010-04-09 NI NI201000049A patent/NI201000049A/es unknown
-
2014
- 2014-10-15 CY CY20141100844T patent/CY1116540T1/el unknown
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